解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Aerosol bolus dispersion was measured in the first branching generations of a replicate hollow cast. The cast was made from a solid cast of a beagle-dog tracheobronchial tree. The dispersion was measured after penetration of boluses into different volumetric depths, with different particle sizes and flow rates into th...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509031756
更新日期:1995-07-01 00:00:00
abstract::Endothelin-1 (ET-1) has constrictor and mitogenic effects on airway smooth muscle strips and cultured cells, respectively. This study addresses the type of the ET receptor subtype(s) present on ovine airway smooth muscle cells and the possibility of autocrine effects. The expression of the preproendothelin-1 gene was ...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509023719
更新日期:1995-05-01 00:00:00
abstract::This study investigated whether interleukin-1 (IL-1) inhibitory activity in LPS-stimulated culture supernatants of alveolar macrophages and epithelioid cells obtained from rabbit lung granulomas induced by complete Freund's adjuvant (CFA) was identical to IL-1 receptor antagonist (IL-1ra) and examined the changes of I...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509068834
更新日期:1995-03-01 00:00:00
abstract::The role of bombesin was investigated in the course of the pulmonary inflammation and fibrosis (PF) elicited by the intratracheal (IT) or intravenous (i.v.) administration of bleomycin in mice. Bleomycin-induced alveolitis was associated with an accumulation of cells, presumably macrophages, containing bombesin, as ev...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509068829
更新日期:1995-03-01 00:00:00
abstract::An IgM monoclonal antibody (1D9/B3) is characterized, which specifically recognizes basal cells of the upper airway epithelium. Although morphological features have been used to follow cell lineage and differentiation, an objective assessment of differentiation can be enhanced by characterizing the expression of speci...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509031741
更新日期:1995-01-01 00:00:00
abstract::An improved method has been developed for separation of an enriched population of mouse type 2 pneumocytes, based on differential adherence and size fractionation of cells dissociated with trypsin. These cells were successfully maintained in primary culture in serum-free medium MCDB 201 supplemented with albumin, tran...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509031746
更新日期:1995-01-01 00:00:00
abstract::Sirius Red staining is presented as a method for collagen determination, enabling quantitative morphometric measurements to be performed in locally defined tissue areas. The advantage of this method is especially shown for alveolar lung tissue. By excluding the bronchial areas in the tissue sections, the differences i...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509031745
更新日期:1995-01-01 00:00:00
abstract::It has been suggested that increased recruitment of phagocytes and subsequent clearance of particles may follow instillation of a leukocyte chemoattractant to lungs containing silica. The present study quantitated serially the silica content in alveolar spaces, in lung tissue and in hilar lymph nodes of mice that rece...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149409064384
更新日期:1994-05-01 00:00:00
abstract::Previous experiments with the sheep model of silicosis have demonstrated a reduction of the pathological activity of quartz after treatments with aluminum lactate (Al-lac), such as Al-lac pretreatment of intratracheally injected quartz or Al-lac inhalation of quartz-exposed animals. Preliminary data also suggested a m...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149409064380
更新日期:1994-03-01 00:00:00
abstract::CTP:cholinephosphate cytidylyltransferase (CT) is a key enzyme required for surfactant phosphatidylcholine synthesis, and its activity is regulated by lung lipids. This study evaluated the effect of epidermal growth factor (EGF) on the phospholipid content and the expression of CT in the lung following direct in vivo ...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149409064369
更新日期:1994-01-01 00:00:00
abstract::The diabetic pregnancy is characterized by a delay in the process of fetal lung maturation. To determine whether high glucose conditions per se have an adverse impact on fetal lung phospholipid metabolism, 20-day fetal rat lung explants were cultured in F-12 medium (10 mM glucose) to which glucose was added to achieve...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149309064361
更新日期:1993-11-01 00:00:00
abstract::It was hypothesized that IL-8, a neutrophil chemotaxin, contributes to the influx of neutrophils into the pleural cavity of patients with pleural effusions. Pleural fluids were collected from 57 patients including 13 with effusions due to congestive heart failure, 28 with pleural involvement by carcinoma, 5 with empye...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149309031730
更新日期:1993-09-01 00:00:00
abstract::Direct measurements of pleural fluid hydrostatic and colloid osmotic pressures after infusion of saline, bovine serum albumin, or silicone into the pleural space were coupled with ultrastructural morphometric analyses to assess the response of pleural mesothelial cells to hydrothorax. Increases of hydrostatic pressure...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149309064347
更新日期:1993-05-01 00:00:00
