Abstract:
:Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided the basis for establishment of a simplified test system for investigating new compounds which alter prostaglandin synthesis and might therefore affect inflammatory response. It was also observed that these endothelial cells do not metabolize prostaglandins via 15-hydroxyprostaglandin dehydrogenase.
journal_name
Inflammationjournal_title
Inflammationauthors
Jose PJ,Page DA,Wolstenholme BE,Williams TJ,Dumonde DCdoi
10.1007/BF00911100subject
Has Abstractpub_date
1981-12-01 00:00:00pages
363-78issue
4eissn
0360-3997issn
1573-2576journal_volume
5pub_type
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