Abstract：
:Stacks of six membrane filters (8-mu pore size) were placed over the mouths of plastic tubes. The tubes were filled with casein (test) or NaCl (control) solution and implanted subcutaneously in white rats; each animal received one tube with casein and one control tube. After 12, 18, 24, and 36 h, the tubes were removed and the filters stained and examined microscopically. Immigrant neutrophils were found either individually or in spherical aggregations within the filter meshwork. Crucial factors in the formation of aggregates included the frequency of individual cells, the chemotactic milieu (casein or NaCl), the duration of exposure, and the location within the filter stacks. The size of the aggregates depended on the duration of exposure. The phenomenon of "neutrophil aggregation" is thought to participate in the formation of the granulocyte wall around a focus of inflammation.
journal_name
Inflammationjournal_title
Inflammationauthors
Egger G,Porta S,Gollmann Ddoi
10.1007/BF00916239subject
Has Abstractpub_date
1982-06-01 00:00:00pages
147-59issue
2eissn
0360-3997issn
1573-2576journal_volume
6pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract：:The anti-inflammatory activities of kakkalide, a major constituent of the flower of Pueraria thunbergiana, and irisolidone, a metabolite of kakkalide produced by intestinal microflora, against carrageenan-induced inflammation in air pouches on the backs of mice and in lipopolysaccharide (LPS)-stimulated peritoneal mac...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-010-9240-1
更新日期：2011-10-01 00:00:00
abstract：:Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-017-0594-5
更新日期：2017-10-01 00:00:00
abstract：:Four methods of severe disruption of human neutrophil membrane integrity resulted in the formation of substantial amounts of leukotriene B4 and its isomers. This synthesis took place from endogenous substrate in the absence of any cell activators. It is postulated that leukotriene formation could be a preserved cell f...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00916396
更新日期：1988-04-01 00:00:00
abstract：:Tumour necrosis factor-α (TNFα) and polymorphonuclear neutrophils play key and interrelated roles in the inflammatory response against infectious agents. However, these entities can mediate significant tissue damage if their biological activity becomes deregulated. We have previously shown that canine hyperimmune froz...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-010-9289-x
更新日期：2012-02-01 00:00:00
abstract：:Factors affecting the retinoic acid modulated expression of mucin mRNA in rat tracheal cultures were studied. Actinomycin D had no effect on mucin mRNA in cultures grown with retinoic acid (RA+). The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D. Cyclohexim...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF01535255
更新日期：1994-12-01 00:00:00
abstract：:Calgranulins are small calcium-binding proteins with several immunological functions involved in inflammatory processes. Calgranulin A is reported to be mainly associated with acute inflammation while calgranulin B seems to play a role in chronic inflammatory disorders. In this study we used a proteomic approach to an...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-008-9085-z
更新日期：2008-10-01 00:00:00
abstract：:It is well established that a high-fat diet (HFD) can lead to overweight and ultimately to obesity, as well as promoting low-grade chronic inflammation associated with increased levels of such mediators as TNF-α, IL-1, and IL-6. Bone marrow mesenchymal stem cells (MSCs), which are involved in hematopoietic niches and ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-012-9557-z
更新日期：2013-04-01 00:00:00
abstract：:Nitric Oxide (NO) is a reactive metabolite produced by stimulated macrophages, and it has been demonstrated to exert cytotoxic actions on a number of microbes, parasites, and tumor cells. In addition, NO has been reported to have an autotoxic effect on murine macrophages, its site of synthesis. We have investigated th...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF01487404
更新日期：1996-04-01 00:00:00
abstract：:Interactions of macrophages with epithelium represent one of the pathways involved in regulating local immune mechanisms. We studied the effect of cell-cell contact with an epithelial monolayer on the phenotype of macrophages. Human monocytes and THP-1 macrophages were co-cultured with monolayers of human bronchial ep...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1010975804179
更新日期：2001-08-01 00:00:00
abstract：:We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-007-9020-8
更新日期：2007-04-01 00:00:00
abstract：:Praeruptorin C, D, and E (PC, PD, and PE) are three pyranocoumarins isolated from the dried root of Peucedanum praeruptorum Dunn of Umbelliferae. In the present study, we investigated the anti-inflammatory effect of these compounds in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Pyranocoumarins signi...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-011-9400-y
更新日期：2012-06-01 00:00:00
abstract：:Thromboxane (Tx) A2 generation and subsequent selective pulmonary sequestration of neutrophils (PMNs) is characteristic of several forms of the adult respiratory distress syndrome (ARDS). Therefore, we examined PMN-dependent adhesion to cultured pulmonary microvessel and aortic endothelium (EC) in response to U46,619 ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00918645
更新日期：1991-06-01 00:00:00
abstract：:Nicotine has anti- and pro-inflammatory properties in various cells. Its role in aortic vascular smooth muscle cells (VSMC) was explored. Human aortic VSMC were cultured. After nicotine (1.0 μM) and/or pyrrolidinedithiocarbamic acid (PDTC, 50 μM) treatment, the activation of nuclear factor κB (NFκB) was investigated. ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-011-9324-6
更新日期：2012-02-01 00:00:00
abstract：:Aberrant activation of the NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, triggers a pathogenic inflammatory response in many inherited neurodegenerative disorders. Inflammation has recently been associated with valosin-containing protein (VCP)-associated diseases, caused by mi...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-016-0449-5
