Basement membranes and pulmonary development.

abstract：AIM OF THE STUDY:The current investigation was taken to scrutinize the action of tranilast on the airway remodeling in chronic asthma in mice. MATERIALS AND METHODS:Intraperitoneal injection of ovalbumin was applied to mice for sensitization and subsequent inhalation of 1% ovalbumin three times week for 10 weeks for c...

journal_title：Experimental lung research

authors： Nader MA,Gameil N,Abdelaziz RR,Zalata KR,Osman A,Zedan MM,Abo-Elkheir N,Elsiddig AA,Zedan M

更新日期：2016-08-01 00:00:00

abstract：:An improved method has been developed for separation of an enriched population of mouse type 2 pneumocytes, based on differential adherence and size fractionation of cells dissociated with trypsin. These cells were successfully maintained in primary culture in serum-free medium MCDB 201 supplemented with albumin, tran...

journal_title：Experimental lung research

authors： Kumar RK,Li W,O'Grady R

更新日期：1995-01-01 00:00:00

abstract：:A tandem repeat region in the second intron of the K-ras gene has been reported to be a possible regulatory site for transcription. In this study, a second protein-binding site was identified and characterized. It lies downstream (nucleotides 463 to 509) of the tandem repeat region. A T--> C base variation at nucleoti...

journal_title：Experimental lung research

authors： Chen B,Wang Y,You M

更新日期：2005-03-01 00:00:00

abstract：:Purpose/Aim of Study: Studies of pulmonary fibrosis (PF) have resulted in DNA damage, inflammatory response, and cellular senescence being widely hypothesized to play a role in the progression of the disease. Utilizing these aforementioned terms, genomics databases were interrogated along with the term, "pulmonary fib...

journal_title：Experimental lung research

authors： Beach TA,Johnston CJ,Groves AM,Williams JP,Finkelstein JN

更新日期：2017-04-01 00:00:00

abstract：:Emerging data indicate that endothelial-mesenchymal transition (EndMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). A previous study noted that blocking the activity of protein phosphatase 2 A (PP2A) could attenuate EndMT. However, the treatment effects of PP2A inhibitors in pulmonary fibros...

journal_title：Experimental lung research

authors： Yu J,Deng Y,Han M

更新日期：2020-09-01 00:00:00

abstract：:Few studies are available about the role of dietary zinc (Zn) in respiratory diseases. Adult male rats were divided into 2 groups and fed respectively a moderate Zn-deficient diet and a Zn-adequate control diet. In lung tissue at 2 months, thiobarbituric acid-reactive species (TBARS), total glutathione, glutathione di...

journal_title：Experimental lung research

authors： Gomez NN,Fernandez MR,Zirulnik F,Gil E,Scardapane L,Ojeda MS,Gimenez MS

更新日期：2003-10-01 00:00:00

abstract：:A specific form of flavin monooxygenase has been identified in the lungs of a number of species. Distribution of the pulmonary flavin-containing monooxygenase (FMOp) is of interest because it oxidatively metabolizes a wide variety of nitrogen-, sulfur-, and phosphorous-containing xenobiotics, some of which form highly...

journal_title：Experimental lung research

authors： Overby L,Nishio SJ,Lawton MP,Plopper CG,Philpot RM

更新日期：1992-01-01 00:00:00

abstract：:Alveolar cells were evaluated in BALB/c mice exposed to smoke from 9 cigarettes per day. The mice were sacrificed at 1, 5, and 10 days and examined by lung morphometry and immunohistochemical staining of alveolar macrophages for tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-12, and tissue inhibitor...

journal_title：Experimental lung research

authors： da Hora K,Valença SS,Porto LC

更新日期：2005-10-01 00:00:00

abstract：:The aim of the study was to identify the effects on the lung after subchronic glass fiber intratracheal instillation study on rats. We evaluated the toxicological effects on the lung: persistent inflammatory reaction, cell proliferation, and pulmonary fibrosis on histopathological examination. We performed a glass fib...

journal_title：Experimental lung research

authors： Domokos-Hancu B,Man MA,Liana H,Pop CM

更新日期：2014-03-01 00:00:00

abstract：:Urban air consists of a combination of environmental pollutants. Recent studies have suggested that normally innocuous doses of a particular pollutant may be rendered more toxic to the lung if primed by earlier events. Pulmonary inflammation has been observed in humans and in many animal species after endotoxin and oz...