abstract::A small subpopulation of pulmonary epithelial cells (PE) proliferates in low-density primary culture of alveolar type II cells and forms colonies of cells that could be passaged for several generations and that in some respects maintain a differentiated phenotype of the alveolar type II cells. At this time it is not k...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149309031717
更新日期:1993-03-01 00:00:00
abstract::Administering liposome-encapsulated drugs by aerosols could be a feasible way of targeting drugs to the lung, specifically to pulmonary alveolar macrophages (AM). In the mouse model, we characterized uptake of carboxyfluorescein- (CF-) labeled liposomes by AM in vivo after acute inhalation of liposome aerosols, and th...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149309071077
更新日期:1993-01-01 00:00:00
abstract::The developmental regulation of the rabbit surfactant-associated proteins, SP-A, SP-B, and SP-C, was investigated using Northern blot analysis. These proteins comprise approximately 10% by weight of pulmonary surfactant, a lipoprotein secreted by type II cells that reduces surface tension at the air-alveolar interface...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149209031707
更新日期:1992-11-01 00:00:00
abstract::A cast of human tracheobronchial airways, which is complete to airways less than 0.1 cm in diameter, was employed for experimental studies of gas convective transport by high-frequency ventilation (HFV). The cast was ventilated with gases of different kinematic viscosity (He, air, and SF6) and tidal volumes of 10-60 m...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149209031698
更新日期:1992-09-01 00:00:00
abstract::Understanding the effects from long-term exposure to individual ambient air pollutants and mixtures of pollutants is necessary for adequate assessment of health risk. This study examined quantitative and temporal alterations in tracheobronchial mucociliary clearance function and bronchial epithelial secretory cells in...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149209064343
更新日期:1992-07-01 00:00:00
abstract::Eprazinone therapy improves pulmonary function and arterial pO2 in patients with chronic bronchitis; however, the mechanism of action is unknown. The purpose of this study was to determine if eprazinone alters either lung surfactant levels in bronchoalveolar lavage fluid (BAL) of normal rats, or ion transport across c...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149209031693
更新日期:1992-05-01 00:00:00
abstract::Male Sprague-Dawley rats were placed in hypobaric hypoxia for 17-21 d (FIO2 10%) to establish pulmonary hypertension (PH) and control rats were kept in normobaric room air. Right mean atrial and ventricular pressures (PRA, PRV) were recorded, left ventricular (LV) blood was collected, and lungs were perfused with hepa...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149209031681
更新日期:1992-03-01 00:00:00
abstract::A specific form of flavin monooxygenase has been identified in the lungs of a number of species. Distribution of the pulmonary flavin-containing monooxygenase (FMOp) is of interest because it oxidatively metabolizes a wide variety of nitrogen-, sulfur-, and phosphorous-containing xenobiotics, some of which form highly...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149209020656
更新日期:1992-01-01 00:00:00
abstract::The inhalation of inorganic dust can lead to the development of interstitial pulmonary fibrosis, characterized by the accumulation of fibroblasts and connective tissue matrix in the lung interstitium. The fibrosis causes alterations in the architecture of the lung parenchyma, resulting in abnormal gas exchange and hyp...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149109064332
更新日期:1991-11-01 00:00:00
abstract::It is evident that much remains to be learned about the nasal passages and their responses to toxic materials. For the nose of both laboratory animals and humans, information is needed in the areas of anatomy, physiology, biochemistry, neurobiology, physiopathology, and oncology. This article briefly discussed toxic a...
journal_title:Experimental lung research
pub_type: 杂志文章,评审
doi:10.3109/01902149109064322
更新日期:1991-09-01 00:00:00
abstract::The role of the Clara and type II cell in the development of pulmonary tumors in the A/J mouse and Fischer rat was investigated by determining the relationship of DNA methylation and repair in pulmonary cells to oncogene activation and by characterizing the morphology of pulmonary tumors induced by treatment with 4-(m...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149109064417
更新日期:1991-03-01 00:00:00
abstract::This report describes the protocol for the strain A mouse lung tumor bioassay and summarizes results on selected chemicals that have been tested for carcinogenicity in the assay. The assay is of 6 months duration and can distinguish 2-fold differences in carcinogenic potential of compounds from several chemical classe...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149109064428
更新日期:1991-03-01 00:00:00
abstract::A number of novel chemotactic cytokines are becoming increasingly recognized as important participants in the elicitation of specific inflammatory cells from the peripheral blood to sites of inflammation. Recent observations have now demonstrated that certain chemotactic cytokines possess specificity for the selected ...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149109063278
更新日期:1991-01-01 00:00:00
abstract::Verapamil, a calcium channel blocker has been used with partial success in cases of primary pulmonary hypertension, as well as to reduce hypoxia-induced pulmonary hypertension (PH) in rats. However, its effect on monocrotaline (MCT)-induced PH in rats is not known. We studied the effect of verapamil on MCT-induced PH....
