Beyond toll-like receptors: Porphyromonas gingivalis induces IL-6, IL-8, and VCAM-1 expression through NOD-mediated NF-κB and ERK signaling pathways in periodontal fibroblasts.

abstract：:Heat shock (HS) proteins (HSP) are a family of molecular chaperones induced by environmental stresses such as oxidative injury, and contribute to protection from and adaptation to cellular stress. We investigated in human monocytes the expression and subcellular distribution of hsp70 and hsc70 after HS and inflammatio...

journal_title：Inflammation

authors： Mariéthoz E,Jacquier-Sarlin MR,Multhoff G,Healy AM,Tacchini-Cottier F,Polla BS

更新日期：1997-12-01 00:00:00

abstract：:It is well established that a high-fat diet (HFD) can lead to overweight and ultimately to obesity, as well as promoting low-grade chronic inflammation associated with increased levels of such mediators as TNF-α, IL-1, and IL-6. Bone marrow mesenchymal stem cells (MSCs), which are involved in hematopoietic niches and ...

journal_title：Inflammation

authors： Cortez M,Carmo LS,Rogero MM,Borelli P,Fock RA

更新日期：2013-04-01 00:00:00

abstract：:To study the efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of severe acute pancreatitis. SAP rat models were prepared and randomly divided into model control group and treated group. The sham-operated group was also set. At 3, 6 and 12 h after operation, the mortality rate, ascitic volumes,...

journal_title：Inflammation

authors： Zhang R,Zhang X,Zhang J,Wu J,Ye Q,Xu R,Ye J,Fang X,Jin L,He J,Yuan W

更新日期：2009-04-01 00:00:00

abstract：:In the present study, we investigated the effect of lipoxin A4 on myocardial ischemia-reperfusion injury (IRI) following cardiac arrest (CA) in a rabbit model. Lipoxin A4 is a metabolite of arachidonic acid in the eicosanoid, it is called "brake signal" for its anti-inflammatory activity. Some inflammatory factors (IL...

journal_title：Inflammation

authors： Chen Z,Wu Z,Huang C,Zhao Y,Zhou Y,Zhou X,Lu X,Mao L,Li S

更新日期：2013-04-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is demonstrated to cause "two-hit" injury to liver. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LPS clearance. Hepatocyte nuclear factor-1 alpha (HNF-1α) and sterol regulatory element-binding protein 2 (SREBP2) were reported to be responsible for PCSK9 gene...

journal_title：Inflammation

authors： Zou Y,Li S,Xu B,Guo H,Zhang S,Cai Y

更新日期：2020-02-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a disease characterized by skin and internal organ involvement. There is progressive accumulation of extracellular matrix components in the skin and involved organs. Tissue fibrosis is the prominent reason for mortality, and still, there is no satisfactory treatment. The aim of this study w...

journal_title：Inflammation

authors： Demir T,Turkbeyler I,Kaplan DS,Pehlivan Y,Orkmez M,Tutar E,Taysi S,Kisacik B,Onat AM,Bagcı C

更新日期：2013-02-01 00:00:00

abstract：:Leukocyte chemoattractants markedly alter the morphology and membrane functions of leukocytes. Bacterial collagenase causes a change in cell shape similar to that seen with the leukocyte chemoattractant, f-Met-Leu-Phe, and also promotes capping of concanavalin A. Human neutrophils in suspension or adherent to cover gl...

journal_title：Inflammation

authors： Walter RJ

更新日期：1986-12-01 00:00:00

abstract：:This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy i...

journal_title：Inflammation

authors： Qin HB,Xu B,Mei JJ,Li D,Liu JJ,Zhao DY,Liu F

更新日期：2012-08-01 00:00:00

abstract：:A new in vivo method for measuring leukocyte migration in man involves the insertion of "platelets" prepared from membrane filters into the lower conjunctival sac. The "platelets" contain casein and are coated unilaterally with a foil, permitting the casein to diffuse in one direction only. A chemotactic gradient is t...

journal_title：Inflammation

authors： Egger G

更新日期：1980-06-01 00:00:00

abstract：:Type I allergy is characterized by the release of granule-associated mediators, lipid-derived substances, cytokines, and chemokines by activated mast cells. To evaluate the anti-allergic effects of macelignan isolated from Myristica fragrans Houtt., we determined its ability to inhibit calcium (Ca(2+)) influx, degranu...

journal_title：Inflammation

authors： Han YS,Kim MS,Hwang JK

更新日期：2012-10-01 00:00:00

abstract：:Corynoline, a bioactive compound isolated from Corydalis bungeana Turcz., has been known to have anti-inflammatory activity. However, its effects on the inflammation of the cardiovascular system have not been reported yet. The aim of this study was to investigate the anti-inflammatory effects of corynoline on lipopoly...

