Antiinflammatory action of thielocin A1 beta, a group II phospholipase A2 specific inhibitor, in rat carrageenan-induced pleurisy.

abstract：:This study examined the hypothesis that tumor cells metastatic to the pleura secrete a soluble factor(s) that directly increases endothelial cell permeability. Nitrocellulose filters were endothelialized with bovine pulmonary artery endothelial cells and exposed to conditioned media from either human lung adenocarcino...

journal_title：Inflammation

authors： Payne DK,Fuseler JW,Owens MW

更新日期：1994-08-01 00:00:00

abstract：:Immune dysfunction contributes to secondary infection and worse outcomes in sepsis. Regulatory T cells (Tregs) have been implicated in sepsis-induced immunosuppression. Nevertheless, the role of Tregs in secondary infection after sepsis remains to be determined. In the present study, a two-hit model which mimics clini...

journal_title：Inflammation

authors： Hu ZQ,Yao YM,Chen W,Bian JL,Zhao LJ,Chen LW,Hong GL,Lu ZQ,Zhao GJ

更新日期：2018-10-01 00:00:00

abstract：:The aim of this present study is to compare the effect of pressure-controlled ventilation and volume-controlled ventilation on pulmonary mechanics and inflammatory markers in prone position. The study included 41 patients undergoing to vertebrae surgery. The patients were randomized into two groups: Group 1 received v...

journal_title：Inflammation

authors： Şenay H,Sıvacı R,Kokulu S,Koca B,Bakı ED,Ela Y

更新日期：2016-08-01 00:00:00

abstract：:CD4(+)Foxp3(+)T cells (Tregs) mediate homeostatic peripheral tolerance by suppressing helper T2 cells in allergy. However, the regulation of asthmatic inflammation by local (in situ) Tregs in asthma remains unclear. BALB/c mice sensitized and challenged with ovalbumin (OVA) (asthma group) developed asthmatic inflammat...

journal_title：Inflammation

authors： Nakashima T,Hayashi T,Mizuno T

更新日期：2014-10-01 00:00:00

abstract：:The benzylideneacetophenone derivative JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] (JC3) was synthesized by modifying yakuchinone B obtained from the seeds of Alpinia oxyphylla, a member of the ginger family (Zingiberaceae), which are widely used as a folk remedy and as an anti-inflammatory. The aim o...

journal_title：Inflammation

authors： Sur B,Kang S,Kim M,Oh S

更新日期：2019-06-01 00:00:00

abstract：:Recent studies have demonstrated that a calcium-sensitive protease converts Ca2+/phospholipid-dependent protein kinase C to a Ca2+/phospholipid-independent form during the activation of human neutrophils. In this paper, the results of the purification and characterization of a calcium-dependent cytosolic protease from...

journal_title：Inflammation

authors： Legendre JL,Jones HP

更新日期：1988-02-01 00:00:00

abstract：:Human neutrophils were demonstrated to possess interleukin-2 receptor (IL-2R) beta and gamma chains, not alpha chain and the binding of IL-2 to the IL-2R beta chain on neutrophils plays an important regulatory role in neutrophil functions. We have investigated in this study the hypothesis that recombinant human IL-2 (...

journal_title：Inflammation

authors： Li J,Gyorffy S,Lee S,Kwok CS

更新日期：1996-08-01 00:00:00

abstract：:The influences of extracellular Ca2+ and Mg2+ on chemotactic factor-induced rabbit polymorphonuclear neutrophil (PMN) aggregation was studied using a recently described Coulter counter assay technique. Compared with those of other PMN functional assays (adhesion, chemotaxis, degranulation, and phagocytosis), the catio...

journal_title：Inflammation

authors： O'Flaherty JT,Showell HJ,Ward PA

更新日期：1977-12-01 00:00:00

abstract：:Diets enriched in omega-3 fatty acids exert antiinflammatory properties by suppressing some neutrophil (PMN) functions. Changes in cytosolic Ca2+ concentration, [Ca2+]i, are important for PMN activation and are in part regulated by membrane Ca2+ ATPases. Since membrane proteins are influenced by their lipid environmen...

journal_title：Inflammation

authors： Georgilis K,Klempner MS

更新日期：1988-10-01 00:00:00

abstract：:It is well established that a high-fat diet (HFD) can lead to overweight and ultimately to obesity, as well as promoting low-grade chronic inflammation associated with increased levels of such mediators as TNF-α, IL-1, and IL-6. Bone marrow mesenchymal stem cells (MSCs), which are involved in hematopoietic niches and ...

