Abstract:
:A heat-stable factor present in extracts of human blood leukocytes is capable of lysing young Staphylococcus aureus at pH 5.0. Lysis is characterized by breakdown of cell-wall components as judged by electron microscopic and biochemical analysis. The leukocyte extracts can be replaced by a variety of agents known to injure cell membranes, e.g., leukocyte cationic protein histone, polymyxin B, colimycin, phospholipase A, and lysolecithin. The mechanisms by which all these agents bring about the degradation of the staphylococcal walls was studied. By using 14C-labeled cell walls devoid of cytoplasmic structures, it was demonstrated that none of the above-mentioned agents had a direct lytic effect on purified cell walls. On the other hand, when any of these agents first interacted with intact staphylococci, a factor (presumably an autolysin) was generated that directly lysed the cell walls. Lysis of cell walls in the presence of intact staphylococci used as a source of autolysin was strongly inhibited by a variety of anionic polyelectrolytes such as heparine and liquoid. The possible role played by bacterial autolysins in the generation of microbial cell-wall components capable of triggering chronic inflammation is discussed.
journal_name
Inflammationjournal_title
Inflammationauthors
Lahav M,Ginsburg Idoi
10.1007/BF00918678subject
Has Abstractpub_date
1977-06-01 00:00:00pages
165-77issue
2eissn
0360-3997issn
1573-2576journal_volume
2pub_type
杂志文章相关文献
INFLAMMATION文献大全abstract::Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01106-x
更新日期:2020-04-01 00:00:00
abstract::In this study, the effects of tyrosol were investigated in DSS-induced experimental ulcerative colitis model. For this purpose, rats were divided into five groups of seven rats in each: control group, colitis group (DSS-4%), tyrosol group (tyrosol 20 mg/kg), sulfasalazine (sulfasalazine+DSS 100 mg/kg), and treatment g...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01028-8
更新日期:2019-10-01 00:00:00
abstract::The aim of this study is to explore the dynamic changes in IL-17-expressing T cells (Th17)/Treg expression in monophasic experimental autoimmune uveitis (mEAU). mEAU was induced in Lewis rats with IRBP1177-1191 peptide and evaluated clinically and pathologically on days 9, 13, 18, 23, 28, 35, and 48. Lymphocytes isola...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-015-0229-7
更新日期:2016-02-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic inflammation that can lead to loss of range of joint abnormalities in severe cases. Diosgenin has anti-inflammatory effects. This paper discussed the effect and mechanism of diosgenin on excessive proliferation and inflammatory response of synovial cells in RA. CCK-8 detected the...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01389-5
更新日期:2020-11-25 00:00:00
abstract::Intrapleural tetracycline (TCN) results in pleural macrophage influx and pleural fibrosis; intrapleural carrageenan (CAR) induces macrophage influx without fibrosis. Because macrophage products can modulate mesothelial cell activity, we investigated the role of TCN- and CAR-induced pleural macrophages on mesothelial c...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916387
更新日期:1993-02-01 00:00:00
abstract::Recent studies have demonstrated that a calcium-sensitive protease converts Ca2+/phospholipid-dependent protein kinase C to a Ca2+/phospholipid-independent form during the activation of human neutrophils. In this paper, the results of the purification and characterization of a calcium-dependent cytosolic protease from...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00915892
更新日期:1988-02-01 00:00:00
abstract::We have previously shown that deuterium oxide (D2O) enhances the oxidation of methionine, a myeloperoxidase (MPO) -mediated reaction, by human neutrophils during phagocytosis. However, D2O has no effect on the oxidation of methionine by the purified MPO-H2O2-Cl- system. To explain this observation, we studied the effe...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00917309
更新日期:1982-12-01 00:00:00
abstract::We investigated whether TESPA1 gene polymorphisms were associated with increased risk of developing ankylosing spondylitis (AS). We also studied whether TESPA1 gene interacts with environmental factors. A total of 494 patients with AS and 478 matched healthy controls were genotyped for four SNPs (rs1801876, rs2171497,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-014-9936-8
更新日期:2014-12-01 00:00:00
abstract::The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00920476
更新日期:1993-12-01 00:00:00
abstract::Aberrant activation of the NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, triggers a pathogenic inflammatory response in many inherited neurodegenerative disorders. Inflammation has recently been associated with valosin-containing protein (VCP)-associated diseases, caused by mi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0449-5
更新日期:2017-02-01 00:00:00
abstract::Sjögren's syndrome (SS) is a chronic autoimmune disease targeting salivary and lacrimal glands. C-X-C motif chemokine ligand 10 (CXCL10) expression is upregulated in lip salivary glands (LSGs) of primary SS (pSS) patients, and CXCL10 involved in SS pathogenesis via immune-cell accumulation. Moreover, interferon (IFN)-...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01322-w
更新日期:2021-02-01 00:00:00
abstract::The biological effects of asiatic acid (AA) on spinal cord injury (SCI)-induced acute lung injury (ALI) have not been investigated. We aimed to investigate the therapeutic efficacy and molecular mechanisms of AA on SCI-induced ALI. One-hundred and fifty Sprague-Dawley rats were randomly assigned to five groups: sham, ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0414-3
更新日期:2016-12-01 00:00:00
abstract::The aim of the study was to determine the effect of direct application of rifampin, povidone-iodine, and hydrogen peroxide on the formation of epidural fibrosis in rats. Forty-eight adult male Wistar albino rats were equally and randomly divided into four groups (laminectomy, topical rifampin, topical povidone-iodine,...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0383-6