journal_title：Experimental lung research

authors： Johnston CJ,Oberdörster G,Gelein R,Finkelstein JN

更新日期：2002-09-01 00:00:00

abstract：:The Ca(2+)-mobilizing actions of adenosine 5'-triphosphate (ATP), bradykinin, and histamine were compared in phenotypically distinct human nasal epithelial (HNE) cell types and as a function of time in cell culture. Single-cell measurements of intracellular free Ca2+ (Ca2+i, Fura-2 fluorescence) were recorded in cilia...

journal_title：Experimental lung research

authors： Paradiso AM,Brown HA,Ye H,Harden TK,Boucher RC

更新日期：1999-06-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) as a complex disease with genetic and environmental compound is one of the leading causes of death in worldwide. This disease is characterized by lower airway inflammation, and increases risk of lung cancer in smokers. Micro-RNA (miRNA) molecules are key regulators in gene ...

journal_title：Experimental lung research

authors： Akbas F,Coskunpinar E,Aynaci E,Oltulu YM,Yildiz P

更新日期：2012-08-01 00:00:00

abstract：:The developmental regulation of the rabbit surfactant-associated proteins, SP-A, SP-B, and SP-C, was investigated using Northern blot analysis. These proteins comprise approximately 10% by weight of pulmonary surfactant, a lipoprotein secreted by type II cells that reduces surface tension at the air-alveolar interface...

journal_title：Experimental lung research

authors： Durham PL,Nanthakumar EJ,Snyder JM

更新日期：1992-11-01 00:00:00

abstract：:The authors recently showed that preterm birth per se, in the absence of assisted ventilation or elevated inhaled oxygen levels, alters the structure of the airway walls in young lambs. The initial aim of the present study was to determine whether these changes persist into adulthood. Preterm (P; n = 7) lambs were del...

journal_title：Experimental lung research

authors： Snibson K,Harding R

更新日期：2008-02-01 00:00:00

abstract：:Acute lung injury (ALI) is often associated with sepsis and is the most common cause of acute respiratory failure. The authors evaluated the role of the heme oxygenase (HO)/carbon monoxide (CO) system on lung injury in a cecal ligation and puncture (CLP)-induced mouse model of ALI. The authors established CLP-induced ...

journal_title：Experimental lung research

authors： Fei D,Meng X,Kang K,Nan C,Zhao M,Pan S,Gao M,Yang S,Zhao M

更新日期：2012-05-01 00:00:00

abstract：:The percentage 24-h lung retention of 4-micrometers monodispersed Teflon particles, aerodynamic diameter about 6 micrometers, was studied twice in 8 healthy nonsmokers. The particles were inhaled at 0.5 liter/sec with maximally deep breaths. Bronchoconstriction was induced by inhalation of a methacholine-bromide aeros...

journal_title：Experimental lung research

authors： Svartengren M,Philipson K,Linnman L,Camner P

更新日期：1984-01-01 00:00:00

abstract：:Lung cancer is the leading cause of death of both men and women across the world. Overexpression and activating mutations of the epidermal growth factor receptor-1 (EGFR1) are frequently observed and associated with poor prognosis. To inhibit the function of EGFR1, multiple antibodies and small-molecule tyrosine kinas...

journal_title：Experimental lung research

authors： Gorgisen G,Ozes D,Pehlivanoglu S,Erdogan A,Dertsiz L,Ozbilim G,Ozbudak IH,Savas B,Ozes ON

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We have previously reported that N-acetylcysteine (NAC), ambroxol and azithromycin (AZM) (partially) correct the chloride efflux dysfunction in cystic fibrosis bronchial epithelial (CFBE) cells with the ΔF508 homozygous mutation in vitro. METHODS:In the present paper, we further investigated p...

journal_title：Experimental lung research

authors： Hussain S,Varelogianni G,Särndahl E,Roomans GM

更新日期：2015-06-01 00:00:00

abstract：:Intraphagosomal pH in rabbit alveolar macrophages was studied using amorphous silica particles (FSP) and yeast particles (FYP) labeled with fluorescein. The pH was estimated from the quotient between the fluorescence intensity at wavelength 519 nm with excitation at wavelengths 495 and 450 nm. Within a factor of 10, p...

journal_title：Experimental lung research

authors： Nyberg K,Johansson A,Camner P

更新日期：1989-01-01 00:00:00

abstract：:Chymase is a chymotrypsin-like serine protease that is present in mast cells. Its activities include various effects associated with inflammatory responses. But little is known about the effects of chymase in pulmonary fibrosis. The mouse silicosis model was induced by intratracheal injection of 10 mg silica. The Ashc...

journal_title：Experimental lung research

authors： Takato H,Yasui M,Ichikawa Y,Waseda Y,Inuzuka K,Nishizawa Y,Tagami A,Fujimura M,Nakao S

