Corynoline Exhibits Anti-inflammatory Effects in Lipopolysaccharide (LPS)-Stimulated Human Umbilical Vein Endothelial Cells through Activating Nrf2.

abstract：:This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release signi...

journal_title：Inflammation

authors： Turner R,Martin M,Schroff J,Treadway W,DeChatelet L

更新日期：1979-07-01 00:00:00

abstract：:The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...

journal_title：Inflammation

authors： Kaufman MR,Babior BM

更新日期：1983-09-01 00:00:00

abstract：:The newly discovered gamma-PKC-related-protein of human leukocytes (gamma-rp) crossreacts with a polyclonal antibody preparation originally designed to be specific for PKC-gamma (gammaMb-Ab). As this antibody is currently the only suitable probe for gamma-rp, we sought to characterize the binding of the two proteins. ...

journal_title：Inflammation

authors： Smallwood JI,Malawista SE

更新日期：1999-08-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease accompanying excessive inflammatory responses. Phosphoinositide 3-kinase p110δ (PI3Kδ) is reported to associate with autoimmune conditions. We here aimed to determine whether selective inhibition of PI3Kδ is effective in a lupus model of BXSB mice, using the ...

journal_title：Inflammation

authors： Wang Y,Zhang L,Wei P,Zhang H,Liu C

更新日期：2014-06-01 00:00:00

abstract：:Salidroside (Sal), a phenylpropanoid glycoside isolated from a popular traditional Chinese medicinal plant Rhodiola rosea L., possesses multiple pharmacological actions. This aim of this study is to investigate the effects of Sal against isoproterenol (ISO)-induced myocardial ischemia. Fifty male Sprague-Dawley rats w...

journal_title：Inflammation

authors： Zhu L,Wei T,Chang X,He H,Gao J,Wen Z,Yan T

更新日期：2015-08-01 00:00:00

abstract：:Comparison of the physiologic responses in rabbits to the intravenous infusion of two polymorphonuclear neutrophil (PMN) activators, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA), has revealed marked differences in kinetics for activation between these agents. FMLP infusion was ass...

journal_title：Inflammation

authors： Lafuze JE,Baker MD,Oakes AL,Baehner RL

更新日期：1987-12-01 00:00:00

abstract：:Chemerin is shown to be associated with inflammation which is involved in the pathogenesis of diabetic nephropathy. This study aims to determine whether rosiglitazone and pioglitazone ameliorate renal function through an effect on the expression of chemerin and ChemR23 in streptozotocin-induced diabetic rats. The rats...

journal_title：Inflammation

authors： Hu W,Yu Q,Zhang J,Liu D

更新日期：2012-08-01 00:00:00

abstract：:We investigated the molecular mechanisms underlying the role of miRNAs in the pathogenesis of psoriasis to discover novel potential diagnostic markers and treatment targets. We screened Chinese Han individuals using gene chip technology to identify differentially expressed miRNAs in the epidermal tissue of lesions fro...

journal_title：Inflammation

authors： Wang Y,Yu X,Wang L,Ma W,Sun Q

更新日期：2018-12-01 00:00:00

abstract：:The aim of the study was to determine the effect of coumaric acid on sciatic nerve ischemia/reperfusion (SNI) injury in rats. The rats were randomly divided into four groups: control group (no medication or surgical procedure), SNI group, SNI + coumaric acid (CA) group, and SNI + methylprednisolone (MP) group. Ischemi...

journal_title：Inflammation

authors： Guven M,Yuksel Y,Sehitoglu MH,Tokmak M,Aras AB,Akman T,Golge UH,Goksel F,Karavelioglu E,Cosar M

更新日期：2015-12-01 00:00:00

abstract：:Asthma is the most common chronic disease of childhood, chronic airway inflammation; bronchial tissue fibrosis, is a pathological feature common to children asthma, and an emerging data has indicted that autophagy plays critical roles in airway inflammation and fibrosis-mediated airway remodeling. The aim of this stud...

journal_title：Inflammation

authors： Li BB,Chen YL,Pang F

更新日期：2020-02-01 00:00:00

abstract：:High concentrations of corticosteroids inhibit granulocyte responses and disrupt agonist receptor function. Dose-response and time-course considerations make it unlikely that these effects are mediated via the glucocorticoid receptor, a concept further supported by the ability of sex steroids to work similar effects. ...

