Abstract:
:Numerous studies have evaluated the association between -159C/T polymorphism of the CD14 gene and asthma risk; however, these studies have yielded inconsistent results. We performed meta-analyses to investigate the association between CD14-159C/T polymorphism and asthma risk. Studies were identified from PubMed, Embase, and two Chinese databases. Odds ratios (ORs) with 95 % confidence interval (CI) were used to evaluate the strength of association. Thirty-six studies were collected for meta-analysis, which involved 6954 cases and 7525 controls. In the overall populations, no significant association between the CD14-159C/T polymorphism and asthma risk was found for the dominant (OR = 0.90, 95 % CI = 0.81-1.01, P = 0.08) or other models; stratified analyses indicated that the CD14-159C/T polymorphism was not associated with asthma risk in Caucasians or Asians or adults or children. Among the atopic asthma populations, no significant results were observed in the all-combined or subgroup analyses. This meta-analysis demonstrates that the CD14-159C/T polymorphism may not be a risk factor for asthma.
journal_name
Inflammationjournal_title
Inflammationauthors
Zhang R,Deng R,Li H,Chen Hdoi
10.1007/s10753-015-0269-zsubject
Has Abstractpub_date
2016-02-01 00:00:00pages
457-466issue
1eissn
0360-3997issn
1573-2576pii
10.1007/s10753-015-0269-zjournal_volume
39pub_type
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