Abstract:
:The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before CO application or topical treatment immediately after CO application (200 μg diluted in 70% acetone) with a single dose of Cur and Nano-cur. After 6 h, the animals were anesthetized and euthanized. The ears were sectioned into disks (6.0 mm diameter) and used to determine edema, myeloperoxidase (MPO) activity, and oxidative stress. Photoacoustic spectroscopy (PAS) was used to evaluate the percutaneous penetration of Cur and Nano-cur. Topical treatment with both preparations had a similar inhibitory effect on the development of edema, MPO activity, and the oxidative response. The PAS technique showed that the percutaneous permeation of both topically applied preparations was similar. Oral Nano-cur administration exerted a higher anti-inflammatory effect than Cur. Topical Cur and Nano-cur application at the same dose similarly inhibited the inflammatory and oxidative responses. Oral Nano-cur administration inhibited such responses at doses that were eight times lower than Cur, suggesting the better bioavailability of Nano-cur compared with Cur.Graphical abstract.
journal_name
Inflammationjournal_title
Inflammationauthors
Lima EP,Gonçalves OH,Ames FQ,Castro-Hoshino LV,Leimann FV,Cuman RKN,Comar JF,Bersani-Amado CAdoi
10.1007/s10753-020-01360-4subject
Has Abstractpub_date
2020-11-09 00:00:00eissn
0360-3997issn
1573-2576pii
10.1007/s10753-020-01360-4pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Obesity provokes an imbalance in the immune system, including an aberrant type I interferon response during some viral infections and after TLR stimulation. SOCS3 overexpression and altered systemic leptin levels could be responsible for the reduced type I interferon production in people with obesity and, eventually, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0452-x
更新日期:2017-02-01 00:00:00
abstract::We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9936-8
更新日期:2014-12-01 00:00:00
abstract::The role of peptide leukotrienes (p-LTs), especially LTC4 and LTD4 in liver disease, was investigated in mice experimental liver injury models. The liver injury was induced by the injection of bacterial lipopolysaccharide (LPS) into Corynebacterium parvum pretreated mice. Carbon tetrachloride (CCl4)-induced liver inju...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914311
更新日期:1989-12-01 00:00:00
abstract::The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...
journal_title:Inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10753-016-0379-2
更新日期:2016-08-01 00:00:00
abstract::Sanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01225-w
更新日期:2020-08-01 00:00:00
abstract::Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9440-y
更新日期:2012-08-01 00:00:00
abstract::Crohn's disease is an idiopathic, chronic inflammation of the gastrointestinal tract that causes narrowing and stricturing of primarily the small and large intestine. Although the mechanism(s) by which chronic inflammation promotes stricture formation remain to be defined, it does appear to be associated histologicall...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916587
更新日期:1993-08-01 00:00:00
abstract::We analyzed the influence of heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) on the generation of IL-1ra, IL-6, IL-10, and IL-12p40 and from leukocyte fractions in vitro. Polymorphonuclear neutrophil leukocytes (PMN) and peripheral blood mononuclear cells (PBMC) from 16 different hea...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1012883916991
更新日期:2001-10-01 00:00:00
abstract::The benzylideneacetophenone derivative JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] (JC3) was synthesized by modifying yakuchinone B obtained from the seeds of Alpinia oxyphylla, a member of the ginger family (Zingiberaceae), which are widely used as a folk remedy and as an anti-inflammatory. The aim o...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0947-8
更新日期:2019-06-01 00:00:00
abstract::Paeonol, a major ingredient isolated from Moutan Cort, has various pharmacological effects. Our previous studies have shown that paeonol can exert antioxidant and anti-inflammatory therapeutic effects on ethanol-induced experimental gastric ulcer (GU). Therefore, in this study, we designed two GU models in rats induce...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01285-y
更新日期:2020-12-01 00:00:00
abstract::This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release signi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00914189
更新日期:1979-07-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which involves many organs and presents with various symptoms. It has been shown that genetic and environmental factors play a major role in this disease and may affect the onset, activity, damage, and mortality of the disease. According to recent stud...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0201-6
更新日期:2015-12-01 00:00:00
abstract::Recent studies show that nuclear factor-kappa B (NF-κB) signaling pathway plays a key role in contributing to the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Tetrahydrocoptisine is one of the main active components of Chelidonium majus L. and has been described to be effective in suppressi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9945-7
更新日期:2014-12-01 00:00:00
abstract::The purpose of this study was to evaluate the rabbit anterior eye chamber as a quantitative measure of leukotaxis using 51Cr-labeled homologous leukocytes and then to determine the effects of ibuprofen on N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced leukotaxis. Leukocyte accumulation was assessed at various...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916277
更新日期:1985-09-01 00:00:00