journal_title：Inflammation

authors： Lamche HR,Silberstein PT,Knabe AC,Thomas DD,Jacob HS,Hammerschmidt DE

更新日期：1990-02-01 00:00:00

abstract：:Numerous cytokines, including vascular endothelial growth factor (VEGF), are implicated in the pathogenesis of sepsis. While overexpression of VEGF produces pulmonary capillary leak, the role of VEGF in sepsis is less clear. We investigated VEGF in sepsis, utilizing a VEGF trap (VEGF(T)). Polymicrobial sepsis was indu...

journal_title：Inflammation

authors： Nolan A,Weiden MD,Thurston G,Gold JA

更新日期：2004-10-01 00:00:00

abstract：:The phenotypic alterations between blood monocytes from 11 patients with end-stage renal disease, who had been on peritoneal dialysis for less than one week, and blood monocytes from 10 healthy controls, were analyzed. In addition, peritoneal macrophages in the dialysate effluent were enclosed. Analysis of functional ...

journal_title：Inflammation

authors： Brauner A,Lu Y,Halldén G,Hylander B,Lundahl J

更新日期：1998-02-01 00:00:00

abstract：:Periodontitis has been advocated as a systematic chronic low-grade infection burden. However, the relationship between periodontitis and bone defect healing has not been elucidated. One hundred and eight male Wister rats were randomly assigned into three groups: control (healthy) group, periodontitis group, and period...

journal_title：Inflammation

authors： Zhou R,Shen L,Yang C,Wang L,Guo H,Yang P,Song A

更新日期：2018-06-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the predominant cause of irreversible blindness in the elderly population. Despite intensive basic and clinical research, its pathogenesis remains unclear. However, evidence suggests that immunological and inflammatory factors contribute to the pathogenesis of AMD. A newly ide...

journal_title：Inflammation

authors： Liu XC,Liu XF,Jian CX,Li CJ,He SZ

更新日期：2012-04-01 00:00:00

abstract：:Recombinant human interleukin-1 beta (IL-1) and tumor necrosis factor-alpha (TNF) synergistically stimulated BALB/c 3T3 cells to produce a chemotactic factor for rat polymorphonuclear leukocytes (PMNs), whereas an addition of 10(-11)-10(-8) M IL-1 or TNF alone to the cell culture resulted in a slight increase in the p...

journal_title：Inflammation

authors： Nakagawa H,Miyai H,Hirata M,Watanabe K,Onuma I

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Accumulation of immune complexes in the mesangium is a common finding. Since migration of macrophages (Mphi) in the mesangium has been demonstrated to be an important event in the development of glomerular lesions, we studied the role of immune complexes and mesangial cell (MC) interaction in the transmigrat...

journal_title：Inflammation

authors： Singhal PC,Gupta S,Sharma P,Shah H,Shah N,Patel P

更新日期：2000-12-01 00:00:00

abstract：:Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we ...

journal_title：Inflammation

authors： Xing SS,Yang J,Li WJ,Li J,Chen L,Yang YT,Lei X,Li J,Wang K,Liu X

更新日期：2020-04-01 00:00:00

abstract：:In order to establish a model of lung disease in which the usefulness of potential antiinflammatory compounds can be evaluated, we have analyzed the biochemical and cellular responses of rabbits to zymosan deposition in their lungs. A suspension of zymosan particles was instilled into the lungs of rabbits using an int...

journal_title：Inflammation

authors： Kuhn SH,Rossouw DJ,Hoffstein S,Finkelstein MC

更新日期：1983-06-01 00:00:00

abstract：:This study aimed to investigate molecule B7-H3 expression profiles of patients with ankylosing spondylitis (AS) and the clinical significance of B7-H3 in the pathogenesis of AS. Serum B7-H3 levels were measured by ELISA in patients with AS and healthy controls. The expression of B7-H3 protein and mRNA on CD14+ monocyt...

journal_title：Inflammation

authors： Yan R,Hu Y,Yu P,Wen H,Feng P,Yang S

更新日期：2015-01-01 00:00:00

abstract：:Sublethal doses of LPS result in increased tolerance to high concentrations of oxygen and this is associated with decreased pulmonary inflammation in a rat model. To investigate the mechanism of decreased neutrophil influx into the lung in this model, we measured levels of mRNA in the lung for the endothelial adhesion...

