Cytokines increase proliferation of human intestinal smooth muscle cells: possible role in inflammation-induced stricture formation.

abstract：:Stacks of six membrane filters (8-mu pore size) were placed over the mouths of plastic tubes. The tubes were filled with casein (test) or NaCl (control) solution and implanted subcutaneously in white rats; each animal received one tube with casein and one control tube. After 12, 18, 24, and 36 h, the tubes were remove...

journal_title：Inflammation

authors： Egger G,Porta S,Gollmann D

更新日期：1982-06-01 00:00:00

abstract：:The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...

journal_title：Inflammation

authors： Kaufman MR,Babior BM

更新日期：1983-09-01 00:00:00

abstract：:Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subp...

journal_title：Inflammation

authors： Zeidler RB,Flynn JA,Arnold JC,Conley NS

更新日期：1987-09-01 00:00:00

abstract：:Lipopolysaccharide (LPS) increases serum TNF-alpha levels due to TNF-alpha secretion by macrophages. The serum TNF-alpha response to LPS was augmented 10x when FcgammaR ligation was induced by the intravenous injection of Gig-coated erythrocytes (IgG) prior to the administration of LPS. The macrophage population respo...

journal_title：Inflammation

authors： Loegering DJ,Lennartz MR

更新日期：2002-12-01 00:00:00

abstract：:Ischemic stroke is a major cause of death and motor disabilities all over the world. It is a muti-factorial disorder associated with inflammatory, apoptotic, and oxidative responses. Nateglinide (NAT), an insulinotropic agent used for the treatment of type 2 diabetes mellitus, recently showed potential anti-inflammato...

journal_title：Inflammation

authors： Saad MAE,Fahmy MIM,Al-Shorbagy M,Assaf N,Hegazy AAE,El-Yamany MF

更新日期：2020-04-01 00:00:00

abstract：:Sanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model...

journal_title：Inflammation

authors： Zhao Y,Xu J

更新日期：2020-08-01 00:00:00

abstract：:Following publication of our article [1], we noticed an error in Fig. 1. ...

journal_title：Inflammation

authors： Zhang X,Chen Y,Yu S,Jin B,Liu W

更新日期：2020-11-10 00:00:00

abstract：:Influenza A virus pandemics and emerging antiviral resistance highlight the urgent need for novel generic pharmacological strategies that reduce both viral replication and inflammation of the lung. We have previously investigated the therapeutic efficacy of recombinant human catalase (rhCAT) against viral pneumonia in...

journal_title：Inflammation

authors： Shi X,Shi Z,Huang H,Zhu H,Zhou P,Zhu H,Ju D

更新日期：2014-06-01 00:00:00

abstract：:A heat-stable factor present in extracts of human blood leukocytes is capable of lysing young Staphylococcus aureus at pH 5.0. Lysis is characterized by breakdown of cell-wall components as judged by electron microscopic and biochemical analysis. The leukocyte extracts can be replaced by a variety of agents known to i...

journal_title：Inflammation

authors： Lahav M,Ginsburg I

更新日期：1977-06-01 00:00:00

abstract：:Exacerbations in chronic obstructive pulmonary disease (COPD) reduce quality of life and are associated with a more rapid deterioration of the disease. Growth differentiation factor-15 (GDF-15) is a novel candidate exacerbation biomarker. In this study, we aimed to assess GDF-15 as a biomarker of acute exacerbation of...

journal_title：Inflammation

authors： Mutlu LC,Altintas N,Aydin M,Tulubas F,Oran M,Kucukyalin V,Kaplan G,Gurel A

更新日期：2015-10-01 00:00:00

abstract：:The 6-kDa early secretory antigenic target (ESAT-6) of Mycobacterium tuberculosis is strongly correlated with subversion of innate immune responses against invading mycobacteria. To understand the role of ESAT-6 in macrophage response against M. tuberculosis, the effects of ESAT-6 on macrophage generation of reactive ...

journal_title：Inflammation

authors： Liu W,Peng Y,Yin Y,Zhou Z,Zhou W,Dai Y

更新日期：2014-06-01 00:00:00

abstract：:The purpose of the study was to explore the association between plasma platelet activating factor (PAF) and platelet activating factor acetylhydrolase (PAF-AH) levels and risk of coronary heart disease (CHD) or blood stasis syndrome (BSS) of CHD. Questionnaire, routine clinical assays and plasma levels of PAF, PAF-AH ...