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149009087885
更新日期:1990-11-01 00:00:00
abstract::Pathophysiologic changes induced by phospholipase A2 (PLA2), a lipolytic enzyme implicated in a variety of pulmonary diseases, were examined in the isolated, perfused guinea pig lung. Thirty microliters of vehicle (saline) or 30 units of PLA2 suspended in saline was given as a bolus injection into either the trachea o...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149009108848
更新日期:1990-07-01 00:00:00
abstract::Confluent cultures of primary hamster tracheal surface epithelial cells are highly enriched with secretory cells resembling airway goblet cells. The cultures secrete lipids, most of which appear to be associated with high-molecular-weight mucinlike glycoproteins (HMW MLGP). In the present communication, we examined th...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149009108845
更新日期:1990-05-01 00:00:00
abstract::In both ovalbumin-sensitized and ovalbumin-challenged guinea pigs, the phospholipid content of bronchoalveolar lavage fluid is decreased with respect to that of controls. In the sensitized guinea pig, the activity of lung membrane phospholipase is increased and the phospholipid content of lung membranes is decreased. ...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149009087876
更新日期:1990-03-01 00:00:00
abstract::We have previously shown that intratracheally instilled silica (quartz) produces both morphologic evidence of emphysema and small-airway changes, and functional evidence of airflow obstruction. To further define the nature of the airflow-associated lesions induced by silica, we compared silica-exposed rats to rats giv...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909069628
更新日期:1989-12-01 00:00:00
abstract::We compared the effects of dexamethasone given to rats from age 4 to 14 days, on alveolar development at age 99 days. Judged by similar nose-to-tail length and body weight, somatic growth was not altered by dexamethasone treatment. Lung volumes in both air- and saline-filled lungs and mean chord length (Lm) were incre...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909069638
更新日期:1989-12-01 00:00:00
abstract::The molecular events involved in both the initiation and development of silicosis are at present poorly defined, although mediators released from macrophages exposed to silica particles are believed to play a role. We have investigated the in vitro production of arachidonic acid (AA) metabolites in adherent bovine alv...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909069615
更新日期:1989-07-01 00:00:00
abstract::Chlorinated amines are long-lived oxidants released from inflammatory cells. They have been observed to alter the function of important inflammatory molecules. Whether they can contribute directly to the inflammatory alteration of cellular barriers is not known. Monolayers of cultured porcine pulmonary artery endothel...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909087864
更新日期:1989-05-01 00:00:00
abstract::The effect of glucocorticoids on the response of adenylate cyclase in fetal rat lung fibroblast and Type II epithelial cell cultures to beta-agonists and prostaglandin E2 (PGE2) was investigated. There was significant stimulation of cyclic AMP synthesis by adrenalin in both fibroblasts and Type II cells, which was pot...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909087863
更新日期:1989-05-01 00:00:00
abstract::Sex-related differences may be present during fetal lung growth and at the onset of surfactant synthesis. In this study we investigated the role of dihydrotestosterone (DHT) and estrogen (EST) on cell division and on labeled palmitate incorporation into disaturated phosphatidylcholine (DSPC) at various times of gestat...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909087851
更新日期:1989-03-01 00:00:00
abstract::Intratracheal bleomycin induces pulmonary fibrosis in experimental animals, but the mechanisms involved are poorly understood. Since altered levels of fatty acid metabolites are associated with bleomycin-induced lung injury, we examined the effects of a change in dietary fat on bleomycin-induced fibrosis. Previously w...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909087861
更新日期:1989-03-01 00:00:00
abstract::Intraphagosomal pH in rabbit alveolar macrophages was studied using amorphous silica particles (FSP) and yeast particles (FYP) labeled with fluorescein. The pH was estimated from the quotient between the fluorescence intensity at wavelength 519 nm with excitation at wavelengths 495 and 450 nm. Within a factor of 10, p...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909069608
更新日期:1989-01-01 00:00:00
abstract::We studied lung clearance of technetium-labeled diethylenetriamine pentaacetic acid [( 99mTc]DTPA), plasma and bronchoalveolar lavage fluid (BALF) concentrations of 6-keto-PGF1 alpha (stable metabolite of prostacyclin, prostaglandin I2, PGI2), TxB2 (stable metabolite of thromboxane A2, TxA2), and leukotriene B4 (LTB4)...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148809087840
更新日期:1988-01-01 00:00:00
abstract::Recently there has been a great deal of interest in exploring possible ways to protect the lung from oxidant damage. Since sulfhydryl compounds are among the most important endogenous antioxidants, their therapeutic use has been proposed. Glutathione (GSH), the main intracellular nonprotein sulfhydryl, plays an import...
journal_title:Experimental lung research
pub_type: 杂志文章,评审
doi:10.3109/01902148809064189
更新日期:1988-01-01 00:00:00