Regulation of silicosis formation by lysophosphatidic acid and its receptors.

abstract：:Few studies are available about the role of dietary zinc (Zn) in respiratory diseases. Adult male rats were divided into 2 groups and fed respectively a moderate Zn-deficient diet and a Zn-adequate control diet. In lung tissue at 2 months, thiobarbituric acid-reactive species (TBARS), total glutathione, glutathione di...

journal_title：Experimental lung research

authors： Gomez NN,Fernandez MR,Zirulnik F,Gil E,Scardapane L,Ojeda MS,Gimenez MS

更新日期：2003-10-01 00:00:00

abstract：:Variable numbers of composite repetitive motifs are found in different individuals within intron 4 of the surfactant protein B (SP-B) gene (Biochem J. 1995;305:583). This study tests the hypothesis that the distribution of SP-B alleles differs among racial/ethnic groups. A total of 412 SP-B alleles were analyzed: 206 ...

journal_title：Experimental lung research

authors： Veletza SV,Rogan PK,TenHave T,Olowe SA,Floros J

更新日期：1996-07-01 00:00:00

abstract：:Inflammation plays a key role in lung injury and in the pathogenesis of asthma. Two murine models of allergic airway inflammation-sensitization and challenge to ovalbumin (OVA) and intratracheal exposure to interleukin-13 (IL13)-were used to evaluate the expression of poly(ADP-ribose) polymerase-1 (PARP-1) in allergic...

journal_title：Experimental lung research

authors： Havranek T,Aujla PK,Nickola TJ,Rose MC,Scavo LM

更新日期：2010-09-01 00:00:00

abstract：:Previous experiments with the sheep model of silicosis have demonstrated a reduction of the pathological activity of quartz after treatments with aluminum lactate (Al-lac), such as Al-lac pretreatment of intratracheally injected quartz or Al-lac inhalation of quartz-exposed animals. Preliminary data also suggested a m...

journal_title：Experimental lung research

authors： Dufresne A,Sébastien P,Michaud D,Perrault G,Bégin R

更新日期：1994-03-01 00:00:00

abstract：:Acute exposure to NO2 is reported to disrupt tight junctions in lung epithelium. We have studied the effects of chronic NO2 exposure and recovery breathing clean air to tight junctions of distal airway and alveolar epithelium. Syrian Golden hamsters were exposed to NO2 (30 PPM) for 5 or 9 months and a group of those a...

journal_title：Experimental lung research

authors： Gordon RE,Solano D,Kleinerman J

更新日期：1986-01-01 00:00:00

abstract：:Two morphologic characteristics have been used to define the nonciliated bronchiolar epithelial cell: abundant agranular endoplasmic reticulum (AER) and membrane-bound avoid granules. To assess the ultrastructural homogeneity of this cell type in the lungs of large domestic mammals used as experimental models in pulmo...

journal_title：Experimental lung research

authors： Plopper CG,Mariassy AT,Hill LH

更新日期：1980-06-01 00:00:00

abstract：:The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF...

journal_title：Experimental lung research

authors： Alho HS,Maasilta PK,Vainikka T,Salminen US

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:This study aims to explore the effect of thymoquinone (TQ) on particulate matter 2.5 (PM2.5)-induced lung injury. METHODS:The PM2.5 sample was provided by Shenyang Environment Monitor Central Station. Lung injury was established by intratracheal instillation PM2.5 (7.5 mg/kg) followed by TQ treatment (20 an...

journal_title：Experimental lung research

authors： Mao M,Li J,Bi A,Jia H,Li Q,Liu Y,Jiang X,Huang D,Xia S

更新日期：2020-10-01 00:00:00

abstract：:Basement membranes (BM) are specialized extracellular matrices (ECM) which serve as complex interfaces between epithelia, peripheral nerves, or muscle cells and their surrounding tissue microenvironments. Their composition is known to include type IV collagen, laminin, entactin, heparan sulfate proteoglycan (HSPG, per...

journal_title：Experimental lung research

authors： Sannes PL,Wang J

更新日期：1997-03-01 00:00:00

abstract：:The streptozotocin-induced diabetic (STZ-DB) rat model is associated with fetal hyperglycemia, but with low to normal plasma insulin concentration. Because surfactant protein (SP) mRNA content in fetal rat lung is decreased in STZ-DB pregnancy, we investigated the effect of increasing concentrations of glucose on SP g...

