N-acetylcysteine and azithromycin affect the innate immune response in cystic fibrosis bronchial epithelial cells in vitro.

abstract：:Mechanical strain initiates a variety of responses in pulmonary epithelial cells. The signaling pathways and molecular alterations leading to these responses remain unclear To identify novel signal transduction pathways activated by strain, macroarray analysis was performed on strained pulmonary epithelial cells. Glut...

journal_title：Experimental lung research

authors： Chess PR,O'Reilly MA,Toia L

更新日期：2004-12-01 00:00:00

abstract：:Irreversible lung parenchymal injury is usually healed by fibrosis, which depends on the abilities of fibroblasts to proliferate, migrate into the wound, and survive. Because the lung is frequently exposed to increased oxidative stress, which is thought to mediate apoptosis, we examined whether oxidative stress induce...

journal_title：Experimental lung research

authors： Takahashi A,Aoshiba K,Nagai A

更新日期：2002-06-01 00:00:00

abstract：:Studies demonstrated that pathophysiological abnormalities of airway smooth muscle (ASM) contribute significantly to chronic obstructive pulmonary disease (COPD) pathogenesis, the aim of this study is to investigate heat shock protein 70 (Hsp70) in ASM in COPD. ASM from 8 COPD patients and 6 controls were isolated for...

journal_title：Experimental lung research

authors： Xie J,Zhao J,Xiao C,Xu Y,Yang S,Ni W

更新日期：2010-05-01 00:00:00

abstract：:A tandem repeat region in the second intron of the K-ras gene has been reported to be a possible regulatory site for transcription. In this study, a second protein-binding site was identified and characterized. It lies downstream (nucleotides 463 to 509) of the tandem repeat region. A T--> C base variation at nucleoti...

journal_title：Experimental lung research

authors： Chen B,Wang Y,You M

更新日期：2005-03-01 00:00:00

abstract：AIM OF THE STUDY:The current investigation was taken to scrutinize the action of tranilast on the airway remodeling in chronic asthma in mice. MATERIALS AND METHODS:Intraperitoneal injection of ovalbumin was applied to mice for sensitization and subsequent inhalation of 1% ovalbumin three times week for 10 weeks for c...

journal_title：Experimental lung research

authors： Nader MA,Gameil N,Abdelaziz RR,Zalata KR,Osman A,Zedan MM,Abo-Elkheir N,Elsiddig AA,Zedan M

更新日期：2016-08-01 00:00:00

abstract：:B6C3F1 female mice were exposed to cigarette smoke (CS) (250 mg/m3 total particulate material) or filtered air (FA), 6 hours/day, 5 days/week, for 6, 7, or 10 weeks, or to CS for 6 weeks, then FA for 1 or 4 additional weeks. Exposure to CS increased macrophages, neutrophils, lymphocytes, and matrix metalloproteinase (...

journal_title：Experimental lung research

authors： Seagrave J,Barr EB,March TH,Nikula KJ

更新日期：2004-01-01 00:00:00

abstract：:The role of type II epithelial cell proliferation in repair of diffuse alveolar epithelial injury was examined using two pneumotoxicants, 3-methylindole (3-MI) and monocrotaline (MCT). It was hypothesized that if MCT inhibits type II epithelial cell mitosis, then pulmonary fibrosis would result after diffuse 3-MI-indu...

journal_title：Experimental lung research

authors： Woods LW,Wilson DW,Segall HJ

更新日期：1999-03-01 00:00:00

abstract：:We hypothesized that replication-deficient adenovirus (Ad), when complexed with plasmid DNA (pl) and cationic liposomes (L), would enhance liposome-mediated gene transfer in cultured human airway epithelial cells. Pl/L/Ad complexes were formed using charge-charge interactions. A gel electrophoresis retardation assay s...

journal_title：Experimental lung research

authors： Stecenko A,King G,Torii K,Gao X,Persmark M,Shih K,Brigham K,Raja-Walia R

更新日期：2000-04-01 00:00:00

abstract：:Excess production of neutrophil elastase contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the role of neutrophil elastase in the repair process following ALI/ARDS is not well understood. The objective of this study was to evaluate the effect of neutrop...

journal_title：Experimental lung research

authors： Fujino N,Kubo H,Suzuki T,He M,Suzuki T,Yamada M,Takahashi T,Ota C,Yamaya M

更新日期：2012-02-01 00:00:00

abstract：:Mesothelial cells proliferate soon after asbestos deposition in the lung. The present study investigates whether the known mesothelial cell mitogens keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF) are present in the lung and specifically in the pleural cavity during the phase of mesothelial cell gr...

