Decreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome. Comparison with endotoxin and cytokine effects on normal cells.

abstract：:Cyanidin-3-O-glucoside (C3G), an anthocyanin belonging to the flavonoid family and commonly present in food and vegetables in human diet, has exhibited anti-inflammatory and anti-oxidant effects. This study aimed to investigate the protective ability of C3G against inflammatory and oxidative injuries, as well as to cl...

journal_title：Inflammation

authors： Ma MM,Li Y,Liu XY,Zhu WW,Ren X,Kong GQ,Huang X,Wang LP,Luo LQ,Wang XZ

更新日期：2015-08-01 00:00:00

abstract：:Multiple forms of soluble phospholipase A2 (PLA2) are known to coexist in venoms of individual reptilian species. While similar observations in several mammalian species suggest that this is a common phenomenon, the functional implications are not yet understood. In attempting to devise therapeutic strategies for trea...

journal_title：Inflammation

authors： Vadas P,Pruzanski W,Stefanski E,Sternby B

更新日期：1990-04-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which involves many organs and presents with various symptoms. It has been shown that genetic and environmental factors play a major role in this disease and may affect the onset, activity, damage, and mortality of the disease. According to recent stud...

journal_title：Inflammation

authors： Alesaeidi S,Karami J,Mahmoudi M,Akbarian M,Poursani S,Amirzadeh A,Haddadi NS,Saffari E,Jamshidi AR

更新日期：2015-12-01 00:00:00

abstract：:Superoxide dismutase (SOD) is known to regulate the level of superoxide radicals inside cells. The purpose of this work was to investigate the role of SOD activity in tissue damage produced by superoxide radicals. SOD was measured in polymorphonuclear cells of patients with rheumatoid arthritis and controls. The disti...

journal_title：Inflammation

authors： Pasquier C,Mach PS,Raichvarg D,Sarfati G,Amor B,Delbarre F

更新日期：1984-03-01 00:00:00

abstract：:Rheumatoid synovial fluids generated significantly greater amounts of superoxide, lysosomal enzymes, and superoxide dismutase from neutrophils into extracellular fluid than osteoarthritic synovial fluids. Rheumatoid factors isolated from serum suppressed superoxide-generating activity of performed immune complexes, bu...

journal_title：Inflammation

authors： Shingu M,Todoroki T,Nobunaga M

更新日期：1987-06-01 00:00:00

abstract：:Exposure to ultraviolet (UV) light impairs the function of inflammatory cells. Urocanic acid (UCA) in an stratum corneum has been suggested as a mediator in the immunosuppression of lymphoid cells detected after irradiation with UVB (UV wavelengths 280-320 nm). In this study, we examined the effects of the two UCA iso...

journal_title：Inflammation

authors： Kivistö K,Punnonen K,Toppari J,Leino L

更新日期：1996-10-01 00:00:00

abstract：:The release of inflammatory cytokines and chemokines and autophagy has been reported to be involved in the pathogenic mechanism of acute lung injury (ALI). Reportedly, alpha-7 nicotinic acetylcholine receptors (α7nAchR) might play a protective role in LPS-induced ALI. In the current research, we established LPS-induce...

journal_title：Inflammation

authors： Zhao X,Yu Z,Lv Z,Meng L,Xu J,Yuan S,Fu Z

更新日期：2019-12-01 00:00:00

abstract：:Genetic messages for polypeptide growth factors were assessed in human alveolar macrophages, obtained by bronchoalveolar lavage (BAL) from normal subjects (N = 3) and from patients with pneumonia (N = 3), pulmonary lymphoma (N = 3), and idiopathic pulmonary fibrosis (N = 3). Complementary DNAs (cDNAs) were prepared by...

journal_title：Inflammation

authors： Adolff CH,Golden JA,Kennedy PW,Goetzl EJ,Turck CW

更新日期：1991-08-01 00:00:00

abstract：:Although glucocorticoids (GCs) are effective in inducing remission in systemic lupus erythematosus (SLE) patients, there is a significant variation in response to therapeutic GCs, and some patients do not achieve full remission. The aim of this study was to explore the impact of environmental factors on the efficacy o...

journal_title：Inflammation

authors： Zou YF,Xu JH,Tao JH,Xu SQ,Liu S,Chen SY,Cai J,Lian L,Chen PL,Wang DG,Liu SX,Liang CM,Ye QL,Tian G,Wu M,Pan HF,Pan FM,Su H,Ye DQ

