Acute cigarette smoke exposure alters lung eicosanoid and inflammatory cell concentrations in rabbits.

abstract：:Urban air consists of a combination of environmental pollutants. Recent studies have suggested that normally innocuous doses of a particular pollutant may be rendered more toxic to the lung if primed by earlier events. Pulmonary inflammation has been observed in humans and in many animal species after endotoxin and oz...

journal_title：Experimental lung research

authors： Johnston CJ,Oberdörster G,Gelein R,Finkelstein JN

更新日期：2002-09-01 00:00:00

abstract：:In three experiments, we have explored the uptake and transport of colloidal gold (Au) and iron oxide (Fe2O3) by normal and SO2-injured bronchial epithelium. In the first experiment, mice were exposed to a 2-hr aerosol of Au; in the second experiment, mice were exposed to SO2 (250 ppm) for 3 hr, then to Au; and in the...

journal_title：Experimental lung research

authors： Watson AY,Brain JD

更新日期：1980-03-01 00:00:00

abstract：:We quantified in vivo pulmonary vascular remodeling in a large animal model of pulmonary hypertension (PH). In group PH (n = 6), 3 mg/kg dehydromonocrotaline (DHMC) was administered to 12-week-old beagles via a right atrial injection. Eight weeks after DHMC in group PH, pulmonary artery pressure increased significantl...

journal_title：Experimental lung research

authors： Gust R,Schuster DP

更新日期：2001-01-01 00:00:00

abstract：:Tannic acid was used as a mordant to enhance the preservation of lung phospholipids during fixation and processing for electron microscopy. We found multilamellar bodies within alveolar septa (including type I pneumocytes, capillary endothelial cells, and interstitium) which have not been described previously and whic...

journal_title：Experimental lung research

authors： Kalina M,Young SL

更新日期：1980-08-01 00:00:00

abstract：:Acute exposure to NO2 is reported to disrupt tight junctions in lung epithelium. We have studied the effects of chronic NO2 exposure and recovery breathing clean air to tight junctions of distal airway and alveolar epithelium. Syrian Golden hamsters were exposed to NO2 (30 PPM) for 5 or 9 months and a group of those a...

journal_title：Experimental lung research

authors： Gordon RE,Solano D,Kleinerman J

更新日期：1986-01-01 00:00:00

abstract：:B6C3F1 female mice were exposed to cigarette smoke (CS) (250 mg/m3 total particulate material) or filtered air (FA), 6 hours/day, 5 days/week, for 6, 7, or 10 weeks, or to CS for 6 weeks, then FA for 1 or 4 additional weeks. Exposure to CS increased macrophages, neutrophils, lymphocytes, and matrix metalloproteinase (...

journal_title：Experimental lung research

authors： Seagrave J,Barr EB,March TH,Nikula KJ

更新日期：2004-01-01 00:00:00

abstract：:The structural features of the ovine pleura are described using light, scanning, and transmission electron microscopy. Extensive sampling of the visceral and parietal pleura revealed considerable variation in both surface morphology and pleural interstitial anatomy. Variations of mesothelial surface were encountered a...

journal_title：Experimental lung research

authors： Mariassy AT,Wheeldon EB

更新日期：1983-05-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) during hyperoxia contribute to alveolar epithelial apoptosis. In the present study, the molecular mechanisms of oxidative stress-induced alveolar epithelial cell apoptosis were investigated. The cytoprotective effects of N-acetylcysteine (NAC) were evaluated. Treatments ...

journal_title：Experimental lung research

authors： Fu YQ,Fang F,Lu ZY,Kuang FW,Xu F

更新日期：2010-08-01 00:00:00

abstract：:Immunosuppressive and antiproliferative effects of heparin may be beneficial in the field of solid organ transplantation. The aim of this study was to examine the effect of low-molecular-weight heparin (LMWH) compounds on the development of obliterative airway disease (OAD) in the rat tracheal transplant model. Alloge...

journal_title：Experimental lung research

authors： Fillinger J,Antus B

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:As an angiotensin converting enzyme (ACE) inhibitor, the effects of captopril on inflammation has been previously examined. Captopril has been shown to have anti-inflammatory and antioxidant effects. Imbalance in the oxidant/antioxidant system is one of the major causes of inflammation. In the present study, th...

journal_title：Experimental lung research

authors： Boskabadi J,Mokhtari-Zaer A,Abareshi A,Khazdair MR,Emami B,Mohammadian Roshan N,Hosseini M,Boskabady MH

更新日期：2018-01-01 00:00:00

abstract：:Toluene diisocyanate (TDI) is known as one of causes of occupational asthma and hypersensitivity pneumonitis. To investigate the stimulatory effect on bronchial epithelial cells in response to TDI, the authors examined production of cytokines by the bronchial epithelial cell line BEAS-2B and intercellular signal trans...

