Pyranocoumarins isolated from Peucedanum praeruptorum Dunn suppress lipopolysaccharide-induced inflammatory response in murine macrophages through inhibition of NF-κB and STAT3 activation.

abstract：:The synthetic compound 7-4-[Bis-(2-hydroxyethyl)-amino]-butoxy-5-hydroxy-8-methoxy-2-phenylchromen-4-one (V8) is a novel flavonoid-derived compound. In this study, we investigated the effects of V8 on Toll-like receptor 4 (TLR4)-mediated inflammatory reaction in human cervical cancer SiHa cells and lipopolysaccharide ...

journal_title：Inflammation

authors： He A,Ji R,Shao J,He C,Jin M,Xu Y

更新日期：2016-02-01 00:00:00

abstract：:Heterophragma adenophyllum is a traditional medicinal plant that has been used as anti-inflammatory and to relief muscular tension. In the current research, four isolated constitutes namely lapacho (1), peshawaraquinone (2), indanone derivatives (3), α-lapachone (4) of H. adenophyllum were tested for anti-inflammatory...

journal_title：Inflammation

authors： Abu-Izneid T,Shah ZA,Rauf A,Wadood A,Bawazeer S,Muhammad N,El-Esawi MA,Alhumaydhi FA,Aljohani ASM,El-Sharkawy E,Mubarak MS,Isayeva K,Shariati MA

更新日期：2021-02-01 00:00:00

abstract：:Kurloff cells are mononuclear cells possessing a large cytoplasmic inclusion body specific to the guinea pig. In this report, we present strong evidence that Kurloff cells can mediate NC activity against tumor cells in addition to their previously reported NK activity. Using an 18 h 51Cr-release assay we have shown th...

journal_title：Inflammation

authors： Pouliot N,Maghni K,Sirois P,Rola-Pleszczynski M

更新日期：1996-06-01 00:00:00

abstract：:Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...

journal_title：Inflammation

authors： Kivistö K,Punnonen K,Toppari J,Leino L

更新日期：1996-10-01 00:00:00

abstract：:Numerous cytokines, including vascular endothelial growth factor (VEGF), are implicated in the pathogenesis of sepsis. While overexpression of VEGF produces pulmonary capillary leak, the role of VEGF in sepsis is less clear. We investigated VEGF in sepsis, utilizing a VEGF trap (VEGF(T)). Polymicrobial sepsis was indu...

journal_title：Inflammation

authors： Nolan A,Weiden MD,Thurston G,Gold JA

更新日期：2004-10-01 00:00:00

abstract：:Muscle strength is of importance for postsurgical rehabilitation. Myostatin is a growth factor that regulates the size of muscles and could thus influence muscle mass and function in the postsurgical period. The aim of the present study was to study the changes in myostatin levels during the postsurgical inflammatory ...

journal_title：Inflammation

authors： Åkerfeldt T,Helmersson-Karlqvist J,Gunningberg L,Swenne CL,Larsson A

更新日期：2015-08-01 00:00:00

abstract：:By the use of the nuclear microprobe technique, the concentrations of zinc in isolated erythrocytes, platelets, and granulocytes were measured in patients with rheumatoid arthritis, other inflammatory arthritides, and scleroderma. Markedly reduced cellular zinc values were found compared to those measured in healthy s...

journal_title：Inflammation

authors： Svenson KL,Hällgren R,Johansson E,Lindh U

更新日期：1985-06-01 00:00:00

abstract：:The purpose of this study was to evaluate the rabbit anterior eye chamber as a quantitative measure of leukotaxis using 51Cr-labeled homologous leukocytes and then to determine the effects of ibuprofen on N-formyl-methionyl-leucyl-phenylalanine (FMLP) -induced leukotaxis. Leukocyte accumulation was assessed at various...

journal_title：Inflammation

authors： Shimanuki T,Nakamura RM,Dizerega GS

更新日期：1985-09-01 00:00:00

abstract：:This study analyzed the neutrophils and sera of patients with rheumatoid arthritis and of normal controls. No significant differences were found in the activities of the granular enzymes beta-glucuronidase and lysozyme or the cytoplasmic enzyme lactic dehydrogenase (LDH). Normal neutrophils were found to release signi...

journal_title：Inflammation

authors： Turner R,Martin M,Schroff J,Treadway W,DeChatelet L

更新日期：1979-07-01 00:00:00

abstract：:The influences of extracellular Ca2+ and Mg2+ on chemotactic factor-induced rabbit polymorphonuclear neutrophil (PMN) aggregation was studied using a recently described Coulter counter assay technique. Compared with those of other PMN functional assays (adhesion, chemotaxis, degranulation, and phagocytosis), the catio...

