Cepharanthine attenuates lipopolysaccharide-induced mice mastitis by suppressing the NF-κB signaling pathway.

abstract：:The secretion of calcitonin gene-related peptide (CGRP) and the chemokines KC and MIP-2 are increased in the animal models of endotoxemic and septic shock. We tested whether CGRP could modulate KC and MIP-2 secretion from different sources of macrophages after murine sepsis induced by cecal ligation and puncture (CLP)...

journal_title：Inflammation

authors： Wang X,Ebong SJ,Call DR,Newcomb DE,Bolgos GR,Remick DG

更新日期：2002-08-01 00:00:00

abstract：:In the present study the content of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (-LI) was measured in rats cerebrospinal fluid (CSF), plasma and perfusates (PF) from both elbow enthesis during acute inflammation. Either substance P, SP,...

journal_title：Inflammation

authors： Haker E,Theodorsson E,Lundeberg T

更新日期：1997-02-01 00:00:00

abstract：:We investigated the molecular mechanisms underlying the role of miRNAs in the pathogenesis of psoriasis to discover novel potential diagnostic markers and treatment targets. We screened Chinese Han individuals using gene chip technology to identify differentially expressed miRNAs in the epidermal tissue of lesions fro...

journal_title：Inflammation

authors： Wang Y,Yu X,Wang L,Ma W,Sun Q

更新日期：2018-12-01 00:00:00

abstract：:Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic applications and low-dose application. Thereby, the phagocytotic capabilit...

journal_title：Inflammation

authors： Lessig J,Neu B,Glander HJ,Arnhold J,Reibetanz U

更新日期：2011-04-01 00:00:00

abstract：:Stacks of six membrane filters (8-mu pore size) were placed over the mouths of plastic tubes. The tubes were filled with casein (test) or NaCl (control) solution and implanted subcutaneously in white rats; each animal received one tube with casein and one control tube. After 12, 18, 24, and 36 h, the tubes were remove...

journal_title：Inflammation

authors： Egger G,Porta S,Gollmann D

更新日期：1982-06-01 00:00:00

abstract：:Following publication of our article [1], we noticed an error in Fig. 1. ...

journal_title：Inflammation

authors： Zhang X,Chen Y,Yu S,Jin B,Liu W

更新日期：2020-11-10 00:00:00

abstract：:The aim of our study was to evaluate the pro- and anti-inflammatory cytokine response during acute pancreatitis and its predictive value on severity of disease. A hospital-based prospective clinical study was conducted. Twenty patients with acute pancreatitis were enrolled during a 12-month period. Plasma concentratio...

journal_title：Inflammation

authors： Gunjaca I,Zunic J,Gunjaca M,Kovac Z

更新日期：2012-04-01 00:00:00

abstract：:Diets enriched in omega-3 fatty acids exert antiinflammatory properties by suppressing some neutrophil (PMN) functions. Changes in cytosolic Ca2+ concentration, [Ca2+]i, are important for PMN activation and are in part regulated by membrane Ca2+ ATPases. Since membrane proteins are influenced by their lipid environmen...

journal_title：Inflammation

authors： Georgilis K,Klempner MS

更新日期：1988-10-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is demonstrated to cause "two-hit" injury to liver. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in LPS clearance. Hepatocyte nuclear factor-1 alpha (HNF-1α) and sterol regulatory element-binding protein 2 (SREBP2) were reported to be responsible for PCSK9 gene...

journal_title：Inflammation

authors： Zou Y,Li S,Xu B,Guo H,Zhang S,Cai Y

更新日期：2020-02-01 00:00:00

abstract：:We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells, and dendritic cells migrated to the pleural cavity in a time-depende...

journal_title：Inflammation

authors： Fine JS,Rojas-Triana A,Jackson JV,Engstrom LW,Deno GS,Lundell DJ,Bober LA

更新日期：2003-08-01 00:00:00

abstract：:The widely used mouse air pouch model of acute inflammation is inducible in a variety of inbred strains, but the potential influence of genetic background and gender on inflammation severity has never been examined. We directly compared the degree of inflammation induced in the air pouch model across four commonly uti...

