The involvement of NADPH oxidase-mediated ROS in cytokine secretion from macrophages induced by Mycobacterium tuberculosis ESAT-6.

abstract：:The respiratory epithelium is often exposed to oxidant gases, including ozone from photochemical smog and toxic oxygen metabolites released from neutrophils recruited in conditions of airway inflammation. We evaluated DNA single strand break formation by alkaline elution as a measure of oxidant-induced DNA damage to b...

journal_title：Inflammation

authors： McDonald RJ,Pan LC,St George JA,Hyde DM,Ducore JM

更新日期：1993-12-01 00:00:00

abstract：:Myeloperoxidase (MPO), next to the NO synthase2 (NOS2), and NADPH oxidase, is the key enzyme of the oxidative burst responsible for the antimicrobial immunity. Because MPO participates in the eradication of Mycobacterium tuberculosis in the in vitro model and the extracellular enzyme may activate cells to cytokine syn...

journal_title：Inflammation

authors： Koziol-Montewka M,Kolodziejek A,Oles J

更新日期：2004-04-01 00:00:00

abstract：:Ulcerative colitis (UC) is a serious digestive system disease. Furthermore, the activation of C3a/C3aR axis promoted the expression of caspase-11. And higher levels of caspase-11 could induce the pyroptosis and inflammation of cells. However, some studies suggested that caspase-11 could promote and suppress the inflam...

journal_title：Inflammation

authors： Zhang X,Chen Y,Yu S,Jin B,Liu W

更新日期：2020-12-01 00:00:00

abstract：:Current knowledge implicates pleural mesothelial cells as mainly responsible for inflammatory responses in the pleural space. However, a vast body of recent evidence underscores the important role of fibroblasts in the process of inflammation in several types of tissues. We hypothesize that HPFBs (human pleural fibrob...

journal_title：Inflammation

authors： Loghmani F,Mohammed KA,Nasreen N,Van Horn RD,Hardwick JA,Sanders KL,Antony VB

更新日期：2002-04-01 00:00:00

abstract：:Baicalein shows anti-inflammatory effects in human rheumatoid arthritis fibroblast-like synoviocytes (RAFLS). Considering its anti-proliferatory effects on various cancer cells, we investigated the effects of baicalein on interleukin-1 beta (IL-1β)-induced proliferation of human RAFLS. Cell proliferation was examined ...

journal_title：Inflammation

authors： Chen S,Yang Y,Feng H,Wang H,Zhao R,Liu H

更新日期：2014-02-01 00:00:00

abstract：:Baicalin, a flavonoid monomer derived from Scutellaria baicalensis called Huangqin in mandarin, is the main active ingredient contributing to S. baicalensis' efficacy. It is known in China that baicalin has potential therapeutic effects on inflammatory diseases. However, its anti-inflammatory mechanism has still not b...

journal_title：Inflammation

authors： Dong SJ,Zhong YQ,Lu WT,Li GH,Jiang HL,Mao B

更新日期：2015-08-01 00:00:00

abstract：:Simvastatin, which is primarily prescribed to lower cholesterol, may also mitigate lung injury caused by sepsis, although the mechanisms remain elusive. This study aimed to evaluate the protective effect of simvastatin on acute lung injury in rats with sepsis and to investigate possible mechanisms. Male Wistar rats we...

journal_title：Inflammation

authors： Wang Y,Yang W,Zhao X,Zhang R

更新日期：2018-02-01 00:00:00

abstract：:The present study evaluated the anti-inflammatory effect of nanoencapsulated curcuminoid preparations of poly(vinyl pyrrolidone) (Nano-cur) and free curcuminoids (Cur) in an experimental model of croton oil-induced cutaneous inflammation. Male Swiss mice, weighing 25-30 g, received oral treatment by gavage 1 h before ...

journal_title：Inflammation

authors： Lima EP,Gonçalves OH,Ames FQ,Castro-Hoshino LV,Leimann FV,Cuman RKN,Comar JF,Bersani-Amado CA

更新日期：2020-11-09 00:00:00

abstract：:The aim of this prospective case control study is to determine CD4(+), CD25(+), and FoxP3(+) T regulatory cells (Tregs) and T helper cells (Ths) in obese, asthmatic, asthmatic obese, and healthy children. Obese (n = 40), asthmatic (n = 40), asthmatic obese (n = 40), and healthy children (n = 40) were included in this ...

journal_title：Inflammation

authors： Donma M,Karasu E,Ozdilek B,Turgut B,Topcu B,Nalbantoglu B,Donma O

更新日期：2015-08-01 00:00:00

abstract：:A variety of steroidal and nonsteroidal antiinflammatory agents (NSAs) were compared for their effectiveness against a developing acute inflammatory reaction. Only BW 755C [3-amino-1-(m-trifluoromethyl)-phenyl-2-pyrazole] was immediately effective when administered 2 h after carrageenin, as the 3-h swelling was signif...