journal_title：Inflammation

authors： Liu B,Su K,Wang J,Wang J,Xin Z,Li F,Fu Y

更新日期：2018-10-01 00:00:00

abstract：:Multiple forms of soluble phospholipase A2 (PLA2) are known to coexist in venoms of individual reptilian species. While similar observations in several mammalian species suggest that this is a common phenomenon, the functional implications are not yet understood. In attempting to devise therapeutic strategies for trea...

journal_title：Inflammation

authors： Vadas P,Pruzanski W,Stefanski E,Sternby B

更新日期：1990-04-01 00:00:00

abstract：:High concentrations of corticosteroids inhibit granulocyte responses and disrupt agonist receptor function. Dose-response and time-course considerations make it unlikely that these effects are mediated via the glucocorticoid receptor, a concept further supported by the ability of sex steroids to work similar effects. ...

journal_title：Inflammation

authors： Lamche HR,Silberstein PT,Knabe AC,Thomas DD,Jacob HS,Hammerschmidt DE

更新日期：1990-02-01 00:00:00

abstract：:Nicotine has anti- and pro-inflammatory properties in various cells. Its role in aortic vascular smooth muscle cells (VSMC) was explored. Human aortic VSMC were cultured. After nicotine (1.0 μM) and/or pyrrolidinedithiocarbamic acid (PDTC, 50 μM) treatment, the activation of nuclear factor κB (NFκB) was investigated. ...

journal_title：Inflammation

authors： Wang Y,Zhang F,Yang W,Xue S

更新日期：2012-02-01 00:00:00

abstract：:IL-17-producing Th17 cells and IFN-γ and IL-17 double-producing Th1/17 cells have been identified as the pathogenic cells in inflammatory bowel disease (IBD). Retinoic acid-related orphan receptor γt (RORγt) is a master regulator for the differentiation and activation of Th17 and Th1/17 cells. We discovered a novel or...

journal_title：Inflammation

authors： Igaki K,Nakamura Y,Komoike Y,Uga K,Shibata A,Ishimura Y,Yamasaki M,Tsukimi Y,Tsuchimori N

更新日期：2019-02-01 00:00:00

abstract：:Sjögren's syndrome (SS) is a chronic autoimmune disease targeting salivary and lacrimal glands. C-X-C motif chemokine ligand 10 (CXCL10) expression is upregulated in lip salivary glands (LSGs) of primary SS (pSS) patients, and CXCL10 involved in SS pathogenesis via immune-cell accumulation. Moreover, interferon (IFN)-...

journal_title：Inflammation

authors： Aota K,Yamanoi T,Kani K,Ono S,Momota Y,Azuma M

更新日期：2021-02-01 00:00:00

abstract：:The purpose of this study was to evaluate the rabbit anterior eye chamber as a quantitative measure of leukotaxis using 51Cr-labeled homologous leukocytes and then to determine the effects of ibuprofen on N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced leukotaxis. Leukocyte accumulation was assessed at various...

journal_title：Inflammation

authors： Shimanuki T,Nakamura RM,Dizerega GS

更新日期：1985-09-01 00:00:00

abstract：:Baicalein shows anti-inflammatory effects in human rheumatoid arthritis fibroblast-like synoviocytes (RAFLS). Considering its anti-proliferatory effects on various cancer cells, we investigated the effects of baicalein on interleukin-1 beta (IL-1β)-induced proliferation of human RAFLS. Cell proliferation was examined ...

journal_title：Inflammation

authors： Chen S,Yang Y,Feng H,Wang H,Zhao R,Liu H

更新日期：2014-02-01 00:00:00

abstract：:The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...

journal_title：Inflammation

authors： McDonald RJ,Pan LC,St George JA,Hyde DM,Ducore JM

更新日期：1993-12-01 00:00:00

abstract：:Endothelial activation with excessive recruitment and adhesion of immune cells plays a central role in the progression of sepsis. We established a microfluidic system to study the activation of human umbilical vein endothelial cells by conditioned medium containing plasma from lipopolysaccharide-stimulated whole blood...

journal_title：Inflammation

authors： Eichhorn T,Rauscher S,Hammer C,Gröger M,Fischer MB,Weber V

更新日期：2016-10-01 00:00:00

abstract：:Ulcerative colitis (UC) is a serious digestive system disease. Furthermore, the activation of C3a/C3aR axis promoted the expression of caspase-11. And higher levels of caspase-11 could induce the pyroptosis and inflammation of cells. However, some studies suggested that caspase-11 could promote and suppress the inflam...