journal_title：Inflammation

authors： Delano DL,Montesinos MC,D'Eustachio P,Wiltshire T,Cronstein BN

更新日期：2005-02-01 00:00:00

abstract：:The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...

journal_title：Inflammation

authors： Ahn JK,Kim H,Lee J,Bae EK,Cha HS,Koh EM

更新日期：2008-12-01 00:00:00

abstract：:Many patients with ulcerative colitis suffer from malnutrition and intestinal flora disorders, which affect the postoperative intestinal barrier function of the ileal pouch. This study aimed to investigate the effects of enteral nutrition combined with probiotics after ileal pouch-anal anastomosis in rats. Male Spragu...

journal_title：Inflammation

authors： Zheng T,Gao Y,Xu Y,Chen Z,Wang X,Liu J,Liu G

更新日期：2020-11-05 00:00:00

abstract：:Calgranulins are small calcium-binding proteins with several immunological functions involved in inflammatory processes. Calgranulin A is reported to be mainly associated with acute inflammation while calgranulin B seems to play a role in chronic inflammatory disorders. In this study we used a proteomic approach to an...

journal_title：Inflammation

authors： Bargagli E,Olivieri C,Prasse A,Bianchi N,Magi B,Cianti R,Bini L,Rottoli P

更新日期：2008-10-01 00:00:00

abstract：:Lipopolysaccharide (LPS) can activate endothelial cells and induce inflammatory injury. Toll-like receptor-4 (TLR-4) is integrally involved in LPS signaling and has a requisite role in the activation of nuclear factor (NF)-κB. A number of studies have demonstrated the cytoprotective action of perfluorocarbon (PFC) bot...

journal_title：Inflammation

authors： Xu S,Wang P,Wei K,Liu F,Liang Z,Zhao X,Li A,Chen L

更新日期：2013-04-01 00:00:00

abstract：:T cells adhere to human dermal fibroblasts (HDF). This cellular interaction leads to a pronounced secretion of the proinflammatory cytokines IL-6 and IL-8 via a juxtacrine stimulation induced by HDF-associated IL-1. Upon stimulation, fibroblasts express various surface proteins such as MCH-I molecules, which may inter...

journal_title：Inflammation

authors： Spörri B,Bickel M,Limat A,Waelti ER,Hunziker T,Wiesmann UN

更新日期：1997-08-01 00:00:00

abstract：:TanshinoneIIA (TanIIA) has been demonstrated to possess numerous biological effects. However, the specific effect of TanIIA on macrophage polarization has not been reported. In this study, it was revealed that TanIIA might play a pivotal role in macrophage polarization. As our results indicated, cell morphology was ch...

journal_title：Inflammation

authors： Gao S,Wang Y,Li D,Guo Y,Zhu M,Xu S,Mao J,Fan G

更新日期：2019-02-01 00:00:00

abstract：:Aberrant activation of the NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, triggers a pathogenic inflammatory response in many inherited neurodegenerative disorders. Inflammation has recently been associated with valosin-containing protein (VCP)-associated diseases, caused by mi...

journal_title：Inflammation

authors： Nalbandian A,Khan AA,Srivastava R,Llewellyn KJ,Tan B,Shukr N,Fazli Y,Kimonis VE,BenMohamed L

更新日期：2017-02-01 00:00:00

abstract：:Aseptic joint loosening is a key factor that reduces the life span of arthroplasty. There are currently few effective treatments for joint loosening except surgical revision. We explored the inhibitory effects of p110β-targeted small interfering RNA (siRNA) and lentivirus on particle-induced inflammatory cytokine expr...

journal_title：Inflammation

authors： Huang JB,Ding Y,Huang DS,Zeng WK,Guan ZP,Zhang ML

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Accumulation of immune complexes in the mesangium is a common finding. Since migration of macrophages (Mphi) in the mesangium has been demonstrated to be an important event in the development of glomerular lesions, we studied the role of immune complexes and mesangial cell (MC) interaction in the transmigrat...

journal_title：Inflammation

authors： Singhal PC,Gupta S,Sharma P,Shah H,Shah N,Patel P

更新日期：2000-12-01 00:00:00

abstract：:A rat sponge implant model was used to examine the role of protein kinase C (PKC) in angiogenesis. Neovascular response was determined by measurements of relative sponge blood flow by a 133Xe clearance technique and confirmed histologically. Morphometric analysis was used to quantitate the amount of fibrovascular grow...