journal_title：Inflammation

authors： Zheng GH,Xiong SQ,Mei LJ,Chen HY,Wang T,Chu JF

更新日期：2012-08-01 00:00:00

abstract：:In vivo effects of cytokine-induced neutrophil chemotactic factor (CINC) derived from rats on neutrophil infiltration were investigated using an air-pouch-type inflammation model in rats, and effects of dexamethasone on neutrophil infiltration induced by CINC was also examined in order to gain further insight into the...

journal_title：Inflammation

authors： Hirasawa N,Watanabe M,Mue S,Watanabe K,Tsurufuji S,Ohuchi K

更新日期：1992-04-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease with strong genetic influence, especially upon immune response components. Several cytokines from the toll-like receptors activation pathway display recognized role for RA establishment. However, few studies have verified the role of key mediators suc...

journal_title：Inflammation

authors： Gomes da Silva IIF,Lima CAD,Silva JEA,Rushansky E,Mariano MHQA,Rolim P,Oliveira RDR,Louzada-Júnior P,Souto FO,Crovella S,de Azevêdo Silva J,Sandrin-Garcia P

更新日期：2021-01-06 00:00:00

abstract：:An inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been implicated in the pathogenesis of inflammatory lung diseases such as interstitial pneumonia (IP). To clarify the role of the inflammatory cytokine in the pathogenesis of lung inflammation, we introduced a murine TNF-alpha gene into murine lungs by t...

journal_title：Inflammation

authors： Sakuma-Mochizuki J,Yoshida M,Abe K,Arai T,Mori M,Kaneda Y,Hayashi S

更新日期：2000-02-01 00:00:00

abstract：:Superoxide dismutase (SOD) is known to regulate the level of superoxide radicals inside cells. The purpose of this work was to investigate the role of SOD activity in tissue damage produced by superoxide radicals. SOD was measured in polymorphonuclear cells of patients with rheumatoid arthritis and controls. The disti...

journal_title：Inflammation

authors： Pasquier C,Mach PS,Raichvarg D,Sarfati G,Amor B,Delbarre F

更新日期：1984-03-01 00:00:00

abstract：:Rheumatoid synovial fluids generated significantly greater amounts of superoxide, lysosomal enzymes, and superoxide dismutase from neutrophils into extracellular fluid than osteoarthritic synovial fluids. Rheumatoid factors isolated from serum suppressed superoxide-generating activity of performed immune complexes, bu...

journal_title：Inflammation

authors： Shingu M,Todoroki T,Nobunaga M

更新日期：1987-06-01 00:00:00

abstract：:Although glucocorticoids (GCs) are effective in inducing remission in systemic lupus erythematosus (SLE) patients, there is a significant variation in response to therapeutic GCs, and some patients do not achieve full remission. The aim of this study was to explore the impact of environmental factors on the efficacy o...

journal_title：Inflammation

authors： Zou YF,Xu JH,Tao JH,Xu SQ,Liu S,Chen SY,Cai J,Lian L,Chen PL,Wang DG,Liu SX,Liang CM,Ye QL,Tian G,Wu M,Pan HF,Pan FM,Su H,Ye DQ

更新日期：2013-12-01 00:00:00

abstract：:Sepsis is a systemic inflammatory response syndrome caused by infection. The core mechanism underlying sepsis is immune dysfunction, with macrophages, as important cells of the innate immune system, playing an essential role. Autophagy has been shown to be closely related to inflammation and immunity, and autophagy en...

journal_title：Inflammation

authors： Qiu P,Liu Y,Zhang J

更新日期：2019-02-01 00:00:00

abstract：:Periodontitis has been advocated as a systematic chronic low-grade infection burden. However, the relationship between periodontitis and bone defect healing has not been elucidated. One hundred and eight male Wister rats were randomly assigned into three groups: control (healthy) group, periodontitis group, and period...

journal_title：Inflammation

authors： Zhou R,Shen L,Yang C,Wang L,Guo H,Yang P,Song A

更新日期：2018-06-01 00:00:00

abstract：:Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading cause of morbidity and mortality worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in immune responses. In the current study, we investigated the association of two CD86 p...

