Abstract:
:Patients undergoing lobectomy are at risk of developing acute lung injury resulting from one-lung ventilation (OLV) during surgery. We investigated the morphological and functional behavior of neutrophils in patients who underwent lobectomy and assessed the ability of sivelestat to inhibit neutrophil activity. This was a blinded randomized study. Sixteen patients who underwent lobectomy were given intravenous sivelestat (n = 8) or intravenous saline (n = 8). We studied the cytoskeletal rearrangements of circulating neutrophils by determining the localization of filamentous actin (F-actin). Pulmonary oxygenation was evaluated by measuring the partial pressure of arterial oxygen. We found that the number of circulating, F-actin-rimmed neutrophils increased during OLV and after lung re-expansion. Our results suggest that, in addition to the surgical procedure and OLV, re-expansion of the remaining lung after lobectomy increases the neutrophil activation levels. Furthermore, administration of sivelestat limited neutrophil activation and improved pulmonary oxygenation in our patients.
journal_name
Inflammationjournal_title
Inflammationauthors
Eguchi T,Yoshida K,Kondo R,Hamanaka K,Shiina T,Komatsu Y,Yamamoto H,Kubo K,Hasegawa J,Koizumi Tdoi
10.1007/s10753-013-9689-9subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1479-84issue
6eissn
0360-3997issn
1573-2576journal_volume
36pub_type
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