journal_title：Inflammation

authors： Zhang X,Chen Y,Yu S,Jin B,Liu W

更新日期：2020-12-01 00:00:00

abstract：:The synthetic compound 7-4-[Bis-(2-hydroxyethyl)-amino]-butoxy-5-hydroxy-8-methoxy-2-phenylchromen-4-one (V8) is a novel flavonoid-derived compound. In this study, we investigated the effects of V8 on Toll-like receptor 4 (TLR4)-mediated inflammatory reaction in human cervical cancer SiHa cells and lipopolysaccharide ...

journal_title：Inflammation

authors： He A,Ji R,Shao J,He C,Jin M,Xu Y

更新日期：2016-02-01 00:00:00

abstract：:Kurloff cells are mononuclear cells possessing a large cytoplasmic inclusion body specific to the guinea pig. In this report, we present strong evidence that Kurloff cells can mediate NC activity against tumor cells in addition to their previously reported NK activity. Using an 18 h 51Cr-release assay we have shown th...

journal_title：Inflammation

authors： Pouliot N,Maghni K,Sirois P,Rola-Pleszczynski M

更新日期：1996-06-01 00:00:00

abstract：:Genetic messages for polypeptide growth factors were assessed in human alveolar macrophages, obtained by bronchoalveolar lavage (BAL) from normal subjects (N = 3) and from patients with pneumonia (N = 3), pulmonary lymphoma (N = 3), and idiopathic pulmonary fibrosis (N = 3). Complementary DNAs (cDNAs) were prepared by...

journal_title：Inflammation

authors： Adolff CH,Golden JA,Kennedy PW,Goetzl EJ,Turck CW

更新日期：1991-08-01 00:00:00

abstract：:Stacks of six membrane filters (8-mu pore size) were placed over the mouths of plastic tubes. The tubes were filled with casein (test) or NaCl (control) solution and implanted subcutaneously in white rats; each animal received one tube with casein and one control tube. After 12, 18, 24, and 36 h, the tubes were remove...

journal_title：Inflammation

authors： Egger G,Porta S,Gollmann D

更新日期：1982-06-01 00:00:00

abstract：:Previous reports showed that Maresin 1 (MaR1) possessed organ protection effects and could attenuate acute lung injury. Here, we aim to figure out whether MaR1 can maintain the permeability of lung epithelial cells by regulating the expression of tight junction protein during lung injury. Monolayer of murine lung epit...

journal_title：Inflammation

authors： Chen L,Liu H,Wang Y,Xia H,Gong J,Li B,Yao S,Shang Y

更新日期：2016-12-01 00:00:00

abstract：:The benzylideneacetophenone derivative JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] (JC3) was synthesized by modifying yakuchinone B obtained from the seeds of Alpinia oxyphylla, a member of the ginger family (Zingiberaceae), which are widely used as a folk remedy and as an anti-inflammatory. The aim o...

journal_title：Inflammation

authors： Sur B,Kang S,Kim M,Oh S

更新日期：2019-06-01 00:00:00

abstract：:We have previously shown that deuterium oxide (D2O) enhances the oxidation of methionine, a myeloperoxidase (MPO) -mediated reaction, by human neutrophils during phagocytosis. However, D2O has no effect on the oxidation of methionine by the purified MPO-H2O2-Cl- system. To explain this observation, we studied the effe...

journal_title：Inflammation

authors： Tsan MF,Turkall RM

更新日期：1982-12-01 00:00:00

abstract：:Statins are widely used hypocholesterolemic drugs that block the mevalonate pathway. Some studies have shown that statins may have the potential to inhibit intervertebral disk (IVD) degeneration (IDD). Interleukin (IL)-1β, a catabolic cytokine, is a key regulator of IDD. This study aimed to investigate the mechanism u...

journal_title：Inflammation

authors： Tu J,Li W,Zhang Y,Wu X,Song Y,Kang L,Liu W,Wang K,Li S,Hua W,Yang C

更新日期：2017-06-01 00:00:00

abstract：:Osteoarthritis (OA) is a degenerative joint disease frequently seen in the elderly population. Sinapic acid (SA), a commonly found phenolic acid, has been pharmacologically evaluated for its anti-inflammation effects in various studies. To explore its potential therapeutic role for OA, rat chondrocytes were treated wi...

journal_title：Inflammation

authors： Huang X,Pan Q,Mao Z,Zhang R,Ma X,Xi Y,You H

更新日期：2018-03-01 00:00:00