journal_title：Experimental lung research

authors： Adamson IY,Bakowska J

更新日期：2001-10-01 00:00:00

abstract：:To study the pattern of lymphokines in bleomycin-induced lung injury, T cells were isolated from lung interstitial tissue (LIL), peribronchial lymphatic tissue (PBLT), and bronchoalveolar lavage (BAL) fluid of bleomycin-"sensitive" C57Bl/6 and bleomycin-"resistant" BALB/c mice at 3, 6, and 14 days following intratrach...

journal_title：Experimental lung research

authors： Gur I,Or R,Segel MJ,Shriki M,Izbicki G,Breuer R

更新日期：2000-10-01 00:00:00

abstract：:It has been suggested that increased recruitment of phagocytes and subsequent clearance of particles may follow instillation of a leukocyte chemoattractant to lungs containing silica. The present study quantitated serially the silica content in alveolar spaces, in lung tissue and in hilar lymph nodes of mice that rece...

journal_title：Experimental lung research

authors： Adamson IY,Prieditis H,Bowden DH

更新日期：1994-05-01 00:00:00

abstract：:The Ca(2+)-mobilizing actions of adenosine 5'-triphosphate (ATP), bradykinin, and histamine were compared in phenotypically distinct human nasal epithelial (HNE) cell types and as a function of time in cell culture. Single-cell measurements of intracellular free Ca2+ (Ca2+i, Fura-2 fluorescence) were recorded in cilia...

journal_title：Experimental lung research

authors： Paradiso AM,Brown HA,Ye H,Harden TK,Boucher RC

更新日期：1999-06-01 00:00:00

abstract：:Immunosuppressive and antiproliferative effects of heparin may be beneficial in the field of solid organ transplantation. The aim of this study was to examine the effect of low-molecular-weight heparin (LMWH) compounds on the development of obliterative airway disease (OAD) in the rat tracheal transplant model. Alloge...

journal_title：Experimental lung research

authors： Fillinger J,Antus B

更新日期：2010-12-01 00:00:00

abstract：:Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary sm...

journal_title：Experimental lung research

authors： Miko E,Czimmerer Z,Csánky E,Boros G,Buslig J,Dezso B,Scholtz B

更新日期：2009-10-01 00:00:00

abstract：:The aim of the study was to identify the effects on the lung after subchronic glass fiber intratracheal instillation study on rats. We evaluated the toxicological effects on the lung: persistent inflammatory reaction, cell proliferation, and pulmonary fibrosis on histopathological examination. We performed a glass fib...

journal_title：Experimental lung research

authors： Domokos-Hancu B,Man MA,Liana H,Pop CM

更新日期：2014-03-01 00:00:00

abstract：:To better understand the mechanisms by which neutrophils migrate into the airways, we constructed a novel in vitro model system with human umbilical vein endothelial cell (HUVE) monolayers grown on top of permeable filters and human lung Type II-like alveolar epithelial cell (A549) monolayers grown on the undersurface...

journal_title：Experimental lung research

authors： Casale TB,Mower DA,Carolan EJ

更新日期：1998-11-01 00:00:00

abstract：:The streptozotocin-induced diabetic (STZ-DB) rat model is associated with fetal hyperglycemia, but with low to normal plasma insulin concentration. Because surfactant protein (SP) mRNA content in fetal rat lung is decreased in STZ-DB pregnancy, we investigated the effect of increasing concentrations of glucose on SP g...

journal_title：Experimental lung research

authors： Rayani HH,Gewolb IH,Floros J

更新日期：1999-01-01 00:00:00

abstract：:Paraquat accumulation into rat lung slices was unaffected by hypoxia (PO2 = 645 mm Hg) but was inhibited by hypoxia. The IC50 (IC50 = partial pressure of O2 resulting in a 50% inhibition of paraquat accumulation) for paraquat accumulation was P02 = 50 mm Hg; significant accumulation could be observed after 1 or 2 hr o...

journal_title：Experimental lung research

authors： Montgomery MR,Wyatt I,Smith LL

更新日期：1980-08-01 00:00:00

abstract：AIM OF THE STUDY:Interleukin (IL)-10 is an anti-inflammatory cytokine, but its role in cigarette smoke (CS)-induced inflammation and chronic obstructive pulmonary disease (COPD) has not been fully elucidated. The purpose of this study was to investigate the effect of IL-10 deficiency on CS-induced pulmonary inflammatio...

journal_title：Experimental lung research

authors： Higaki M,Wada H,Mikura S,Yasutake T,Nakamura M,Niikura M,Kobayashi F,Kamma H,Kamiya S,Ito K,Barnes PJ,Goto H,Takizawa H