更新日期:2016-08-01 00:00:00
abstract::Nicotine has anti- and pro-inflammatory properties in various cells. Its role in aortic vascular smooth muscle cells (VSMC) was explored. Human aortic VSMC were cultured. After nicotine (1.0 μM) and/or pyrrolidinedithiocarbamic acid (PDTC, 50 μM) treatment, the activation of nuclear factor κB (NFκB) was investigated. ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9324-6
更新日期:2012-02-01 00:00:00
abstract::Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01295-w
更新日期:2020-12-01 00:00:00
abstract::Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of p110β-targeted small interfering RNA (siRNA) and lentivirus on particle-induced inflammatory cytokine expr...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9636-9
更新日期:2013-10-01 00:00:00
abstract::Current treatments for ischemia-reperfusion (IR)-induced acute lung injury are limited. Mesenchymal stem cell-conditioned medium (CM) has been reported to attenuate lung injury. Neural crest stem cells (NCSCs), a type of multipotent stem cells, are more easily obtained than mesenchymal stem cells. We hypothesize that ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-017-0594-5
更新日期:2017-10-01 00:00:00
abstract::We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF01487746
更新日期:1996-02-01 00:00:00
abstract::Extracellular phospholipase A2 (PLA2) activity was detected in exudate from rat carrageenan-induced pleurisy using [3H]oleic acid-labeled Escherichia coli as substrate. Both exudate volume and PLA2 activity increased up to 24 h after carrageenin injection. Specific absorption of this activity by anti-group II PLA2 (PL...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/BF00916098
更新日期:1993-04-01 00:00:00
abstract::Integrin-α9 (ITGA9) and its corresponding ligands are involved in inflammatory and immune responses. The present study aimed to investigate whether ITGA9 participates in the development of chronic periodontitis (ChP) and to explore the underlying mechanisms. We collected gingival tissue and gingival crevicular fluid i...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01226-9
更新日期:2020-08-01 00:00:00
abstract::Potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1), a long non-coding RNA found in the KCNQ1 locus, has been evidenced to play important roles in the aggravation of inflammatory and oxidative stresses under hypoxia, but whether and how KCNQ1OT1 contributes to neuronal damages in the cere...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-020-01257-2
更新日期:2020-10-01 00:00:00
abstract::The benzylideneacetophenone derivative JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] (JC3) was synthesized by modifying yakuchinone B obtained from the seeds of Alpinia oxyphylla, a member of the ginger family (Zingiberaceae), which are widely used as a folk remedy and as an anti-inflammatory. The aim o...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-018-0947-8
更新日期:2019-06-01 00:00:00
abstract::Interleukin-1 receptor-associated kinase (IRAK1) is a key regulatory protein in TLR/IL1R-mediated cell activation during inflammatory response. Studies indicated that pending on the nature of the used inflammatory model, downregulation of IRAK1 may be beneficial or detrimental. However, the role of IRAK1 in affecting ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9692-1
更新日期:2013-12-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) with exogenous cassette DNA containing the methicillin-resistant gene mecA (SCCmec) poses a problem as a drug-resistant bacterium responsible for hospital- and community-acquired infections. The frequency of MRSA detection has recently been increasing rapidly in Japan...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-011-9395-4
更新日期:2012-06-01 00:00:00
abstract::IFN-τ, which is a type I interferon with low cytotoxicity, is defined as a pregnancy recognition signal in ruminants. Type I interferons have been used as anti-inflammatory agents, but their side effects limit their clinical application. The present study aimed to determine the anti-inflammatory effects of IFN-τ in a ...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-016-0348-9
更新日期:2016-06-01 00:00:00
abstract::To investigate whether oligomerization domains (NODs) are involved in Porphyromonas gingivalis-induced interleukin (IL)-6, IL-8, and vascular cell adhesion molecule (VCAM)-1 expression beyond Toll-like receptors (TLRs), we investigated the role of NOD1/2 in P. gingivalis-induced IL-6, IL-8, and VCAM-1 expression in hu...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9766-0
更新日期:2014-04-01 00:00:00
abstract::Recent data have demonstrated the importance of IL-18 in the induction and perpetuation of chronic inflammation in experimental arthritis. The aim of the present study was to elucidate whether IL-18 has any indirect effects on osteoclastogenesis by regulating the production of molecules from fibroblast-like synoviocyt...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-012-9524-8
更新日期:2013-02-01 00:00:00
abstract::Berberine (Ber), the major constituent of Coptidis Rhizoma, possesses anti-inflammatory properties. In this study, we investigated the effects of Ber on cigarette smoke (CS)-mediated acute lung inflammation. C57BL/6 mice (6-8 weeks) were exposed to CS to induce acute lung injury. Ber was used to pretreat CS-exposed mi...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-013-9640-0
更新日期:2013-10-01 00:00:00
abstract::The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...
journal_title:Inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1007/s10753-016-0379-2
更新日期:2016-08-01 00:00:00
abstract::Lipopolysaccharide (LPS) is demonstrated to cause "two-hit" injury to liver. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LPS clearance. Hepatocyte nuclear factor-1 alpha (HNF-1α) and sterol regulatory element-binding protein 2 (SREBP2) were reported to be responsible for PCSK9 gene...
journal_title:Inflammation
pub_type: 杂志文章
doi:10.1007/s10753-019-01114-x
更新日期:2020-02-01 00:00:00