Effects of postnatal dexamethasone treatment on development of alveoli in adult rats.

abstract：PURPOSE:As an angiotensin converting enzyme (ACE) inhibitor, the effects of captopril on inflammation has been previously examined. Captopril has been shown to have anti-inflammatory and antioxidant effects. Imbalance in the oxidant/antioxidant system is one of the major causes of inflammation. In the present study, th...

journal_title：Experimental lung research

authors： Boskabadi J,Mokhtari-Zaer A,Abareshi A,Khazdair MR,Emami B,Mohammadian Roshan N,Hosseini M,Boskabady MH

更新日期：2018-01-01 00:00:00

abstract：:Studies demonstrated that pathophysiological abnormalities of airway smooth muscle (ASM) contribute significantly to chronic obstructive pulmonary disease (COPD) pathogenesis, the aim of this study is to investigate heat shock protein 70 (Hsp70) in ASM in COPD. ASM from 8 COPD patients and 6 controls were isolated for...

journal_title：Experimental lung research

authors： Xie J,Zhao J,Xiao C,Xu Y,Yang S,Ni W

更新日期：2010-05-01 00:00:00

abstract：:The effect of a receptor binding protein for tumor necrosis factor (TNFrbp) on cell infiltration, bronchial hyperreactivity, and release of inflammatory mediators were studied following antigen challenge in sensitized rats. A 3-fold increase in total cell number, mainly neutrophils and eosinophils, was noted in bronch...

journal_title：Experimental lung research

authors： Carvalho CR,Jancar S,Conroy D,Sirois P

更新日期：2001-03-01 00:00:00

abstract：:Hypothyroid adult rats were injected intravenously with [3, 5, 3'-125I]triiodothyronine (T3) or [125I]thyroxine (T4). Others were similarly treated except for the addition of a 500-fold excess of the appropriate unlabeled hormone. Light microscopic autoradiography of semithin sections of lung from these animals demons...

journal_title：Experimental lung research

authors： Smith DM,Hitchcock KR

更新日期：1983-09-01 00:00:00

abstract：:Confluent cultures of primary hamster tracheal surface epithelial cells are highly enriched with secretory cells resembling airway goblet cells. The cultures secrete lipids, most of which appear to be associated with high-molecular-weight mucinlike glycoproteins (HMW MLGP). In the present communication, we examined th...

journal_title：Experimental lung research

authors： Kim KC,Singh BN

更新日期：1990-05-01 00:00:00

abstract：:Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine m...

journal_title：Experimental lung research

authors： Suh GY,Ham HS,Lee SH,Choi JC,Koh WJ,Kim SY,Lee J,Han J,Kim HP,Choi AM,Kwon OJ

更新日期：2006-01-01 00:00:00

abstract：:The Ca(2+)-mobilizing actions of adenosine 5'-triphosphate (ATP), bradykinin, and histamine were compared in phenotypically distinct human nasal epithelial (HNE) cell types and as a function of time in cell culture. Single-cell measurements of intracellular free Ca2+ (Ca2+i, Fura-2 fluorescence) were recorded in cilia...

journal_title：Experimental lung research

authors： Paradiso AM,Brown HA,Ye H,Harden TK,Boucher RC

更新日期：1999-06-01 00:00:00

abstract：:In three experiments, we have explored the uptake and transport of colloidal gold (Au) and iron oxide (Fe2O3) by normal and SO2-injured bronchial epithelium. In the first experiment, mice were exposed to a 2-hr aerosol of Au; in the second experiment, mice were exposed to SO2 (250 ppm) for 3 hr, then to Au; and in the...

journal_title：Experimental lung research

authors： Watson AY,Brain JD

更新日期：1980-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We have previously reported that N-acetylcysteine (NAC), ambroxol and azithromycin (AZM) (partially) correct the chloride efflux dysfunction in cystic fibrosis bronchial epithelial (CFBE) cells with the ΔF508 homozygous mutation in vitro. METHODS:In the present paper, we further investigated p...

journal_title：Experimental lung research

authors： Hussain S,Varelogianni G,Särndahl E,Roomans GM

更新日期：2015-06-01 00:00:00

abstract：:Previous studies have indicated increased plasma levels of inducible nitric oxide synthase in lung. This study further examines the pulmonary expression of nitric oxide synthase (NOS) isoforms in an ovine model of acute lung injury induced by smoke inhalation and burn injury (S+B injury). Female range bred sheep (4 pe...

journal_title：Experimental lung research

authors： Cox RA,Jacob S,Oliveras G,Murakami K,Enkhbaatar P,Traber L,Schmalstieg FC,Herndon DN,Traber DL,Hawkins HK