journal_title：Experimental lung research

authors： Rayani HH,Gewolb IH,Floros J

更新日期：1999-01-01 00:00:00

abstract：:In order to investigate some of the characteristics of superoxide anion release from alveolar macrophages, the effects of substances known to influence superoxide release from polymorphonuclear leukocytes (PMN) were studied in rat alveolar macrophages. There is a relatively small, but constant, amount of superoxide re...

journal_title：Experimental lung research

authors： Sweeney TD,Castranova V,Bowman L,Miles PR

更新日期：1981-05-01 00:00:00

abstract：:A cast of human tracheobronchial airways, which is complete to airways less than 0.1 cm in diameter, was employed for experimental studies of gas convective transport by high-frequency ventilation (HFV). The cast was ventilated with gases of different kinematic viscosity (He, air, and SF6) and tidal volumes of 10-60 m...

journal_title：Experimental lung research

authors： Fang CP,Cohen BS,Lippmann M

更新日期：1992-09-01 00:00:00

abstract：:Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To further assess the toxic effects of amiodarone on lung tissue, Syrian hamsters were given a single intratracheal insufflation of the agent an...

journal_title：Experimental lung research

authors： Cantor JO,Osman M,Cerreta JM,Suarez R,Mandl I,Turino GM

更新日期：1984-01-01 00:00:00

abstract：:This study investigated whether interleukin-1 (IL-1) inhibitory activity in LPS-stimulated culture supernatants of alveolar macrophages and epithelioid cells obtained from rabbit lung granulomas induced by complete Freund's adjuvant (CFA) was identical to IL-1 receptor antagonist (IL-1ra) and examined the changes of I...

journal_title：Experimental lung research

authors： Shigenaga T,Abe Y,Miyazaki E,Kita S,Tsuda T

更新日期：1995-03-01 00:00:00

abstract：AIM OF THE STUDY:Nucleic acid-based therapies have the potential to provide clinically meaningful benefit across a wide spectrum of lung disease. However, in vivo delivery remains a challenge. Here we examined the feasibility of using electrospray to deliver nucleic acids to both porcine tracheal tissue sections and wh...

journal_title：Experimental lung research

authors： Riddell P,Gilbert JL,Molloy EL,Finnegan S,Egan JJ,O'Dea S

更新日期：2018-01-01 00:00:00

abstract：:The effects of activated leukocytes on surfactant function and composition were examined to better define the mechanisms by which acute inflammation contributes to respiratory distress syndrome (ARDS). Peripheral blood leukocytes from healthy volunteers were incubated in vitro with surfactant for 4 hours: (1) in the a...

journal_title：Experimental lung research

authors： Schochett P,Mora R,Mark L,Butler M,Ingenito EP

更新日期：1999-10-01 00:00:00

abstract：:In both ovalbumin-sensitized and ovalbumin-challenged guinea pigs, the phospholipid content of bronchoalveolar lavage fluid is decreased with respect to that of controls. In the sensitized guinea pig, the activity of lung membrane phospholipase is increased and the phospholipid content of lung membranes is decreased. ...

journal_title：Experimental lung research

authors： Rami J,Brondel L,Rivière D,Besombes JP

更新日期：1990-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) as a complex disease with genetic and environmental compound is one of the leading causes of death in worldwide. This disease is characterized by lower airway inflammation, and increases risk of lung cancer in smokers. Micro-RNA (miRNA) molecules are key regulators in gene ...

journal_title：Experimental lung research

authors： Akbas F,Coskunpinar E,Aynaci E,Oltulu YM,Yildiz P

更新日期：2012-08-01 00:00:00

abstract：:Male Sprague-Dawley rats were placed in hypobaric hypoxia for 17-21 d (FIO2 10%) to establish pulmonary hypertension (PH) and control rats were kept in normobaric room air. Right mean atrial and ventricular pressures (PRA, PRV) were recorded, left ventricular (LV) blood was collected, and lungs were perfused with hepa...

journal_title：Experimental lung research

authors： Keith IM,Ekman R

更新日期：1992-03-01 00:00:00

abstract：:Eprazinone therapy improves pulmonary function and arterial pO2 in patients with chronic bronchitis; however, the mechanism of action is unknown. The purpose of this study was to determine if eprazinone alters either lung surfactant levels in bronchoalveolar lavage fluid (BAL) of normal rats, or ion transport across c...