journal_title：Inflammation

authors： Holsapple MP,Yim GK

更新日期：1984-09-01 00:00:00

abstract：:Neutrophil production of reactive oxygen species is dependent on an assembly process that involves a translocation of the cytosolic NADPH-oxidase components (p47phox; p67phox; Rac2) to a b cytochrome containing membrane. Based on the fact that an intracellular Ca2+ rise can activate the oxidase without any extracellul...

journal_title：Inflammation

authors： Movitz C,Sjölin C,Dahlgren C

更新日期：1997-10-01 00:00:00

abstract：:The purpose of the study was to explore the association between plasma platelet activating factor (PAF) and platelet activating factor acetylhydrolase (PAF-AH) levels and risk of coronary heart disease (CHD) or blood stasis syndrome (BSS) of CHD. Questionnaire, routine clinical assays and plasma levels of PAF, PAF-AH ...

journal_title：Inflammation

authors： Zheng GH,Xiong SQ,Mei LJ,Chen HY,Wang T,Chu JF

更新日期：2012-08-01 00:00:00

abstract：:Prostaglandin production was studied in cultures of pig aorta endothelial cells using radioimmunoassay, radiochromatography, and smooth muscle bioassay. PGE2 was produced in higher concentrations than other prostaglandins. Bradykinin produced a rapid dose-related stimulation of PGE2 production. These results provided ...

journal_title：Inflammation

authors： Jose PJ,Page DA,Wolstenholme BE,Williams TJ,Dumonde DC

更新日期：1981-12-01 00:00:00

abstract：:Treg cells are crucial for maintaining immune homeostasis in CP/CPPS, but the molecular mechanisms underlying the modulation of the function of Treg in CP/CPPS remain unclear. The main purpose of this study is to investigate the relationship between immunosuppressive function of Treg and the methylation level of Foxp3...

journal_title：Inflammation

authors： Chen J,Zhan C,Zhang L,Zhang L,Liu Y,Zhang Y,Du H,Liang C,Chen X

更新日期：2019-10-01 00:00:00

abstract：:The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovere...

journal_title：Inflammation

authors： Liu J,Cheng Y,Zhang X,Zhang X,Chen S,Hu Z,Zhou C,Zhang E,Ma S

更新日期：2015-10-01 00:00:00

abstract：:Salidroside (Sal), a phenylpropanoid glycoside isolated from a popular traditional Chinese medicinal plant Rhodiola rosea L., possesses multiple pharmacological actions. This aim of this study is to investigate the effects of Sal against isoproterenol (ISO)-induced myocardial ischemia. Fifty male Sprague-Dawley rats w...

journal_title：Inflammation

authors： Zhu L,Wei T,Chang X,He H,Gao J,Wen Z,Yan T

更新日期：2015-08-01 00:00:00

abstract：:Interferon gamma (IFNγ)-mediated activation of the myelomonocytic cell line HL-60 and peripheral blood monocytes will induce expression of an epitope for the monoclonal antibody which recognizes human αEβ7 integrin, HML-1. Here, we found that the anti-human αEβ7 monoclonal antibody Ber-ACT8 did not recognize IFNγ-stim...

journal_title：Inflammation

authors： Miller LA,Li C,Hyde DM

更新日期：2000-06-01 00:00:00

abstract：:Enzyme-inducing drugs such as phenobarbital (PB) increase serum concentrations of an acute-phase protein, alpha 1-acid glycoprotein (AGP), in man, dogs, and rats via an unknown mechanism. We studied the effects of PB on components of an acute inflammatory reaction in rats in order to determine if PB acts only on this ...

journal_title：Inflammation

authors： Levy FE,Chauvelot-Moachon L,Florentin I,Forest M,Poüs C,Fournier C,Giroud JP

更新日期：1991-12-01 00:00:00

abstract：:A full understanding of rheumatoid arthritis depends on the appreciation of clinical, radiological, immunological, genetic, biochemical, and structural mechanisms. Rheumatoid arthritis is characterized by the destruction of tissue structures such as articular cartilage and bone, but may also involve tendonous tissue, ...

journal_title：Inflammation

authors： Fassbender HG

更新日期：1984-06-01 00:00:00

abstract：:Interactions of macrophages with epithelium represent one of the pathways involved in regulating local immune mechanisms. We studied the effect of cell-cell contact with an epithelial monolayer on the phenotype of macrophages. Human monocytes and THP-1 macrophages were co-cultured with monolayers of human bronchial ep...

