Vascular endothelial growth factor blockade reduces plasma cytokines in a murine model of polymicrobial sepsis.

abstract：:Endothelial-neutrophil adhesion is a critical step in acute inflammatory diseases, which is mediated in part by P-selectin and platelet-activating factor (PAF). Nitric oxide (NO) is well known as an endogenous second messenger derived from endothelial cells, and regulates many important physiological events, however, ...

journal_title：Inflammation

authors： Okayama N,Coe L,Itoh M,Alexander JS

更新日期：1999-02-01 00:00:00

abstract：:Although assist ventilation with FIO2 0.21 is the preferable mode of ventilation in the intensive care unit, sometimes controlled ventilation with hyperoxia is needed. But the impact of this setting has not been extensively studied in elderly subjects. We hypothesized that a high fraction of inspired oxygen (FiO(2)) a...

journal_title：Inflammation

authors： Andrade PV,dos Santos JM,Silva HC,Wilbert DD,Cavassani SS,Oliveira-Júnior IS

更新日期：2014-04-01 00:00:00

abstract：:Extracellular phospholipase A2 (PLA2) activity was detected in exudate from rat carrageenan-induced pleurisy using [3H]oleic acid-labeled Escherichia coli as substrate. Both exudate volume and PLA2 activity increased up to 24 h after carrageenin injection. Specific absorption of this activity by anti-group II PLA2 (PL...

journal_title：Inflammation

authors： Tanaka K,Kato T,Matsumoto K,Yoshida T

更新日期：1993-04-01 00:00:00

abstract：:The intracellular signaling pathways involved in human monocyte chemotaxis toward a variety of chemoattractant molecules were evaluated using selected pharmacological agents. Neither phosphatidylinositol-3-kinase (P13K) or extracellular signal-regulated kinase (ERK) activity were required for monocyte migration toward...

journal_title：Inflammation

authors： Fine JS,Byrnes HD,Zavodny PJ,Hipkin RW

更新日期：2001-04-01 00:00:00

abstract：:The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree of inflammation induced in the air pouch model across four commonly uti...

journal_title：Inflammation

authors： Delano DL,Montesinos MC,D'Eustachio P,Wiltshire T,Cronstein BN

更新日期：2005-02-01 00:00:00

abstract：:Air pollution events frequently occur in China during the winter. Most investigations of pollution studies have focused on the physical and chemical properties of PM2.5. Many of these studies have indicated that PM2.5 exacerbates asthma or eosinophil inflammation. However, few studies have evaluated the relationship b...

journal_title：Inflammation

authors： Zheng XY,Tong L,Shen D,Yu JE,Hu ZQ,Li YJ,Zhang LJ,Xue EF,Tang HF

更新日期：2020-02-01 00:00:00

abstract：:Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...

journal_title：Inflammation

authors： Koziol-Montewka M,Kolodziejek A,Oles J

更新日期：2004-04-01 00:00:00

abstract：:Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...

journal_title：Inflammation

authors： Dongsheng Z,Zhiguang F,Junfeng J,Zifan L,Li W

更新日期：2017-10-01 00:00:00

abstract：:The objective of this study was to compare systemic and local cytokine profiles and neutrophil responses in patients with severe versus non-severe community-acquired pneumonia (CAP). Hospitalized patients with CAP were grouped according to the pneumonia severity index (PSI), as non-severe (PSI < 91 points) or severe (...

journal_title：Inflammation

authors： Fernandez-Botran R,Uriarte SM,Arnold FW,Rodriguez-Hernandez L,Rane MJ,Peyrani P,Wiemken T,Kelley R,Uppatla S,Cavallazzi R,Blasi F,Morlacchi L,Aliberti S,Jonsson C,Ramirez JA,Bordon J

更新日期：2014-08-01 00:00:00

abstract：:Rabbits were injected intramuscularly with cortisone acetate (2 mg/kg) on alternate days. Six days after the first injection these rabbits and controls were injected intradermally in multiple sites with BCG (the vaccine strain of tubercle bacillus). Periodically, over the next 2 months, the resulting lesions were meas...