journal_title：Inflammation

authors： Cortez M,Carmo LS,Rogero MM,Borelli P,Fock RA

更新日期：2013-04-01 00:00:00

abstract：:Crohn's disease is an idiopathic, chronic inflammation of the gastrointestinal tract that causes narrowing and stricturing of primarily the small and large intestine. Although the mechanism(s) by which chronic inflammation promotes stricture formation remain to be defined, it does appear to be associated histologicall...

journal_title：Inflammation

authors： Owens MW,Grisham MB

更新日期：1993-08-01 00:00:00

abstract：:Recent studies show that nuclear factor-kappa B (NF-κB) signaling pathway plays a key role in contributing to the development of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Tetrahydrocoptisine is one of the main active components of Chelidonium majus L. and has been described to be effective in suppressi...

journal_title：Inflammation

authors： Li W,Huang H,Niu X,Fan T,Hu H,Li Y,Yao H,Li H,Mu Q

更新日期：2014-12-01 00:00:00

abstract：:Endoplasmic reticulum stress (ERS) plays an important role in cerebral ischemia-reperfusion injury (CIRI) by regulating apoptosis. Although the role of long non-coding RNA (LncRNA) KCNQ1OT1 in CIRI has been reported, the specific mechanism is still unclear. In this paper, the regulation of ERS by LncRNA KCNQ1OT1 in CI...

journal_title：Inflammation

authors： Li Y,Yi M,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-12-01 00:00:00

abstract：:Superoxide dismutase (SOD) is known to regulate the level of superoxide radicals inside cells. The purpose of this work was to investigate the role of SOD activity in tissue damage produced by superoxide radicals. SOD was measured in polymorphonuclear cells of patients with rheumatoid arthritis and controls. The disti...

journal_title：Inflammation

authors： Pasquier C,Mach PS,Raichvarg D,Sarfati G,Amor B,Delbarre F

更新日期：1984-03-01 00:00:00

abstract：:A heat-stable factor present in extracts of human blood leukocytes is capable of lysing young Staphylococcus aureus at pH 5.0. Lysis is characterized by breakdown of cell-wall components as judged by electron microscopic and biochemical analysis. The leukocyte extracts can be replaced by a variety of agents known to i...

journal_title：Inflammation

authors： Lahav M,Ginsburg I

更新日期：1977-06-01 00:00:00

abstract：:In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, t...

journal_title：Inflammation

authors： Sabina EP,Nagar S,Rasool M

更新日期：2011-06-01 00:00:00

abstract：:The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...

journal_title：Inflammation

authors： Kaufman MR,Babior BM

更新日期：1983-09-01 00:00:00

abstract：:Sepsis, a clinical syndrome occurring in patients following infection or injury, is a leading cause of morbidity and mortality worldwide. CD86 (B7-2) is a costimulatory molecule on antigen-presenting cells and plays critical roles in immune responses. In the current study, we investigated the association of two CD86 p...

journal_title：Inflammation

authors： Song H,Tang L,Xu M,Li H,Xu S,Li G,Bao X,Sun B,Cheng T,Yang Q,Bai J

更新日期：2015-04-01 00:00:00

abstract：:T cells adhere to human dermal fibroblasts (HDF). This cellular interaction leads to a pronounced secretion of the proinflammatory cytokines IL-6 and IL-8 via a juxtacrine stimulation induced by HDF-associated IL-1. Upon stimulation, fibroblasts express various surface proteins such as MCH-I molecules, which may inter...

journal_title：Inflammation

authors： Spörri B,Bickel M,Limat A,Waelti ER,Hunziker T,Wiesmann UN

更新日期：1997-08-01 00:00:00

abstract：:Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided ...

journal_title：Inflammation

authors： Jose PJ,Page DA,Wolstenholme BE,Williams TJ,Dumonde DC

更新日期：1981-12-01 00:00:00

abstract：:Ziprasidone (ZIP) is an effective antipsychotic with low side effects than other second-generation antipsychotics. Despite this, there are reports of adverse events and previous studies associating the use of ZIP the inflammatory response. It is possible to infer that bioactive molecules present in some foods could at...

journal_title：Inflammation

authors： Duarte T,Barbisan F,da Cunha BSN,Azzolin VF,Turra BO,Duarte MMMF,da Cruz Jung IE,Ribeiro EE,do Prado-Lima PA,da Cruz IBM

