Abstract:
:The present study aimed to determine the protective effects and the underlying mechanisms of astragalin (AG) on ovalbumin (OVA)-induced allergic inflammation in a mouse model of allergic asthma. Our study demonstrated that AG inhibited OVA-induced increases in eosinophil count; IL-4, IL-5, IL-13, and IgE were recovered in bronchoalveolar lavage fluid, and increased IFN-γ level in bronchoalveolar lavage fluid. Histological studies demonstrated that AG substantially inhibited OVA-induced eosinophilia in lung tissue. Western blot analysis demonstrated that AG treatments markedly inhibited OVA-induced SOCS-3 expression and enhancement of SOCS-5 expression in an asthma model. Our findings support the possible use of AG as a therapeutic drug for patients with allergic asthma.
journal_name
Inflammationjournal_title
Inflammationauthors
Liu J,Cheng Y,Zhang X,Zhang X,Chen S,Hu Z,Zhou C,Zhang E,Ma Sdoi
10.1007/s10753-015-0181-6subject
Has Abstractpub_date
2015-10-01 00:00:00pages
2007-16issue
5eissn
0360-3997issn
1573-2576journal_volume
38pub_type
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