更新日期：2013-12-01 00:00:00

abstract：:Slow translocation of protein kinase C was observed by both auranofin and gold sodium thiomalate pretreatment of neutrophils. Both gold compounds failed to influence the activity of this enzyme directly when cell-free studies were performed. In intact neutrophils incubated with 5.1-20.3 microM auranofin, protein kinas...

journal_title：Inflammation

authors： Parente JE,Davis P,Wong K

更新日期：1987-09-01 00:00:00

abstract：:Aberrant activation of the NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome, triggers a pathogenic inflammatory response in many inherited neurodegenerative disorders. Inflammation has recently been associated with valosin-containing protein (VCP)-associated diseases, caused by mi...

journal_title：Inflammation

authors： Nalbandian A,Khan AA,Srivastava R,Llewellyn KJ,Tan B,Shukr N,Fazli Y,Kimonis VE,BenMohamed L

更新日期：2017-02-01 00:00:00

abstract：:The present study was designed to evaluate inflammatory changes in collapsed lungs during one-lung ventilation using the assistance of a bronchoscopic microsampling probe. Serial albumin and interleukin (IL)-8 concentrations in epithelial lining fluid (ELF) were measured in seven patients undergoing resection of lung ...

journal_title：Inflammation

authors： Komatsu Y,Yamamoto H,Tsushima K,Furuya S,Yoshikawa S,Yasuo M,Kubo K,Yamazaki Y,Hasegawa J,Eguchi T,Kondo R,Yoshida K,Koizumi T

更新日期：2012-12-01 00:00:00

abstract：:Acute lung injury (ALI) is a serious disease with morbidity and mortality in patients. Engeletin (dihydrokaempferol 3-rhamnoside) is a flavanonol glycoside. It can be found in the skin of white grapes and white wine and is widely distributed in southeast Asia. In our study, we evaluated the protective and therapeutic ...

journal_title：Inflammation

authors： Jiang X,Chen L,Zhang Z,Sun Y,Wang X,Wei J

更新日期：2018-08-01 00:00:00

abstract：:We analyzed the effect of the PAF receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride (SM-12502) on human platelet aggregation as well as mediator release. After incubation of human platelet with different concentrations of SM-12502 the cells were subsequently stimulated with either t...

journal_title：Inflammation

authors： Köller M,Hilger RA,König W

更新日期：1996-02-01 00:00:00

abstract：:Stacks of six membrane filters (8-mu pore size) were placed over the mouths of plastic tubes. The tubes were filled with casein (test) or NaCl (control) solution and implanted subcutaneously in white rats; each animal received one tube with casein and one control tube. After 12, 18, 24, and 36 h, the tubes were remove...

journal_title：Inflammation

authors： Egger G,Porta S,Gollmann D

更新日期：1982-06-01 00:00:00

abstract：:We compared exhaled breath condensate (EBC) and induced sputum (IS) for assessing inflammation in pulmonary diseases in patients with obstructive lung disease (n = 20), persistent cough >6 months (n = 20), interstitial lung disease (n = 25) and controls (n = 10). EBC was collected by suspending a Teflon perfluoroalkox...

journal_title：Inflammation

authors： Fireman E,Shtark M,Priel IE,Shiner R,Mor R,Kivity S,Fireman Z

更新日期：2007-04-01 00:00:00

abstract：:The present study aimed at characterizing the phenotype and functions of adherent synovial fluid (SF) cells derived from rheumatoid arthritis (RA), comparing with fibroblast-like synoviocytes (FLS) derived from RA synovial tissue (ST). Adherent SF-derived cells were spindle-shaped from passages 1-6 under light microsc...

journal_title：Inflammation

authors： Ahn JK,Kim H,Lee J,Bae EK,Cha HS,Koh EM

更新日期：2008-12-01 00:00:00

abstract：:Cardiovascular diseases, including acute coronary syndrome (ACS), are the leading cause of death among humans. Adhesion proteins, owing to their involvement in the initiation and progression of atherosclerotic lesions, contribute to the progression of coronary disease and ACS occurrence. Considering ambiguosity of res...

journal_title：Inflammation

authors： Dabek J,Ligus J,Szota J

更新日期：2010-12-01 00:00:00

abstract：:Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...

journal_title：Inflammation

authors： Wang Y,Yang W,Zhao X,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:The respiratory burst is a series of metabolic events which result in the production of microbicidal oxidants by phagocytes. The enzyme responsible for the respiratory burst is a membrane-bound oxidase which catalyzes the production of O-2 by the NADPH-dependent reduction of oxygen. Activity of this oxidase is diminis...