journal_title：Experimental lung research

authors： Ogawa H,Inoue S,Ogushi F,Ogura H,Nakamura Y

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We have previously reported that N-acetylcysteine (NAC), ambroxol and azithromycin (AZM) (partially) correct the chloride efflux dysfunction in cystic fibrosis bronchial epithelial (CFBE) cells with the ΔF508 homozygous mutation in vitro. METHODS:In the present paper, we further investigated p...

journal_title：Experimental lung research

authors： Hussain S,Varelogianni G,Särndahl E,Roomans GM

更新日期：2015-06-01 00:00:00

abstract：:Survival of mice after Klebsiella pneumoniae infection and phagocytosis by alveolar macrophages (AMs), in the presence or absence of ozone (O(3)) exposure prior to infection, is sex dependent. The objective of this work was to study the role of gonadal hormones, 5α-dihydrotestosterone (DHT) and 17β-estradiol (E(2)), o...

journal_title：Experimental lung research

authors： Durrani F,Phelps DS,Weisz J,Silveyra P,Hu S,Mikerov AN,Floros J

更新日期：2012-05-01 00:00:00

abstract：:It has been suggested that increased recruitment of phagocytes and subsequent clearance of particles may follow instillation of a leukocyte chemoattractant to lungs containing silica. The present study quantitated serially the silica content in alveolar spaces, in lung tissue and in hilar lymph nodes of mice that rece...

journal_title：Experimental lung research

authors： Adamson IY,Prieditis H,Bowden DH

更新日期：1994-05-01 00:00:00

abstract：:Distinct barrier lesions and an apical-basal distribution of alveolar edema fluid in either moderate or high elevated pressure edema lungs have been found in previous studies. In the present study, quantitative measurements were obtained by using electron microscopy and morphometry of extravascular lung water and barr...

journal_title：Experimental lung research

authors： Wu DX,Weibel ER,Bachofen H,Schürch S

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Mechanisms linking behavioral stress and inflammation are poorly understood, mainly in distal lung tissue. OBJECTIVE:We have investigated whether the forced swim stress (FS) could modulate lung tissue mechanics, iNOS, cytokines, oxidative stress activation, eosinophilic recruitment, and remodeling in guinea...

journal_title：Experimental lung research

authors： Reis FG,Marques RH,Starling CM,Almeida-Reis R,Vieira RP,Cabido CT,Silva LF,Lanças T,Dolhnikoff M,Martins MA,Leick-Maldonado EA,Prado CM,Tibério IF

更新日期：2012-09-01 00:00:00

abstract：:Purpose/Aim: More and more evidences suggest that airway remodeling of fibrotic lung diseases may be associated with epithelial-mesenchymal transition (EMT) of human A549 cells induced by transforming growth factor (TGF)-β1. Schisandrin B (Sch B) is the highest content of dibenzocyclooctadiene lignans in Schisandra ch...

journal_title：Experimental lung research

authors： Zhuang W,Li Z,Dong X,Zhao N,Liu Y,Wang C,Chen J

更新日期：2019-01-01 00:00:00

abstract：:Intratracheal bleomycin induces pulmonary fibrosis in experimental animals, but the mechanisms involved are poorly understood. Since altered levels of fatty acid metabolites are associated with bleomycin-induced lung injury, we examined the effects of a change in dietary fat on bleomycin-induced fibrosis. Previously w...

journal_title：Experimental lung research

authors： Kennedy JI Jr,Chandler DB,Fulmer JD,Wert MB,Grizzle WE

更新日期：1989-03-01 00:00:00

abstract：:The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF...

journal_title：Experimental lung research

authors： Alho HS,Maasilta PK,Vainikka T,Salminen US

更新日期：2007-08-01 00:00:00

abstract：AIMS:As a transcription factor of the nuclear receptor superfamily, neuron-derived orphan receptor 1 (NOR1) is induced rapidly in response to various extracellular stimuli. But, it is still unclear its role in pulmonary artery smooth muscle cells proliferation. MATERIALS AND METHODS:Human PASMCs were cultured in vitro...

journal_title：Experimental lung research

authors： Wang CG,Lei W,Li C,Zeng DX,Huang JA

更新日期：2015-05-01 00:00:00

abstract：:Endothelin-1 (ET-1) has constrictor and mitogenic effects on airway smooth muscle strips and cultured cells, respectively. This study addresses the type of the ET receptor subtype(s) present on ovine airway smooth muscle cells and the possibility of autocrine effects. The expression of the preproendothelin-1 gene was ...