journal_title：Inflammation

authors： Striz I,Slavcev A,Kalanin J,Jaresová M,Rennard SI

更新日期：2001-08-01 00:00:00

abstract：:Drug delivery into immune cells has high potential for the treatment of all kinds of inflammation, allowing a target-oriented transport of active agents. The advantage of this local drug release is the prevention of negative effects of systemic applications and low-dose application. Thereby, the phagocytotic capabilit...

journal_title：Inflammation

authors： Lessig J,Neu B,Glander HJ,Arnhold J,Reibetanz U

更新日期：2011-04-01 00:00:00

abstract：:Nicotine has anti- and pro-inflammatory properties in various cells. Its role in aortic vascular smooth muscle cells (VSMC) was explored. Human aortic VSMC were cultured. After nicotine (1.0 μM) and/or pyrrolidinedithiocarbamic acid (PDTC, 50 μM) treatment, the activation of nuclear factor κB (NFκB) was investigated. ...

journal_title：Inflammation

authors： Wang Y,Zhang F,Yang W,Xue S

更新日期：2012-02-01 00:00:00

abstract：:To study the efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of severe acute pancreatitis. SAP rat models were prepared and randomly divided into model control group and treated group. The sham-operated group was also set. At 3, 6 and 12 h after operation, the mortality rate, ascitic volumes,...

journal_title：Inflammation

authors： Zhang R,Zhang X,Zhang J,Wu J,Ye Q,Xu R,Ye J,Fang X,Jin L,He J,Yuan W

更新日期：2009-04-01 00:00:00

abstract：:The biological effects of asiatic acid (AA) on spinal cord injury (SCI)-induced acute lung injury (ALI) have not been investigated. We aimed to investigate the therapeutic efficacy and molecular mechanisms of AA on SCI-induced ALI. One-hundred and fifty Sprague-Dawley rats were randomly assigned to five groups: sham, ...

journal_title：Inflammation

authors： Jiang W,Li M,He F,Yao W,Bian Z,Wang X,Zhu L

更新日期：2016-12-01 00:00:00

abstract：:The original version of this article contained mistakes, and the authors would like to correct them. ...

journal_title：Inflammation

authors： Wang Y,Han CC,Cui D,Luo TT,Li Y,Zhang Y,Ma Y,Wei W

更新日期：2018-06-01 00:00:00

abstract：:Acute lung injury (ALI) is a serious disease with morbidity and mortality in patients. Engeletin (dihydrokaempferol 3-rhamnoside) is a flavanonol glycoside. It can be found in the skin of white grapes and white wine and is widely distributed in southeast Asia. In our study, we evaluated the protective and therapeutic ...

journal_title：Inflammation

authors： Jiang X,Chen L,Zhang Z,Sun Y,Wang X,Wei J

更新日期：2018-08-01 00:00:00

abstract：:Mastitis is a major disease in humans and other animals and is characterized by mammary gland inflammation. It is a major disease of the dairy industry. Bergenin is an active constituent of the plants of genus Bergenia. Research indicates that bergenin has multiple biological activities, including anti-inflammatory an...

journal_title：Inflammation

authors： Gao XJ,Guo MY,Zhang ZC,Wang TC,Cao YG,Zhang NS

更新日期：2015-01-01 00:00:00

abstract：:Polymorphonuclear neutrophil (PMN) function is thought to be critical in resistance to infectious agents and this implies that the PMN must be able to migrate into, and to function in, environments that may have high levels of bacterial lipopolysaccharide (LPS). Therefore, we have evaluated the effect of LPS on the in...

journal_title：Inflammation

authors： Creamer HR,Hunter N,Bullock WW,Gabler WL

更新日期：1991-06-01 00:00:00

abstract：:Previous studies indicate that aspirin can promote neutrophil (PMN) adhesion to endothelial cells and neutrophil-mediated endothelial cell detachment. The objectives of the present study were to determine whether PMN adhesion is a prerequisite for aspirin-induced, PMN-mediated endothelial cell detachment and whether n...

journal_title：Inflammation

authors： Yoshida N,Cepinskas G,Granger DN,Anderson DC,Wolf RE,Kvietys PR

更新日期：1995-06-01 00:00:00

abstract：:A rat sponge implant model was used to examine the role of protein kinase C (PKC) in angiogenesis. Neovascular response was determined by measurements of relative sponge blood flow by a 133Xe clearance technique and confirmed histologically. Morphometric analysis was used to quantitate the amount of fibrovascular grow...

journal_title：Inflammation

authors： Hu DE,Fan TP

更新日期：1995-02-01 00:00:00