Abstract:
:This study investigated the expression of miRNA-221 in asthmatics in order to determine whether miRNA-221 plays a role in the development of asthma. Real-time PCR was used to detect the miRNA-221 in both asthmatic and control subjects. In addition, airway inflammation was evaluated by cell counting and tissue biopsy in the OVA-induced murine asthma model. miRNA-221 was differentially expressed in asthmatics and control subjects, and miRNA-221 blockade resulted in a reduction of airway inflammation in the OVA-induced murine asthma model. We conclude that miRNA-221 participates in the pathogenesis of asthma and that inhibition of miRNA-221 suppresses airway inflammation in asthmatics.
journal_name
Inflammationjournal_title
Inflammationauthors
Qin HB,Xu B,Mei JJ,Li D,Liu JJ,Zhao DY,Liu Fdoi
10.1007/s10753-012-9474-1subject
Has Abstractpub_date
2012-08-01 00:00:00pages
1595-9issue
4eissn
0360-3997issn
1573-2576journal_volume
35pub_type
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