journal_title：Inflammation

authors： O'Flaherty JT,Showell HJ,Ward PA

更新日期：1977-12-01 00:00:00

abstract：:The present study was designed to address the relationship between iron homeostasis and bone metabolism. Cultured hFOB 1.19 osteoblasts were incubated with selected concentrations of hepcidin (50, 100, and 200 nmol/L) for 20 h, harvested for extraction of total RNA and proteins, and the expression of ferroportin 1 was...

journal_title：Inflammation

authors： Xu Y,Zhang W,Zhang P,Xiao L,Wang A,Sirois P,Li K

更新日期：2012-06-01 00:00:00

abstract：:Diabetic retinopathy shares some similarity with chronic inflammation and Müller cells dysfunction may play an important role in its initiation and progression since these cells are thought to be a major source of inflammatory factors. The goal of this study was to examine the effect of cytokines on human retinal Müll...

journal_title：Inflammation

authors： Liu X,Ye F,Xiong H,Hu D,Limb GA,Xie T,Peng L,Yang W,Sun Y,Zhou M,Song E,Zhang DY

更新日期：2014-10-01 00:00:00

abstract：:Intervertebral disc degeneration (IVDD) is considered to be the fundamental cause of the occurrence and development of lumbar disc herniation (LDH). The degeneration of IVDD is mainly caused by the participation of inflammatory factors. Thus, it is of great significance to analyze the pathogenesis of IVDD, which may g...

journal_title：Inflammation

authors： Lin X,Lin Q

更新日期：2020-10-01 00:00:00

abstract：:In vivo effects of cytokine-induced neutrophil chemotactic factor (CINC) derived from rats on neutrophil infiltration were investigated using an air-pouch-type inflammation model in rats, and effects of dexamethasone on neutrophil infiltration induced by CINC was also examined in order to gain further insight into the...

journal_title：Inflammation

authors： Hirasawa N,Watanabe M,Mue S,Watanabe K,Tsurufuji S,Ohuchi K

更新日期：1992-04-01 00:00:00

abstract：:There is substantial evidence suggesting that the Ras inhibitor farnesylthiosalicylic acid (FTS) may modulate various aspects of immune function and inflammation in addition to its well known anti-cancer activity. In this regard, we have recently shown that FTS suppresses T lymphocyte-mediated immune responses. Mast c...

journal_title：Inflammation

authors： Mor A,Ben-Moshe O,Mekori YA,Kloog Y

更新日期：2011-10-01 00:00:00

abstract：:This experiment was conducted to investigate the effects of a benzylideneacetophenone derivative ((2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one (JC3)) on trimellitic anhydride (TMA)-induced atopic dermatitis (AD)-like symptoms in mice. To induce AD, the dorsal skins of mice were treated with 5% TMA on day 0 a...

journal_title：Inflammation

authors： Sur B,Kang S,Kim M,Oh S

更新日期：2019-06-01 00:00:00

abstract：:Oroxylin A, a natural flavonoid isolated from the medicinal herb Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory property. In this study, we aimed to investigate the protective effects and mechanism of oroxylin A on allergic inflammation in OVA-induced asthma murine model. BABL/c mice were ...

journal_title：Inflammation

authors： Zhou DG,Diao BZ,Zhou W,Feng JL

更新日期：2016-04-01 00:00:00

abstract：:Various disease states are associated with eosinophilia and the release of eosinophil peroxidase (EPO) into the microenvironment. The present study targets the effects of low levels of EPO on macrophage (M phi) phagocytosis and intracellular killing of Candida albicans as well as M phi oxidative activity measured as t...

journal_title：Inflammation

authors： Lefkowitz DL,Lincoln JA,Howard KR,Stuart R,Lefkowitz SS,Allen RC

更新日期：1997-04-01 00:00:00

abstract：:Lipids from the sputum of patients with asthma and with cystic fibrosis were isolated and characterized. In both cases, lipids constituted approximately 30% of the dry material. Phosphatidlycholine was the most abundant lipid, Significant amounts of phosphatidylethanolamine and phosphatidylglycerol were present. Hexos...

journal_title：Inflammation

authors： Sahu S,Lynn WS

更新日期：1978-03-01 00:00:00

abstract：:Interleukin (IL)-8 and neutrophil inflammation play a vital role in the pathogenesis of chronic inflammatory airway diseases. A disintegrin and metalloproteinase 17 (ADAM17) cleaves ectodomains of various transmembrane proteins and is an important regulator of almost every cellular event. The aim of this work was to i...