journal_title：Experimental lung research

authors： Ergul A,Glassberg MK,Wanner A,Puett D

更新日期：1995-05-01 00:00:00

abstract：:Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To further assess the toxic effects of amiodarone on lung tissue, Syrian hamsters were given a single intratracheal insufflation of the agent an...

journal_title：Experimental lung research

authors： Cantor JO,Osman M,Cerreta JM,Suarez R,Mandl I,Turino GM

更新日期：1984-01-01 00:00:00

abstract：:Mechanical ventilation (MV) is well known to potentially cause ventilator-associated lung injury (VALI). It has also been reported recently that activation of invariant natural killer T (iNKT) cells is involved in the onset/progression of airway inflammation. We analyzed the roles of inflammatory cells, including iNKT...

journal_title：Experimental lung research

authors： Shiga Y,Sugamata R,Iwamura C,Nagao T,Zao J,Kawakami K,Kawachi S,Nakayama T,Suzuki K

更新日期：2014-02-01 00:00:00

abstract：:In order to study the kinetics and pathways of protein transfer in pleural effusion, rats with pleurisy associated with hyperoxic pulmonary edema were injected either intrapleurally or intravenously with tracers. 125I-Albumin was used to obtain quantitative data. Anti horseradish peroxidase used as a morphological tra...

journal_title：Experimental lung research

authors： Bernaudin JF,Theven D,Pinchon MC,Brun-Pascaud M,Bellon B,Pocidalo JJ

更新日期：1986-01-01 00:00:00

abstract：:During lung development, the extracellular matrix undergoes dynamic remodeling. Matrix metalloproteinases (MMPs), and tissue inhibitors of matrix metalloproteinases (TIMPs), are important enzymes that participate in regulating tissue remodeling. There is an abnormal balance of the synthesis and degradation of collagen...

journal_title：Experimental lung research

authors： Lemke RP,Zhang W,Balcerazak D,Kobayashi K,Schwingshackl A,Cheung PY,Dixon WT,Baracos VE,Greer JJ

更新日期：2003-06-01 00:00:00

abstract：:The integrity of the respiratory epithelium is crucial for airway homeostasis. Tobacco smoke exposure and recurrent infections of the airways play a crucial role in the progression and in the decline of the respiratory function in chronic obstructive pulmonary disease (COPD). The aim of this study was to detect differ...

journal_title：Experimental lung research

authors： D'Anna C,Cigna D,Di Sano C,Di Vincenzo S,Dino P,Ferraro M,Bini L,Bianchi L,Di Gaudio F,Gjomarkaj M,Pace E

更新日期：2017-01-01 00:00:00

abstract：:Diesel exhaust particles (DEP) are associated with respiratory disease and exposure to diesel exhaust induces an inflammatory response associated with marked leukocytic infiltration in the lung. This study examined whether neutrophils are activated by the active component of DEP (methanol extract of DEP [me-DEP]). The...

journal_title：Experimental lung research

authors： Matsuzaki T,Amakawa K,Yamaguchi K,Ishizaka A,Terashima T,Matsumaru A,Morishita T

更新日期：2006-10-01 00:00:00

abstract：:Few studies are available about the role of dietary zinc (Zn) in respiratory diseases. Adult male rats were divided into 2 groups and fed respectively a moderate Zn-deficient diet and a Zn-adequate control diet. In lung tissue at 2 months, thiobarbituric acid-reactive species (TBARS), total glutathione, glutathione di...

journal_title：Experimental lung research

authors： Gomez NN,Fernandez MR,Zirulnik F,Gil E,Scardapane L,Ojeda MS,Gimenez MS

更新日期：2003-10-01 00:00:00

abstract：:Lung injury and inflammation are associated with exposure to various types of particulate air pollutants. The present study was used to determine whether metalloproteinases (MMPs) are secreted after instilling dust samples into the lung, and to relate levels of specific MMPs to different fractions of the ambient air p...

journal_title：Experimental lung research

authors： Adamson IY,Vincent R,Bakowska J

更新日期：2003-09-01 00:00:00

abstract：:Administering liposome-encapsulated drugs by aerosols could be a feasible way of targeting drugs to the lung, specifically to pulmonary alveolar macrophages (AM). In the mouse model, we characterized uptake of carboxyfluorescein- (CF-) labeled liposomes by AM in vivo after acute inhalation of liposome aerosols, and th...

journal_title：Experimental lung research

authors： Myers MA,Thomas DA,Straub L,Soucy DW,Niven RW,Kaltenbach M,Hood CI,Schreier H,Gonzalez-Rothi RJ

更新日期：1993-01-01 00:00:00