Abstract:
:1-O-Alkyl-2-O-acetyl-sn-glycerol-3-phosphorylcholine (i.e., platelet-activating factor) was prepared and confirmed to possess potent platelet aggregating activity. It was also potent in aggregating and degranulating rabbit and human neutrophils. When injected into rabbits, the lipid induced profound neutropenia, thrombocytopenia, and anaphylactic symptoms. The lyso derivative of this lipid, 1-O-alkyl-sn-glycerol-3-phosphorylcholine, was inactive or several orders of magnitude weaker in inducing these responses. The acetylated lipid appears to be a potent stimulator of both platelets and neutrophils. Its anaphylactic-like toxicity may be related, at least in part, to its ability to aggregate or otherwise stimulate these cells.
journal_name
Inflammationjournal_title
Inflammationauthors
O'Flaherty JT,Miller CH,Lewis JC,Wykle RL,Bass DA,McCall CE,Waite M,DeChatelet LRdoi
10.1007/BF00914443subject
Has Abstractpub_date
1981-09-01 00:00:00pages
193-201issue
3eissn
0360-3997issn
1573-2576journal_volume
5pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Previous studies have suggested that Interleukin-6 (IL-6) acts as a marker of vasculitis. To determine the role of IL-6 in vasculitis we utilized two models of immune complex induced vascular injury (dermal Arthus and acute pulmonary alveolitis) in IL-6 deficient (IL-6(-/-)) and IL-6 sufficient (IL-6(+/+)) mice. Plasm...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-006-9011-1
更新日期:2005-12-01 00:00:00
abstract::Baicalin, a flavonoid monomer derived from Scutellaria baicalensis called Huangqin in mandarin, is the main active ingredient contributing to S. baicalensis' efficacy. It is known in China that baicalin has potential therapeutic effects on inflammatory diseases. However, its anti-inflammatory mechanism has still not b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0124-2
更新日期:2015-08-01 00:00:00
abstract::Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0317-3
更新日期:2016-04-01 00:00:00
abstract::To determine the effect of heat stress on histopathology of acute lung injury (ALI) caused by administration of lipopolysaccharide (LPS), and to determine the roles of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, IL-10 and surfactants in heat-induced tolerance to ALI, we administe...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1011040515262
更新日期:2001-06-01 00:00:00
abstract::Numerous cytokines, including vascular endothelial growth factor (VEGF), are implicated in the pathogenesis of sepsis. While overexpression of VEGF produces pulmonary capillary leak, the role of VEGF in sepsis is less clear. We investigated VEGF in sepsis, utilizing a VEGF trap (VEGF(T)). Polymicrobial sepsis was indu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-004-6050-3
更新日期:2004-10-01 00:00:00
abstract::We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9936-8
更新日期:2014-12-01 00:00:00
abstract::Naringin (COG) is a flavanone with various bioactivities including an expectorant effect, antitussive effect, and inhibitory effect on asthma and acute lung injury. The aims of the present study were to investigate the antiarthritis activities of COG and elucidate the underlying mechanisms with regard to its molecular...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0027-7
更新日期:2015-02-01 00:00:00
abstract::Inflammatory bowel disease (IBD) in humans is closely related to bacterial infection and the disruption of the intestinal barrier. Paeoniflorin (PF), a bioactive compound from Paeonia lactiflora Pallas plants, exerts a potential effect of anti-inflammatory reported in various researches. However, the effect of PF on i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01085-z
更新日期:2019-12-01 00:00:00
abstract::We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells, and dendritic cells migrated to the pleural cavity in a time-depende...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1025076111950
更新日期:2003-08-01 00:00:00
abstract::Type I allergy is characterized by the release of granule-associated mediators, lipid-derived substances, cytokines, and chemokines by activated mast cells. To evaluate the anti-allergic effects of macelignan isolated from Myristica fragrans Houtt., we determined its ability to inhibit calcium (Ca(2+)) influx, degranu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9490-1
更新日期:2012-10-01 00:00:00
abstract::Interleukin (IL)-8 and neutrophil inflammation play a vital role in the pathogenesis of chronic inflammatory airway diseases. A disintegrin and metalloproteinase 17 (ADAM17) cleaves ectodomains of various transmembrane proteins and is an important regulator of almost every cellular event. The aim of this work was to i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9386-5
更新日期:2012-06-01 00:00:00
abstract::This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9474-1
更新日期:2012-08-01 00:00:00
abstract::To investigate patients with severe acute pancreatitis (SAP) by dynamic levels of pro-/anti-inflammatory cytokines and endotoxin (ET) in plasma and the relationship between immunity and infection, organ dysfunction. Seventy-two patients with SAP were recruited. The ET, tumor necrosis factor-α (TNF-α), interleukin-6 (I...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9205-4
更新日期:2011-02-01 00:00:00
abstract::Integrin-α9 (ITGA9) and its corresponding ligands are involved in inflammatory and immune responses. The present study aimed to investigate whether ITGA9 participates in the development of chronic periodontitis (ChP) and to explore the underlying mechanisms. We collected gingival tissue and gingival crevicular fluid i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01226-9