更新日期：2017-02-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which involves many organs and presents with various symptoms. It has been shown that genetic and environmental factors play a major role in this disease and may affect the onset, activity, damage, and mortality of the disease. According to recent stud...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-015-0201-6
更新日期：2015-12-01 00:00:00
abstract：:We investigated the molecular mechanisms underlying the role of miRNAs in the pathogenesis of psoriasis to discover novel potential diagnostic markers and treatment targets. We screened Chinese Han individuals using gene chip technology to identify differentially expressed miRNAs in the epidermal tissue of lesions fro...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-018-0859-7
更新日期：2018-12-01 00:00:00
abstract：:In this study, the potential effects of thalidomide (Thal) on bleomycin (BLM)-induced pulmonary fibrosis were investigated. BALB/C mice model of pulmonary fibrosis induced by an intratracheal instillation of BLM was adopted, and then was intraperitoneally injected with Thal (10, 20, 50 mg/kg) daily for 8 days, while t...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-017-0625-2
更新日期：2017-12-01 00:00:00
abstract：:Cepharanthine (CEP), a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata, has been reported to have potent anti-inflammatory properties. However, the anti-inflammatory effects of CEP on a mouse model of lipopolysaccharide (LPS)-induced mastitis and its underlying molecular mechanisms remain to be eluci...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-013-9744-6
更新日期：2014-04-01 00:00:00
abstract：:Interferon gamma (IFNγ)-mediated activation of the myelomonocytic cell line HL-60 and peripheral blood monocytes will induce expression of an epitope for the monoclonal antibody which recognizes human αEβ7 integrin, HML-1. Here, we found that the anti-human αEβ7 monoclonal antibody Ber-ACT8 did not recognize IFNγ-stim...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1007007428255
更新日期：2000-06-01 00:00:00
abstract：:Influenza A virus pandemics and emerging antiviral resistance highlight the urgent need for novel generic pharmacological strategies that reduce both viral replication and inflammation of the lung. We have previously investigated the therapeutic efficacy of recombinant human catalase (rhCAT) against viral pneumonia in...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-013-9800-2
更新日期：2014-06-01 00:00:00
abstract：:The existence of multiple-interactive roles between several signaling pathways in tumorigenesis shows the significance of pharmacological factors like heat shock protein 90 (HSP90) inhibitors which control several signaling pathways simultaneously. HSP90 as a molecular chaperone supports the active conformational stru...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-016-0343-1
更新日期：2016-06-01 00:00:00
abstract：:The etiology of the most autoimmune disorders is largely yet to be understood. However, major target antigens have been determined against some of clinically important molecules of human autoimmune diseases, such as insulin in type 1 diabetes mellitus (T1DM). T1DM is believed to be resulted from immune-mediated destru...
journal_title：Inflammation
pub_type： 杂志文章,评审
doi：10.1007/s10753-012-9555-1
更新日期：2013-04-01 00:00:00
abstract：:This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy i...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-012-9474-1
更新日期：2012-08-01 00:00:00
abstract：:Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00911100
更新日期：1981-12-01 00:00:00
abstract：:In an effort to determine the mechanism of papain action in causing an emphysema-like lesion in hamsters, the number and types of cells and the activities of two lysosomal enzymes in the lung were determined after papain exposure. Three and four weeks after a 3-h exposure to an aerosol of 3% papain the following alter...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF00917321
更新日期：1978-03-01 00:00:00
abstract：:Ovarian cancer is one of the most deadly cancers with rapid proliferation and poor prognosis among patients. Therapies focusing on regulation of tumor immunity and microenvironments are developing. MiR-217 was dysregulated in cancer progress and plays important roles in tumorigenesis and metastasis. However, the role ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-019-01004-2
更新日期：2019-10-01 00:00:00
abstract：:Tissue macrophages can be activated by endogenous danger signals released from cells that are stressed or injured, leading to infiltration of inflammatory macrophages and neutrophils. We postulated that macrophage-related markers might be closely associated with the existence of endogenous danger signals, reflecting o...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-015-0214-1
更新日期：2015-12-01 00:00:00
abstract：:DBA/1LacJ mice were immunized with type II collagen and boosted with bacterial lipopolysaccharide (LPS) 17 days later to induce accelerated arthritis. Clinical signs of inflammation were observed as early as Day 20. Matrix metalloproteinases MMP-2, -3, -9, and -13, but not MMP-12, mRNA levels were increased on Day 24....
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1023/a:1023282701505
更新日期：2003-04-01 00:00:00
abstract：:Macrophage polarization is a dynamic and integral process of tissue inflammation and remodeling. Here we demonstrate an important role of Aurora kinase A in the regulation of inflammatory M1 macrophage polarization. We found that there was an elevated expression of Aurora-A in M1 macrophages and inhibition of Aurora-A...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/s10753-014-9990-2
更新日期：2015-04-01 00:00:00
abstract：:The objective of this study was to determine nitric oxide (NO) and superoxide anion release (O-2) by neutrophils (PMNs) in the septic multiple organ dysfunction syndrome (MODS) and to compare them with the response of normal cells to lipopolysaccharide (LPS) and cytokines. NO production was measured by the release of ...
journal_title：Inflammation
pub_type： 杂志文章
doi：10.1007/BF01534556
更新日期：1994-04-01 00:00:00