journal_title：Inflammation

authors： McCue RE,Dannenberg AM Jr,Higuchi S,Sugimoto M

更新日期：1978-06-01 00:00:00

abstract：:Cardiovascular diseases, including acute coronary syndrome (ACS), are the leading cause of death among humans. Adhesion proteins, owing to their involvement in the initiation and progression of atherosclerotic lesions, contribute to the progression of coronary disease and ACS occurrence. Considering ambiguosity of res...

journal_title：Inflammation

authors： Dabek J,Ligus J,Szota J

更新日期：2010-12-01 00:00:00

abstract：:Interactions between the enteric nervous system and the immune system are suggested to play an important role in the pathophysiology of inflammatory bowel disease (IBD). This study aims to determine if chromogranin A (CgA), chromogranin B (CgB), and secretoneurin (SN) are detectable in feces (F) from patients with col...

journal_title：Inflammation

authors： Wagner M,Stridsberg M,Peterson CG,Sangfelt P,Lampinen M,Carlson M

更新日期：2013-08-01 00:00:00

abstract：:A variety of steroidal and nonsteroidal antiinflammatory agents (NSAs) were compared for their effectiveness against a developing acute inflammatory reaction. Only BW 755C [3-amino-1-(m-trifluoromethyl)-phenyl-2-pyrazole] was immediately effective when administered 2 h after carrageenin, as the 3-h swelling was signif...

journal_title：Inflammation

authors： Holsapple MP,Yim GK

更新日期：1984-09-01 00:00:00

abstract：:The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...

journal_title：Inflammation

authors： Lima EP,Gonçalves OH,Ames FQ,Castro-Hoshino LV,Leimann FV,Cuman RKN,Comar JF,Bersani-Amado CA

更新日期：2020-11-09 00:00:00

abstract：:High concentrations of corticosteroids inhibit granulocyte responses and disrupt agonist receptor function. Dose-response and time-course considerations make it unlikely that these effects are mediated via the glucocorticoid receptor, a concept further supported by the ability of sex steroids to work similar effects. ...

journal_title：Inflammation

authors： Lamche HR,Silberstein PT,Knabe AC,Thomas DD,Jacob HS,Hammerschmidt DE

更新日期：1990-02-01 00:00:00

abstract：:Patients undergoing lobectomy are at risk of developing acute lung injury resulting from one-lung ventilation (OLV) during surgery. We investigated the morphological and functional behavior of neutrophils in patients who underwent lobectomy and assessed the ability of sivelestat to inhibit neutrophil activity. This wa...

journal_title：Inflammation

authors： Eguchi T,Yoshida K,Kondo R,Hamanaka K,Shiina T,Komatsu Y,Yamamoto H,Kubo K,Hasegawa J,Koizumi T

更新日期：2013-12-01 00:00:00

abstract：:The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...

journal_title：Inflammation

authors： Şenay H,Sıvacı R,Kokulu S,Koca B,Bakı ED,Ela Y

更新日期：2016-08-01 00:00:00

abstract：:DBA/1LacJ mice were immunized with type II collagen and boosted with bacterial lipopolysaccharide (LPS) 17 days later to induce accelerated arthritis. Clinical signs of inflammation were observed as early as Day 20. Matrix metalloproteinases MMP-2, -3, -9, and -13, but not MMP-12, mRNA levels were increased on Day 24....

journal_title：Inflammation

authors： Raychaudhuri A,Chou M,Weetall M,Jeng AY

更新日期：2003-04-01 00:00:00

abstract：:Low-grade chronic systemic inflammation is often associated with chronic non-communicable diseases, and its most frequently used marker, the C-reactive protein (CRP), has become an identifier of such diseases as well as an independent predictor for cardiovascular disorders and mortality. CRP is produced in response to...

journal_title：Inflammation

authors： Moreto F,de Oliveira EP,Manda RM,Torezan GA,Teixeira O,Michelin E,Burini RC

更新日期：2013-02-01 00:00:00

abstract：:CD4(+)Foxp3(+)T cells (Tregs) mediate homeostatic peripheral tolerance by suppressing helper T2 cells in allergy. However, the regulation of asthmatic inflammation by local (in situ) Tregs in asthma remains unclear. BALB/c mice sensitized and challenged with ovalbumin (OVA) (asthma group) developed asthmatic inflammat...

journal_title：Inflammation

authors： Nakashima T,Hayashi T,Mizuno T

更新日期：2014-10-01 00:00:00

abstract：:The exact etiology and pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) are still unknown, as a result, available therapeutic options for patients are far from satisfactory. Therefore, there is a need to develop a valid therapeutic approach that can ameliorate the manifestations of CP/CPPS. F...