journal_title：Inflammation

authors： Song H,Tang L,Xu M,Li H,Xu S,Li G,Bao X,Sun B,Cheng T,Yang Q,Bai J

更新日期：2015-04-01 00:00:00

abstract：:The aim of this study is to investigate the effects of molecular hydrogen (H2) and suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, on paraquat (PQ)-stimulated production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-α) in macrophages. First, the PQ optimal concentration...

journal_title：Inflammation

authors： Li J,Wu X,Chen Y,Zeng R,Zhao Y,Chang P,Wang D,Zhao Q,Deng Y,Li Y,Alam HB,Chong W

更新日期：2016-12-01 00:00:00

abstract：:Dysregulated release of neutrophil reactive oxygen species and proteolytic enzymes contributes to both acute and chronic inflammatory diseases. Therefore, molecular regulators of these processes are potential targets for new anti-inflammatory therapies. We have shown previously that myristoylated alanine-rich C-kinase...

journal_title：Inflammation

authors： Sheats MK,Sung EJ,Adler KB,Jones SL

更新日期：2015-01-01 00:00:00

abstract：:Interactions of macrophages with epithelium represent one of the pathways involved in regulating local immune mechanisms. We studied the effect of cell-cell contact with an epithelial monolayer on the phenotype of macrophages. Human monocytes and THP-1 macrophages were co-cultured with monolayers of human bronchial ep...

journal_title：Inflammation

authors： Striz I,Slavcev A,Kalanin J,Jaresová M,Rennard SI

更新日期：2001-08-01 00:00:00

abstract：:After severe burns, a wound revision is often done to remove devitalized tissue and minimize bacterial growth. After such revision, the patient may show signs of sepsis. In a group of burned patients we found a transient endotoxemia, and a subsequent leukocyte activation, monitored as increased expression of the beta ...

journal_title：Inflammation

authors： Ljunghusen O,Berg S,Hed J,Lundahl J,Nettelblad H,Sjögren F,Stendahl O

更新日期：1995-08-01 00:00:00

abstract：:The levels of mRNA for plasma proteins and for metallothionein in rat liver during the acute-phase response were studied by hybridization to specific cDNA probes. The mRNA for alpha 2-macroglobulin, the beta-chain of fibrinogen, alpha 1-acid glycoprotein (so-called acute-phase reactants) reached a maximum level betwee...

journal_title：Inflammation

authors： Schreiber G,Aldred AR,Thomas T,Birch HE,Dickson PW,Tu GF,Heinrich PC,Northemann W,Howlett GJ,de Jong FA

更新日期：1986-03-01 00:00:00

abstract：:Lipopolysaccharide (LPS) can activate endothelial cells and induce inflammatory injury. Toll-like receptor-4 (TLR-4) is integrally involved in LPS signaling and has a requisite role in the activation of nuclear factor (NF)-κB. A number of studies have demonstrated the cytoprotective action of perfluorocarbon (PFC) bot...

journal_title：Inflammation

authors： Xu S,Wang P,Wei K,Liu F,Liang Z,Zhao X,Li A,Chen L

更新日期：2013-04-01 00:00:00

abstract：:Sepsis is a major cause of morbidity and mortality in critically ill patients. MD-2 is a 25-kDa lipopolysaccharide (LPS)-binding protein that forms a heterodimer with TLR42, but its regulation in sepsis is not clear. This study aims to investigate the molecular mechanism of regulation of MD-2. Inflammation cytokines i...

journal_title：Inflammation

authors： Wang Y,Li T,Wu B,Liu H,Luo J,Feng D,Shi Y

更新日期：2014-12-01 00:00:00

abstract：:The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree of inflammation induced in the air pouch model across four commonly uti...

journal_title：Inflammation

authors： Delano DL,Montesinos MC,D'Eustachio P,Wiltshire T,Cronstein BN

更新日期：2005-02-01 00:00:00

abstract：:Muscle strength is of importance for postsurgical rehabilitation. Myostatin is a growth factor that regulates the size of muscles and could thus influence muscle mass and function in the postsurgical period. The aim of the present study was to study the changes in myostatin levels during the postsurgical inflammatory ...

journal_title：Inflammation

authors： Åkerfeldt T,Helmersson-Karlqvist J,Gunningberg L,Swenne CL,Larsson A

更新日期：2015-08-01 00:00:00