更新日期：2019-06-01 00:00:00

abstract：:Ovarian cancer is one of the most deadly cancers with rapid proliferation and poor prognosis among patients. Therapies focusing on regulation of tumor immunity and microenvironments are developing. MiR-217 was dysregulated in cancer progress and plays important roles in tumorigenesis and metastasis. However, the role ...

journal_title：Inflammation

authors： Jiang B,Zhu SJ,Xiao SS,Xue M

更新日期：2019-10-01 00:00:00

abstract：:Integrin-α9 (ITGA9) and its corresponding ligands are involved in inflammatory and immune responses. The present study aimed to investigate whether ITGA9 participates in the development of chronic periodontitis (ChP) and to explore the underlying mechanisms. We collected gingival tissue and gingival crevicular fluid i...

journal_title：Inflammation

authors： Xu S,Jiang C,Liu H,Zhang H,Liao H,Wang X,Yao S,Ma L,Guo Y,Cao Z

更新日期：2020-08-01 00:00:00

abstract：:The release of inflammatory cytokines and chemokines and autophagy has been reported to be involved in the pathogenic mechanism of acute lung injury (ALI). Reportedly, alpha-7 nicotinic acetylcholine receptors (α7nAchR) might play a protective role in LPS-induced ALI. In the current research, we established LPS-induce...

journal_title：Inflammation

authors： Zhao X,Yu Z,Lv Z,Meng L,Xu J,Yuan S,Fu Z

更新日期：2019-12-01 00:00:00

abstract：:After severe burns, a wound revision is often done to remove devitalized tissue and minimize bacterial growth. After such revision, the patient may show signs of sepsis. In a group of burned patients we found a transient endotoxemia, and a subsequent leukocyte activation, monitored as increased expression of the beta ...

journal_title：Inflammation

authors： Ljunghusen O,Berg S,Hed J,Lundahl J,Nettelblad H,Sjögren F,Stendahl O

更新日期：1995-08-01 00:00:00

abstract：:1-O-Alkyl-2-O-acetyl-sn-glycerol-3-phosphorylcholine (i.e., platelet-activating factor) was prepared and confirmed to possess potent platelet aggregating activity. It was also potent in aggregating and degranulating rabbit and human neutrophils. When injected into rabbits, the lipid induced profound neutropenia, throm...

journal_title：Inflammation

authors： O'Flaherty JT,Miller CH,Lewis JC,Wykle RL,Bass DA,McCall CE,Waite M,DeChatelet LR

更新日期：1981-09-01 00:00:00

abstract：:The effect of leukocyte hydrolytic enzymes on periodontopathic bacteria was examined in vitro. A frozen and thawed extract of human peripheral blood leukocytes (LE) and human gingival crevicular exudate (GE) were shown to be able to cause the release of 50% of the radioactivity from a leukotoxic strain of Actinobacill...

journal_title：Inflammation

authors： Sela MN

更新日期：1983-06-01 00:00:00

abstract：:Praeruptorin C, D, and E (PC, PD, and PE) are three pyranocoumarins isolated from the dried root of Peucedanum praeruptorum Dunn of Umbelliferae. In the present study, we investigated the anti-inflammatory effect of these compounds in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Pyranocoumarins signi...

journal_title：Inflammation

authors： Yu PJ,Jin H,Zhang JY,Wang GF,Li JR,Zhu ZG,Tian YX,Wu SY,Xu W,Zhang JJ,Wu SG

更新日期：2012-06-01 00:00:00

abstract：:We have previously reported the antifibrotic effects of pirfenidone (PD) in the bleomycin (BL)-hamster model of lung fibrosis. Since the development of fibrosis is generally preceded by acute lung inflammation, the present study was conducted to find out if dietary intake of PD (0.5%) has any effects on BL-induced lun...

journal_title：Inflammation

authors： Iyer SN,Hyde DM,Giri SN

更新日期：2000-10-01 00:00:00

abstract：:Activated macrophages exhibiting diverse phenotypes and various functions contribute to the pathogenesis or amelioration of different diseases like cancer, inflammation, and infectious and autoimmune diseases. However, the mechanisms of macrophage polarization in inflamed joint and its effects on rheumatoid arthritis ...

journal_title：Inflammation

authors： Dongsheng Z,Zhiguang F,Junfeng J,Zifan L,Li W

更新日期：2017-10-01 00:00:00