更新日期：2011-03-01 00:00:00

abstract：:Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine m...

journal_title：Experimental lung research

authors： Suh GY,Ham HS,Lee SH,Choi JC,Koh WJ,Kim SY,Lee J,Han J,Kim HP,Choi AM,Kwon OJ

更新日期：2006-01-01 00:00:00

abstract：:Electrical stimulation of the cervical vagus nerve of rats is known to increase vascular permeability in the trachea. In the present study, we sought to further characterize this neurogenic inflammatory response by defining the relationship between the parameters of electrical stimulation of the vagus nerve and the ma...

journal_title：Experimental lung research

authors： Brokaw JJ,McDonald DM

更新日期：1988-01-01 00:00:00

abstract：:Freeze-fracture was used to study the nonciliated epithelial (Clara) cell of rat bronchiole. En face views of the P face of the luminal cell membrane reveal particle-free bulging and circular depressions at the presumptive sites of the membrane fusion between the cell membrane and secretory granule membrane. Cross fra...

journal_title：Experimental lung research

authors： Yoneda K,Birk MG

更新日期：1981-08-01 00:00:00

abstract：:We studied lung clearance of technetium-labeled diethylenetriamine pentaacetic acid [( 99mTc]DTPA), plasma and bronchoalveolar lavage fluid (BALF) concentrations of 6-keto-PGF1 alpha (stable metabolite of prostacyclin, prostaglandin I2, PGI2), TxB2 (stable metabolite of thromboxane A2, TxA2), and leukotriene B4 (LTB4)...

journal_title：Experimental lung research

authors： Witten ML,Quan SF,Sobonya RE,Bruck D,Devine L,Lemen RJ

更新日期：1988-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were placed in hypobaric hypoxia for 17-21 d (FIO2 10%) to establish pulmonary hypertension (PH) and control rats were kept in normobaric room air. Right mean atrial and ventricular pressures (PRA, PRV) were recorded, left ventricular (LV) blood was collected, and lungs were perfused with hepa...

journal_title：Experimental lung research

authors： Keith IM,Ekman R

更新日期：1992-03-01 00:00:00

abstract：:We determined optimum conditions for delivering DNA to transformed human bronchial epithelial cells expressing wild-type (BEAS) or abnormal (2CF) cystic fibrosis transmembrane conductance regulator (CFTR) using cationic liposomes (Lipofectin, [N-(N,N-dimethylaminoethane)carbamyl] cholesterol[DC-Chol]/dioleoylphosphati...

journal_title：Experimental lung research

authors： Peters MT,Brigham KL,King GA,Meyrick BO,Gao X,Stecenko AA

更新日期：1999-04-01 00:00:00

abstract：:The effects of Zizyphi fructus, a major constituent of Chinese anti-asthmatic herbal medicine, on ciliary motility and nitric oxide (NO) generation in canine cultured tracheal epithelium were studied by the microphoto-oscillation method and the specific amperometric method, respectively. Addition of Zizyphi fructus at...

journal_title：Experimental lung research

authors： Tamaoki J,Kondo M,Tagaya E,Takemura K,Konno K

更新日期：1996-05-01 00:00:00

abstract：:Direct measurements of pleural fluid hydrostatic and colloid osmotic pressures after infusion of saline, bovine serum albumin, or silicone into the pleural space were coupled with ultrastructural morphometric analyses to assess the response of pleural mesothelial cells to hydrothorax. Increases of hydrostatic pressure...

journal_title：Experimental lung research

authors： Shumko JZ,Feinberg RN,Shalvoy RM,DeFouw DO

更新日期：1993-05-01 00:00:00

abstract：PURPOSE:As an angiotensin converting enzyme (ACE) inhibitor, the effects of captopril on inflammation has been previously examined. Captopril has been shown to have anti-inflammatory and antioxidant effects. Imbalance in the oxidant/antioxidant system is one of the major causes of inflammation. In the present study, th...

journal_title：Experimental lung research

authors： Boskabadi J,Mokhtari-Zaer A,Abareshi A,Khazdair MR,Emami B,Mohammadian Roshan N,Hosseini M,Boskabady MH

更新日期：2018-01-01 00:00:00

abstract：:Chlorinated amines are long-lived oxidants released from inflammatory cells. They have been observed to alter the function of important inflammatory molecules. Whether they can contribute directly to the inflammatory alteration of cellular barriers is not known. Monolayers of cultured porcine pulmonary artery endothel...

journal_title：Experimental lung research

authors： Shasby DM,Hampson F

更新日期：1989-05-01 00:00:00