journal_title：Inflammation

authors： Kaufman MR,Babior BM

更新日期：1983-09-01 00:00:00

abstract：:The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...

journal_title：Inflammation

authors： Lima EP,Gonçalves OH,Ames FQ,Castro-Hoshino LV,Leimann FV,Cuman RKN,Comar JF,Bersani-Amado CA

更新日期：2020-11-09 00:00:00

abstract：:The effects were studied of the non-specific phosphodiesterase inhibitor, theophylline (37.5-300 microM), on intracellular levels of cyclic adenosine monophosphate (cAMP) and superoxide generation following exposure of human neutrophils to four different stimuli of neutrophil membrane-associated oxidative metabolism, ...

journal_title：Inflammation

authors： Mahomed AG,Theron AJ,Anderson R,Feldman C

更新日期：1998-12-01 00:00:00

abstract：:Potassium voltage-gated channel subfamily Q member 1 opposite strand 1 (KCNQ1OT1), a long non-coding RNA found in the KCNQ1 locus, has been evidenced to play important roles in the aggravation of inflammatory and oxidative stresses under hypoxia, but whether and how KCNQ1OT1 contributes to neuronal damages in the cere...

journal_title：Inflammation

authors： Yi M,Li Y,Wang D,Zhang Q,Yang L,Yang C

更新日期：2020-10-01 00:00:00

abstract：:The diabetic organism is unable to produce normal amount of granulation tissue which results in delayed wound healing, a significant clinical problem. In the present study, the effect of oral administration of aminoguanidine (AG), in the diabetes-induced inhibition of angiogenesis and granulation tissue formation was ...

journal_title：Inflammation

authors： Teixeira AS,Caliari MV,Rocha OA,Machado RD,Andrade SP

更新日期：1999-12-01 00:00:00

abstract：:CD4+ T cell subset imbalance plays an important role in the development of diabetic complications. Neutrophils have recently been known as the regulator of CD4+ T cell differentiation. However, whether neutrophils affect CD4+ T cell population in diabetes is still elusive. In this study, we investigated the effect of ...

journal_title：Inflammation

authors： Lu H,Xu S,Liang X,Dai Y,Huang Z,Ren Y,Lin J,Liu X

更新日期：2019-04-01 00:00:00

abstract：:Lipids from the sputum of patients with asthma and with cystic fibrosis were isolated and characterized. In both cases, lipids constituted approximately 30% of the dry material. Phosphatidlycholine was the most abundant lipid, Significant amounts of phosphatidylethanolamine and phosphatidylglycerol were present. Hexos...

journal_title：Inflammation

authors： Sahu S,Lynn WS

更新日期：1978-03-01 00:00:00

abstract：:To determine the effect of heat stress on histopathology of acute lung injury (ALI) caused by administration of lipopolysaccharide (LPS), and to determine the roles of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, interferon (IFN)-gamma, IL-10 and surfactants in heat-induced tolerance to ALI, we administe...

journal_title：Inflammation

authors： Koh Y,Lee YM,Lim CM,Lee SS,Shim TS,Lee SD,Kim WS,Kim DS,Kim WD

更新日期：2001-06-01 00:00:00

abstract：:1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects ...

journal_title：Inflammation

authors： Li Y,Lai Y,Wang Y,Liu N,Zhang F,Xu P

更新日期：2016-08-01 00:00:00

abstract：:Free radicals play an important role in the initiation and progression of inflammatory bowel disease (IBD). Therefore, the reduction or elimination of adverse oxidant effects can provide novel therapy for IBD. Here, the antioxidant capacity and protective effects of a new class of chemically modified hetastarch (polyn...

journal_title：Inflammation

authors： Park JH,Ma L,Oshima T,Carter P,Coe L,Ma JW,Specian R,Grisham MB,Trimble CE,Hsia CJ,Liu JE,Alexander JS

更新日期：2002-02-01 00:00:00

abstract：:Praeruptorin C, D, and E (PC, PD, and PE) are three pyranocoumarins isolated from the dried root of Peucedanum praeruptorum Dunn of Umbelliferae. In the present study, we investigated the anti-inflammatory effect of these compounds in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Pyranocoumarins signi...

journal_title：Inflammation

authors： Yu PJ,Jin H,Zhang JY,Wang GF,Li JR,Zhu ZG,Tian YX,Wu SY,Xu W,Zhang JJ,Wu SG

更新日期：2012-06-01 00:00:00