更新日期:2020-08-01 00:00:00
abstract::Ruta graveolens L. (Rutaceae) are traditionally used for the treatment of rheumatism, arthritis and other inflammatory conditions in the traditional medicine of India, were evaluated for their protective effect in acute and chronic models of inflammation. Carrageenan induced rat paw edema and adjuvant induced arthriti...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9154-y
更新日期:2010-02-01 00:00:00
abstract::Comparison of the physiologic responses in rabbits to the intravenous infusion of two polymorphonuclear neutrophil (PMN) activators, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA), has revealed marked differences in kinetics for activation between these agents. FMLP infusion was ass...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915990
更新日期:1987-12-01 00:00:00
abstract::The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentratio...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9371-z
更新日期:2012-04-01 00:00:00
abstract::An acute neutrophilic lung injury was compared in Balb/c normal and nu/nu (nude) mice to assess the role of T lymphocytes in the resolution of acute pulmonary neutrophilic inflammation following the administration of endotoxin. Maximal neutrophilic infiltration occurred on day 1 post-endotoxin treatment and declined t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1027393715300
更新日期:1997-06-01 00:00:00
abstract::Air pollution events frequently occur in China during the winter. Most investigations of pollution studies have focused on the physical and chemical properties of PM2.5. Many of these studies have indicated that PM2.5 exacerbates asthma or eosinophil inflammation. However, few studies have evaluated the relationship b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01071-5
更新日期:2020-02-01 00:00:00
abstract::To study the efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of severe acute pancreatitis. SAP rat models were prepared and randomly divided into model control group and treated group. The sham-operated group was also set. At 3, 6 and 12 h after operation, the mortality rate, ascitic volumes,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-009-9109-3
更新日期:2009-04-01 00:00:00
abstract::The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01360-4
更新日期:2020-11-09 00:00:00
abstract::Tumour necrosis factor-α (TNFα) and polymorphonuclear neutrophils play key and interrelated roles in the inflammatory response against infectious agents. However, these entities can mediate significant tissue damage if their biological activity becomes deregulated. We have previously shown that canine hyperimmune froz...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9289-x
更新日期:2012-02-01 00:00:00
abstract::Using crossed immunoelectrophoresis, immunoelectrodiffusion, autoradiography, and equilibrium binding techniques, we demonstrate that the rat fetus, directly challenged in utero at 18 days by a single subcutaneous turpentine injection, presents a complex acute-phase plasma inflammatory response. A number of fetal seru...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918965
更新日期:1989-02-01 00:00:00
abstract::The world's number one cause of death is cardiovascular diseases. The pathogenesis of different disease entities in the cardiovascular disease spectrum is complicated and multifactorial. Inflammation in these complicated etiologies serves as a key position and is a significant cause of atherosclerosis, which contribut...
journal_title:Inflammation
pub_type: 杂志文章,评审
doi:10.1007/s10753-020-01290-1
更新日期:2020-12-01 00:00:00
abstract::We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-007-9020-8
更新日期:2007-04-01 00:00:00
abstract::Macrophages are one of the most heterogenic immune cells involved in skeletal muscle regeneration. After skeletal muscle damage, M1 phenotypes exhibit pro-inflammatory reaction. In a later stage, they are converted to M2 phenotypes with anti-inflammatory properties. To study when gene expressions of macrophage polariz...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-0024-x
更新日期:2015-02-01 00:00:00
abstract::Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01076-0
更新日期:2020-02-01 00:00:00
abstract::Aberrant activation of the NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, triggers a pathogenic inflammatory response in many inherited neurodegenerative disorders. Inflammation has recently been associated with valosin-containing protein (VCP)-associated diseases, caused by mi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0449-5
更新日期:2017-02-01 00:00:00
abstract::An inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been implicated in the pathogenesis of inflammatory lung diseases such as interstitial pneumonia (IP). To clarify the role of the inflammatory cytokine in the pathogenesis of lung inflammation, we introduced a murine TNF-alpha gene into murine lungs by t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1006992408052
更新日期:2000-02-01 00:00:00
abstract::This study examined the hypothesis that tumor cells metastatic to the pleura secrete a soluble factor(s) that directly increases endothelial cell permeability. Nitrocellulose filters were endothelialized with bovine pulmonary artery endothelial cells and exposed to conditioned media from either human lung adenocarcino...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01534438
更新日期:1994-08-01 00:00:00