abstract::In an effort to determine the mechanism of papain action in causing an emphysema-like lesion in hamsters, the number and types of cells and the activities of two lysosomal enzymes in the lung were determined after papain exposure. Three and four weeks after a 3-h exposure to an aerosol of 3% papain the following alter...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917321
更新日期:1978-03-01 00:00:00
abstract::Calgranulins are small calcium-binding proteins with several immunological functions involved in inflammatory processes. Calgranulin A is reported to be mainly associated with acute inflammation while calgranulin B seems to play a role in chronic inflammatory disorders. In this study we used a proteomic approach to an...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-008-9085-z
更新日期:2008-10-01 00:00:00
abstract::Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487038
更新日期:1996-10-01 00:00:00
abstract::The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9411-8
更新日期:2012-06-01 00:00:00
abstract::In this study, the effects of tyrosol were investigated in DSS-induced experimental ulcerative colitis model. For this purpose, rats were divided into five groups of seven rats in each: control group, colitis group (DSS-4%), tyrosol group (tyrosol 20 mg/kg), sulfasalazine (sulfasalazine+DSS 100 mg/kg), and treatment g...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01028-8
更新日期:2019-10-01 00:00:00
abstract::Interactions of macrophages with epithelium represent one of the pathways involved in regulating local immune mechanisms. We studied the effect of cell-cell contact with an epithelial monolayer on the phenotype of macrophages. Human monocytes and THP-1 macrophages were co-cultured with monolayers of human bronchial ep...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1023/a:1010975804179
更新日期:2001-08-01 00:00:00
abstract::The molecular mechanisms of innate immunity are closely associated with the development of non-alcoholic fatty liver disease (NAFLD). TNF-α is a key cytokine involved in the pathogenesis of metabolic inflammation like NAFLD. Melanoma differentiation-associated gene 5 (MDA5) is a member of the intracellular RNA helicas...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01073-3
更新日期:2019-12-01 00:00:00
abstract::Protamine sulfate induces enzyme secretion from rabbit neutrophils. Enzyme secretion is mainly due to exocytosis but, depending on the experimental conditions, a small amount of cytolysis may occur. As compared with stimulation of neutrophil functions by other activators, protamine sulfate-induced enzyme release by ex...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915825
更新日期:1986-12-01 00:00:00
abstract::Human blood leukocytes generated large amounts of superoxide (O2-) following stimulation by certain "cocktails" of soluble agents consisting of poly-L-arginine (PARG), phytohemagglutinin, the chemotactic peptide formyl-methionyl-leucyl-phenylalanine and polyanethole sulfanote (liquoid). A variety of cytochalasins, whi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916335
更新日期:1985-12-01 00:00:00
abstract::Shock is associated with inflammation-induced endothelial dysfunction. The aim of this study was to determine time-dependent alteration of blood biomarkers related to endothelial function in hemorrhagic and septic shocks. Hemorrhagic shock was induced by bleeding the animals. A cecal ligation and incision model was us...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0660-z
更新日期:2018-02-01 00:00:00
abstract::The liver is an immunocompetent organ that plays a key role in the immune response to infections, and the development of hepatic immune function during early postnatal stages has not been thoroughly characterized. This study analyzed the constitutive expression of complement factors, namely C3 and C9, and pattern reco...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-010-9265-5
更新日期:2011-12-01 00:00:00
abstract::Heterophragma adenophyllum is a traditional medicinal plant that has been used as anti-inflammatory and to relief muscular tension. In the current research, four isolated constitutes namely lapacho (1), peshawaraquinone (2), indanone derivatives (3), α-lapachone (4) of H. adenophyllum were tested for anti-inflammatory...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01333-7
更新日期:2021-02-01 00:00:00
abstract::To investigate the effect of dexmedetomidine post-conditioning on the inflammatory response and autophagy effect of focal cerebral ischemia reperfusion injury in rats, and further to study its potential mechanisms. Water maze was conducted to evaluate spatial learning and memory ability of middle cerebral artery occlu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01082-2
更新日期:2019-12-01 00:00:00
abstract::Two different substances, glycogen and thioglycollate, were used to recruit early peritoneal exudate cells (4h). In the acute phase of the inflammatory response the cellular infiltrate is large, and the predominant cell (greater than 95%) is the polymorphonuclear neutrophil. Supernatant had differing effects on lympho...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00910714
更新日期:1982-03-01 00:00:00
abstract::Exacerbations in chronic obstructive pulmonary disease (COPD) reduce quality of life and are associated with a more rapid deterioration of the disease. Growth differentiation factor-15 (GDF-15) is a novel candidate exacerbation biomarker. In this study, we aimed to assess GDF-15 as a biomarker of acute exacerbation of...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0158-5
更新日期:2015-10-01 00:00:00
abstract::C3b receptor (CR1) expression by neutrophils (PMNs) and erythrocytes (Es) from patients with chronic granulomatous disease (CGD) or with hyper-IgE, frequent infection (Job's) syndrome was compared with that of control subjects. The control subjects consisted of one group of patients with infections and a second group ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00918218
更新日期:1984-12-01 00:00:00