Abstract:
:Hypercholesterolemia contributes to cardiovascular diseases, but its direct effect on lung is little known. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been shown to exert numerous effects that are dependent and independent of their cholesterol-lowering property. The authors hypothesized that atorvastatin would attenuate hypercholesterolemia-induced lesion in lung. Fifteen rabbits were randomly divided into control group, high-cholesterol forage group, and atrovastatin treatment group. Body weight and blood lipid were measured. All lung tissue and pulmonary arteries were collected for histopathology and immunohistochemistry. Alveolar macrophages (AMs) were cultured and activation of nuclear factor (NF)-κB was detected. Concentrations of interleukin (IL)-6 were measured in serum, bronchoalveolar lavage fluid (BALF), and culture supernatants of AMs. Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) of high-cholesterol forage group were higher than control group (P < .05). There were infiltrating of AMs and lymphocytes in lung tissue of high-cholesterol forage group. NF-κB activity in AMs and concentrations of IL-6 in serum, BALF, and culture supernatants of AMs were higher than those of control group (P < .01), and so were all vascular remodeling indexes. TC and LDL-C and other indexes of atrovastatin treatment group were decreased (P < .05). Hypercholesterolemia induced pulmonary inflammatory Infiltration and vascular remodeling. Atorvastatin attenuated inflammatory infiltration and vascular remodeling in lung of hypercholesterolemia rabbits.
journal_name
Exp Lung Resjournal_title
Experimental lung researchauthors
Duan S,Zhang Y,Wu SJ,Jiang LZ,Zhang J,Gan Y,Chen P,Zhao SP,Li GYdoi
10.3109/01902141003739715subject
Has Abstractpub_date
2010-12-01 00:00:00pages
573-92issue
10eissn
0190-2148issn
1521-0499journal_volume
36pub_type
杂志文章abstract::Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary sm...
journal_title:Experimental lung research
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doi:10.3109/01902140902822312
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abstract::Chronic obstructive pulmonary disease (COPD) as a complex disease with genetic and environmental compound is one of the leading causes of death in worldwide. This disease is characterized by lower airway inflammation, and increases risk of lung cancer in smokers. Micro-RNA (miRNA) molecules are key regulators in gene ...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148.2012.689088
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abstract::The aim of the study was to identify the effects on the lung after subchronic glass fiber intratracheal instillation study on rats. We evaluated the toxicological effects on the lung: persistent inflammatory reaction, cell proliferation, and pulmonary fibrosis on histopathological examination. We performed a glass fib...
journal_title:Experimental lung research
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doi:10.3109/01902148.2013.860568
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509031767
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journal_title:Experimental lung research
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abstract:AIM OF THE STUDY:Nucleic acid-based therapies have the potential to provide clinically meaningful benefit across a wide spectrum of lung disease. However, in vivo delivery remains a challenge. Here we examined the feasibility of using electrospray to deliver nucleic acids to both porcine tracheal tissue sections and wh...
journal_title:Experimental lung research
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journal_title:Experimental lung research
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doi:10.3109/01902149209031698
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509031741
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journal_title:Experimental lung research
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doi:10.3109/01902149309031717
更新日期:1993-03-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902140601113088
更新日期:2007-01-01 00:00:00
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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更新日期:1996-09-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148.2015.1046200
更新日期:2015-01-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902148.2020.1809750
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journal_title:Experimental lung research
pub_type: 杂志文章,评审
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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更新日期:2010-09-01 00:00:00
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journal_title:Experimental lung research
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doi:10.1080/01902148.2019.1642968
更新日期:2019-09-01 00:00:00
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journal_title:Experimental lung research
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doi:10.1080/01902140490252858
更新日期:2004-01-01 00:00:00
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journal_title:Experimental lung research
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doi:10.3109/01902149709046048
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journal_title:Experimental lung research
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doi:10.3109/01902148909069628
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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更新日期:1992-05-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148.2013.858196
更新日期:2014-02-01 00:00:00
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更新日期:2018-08-01 00:00:00
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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doi:10.3109/01902149609031774
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journal_title:Experimental lung research
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更新日期:1998-07-01 00:00:00