journal_title：Inflammation

authors： Cheng Y,Cao Y,Ihsan AU,Khan FU,Li X,Xie D,Cui X,Wang W,Liu Z,Li C,Ahmad KA,Sembatya KR,Mikrani R,Zhou X

更新日期：2019-06-01 00:00:00

abstract：:Recent data demonstrated that chemokine CXCL13 mediates neuroinflammation and contributes to the maintenance of neuropathic pain after nerve injury in the spinal cord. Pro-nociceptive chemokines activate mitogen-activated protein kinases (MAPKs) which are potential signaling pathways contributing to the nociceptive be...

journal_title：Inflammation

authors： Zhang Q,Zhu MD,Cao DL,Bai XQ,Gao YJ,Wu XB

更新日期：2017-06-01 00:00:00

abstract：:Factors affecting the retinoic acid modulated expression of mucin mRNA in rat tracheal cultures were studied. Actinomycin D had no effect on mucin mRNA in cultures grown with retinoic acid (RA+). The usual precipitous drop in mucin mRNA in cultures lacking retinoic acid (RA-) was prevented by actinomycin D. Cyclohexim...

journal_title：Inflammation

authors： Bhattacharyya SN,Ashbaugh P,Kaufman B,Manna B

更新日期：1994-12-01 00:00:00

abstract：:Sanggenon C (SC), a natural flavonoid extracted from Cortex Mori (Sang Bai Pi), is reported to possess anti-inflammatory and antioxidant properties in hypoxia. The present study aimed to investigate the therapeutic potential and the underlying mechanisms of SC in cerebral ischemia-reperfusion (I/R) injury. A rat model...

journal_title：Inflammation

authors： Zhao Y,Xu J

更新日期：2020-08-01 00:00:00

abstract：:Comparison of the physiologic responses in rabbits to the intravenous infusion of two polymorphonuclear neutrophil (PMN) activators, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA), has revealed marked differences in kinetics for activation between these agents. FMLP infusion was ass...

journal_title：Inflammation

authors： Lafuze JE,Baker MD,Oakes AL,Baehner RL

更新日期：1987-12-01 00:00:00

abstract：:In an effort to determine the mechanism of papain action in causing an emphysema-like lesion in hamsters, the number and types of cells and the activities of two lysosomal enzymes in the lung were determined after papain exposure. Three and four weeks after a 3-h exposure to an aerosol of 3% papain the following alter...

journal_title：Inflammation

authors： Ackerman NR,Corkey R,Perkins D

更新日期：1978-03-01 00:00:00

abstract：:Obesity provokes an imbalance in the immune system, including an aberrant type I interferon response during some viral infections and after TLR stimulation. SOCS3 overexpression and altered systemic leptin levels could be responsible for the reduced type I interferon production in people with obesity and, eventually, ...

journal_title：Inflammation

authors： Terán-Cabanillas E,Hernández J

更新日期：2017-02-01 00:00:00

abstract：:The objective of this study was to determine nitric oxide (NO) and superoxide anion release (O-2) by neutrophils (PMNs) in the septic multiple organ dysfunction syndrome (MODS) and to compare them with the response of normal cells to lipopolysaccharide (LPS) and cytokines. NO production was measured by the release of ...

journal_title：Inflammation

authors： Carreras MC,Catz SD,Pargament GA,Del Bosco CG,Poderoso JJ

更新日期：1994-04-01 00:00:00

abstract：:Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we ...

journal_title：Inflammation

authors： Xing SS,Yang J,Li WJ,Li J,Chen L,Yang YT,Lei X,Li J,Wang K,Liu X

更新日期：2020-04-01 00:00:00

abstract：:Neurodegenerative diseases such as Alzheimer, Parkinson, amyotrophic lateral sclerosis, and Huntington are incurable and debilitating conditions that result in progressive death of the neurons. The definite diagnosis of a neurodegenerative disorder is disadvantaged by the difficulty in obtaining biopsies and thereby t...

journal_title：Inflammation

authors： Nuzzo D,Picone P,Caruana L,Vasto S,Barera A,Caruso C,Di Carlo M

更新日期：2014-06-01 00:00:00