journal_title：Experimental lung research

authors： Thrall RS,Cloutier MM,Guernsey L,Swayne E,Gionfriddo M

更新日期：1992-05-01 00:00:00

abstract：:Lung disorders such as asthma, acute respiratory distress syndrome (ARDS), chronic obstructive lung disease (COPD), and interstitial lung disease (ILD) show a few common threads of pathogenic mechanisms: inflammation, aberrant immune activity, infection, and fibrosis. Currently no modes of effective treatment are avai...

journal_title：Experimental lung research

authors： Inamdar AC,Inamdar AA

更新日期：2013-10-01 00:00:00

abstract：AIM OF THE STUDY:The current investigation was taken to scrutinize the action of tranilast on the airway remodeling in chronic asthma in mice. MATERIALS AND METHODS:Intraperitoneal injection of ovalbumin was applied to mice for sensitization and subsequent inhalation of 1% ovalbumin three times week for 10 weeks for c...

journal_title：Experimental lung research

authors： Nader MA,Gameil N,Abdelaziz RR,Zalata KR,Osman A,Zedan MM,Abo-Elkheir N,Elsiddig AA,Zedan M

更新日期：2016-08-01 00:00:00

abstract：:The aim of the study was to identify the effects on the lung after subchronic glass fiber intratracheal instillation study on rats. We evaluated the toxicological effects on the lung: persistent inflammatory reaction, cell proliferation, and pulmonary fibrosis on histopathological examination. We performed a glass fib...

journal_title：Experimental lung research

authors： Domokos-Hancu B,Man MA,Liana H,Pop CM

更新日期：2014-03-01 00:00:00

abstract：:The role of the Clara and type II cell in the development of pulmonary tumors in the A/J mouse and Fischer rat was investigated by determining the relationship of DNA methylation and repair in pulmonary cells to oncogene activation and by characterizing the morphology of pulmonary tumors induced by treatment with 4-(m...

journal_title：Experimental lung research

authors： Belinsky SA,Devereux TR,White CM,Foley JF,Maronpot RR,Anderson MW

更新日期：1991-03-01 00:00:00

abstract：:Acute lung injury (ALI) is often associated with sepsis and is the most common cause of acute respiratory failure. The authors evaluated the role of the heme oxygenase (HO)/carbon monoxide (CO) system on lung injury in a cecal ligation and puncture (CLP)-induced mouse model of ALI. The authors established CLP-induced ...

journal_title：Experimental lung research

authors： Fei D,Meng X,Kang K,Nan C,Zhao M,Pan S,Gao M,Yang S,Zhao M

更新日期：2012-05-01 00:00:00

abstract：:COPD remains a public health problem that has yet to be fully recognized by the public, the medical community or public health (government) officials, and much work remains to be done worldwide to reverse the increasing trends of this chronic lung disease. ...

journal_title：Experimental lung research

authors： Hurd S

更新日期：2005-09-01 00:00:00

abstract：:Previously, this laboratory has shown that intratracheally administered hyaluronic acid (HA) significantly reduces air-space enlargement in a hamster model of emphysema induced with pancreatic elastase. Whereas HA was given immediately following elastase in those initial studies, the current investigation determined t...

journal_title：Experimental lung research

authors： Cantor JO,Cerreta JM,Armand G,Turino GM

更新日期：1997-05-01 00:00:00

abstract：:Because high partial pressures of oxygen (O2) can cause peroxidative cleavage of membrane lipids, it is plausible to hypothesize that hyperoxia alters the physical state and composition of lipids in the membranes of pulmonary endothelial cells and that manipulation of the lipid profile may modify endothelial cell tole...

journal_title：Experimental lung research

authors： Block ER

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Inhaled capsaicin (8-methyl-N-vanillyl-6-nonenamide) has been used to induce cough in a safe and dose-dependent manner. Chronic cough is associated with an increased sensitivity to inhaled capsaicin in patients with asthma. The aim of this study was to evaluate clinical impact of capsaicin provocation test f...

journal_title：Experimental lung research

authors： Park KH,Kim BG,Lee PH,Hong J,Lee J,Park SW,Kim DJ,Jang AS

更新日期：2021-02-01 00:00:00

abstract：:The percentage 24-h lung retention of 4-micrometers monodispersed Teflon particles, aerodynamic diameter about 6 micrometers, was studied twice in 8 healthy nonsmokers. The particles were inhaled at 0.5 liter/sec with maximally deep breaths. Bronchoconstriction was induced by inhalation of a methacholine-bromide aeros...

journal_title：Experimental lung research

authors： Svartengren M,Philipson K,Linnman L,Camner P

更新日期：1984-01-01 00:00:00