journal_title：Inflammation

authors： Thompson LR,Keeney SE,Tarrant D,Rudloff E,Dallas DV,Schmalstieg FC

更新日期：2004-06-01 00:00:00

abstract：:Multiple forms of soluble phospholipase A2 (PLA2) are known to coexist in venoms of individual reptilian species. While similar observations in several mammalian species suggest that this is a common phenomenon, the functional implications are not yet understood. In attempting to devise therapeutic strategies for trea...

journal_title：Inflammation

authors： Vadas P,Pruzanski W,Stefanski E,Sternby B

更新日期：1990-04-01 00:00:00

abstract：:Valnemulin reportedly regulates inflammatory responses in addition to its in vitro antibacterial activity. In this study, we established a mouse model of lipopolysaccharide (LPS)-induced inflammatory lung injury and investigated the effect of valnemulin (100 mg/kg) on acute lung injury (ALI) 8 h after LPS challenge. W...

journal_title：Inflammation

authors： Chen Z,Zhang X,Chu X,Zhang X,Song K,Jiang Y,Yu L,Deng X

更新日期：2010-10-01 00:00:00

abstract：:Intrapleural tetracycline (TCN) results in pleural macrophage influx and pleural fibrosis; intrapleural carrageenan (CAR) induces macrophage influx without fibrosis. Because macrophage products can modulate mesothelial cell activity, we investigated the role of TCN- and CAR-induced pleural macrophages on mesothelial c...

journal_title：Inflammation

authors： Baumann MH,Heinrich K,Sahn SA,Strange C

更新日期：1993-02-01 00:00:00

abstract：:Genetic messages for polypeptide growth factors were assessed in human alveolar macrophages, obtained by bronchoalveolar lavage (BAL) from normal subjects (N = 3) and from patients with pneumonia (N = 3), pulmonary lymphoma (N = 3), and idiopathic pulmonary fibrosis (N = 3). Complementary DNAs (cDNAs) were prepared by...

journal_title：Inflammation

authors： Adolff CH,Golden JA,Kennedy PW,Goetzl EJ,Turck CW

更新日期：1991-08-01 00:00:00

abstract：:The aim of this study is to explore the dynamic changes in IL-17-expressing T cells (Th17)/Treg expression in monophasic experimental autoimmune uveitis (mEAU). mEAU was induced in Lewis rats with IRBP1177-1191 peptide and evaluated clinically and pathologically on days 9, 13, 18, 23, 28, 35, and 48. Lymphocytes isola...

journal_title：Inflammation

authors： Zhang L,Wan F,Song J,Tang K,Zheng F,Guo J,Guo D,Bi H

更新日期：2016-02-01 00:00:00

abstract：:CD4(+)Foxp3(+)T cells (Tregs) mediate homeostatic peripheral tolerance by suppressing helper T2 cells in allergy. However, the regulation of asthmatic inflammation by local (in situ) Tregs in asthma remains unclear. BALB/c mice sensitized and challenged with ovalbumin (OVA) (asthma group) developed asthmatic inflammat...

journal_title：Inflammation

authors： Nakashima T,Hayashi T,Mizuno T

更新日期：2014-10-01 00:00:00

abstract：:Interleukin-1 receptor-associated kinase (IRAK1) is a key regulatory protein in TLR/IL1R-mediated cell activation during inflammatory response. Studies indicated that pending on the nature of the used inflammatory model, downregulation of IRAK1 may be beneficial or detrimental. However, the role of IRAK1 in affecting ...

journal_title：Inflammation

authors： Chandra R,Federici S,Bishwas T,Németh ZH,Deitch EA,Thomas JA,Spolarics Z

更新日期：2013-12-01 00:00:00

abstract：:Pig alveolar macrophages are a heterogeneous population of cells. Three subpopulations or bands exist when the whole population is separated according to density. Band 1 cells are the least dense cells and constitute 9% of the total population. Bands 2 and 3 represent 44 and 47% of the total population. The three subp...

journal_title：Inflammation

authors： Zeidler RB,Flynn JA,Arnold JC,Conley NS

更新日期：1987-09-01 00:00:00

abstract：:The aim of this study is to investigate the cardioprotective effects of morroniside in rats following acute myocardial infarction. An acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD) [1]. Following AMI, morroniside was administered intragastrically for 24 h at dos...

journal_title：Inflammation

authors： Yu B,Wang W

更新日期：2018-03-01 00:00:00