Abstract:
:Alveolar cells were evaluated in BALB/c mice exposed to smoke from 9 cigarettes per day. The mice were sacrificed at 1, 5, and 10 days and examined by lung morphometry and immunohistochemical staining of alveolar macrophages for tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-12, and tissue inhibitor of metalloproteinase (TIMP)-2. Cigarette smoke (CS)-exposed mice showed a progressive increase in numbers of alveolar macrophages (AMs) up to 10 days. MMP-12 was increased in AMs compared to the control group. The number of AMs with TNF-alpha and TIMP-2 labeling was higher at 5 days but decreased at 10 days. Short-term CS exposure induced pulmonary inflammation with major participation of MMP-12-positive AMs.
journal_name
Exp Lung Resjournal_title
Experimental lung researchauthors
da Hora K,Valença SS,Porto LCdoi
10.1080/01902140500324828subject
Has Abstractpub_date
2005-10-01 00:00:00pages
759-70issue
8eissn
0190-2148issn
1521-0499pii
X0217JM831226NJ3journal_volume
31pub_type
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