更新日期：2009-03-01 00:00:00

abstract：:Tannic acid was used as a mordant to enhance the preservation of lung phospholipids during fixation and processing for electron microscopy. We found multilamellar bodies within alveolar septa (including type I pneumocytes, capillary endothelial cells, and interstitium) which have not been described previously and whic...

journal_title：Experimental lung research

authors： Kalina M,Young SL

更新日期：1980-08-01 00:00:00

abstract：:Nuclear factor kappa B (NF-kappa B) is a critical transcription factor for the production of many inflammatory cytokines. It is activated in the airway epithelium of human asthmatics and in mice after allergic stimulation. To examine the role of NF-kappa B activation in allergic inflammation, the authors generated tra...

journal_title：Experimental lung research

authors： Sheller JR,Polosukhin VV,Mitchell D,Cheng DS,Peebles RS,Blackwell TS

更新日期：2009-12-01 00:00:00

abstract：:Aberrant expression of key cell cycle regulatory genes is essential for the immortalization and transformation of cells in vitro. We examined 20 mouse lung epithelial cell lines (2 nontumorigenic, 5 nonmetastatic, and 13 metastatic) for mutations or alterations in the expression of key components of the Rb pathway (pR...

journal_title：Experimental lung research

authors： McDoniels-Silvers AL,Herzog CR,Tyson FL,Malkinson AM,You M

更新日期：2001-04-01 00:00:00

abstract：:A specific form of flavin monooxygenase has been identified in the lungs of a number of species. Distribution of the pulmonary flavin-containing monooxygenase (FMOp) is of interest because it oxidatively metabolizes a wide variety of nitrogen-, sulfur-, and phosphorous-containing xenobiotics, some of which form highly...

journal_title：Experimental lung research

authors： Overby L,Nishio SJ,Lawton MP,Plopper CG,Philpot RM

更新日期：1992-01-01 00:00:00

abstract：:We studied lung clearance of technetium-labeled diethylenetriamine pentaacetic acid [( 99mTc]DTPA), plasma and bronchoalveolar lavage fluid (BALF) concentrations of 6-keto-PGF1 alpha (stable metabolite of prostacyclin, prostaglandin I2, PGI2), TxB2 (stable metabolite of thromboxane A2, TxA2), and leukotriene B4 (LTB4)...

journal_title：Experimental lung research

authors： Witten ML,Quan SF,Sobonya RE,Bruck D,Devine L,Lemen RJ

更新日期：1988-01-01 00:00:00

abstract：:Investigations on leukocyte populations in the lung have shown that lymphocytes are found in different anatomical compartments. Lymphocytes can be seen to a different extent in the lung interstitium, the epithelium and lamina propria of the bronchi, the bronchoalveolar space, and the marginal lung vascular bed. Previo...

journal_title：Experimental lung research

authors： Fliegert FG,Tschernig T,Pabst R

更新日期：1996-11-01 00:00:00

abstract：:Because high partial pressures of oxygen (O2) can cause peroxidative cleavage of membrane lipids, it is plausible to hypothesize that hyperoxia alters the physical state and composition of lipids in the membranes of pulmonary endothelial cells and that manipulation of the lipid profile may modify endothelial cell tole...

journal_title：Experimental lung research

authors： Block ER

更新日期：1988-01-01 00:00:00

abstract：:Silicosis is a serious occupational disease characterized by lung fibrosis that is caused by long-term inhalation of silica-containing fine particles. Lysophosphatidic acid (LPA) and LPA1/3 plays a role in lung fibrosis. Until recently, there has been little research investigating the role of LPA and LPA receptors (LP...

journal_title：Experimental lung research

authors： Cong C,Mao L,Zhang Y,Zhao Z,Xu X,Zhao J

更新日期：2014-09-01 00:00:00

abstract：:Thrombin activates protease-activated receptor (PAR)-1 and induces a myofibroblast phenotype in normal lung fibroblasts. The origins of myofibroblasts are resident fibroblasts, fibrocytes, and epithelial-mesenchymal transition (EMT). We investigated the effects of thrombin, an important mediator of interstitial lung f...

journal_title：Experimental lung research

authors： Song JS,Kang CM,Park CK,Yoon HK

更新日期：2013-10-01 00:00:00

abstract：:Nicotine appears to be the primary pharmacologic agent that causes smoking-related pulmonary diseases. An understanding of the effect of nicotine on lungs is essential to develop interventions that can be used to counter smoking-related diseases. Further, it is shown that physical exercise may partially reverse smokin...