journal_title：Inflammation

authors： Li Y,Yan J,Xu W,Wang H,Xia Y

更新日期：2012-06-01 00:00:00

abstract：:NO generation in the course of two acute, non immune, inflammatory reactions (pleurisy induced by rat isologous serum and carrageenan) was assessed by means of nitrite measurement in pleural exudate from 0.5 to 24 h. NO release varied time-dependently, similarly for the two inflammatory reactions. A first, but transie...

journal_title：Inflammation

authors： Regnault C,Roch-Arveiller M,Florentin I,Giroud JP,Postaire E,Delaforge M

更新日期：1996-12-01 00:00:00

abstract：:Release and activation of pro-inflammatory mediators are among the most important induced factors that are involved in the scorpion envenomation pathogenesis. Inflammatory response and lung reactivity were studied in mice following subcutaneous injection with Androctonus australis hector (Aah) venom. Venom immunodetec...

journal_title：Inflammation

authors： Adi-Bessalem S,Mendil A,Hammoudi-Triki D,Laraba-Djebari F

更新日期：2012-04-01 00:00:00

abstract：:Free radicals play an important role in the initiation and progression of inflammatory bowel disease (IBD). Therefore, the reduction or elimination of adverse oxidant effects can provide novel therapy for IBD. Here, the antioxidant capacity and protective effects of a new class of chemically modified hetastarch (polyn...

journal_title：Inflammation

authors： Park JH,Ma L,Oshima T,Carter P,Coe L,Ma JW,Specian R,Grisham MB,Trimble CE,Hsia CJ,Liu JE,Alexander JS

更新日期：2002-02-01 00:00:00

abstract：:Valnemulin reportedly regulates inflammatory responses in addition to its in vitro antibacterial activity. In this study, we established a mouse model of lipopolysaccharide (LPS)-induced inflammatory lung injury and investigated the effect of valnemulin (100 mg/kg) on acute lung injury (ALI) 8 h after LPS challenge. W...

journal_title：Inflammation

authors： Chen Z,Zhang X,Chu X,Zhang X,Song K,Jiang Y,Yu L,Deng X

更新日期：2010-10-01 00:00:00

abstract：:An inflammatory cytokine, tumor necrosis factor (TNF)-alpha, has been implicated in the pathogenesis of inflammatory lung diseases such as interstitial pneumonia (IP). To clarify the role of the inflammatory cytokine in the pathogenesis of lung inflammation, we introduced a murine TNF-alpha gene into murine lungs by t...

journal_title：Inflammation

authors： Sakuma-Mochizuki J,Yoshida M,Abe K,Arai T,Mori M,Kaneda Y,Hayashi S

更新日期：2000-02-01 00:00:00

abstract：:Cepharanthine (CEP), a biscoclaurine alkaloid isolated from Stephania cepharantha Hayata, has been reported to have potent anti-inflammatory properties. However, the anti-inflammatory effects of CEP on a mouse model of lipopolysaccharide (LPS)-induced mastitis and its underlying molecular mechanisms remain to be eluci...

journal_title：Inflammation

authors： Ershun Z,Yunhe F,Zhengkai W,Yongguo C,Naisheng Z,Zhengtao Y

更新日期：2014-04-01 00:00:00

abstract：:Gram-positive and Gram-negative bacteria induce different cytokine patterns in human mononuclear cells. We have seen that Gram-positives preferentially induce IL-12 and TNF-alpha, whereas Gram-negatives induce more IL-10, IL-6, and IL-8. In this study, we compared the capacity of these two groups of bacteria to induce...

journal_title：Inflammation

authors： Hessle CC,Andersson B,Wold AE

更新日期：2003-12-01 00:00:00

abstract：:Ovarian cancer is one of the most deadly cancers with rapid proliferation and poor prognosis among patients. Therapies focusing on regulation of tumor immunity and microenvironments are developing. MiR-217 was dysregulated in cancer progress and plays important roles in tumorigenesis and metastasis. However, the role ...

journal_title：Inflammation

authors： Jiang B,Zhu SJ,Xiao SS,Xue M

更新日期：2019-10-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of 6 months aerobic exercise and diet alone or in combination on markers of inflammation (MOI) in circulation and in adipose abdominal tissue (AT) in obese women. Thirty obese subjects were randomized into a 24-week intervention: (1) exercise (EX), (2) diet (DI),...

journal_title：Inflammation

authors： Lakhdar N,Denguezli M,Zaouali M,Zbidi A,Tabka Z,Bouassida A

更新日期：2013-12-01 00:00:00

abstract：:We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in the presence or absence of CD40LmAb. HUVECs were also directly stimulated with rhCD40L. HUVEC endothelial cycloo...

journal_title：Inflammation

authors： Wu YQ,Chen XS,Chai JB

更新日期：2012-06-01 00:00:00