Abstract:
:B6C3F1 female mice were exposed to cigarette smoke (CS) (250 mg/m3 total particulate material) or filtered air (FA), 6 hours/day, 5 days/week, for 6, 7, or 10 weeks, or to CS for 6 weeks, then FA for 1 or 4 additional weeks. Exposure to CS increased macrophages, neutrophils, lymphocytes, and matrix metalloproteinase (MMP)-2 and MMP-9 content in bronchoalveolar lavage fluid. Partial recovery of most lavage parameters (except lymphocytes) was observed 1 week after cessation of CS exposure with further reductions after 4 weeks, but interstitial inflammation persisted longer. These results support a role for MMPs in CS-induced emphysema and indicate that smoking cessation allows restoration toward normal homeostasis.
journal_name
Exp Lung Resjournal_title
Experimental lung researchauthors
Seagrave J,Barr EB,March TH,Nikula KJdoi
10.1080/01902140490252858subject
Has Abstractpub_date
2004-01-01 00:00:00pages
1-15issue
1eissn
0190-2148issn
1521-0499pii
YJGGWBQLV28W701Ejournal_volume
30pub_type
杂志文章abstract:PURPOSE OF THE STUDY:Workers in enclosed hogbarns experience an increased incidence of airway inflammation and obstructive lung disease, and an aqueous hogbarn dust extract (HDE) induces multiple inflammation-related responses in cultured airway epithelial cells. Epidermal growth factor receptor (EGFR) phosphorylation ...
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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更新日期:2012-09-01 00:00:00
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更新日期:1999-04-01 00:00:00
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