更新日期：2015-01-01 00:00:00

abstract：:Three-day-old rabbits were given intratracheal injections of radiolabeled natural sheep surfactant, rabbit surfactant, or liposomes of dipalmitoylphosphatidylcholine that contained greater than three times the quantity of phosphatidylcholine present in the endogenous surfactant pool. The recoveries of radiolabeled pho...

journal_title：Experimental lung research

authors： Oguchi K,Ikegami M,Jacobs H,Jobe A

更新日期：1985-01-01 00:00:00

abstract：:Freeze-fracture was used to study the nonciliated epithelial (Clara) cell of rat bronchiole. En face views of the P face of the luminal cell membrane reveal particle-free bulging and circular depressions at the presumptive sites of the membrane fusion between the cell membrane and secretory granule membrane. Cross fra...

journal_title：Experimental lung research

authors： Yoneda K,Birk MG

更新日期：1981-08-01 00:00:00

abstract：:Purpose/Aim: More and more evidences suggest that airway remodeling of fibrotic lung diseases may be associated with epithelial-mesenchymal transition (EMT) of human A549 cells induced by transforming growth factor (TGF)-β1. Schisandrin B (Sch B) is the highest content of dibenzocyclooctadiene lignans in Schisandra ch...

journal_title：Experimental lung research

authors： Zhuang W,Li Z,Dong X,Zhao N,Liu Y,Wang C,Chen J

更新日期：2019-01-01 00:00:00

abstract：:A past study demonstrated that all-trans-retinoic acid (ATRA) treatment by intraperitoneal injection in a rat model of elastase-induced emphysema caused tissue regeneration as evidenced by a decrease in alveolar size and lung volume and an increase in alveolar number. We postulated that treatment with this retinoid by...

journal_title：Experimental lung research

authors： March TH,Cossey PY,Esparza DC,Dix KJ,McDonald JD,Bowen LE

更新日期：2004-07-01 00:00:00

abstract：:In order to investigate some of the characteristics of superoxide anion release from alveolar macrophages, the effects of substances known to influence superoxide release from polymorphonuclear leukocytes (PMN) were studied in rat alveolar macrophages. There is a relatively small, but constant, amount of superoxide re...

journal_title：Experimental lung research

authors： Sweeney TD,Castranova V,Bowman L,Miles PR

更新日期：1981-05-01 00:00:00

abstract：:The aim of this study was to determine influence of prenatal granulocyte-macrophage colony-stimulating factor (GM-CSF) administration on lung growth, maturation, and vascular endothelial growth factor (VEGF) expression. Twenty Wistar rats received sterile saline (1 mL) or recombinant human GM-CSF (50 micro g/kg) on da...

journal_title：Experimental lung research

authors： Yuksel H,Yilmaz O,Baytur YB,Ozbilgin K

更新日期：2008-11-01 00:00:00

abstract：:Wild-type K-ras is tumor suppressive in mouse lung, but mutant K-ras is actively oncogenic. Thus, the mutant protein must acquire new, dominant protumorigenic properties. Generation of reactive oxygen species could be one such property. The authors demonstrate increased peroxides in lung epithelial cells (E10)-transfe...

journal_title：Experimental lung research

authors： Maciag A,Anderson LM

更新日期：2005-01-01 00:00:00

abstract：:The role of bombesin was investigated in the course of the pulmonary inflammation and fibrosis (PF) elicited by the intratracheal (IT) or intravenous (i.v.) administration of bleomycin in mice. Bleomycin-induced alveolitis was associated with an accumulation of cells, presumably macrophages, containing bombesin, as ev...

journal_title：Experimental lung research

authors： Piguet PF,Vesin C,Thomas F

更新日期：1995-03-01 00:00:00

abstract：:We set out to determine whether or not the "mucolytic" drug N-acetylcysteine would speed the reversal of cigarette smoke-induced secretory-cell hyperplasia to normal, similar to that found previously for two nonsteroidal antiinflammatory drugs. Cigarette smoke alone significantly (p less than 0.01) increased the numbe...

journal_title：Experimental lung research

authors： Rogers DF,Godfrey RW,Majumdar S,Jeffery PK

更新日期：1988-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) has constrictor and mitogenic effects on airway smooth muscle strips and cultured cells, respectively. This study addresses the type of the ET receptor subtype(s) present on ovine airway smooth muscle cells and the possibility of autocrine effects. The expression of the preproendothelin-1 gene was ...

journal_title：Experimental lung research

authors： Ergul A,Glassberg MK,Wanner A,Puett D

更新日期：1995-05-01 00:00:00