Abstract:
:Various disease states are associated with eosinophilia and the release of eosinophil peroxidase (EPO) into the microenvironment. The present study targets the effects of low levels of EPO on macrophage (M phi) phagocytosis and intracellular killing of Candida albicans as well as M phi oxidative activity measured as the luminescence product of luminol dioxygenation. Resident murine peritoneal M phi were exposed to various concentrations of EPO. Chemiluminescence data indicate that nanomolar concentrations of EPO markedly enhanced the dioxygenation activity (respiratory burst) of M phi. In other studies, the exposure of M phi to 0.17 microM EPO for 10 min. enhanced M phi-mediated candidacidal activity 10 fold. The above data indicate that EPO enhances certain M phi functions. Also the results illustrate a previously un-recognized interaction between eosinophils and M phi and implicate yet another possible role for EPO in host defenses against disease.
journal_name
Inflammationjournal_title
Inflammationauthors
Lefkowitz DL,Lincoln JA,Howard KR,Stuart R,Lefkowitz SS,Allen RCdoi
10.1023/a:1027366119901subject
Has Abstractpub_date
1997-04-01 00:00:00pages
159-72issue
2eissn
0360-3997issn
1573-2576journal_volume
21pub_type
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