journal_title：Experimental lung research

authors： Al-Obaidi S,Mathew TC,Dean E

更新日期：2012-05-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is a leading cause of mortality worldwide. In China, a dramatic increase in the incidence of NSCLC is expected in the next 20 years (Molina et al. Mayo Clin Proc. 2008;83:584–594). Mutated epidermal growth factor receptor (EGFR) status is a known predictor ...

journal_title：Experimental lung research

authors： McMillen E,Ye F,Li G,Wu Y,Yin G,Liu W

更新日期：2010-11-01 00:00:00

abstract：:Mechanical ventilation (MV) is well known to potentially cause ventilator-associated lung injury (VALI). It has also been reported recently that activation of invariant natural killer T (iNKT) cells is involved in the onset/progression of airway inflammation. We analyzed the roles of inflammatory cells, including iNKT...

journal_title：Experimental lung research

authors： Shiga Y,Sugamata R,Iwamura C,Nagao T,Zao J,Kawakami K,Kawachi S,Nakayama T,Suzuki K

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Bronchopulmonary dysplasia (BPD) is a main chronic lung disease commonly occurs in preterm infants. BPD is characterized by impaired alveolarization and vascularization of the developing lung. Transforming growth factor-β (TGF-β) signaling pathway is known to play an important role during lung vascular devel...

journal_title：Experimental lung research

authors： Jin M,Lee J,Lee KY,Jin Z,Pak JH,Kim HS

更新日期：2016-09-01 00:00:00

abstract：:Previous experiments with the sheep model of silicosis have demonstrated a reduction of the pathological activity of quartz after treatments with aluminum lactate (Al-lac), such as Al-lac pretreatment of intratracheally injected quartz or Al-lac inhalation of quartz-exposed animals. Preliminary data also suggested a m...

journal_title：Experimental lung research

authors： Dufresne A,Sébastien P,Michaud D,Perrault G,Bégin R

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:HSPGs are glycoproteins containing covalently attached heparan sulfate (HS) chains which bind to growth factors, chemokines, etc., and regulate various aspects of inflammation including cell recruitment. We previously showed that deletion of endothelial N-acetylglucosamine N-deacetylase-N-sulfotransferase-1 ...

journal_title：Experimental lung research

authors： Ge XN,Bastan I,Ha SG,Greenberg YG,Esko JD,Rao SP,Sriramarao P

更新日期：2018-03-01 00:00:00

abstract：:Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To further assess the toxic effects of amiodarone on lung tissue, Syrian hamsters were given a single intratracheal insufflation of the agent an...

journal_title：Experimental lung research

authors： Cantor JO,Osman M,Cerreta JM,Suarez R,Mandl I,Turino GM

更新日期：1984-01-01 00:00:00

abstract：:Understanding the effects from long-term exposure to individual ambient air pollutants and mixtures of pollutants is necessary for adequate assessment of health risk. This study examined quantitative and temporal alterations in tracheobronchial mucociliary clearance function and bronchial epithelial secretory cells in...

journal_title：Experimental lung research

authors： Schlesinger RB,Gorczynski JE,Dennison J,Richards L,Kinney PL,Bosland MC

更新日期：1992-07-01 00:00:00

abstract：PURPOSE OF THE STUDY:Workers in enclosed hogbarns experience an increased incidence of airway inflammation and obstructive lung disease, and an aqueous hogbarn dust extract (HDE) induces multiple inflammation-related responses in cultured airway epithelial cells. Epidermal growth factor receptor (EGFR) phosphorylation ...

journal_title：Experimental lung research

authors： Dodmane PR,Schulte NA,Heires AJ,Band H,Romberger DJ,Toews ML

更新日期：2018-12-01 00:00:00

abstract：:Irreversible lung parenchymal injury is usually healed by fibrosis, which depends on the abilities of fibroblasts to proliferate, migrate into the wound, and survive. Because the lung is frequently exposed to increased oxidative stress, which is thought to mediate apoptosis, we examined whether oxidative stress induce...

journal_title：Experimental lung research

authors： Takahashi A,Aoshiba K,Nagai A

更新日期：2002-06-01 00:00:00

abstract：:The effects of activated leukocytes on surfactant function and composition were examined to better define the mechanisms by which acute inflammation contributes to respiratory distress syndrome (ARDS). Peripheral blood leukocytes from healthy volunteers were incubated in vitro with surfactant for 4 hours: (1) in the a...

journal_title：Experimental lung research

authors： Schochett P,Mora R,Mark L,Butler M,Ingenito EP

更新日期：1999-10-01 00:00:00