journal_title：Inflammation

authors： Hu DE,Fan TP

更新日期：1995-02-01 00:00:00

abstract：:Treg cells are crucial for maintaining immune homeostasis in CP/CPPS, but the molecular mechanisms underlying the modulation of the function of Treg in CP/CPPS remain unclear. The main purpose of this study is to investigate the relationship between immunosuppressive function of Treg and the methylation level of Foxp3...

journal_title：Inflammation

authors： Chen J,Zhan C,Zhang L,Zhang L,Liu Y,Zhang Y,Du H,Liang C,Chen X

更新日期：2019-10-01 00:00:00

abstract：:This study investigated the protective effect of Lactobacillus plantarum NDC 75017 (L. plantarum NDC 75017) against acute liver injury induced by lipopolysaccharide (LPS). Thirty male mice were randomly divided into the control, LPS, and LPS + L. plantarum NDC 75017 groups. In the LPS + L. plantarum group, the mice we...

journal_title：Inflammation

authors： Peng X,Jiang Y

更新日期：2014-10-01 00:00:00

abstract：:Ulcerative colitis (UC) is a serious digestive system disease. Furthermore, the activation of C3a/C3aR axis promoted the expression of caspase-11. And higher levels of caspase-11 could induce the pyroptosis and inflammation of cells. However, some studies suggested that caspase-11 could promote and suppress the inflam...

journal_title：Inflammation

authors： Zhang X,Chen Y,Yu S,Jin B,Liu W

更新日期：2020-12-01 00:00:00

abstract：:The possibility of inflammation and neutrophil activation in response to indoor air pollution (IAP) from biomass fuel use has been investigated. For this, 142 premenopausal, never-smoking women (median age, 34 years) who cook exclusively with biomass (wood, dung, crop wastes) and 126 age-matched control women who cook...

journal_title：Inflammation

authors： Banerjee A,Mondal NK,Das D,Ray MR

更新日期：2012-04-01 00:00:00

abstract：:Sublethal doses of LPS result in increased tolerance to high concentrations of oxygen and this is associated with decreased pulmonary inflammation in a rat model. To investigate the mechanism of decreased neutrophil influx into the lung in this model, we measured levels of mRNA in the lung for the endothelial adhesion...

journal_title：Inflammation

authors： Thompson LR,Keeney SE,Tarrant D,Rudloff E,Dallas DV,Schmalstieg FC

更新日期：2004-06-01 00:00:00

abstract：:Recent studies have demonstrated that a calcium-sensitive protease converts Ca2+/phospholipid-dependent protein kinase C to a Ca2+/phospholipid-independent form during the activation of human neutrophils. In this paper, the results of the purification and characterization of a calcium-dependent cytosolic protease from...

journal_title：Inflammation

authors： Legendre JL,Jones HP

更新日期：1988-02-01 00:00:00

abstract：:Patients undergoing lobectomy are at risk of developing acute lung injury resulting from one-lung ventilation (OLV) during surgery. We investigated the morphological and functional behavior of neutrophils in patients who underwent lobectomy and assessed the ability of sivelestat to inhibit neutrophil activity. This wa...

journal_title：Inflammation

authors： Eguchi T,Yoshida K,Kondo R,Hamanaka K,Shiina T,Komatsu Y,Yamamoto H,Kubo K,Hasegawa J,Koizumi T

更新日期：2013-12-01 00:00:00

abstract：:The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...

journal_title：Inflammation

authors： McDonald RJ,Pan LC,St George JA,Hyde DM,Ducore JM

更新日期：1993-12-01 00:00:00

abstract：:Endothelial-neutrophil adhesion is a critical step in acute inflammatory diseases, which is mediated in part by P-selectin and platelet-activating factor (PAF). Nitric oxide (NO) is well known as an endogenous second messenger derived from endothelial cells, and regulates many important physiological events, however, ...

journal_title：Inflammation

authors： Okayama N,Coe L,Itoh M,Alexander JS

更新日期：1999-02-01 00:00:00