Zizyphi fructus, a constituent of antiasthmatic herbal medicine, stimulates airway epithelial ciliary motility through nitric oxide generation.

abstract：:In a recent study of the sheep tracheal lobe model, we have demonstrated that surface chemistry modification of quartz by aluminum lactate significantly alters the biological activity of quartz for at least 2 months after exposure. In the present study, we have extended our observations of the biological reaction of t...

journal_title：Experimental lung research

authors： Bégin R,Massé S,Sébastien P,Martel M,Bossé J,Dubois F,Geoffroy M,Labbé J

更新日期：1987-01-01 00:00:00

abstract：PURPOSE OF THE STUDY:Workers in enclosed hogbarns experience an increased incidence of airway inflammation and obstructive lung disease, and an aqueous hogbarn dust extract (HDE) induces multiple inflammation-related responses in cultured airway epithelial cells. Epidermal growth factor receptor (EGFR) phosphorylation ...

journal_title：Experimental lung research

authors： Dodmane PR,Schulte NA,Heires AJ,Band H,Romberger DJ,Toews ML

更新日期：2018-12-01 00:00:00

abstract：:We quantified in vivo pulmonary vascular remodeling in a large animal model of pulmonary hypertension (PH). In group PH (n = 6), 3 mg/kg dehydromonocrotaline (DHMC) was administered to 12-week-old beagles via a right atrial injection. Eight weeks after DHMC in group PH, pulmonary artery pressure increased significantl...

journal_title：Experimental lung research

authors： Gust R,Schuster DP

更新日期：2001-01-01 00:00:00

abstract：:Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To further assess the toxic effects of amiodarone on lung tissue, Syrian hamsters were given a single intratracheal insufflation of the agent an...

journal_title：Experimental lung research

authors： Cantor JO,Osman M,Cerreta JM,Suarez R,Mandl I,Turino GM

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:This study aims to explore the effect of thymoquinone (TQ) on particulate matter 2.5 (PM2.5)-induced lung injury. METHODS:The PM2.5 sample was provided by Shenyang Environment Monitor Central Station. Lung injury was established by intratracheal instillation PM2.5 (7.5 mg/kg) followed by TQ treatment (20 an...

journal_title：Experimental lung research

authors： Mao M,Li J,Bi A,Jia H,Li Q,Liu Y,Jiang X,Huang D,Xia S

更新日期：2020-10-01 00:00:00

abstract：:This study evaluated polymorphonuclear leukocyte (PMN) involvement in translocation of dust to bronchial lymph nodes after deposition of dust in the lungs of control and neutropenic F344/N rats. Rats were rendered neutropenic with an intraperitoneal (IP) injection of anti-rat PMN antiserum (APA); control rats were inj...

journal_title：Experimental lung research

authors： Snipes MB,Harkema JR,Hotchkiss JA,Bice DE

更新日期：1997-01-01 00:00:00

abstract：:Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary sm...

journal_title：Experimental lung research

authors： Miko E,Czimmerer Z,Csánky E,Boros G,Buslig J,Dezso B,Scholtz B

更新日期：2009-10-01 00:00:00

abstract：:The integrity of the respiratory epithelium is crucial for airway homeostasis. Tobacco smoke exposure and recurrent infections of the airways play a crucial role in the progression and in the decline of the respiratory function in chronic obstructive pulmonary disease (COPD). The aim of this study was to detect differ...

journal_title：Experimental lung research

authors： D'Anna C,Cigna D,Di Sano C,Di Vincenzo S,Dino P,Ferraro M,Bini L,Bianchi L,Di Gaudio F,Gjomarkaj M,Pace E

更新日期：2017-01-01 00:00:00

abstract：:A small subpopulation of pulmonary epithelial cells (PE) proliferates in low-density primary culture of alveolar type II cells and forms colonies of cells that could be passaged for several generations and that in some respects maintain a differentiated phenotype of the alveolar type II cells. At this time it is not k...

journal_title：Experimental lung research

authors： Kalina M,Riklis S,Blau H

更新日期：1993-03-01 00:00:00

abstract：:The influence of gas composition on convective and diffusive gas transport in the lungs was assessed by studying the dispersion of combined particle and argon (Ar) boluses induced by the passage through the lungs filled with three different gas mixtures. Particles, as a "nondiffusing gas," served as a tracer for conve...

journal_title：Experimental lung research

authors： Schulz H,Schulz A,Eder G,Heyder J

更新日期：1995-11-01 00:00:00

abstract：:A deletional analysis of the SP-A1 promoter in NCI-H441 cells was performed to identify potential cis-acting elements involved in phorbol ester-mediated repression of human SP-A transcription. The phorbol ester TPA reduced SP-A1 and SP-A2 promoter activity to approximately 35% to 45% compared to that of control cells....

journal_title：Experimental lung research

authors： Hoover RR,Pavlovic J,Floros J

更新日期：2000-07-01 00:00:00

abstract：:To study the pattern of lymphokines in bleomycin-induced lung injury, T cells were isolated from lung interstitial tissue (LIL), peribronchial lymphatic tissue (PBLT), and bronchoalveolar lavage (BAL) fluid of bleomycin-"sensitive" C57Bl/6 and bleomycin-"resistant" BALB/c mice at 3, 6, and 14 days following intratrach...

journal_title：Experimental lung research

authors： Gur I,Or R,Segel MJ,Shriki M,Izbicki G,Breuer R

更新日期：2000-10-01 00:00:00

abstract：:Pathophysiologic changes induced by phospholipase A2 (PLA2), a lipolytic enzyme implicated in a variety of pulmonary diseases, were examined in the isolated, perfused guinea pig lung. Thirty microliters of vehicle (saline) or 30 units of PLA2 suspended in saline was given as a bolus injection into either the trachea o...

journal_title：Experimental lung research

authors： Durham SK,Selig WM

更新日期：1990-07-01 00:00:00

abstract：:Acute lung injury (ALI) is often associated with sepsis and is the most common cause of acute respiratory failure. The authors evaluated the role of the heme oxygenase (HO)/carbon monoxide (CO) system on lung injury in a cecal ligation and puncture (CLP)-induced mouse model of ALI. The authors established CLP-induced ...

journal_title：Experimental lung research

authors： Fei D,Meng X,Kang K,Nan C,Zhao M,Pan S,Gao M,Yang S,Zhao M

更新日期：2012-05-01 00:00:00

abstract：:During lung development, the extracellular matrix undergoes dynamic remodeling. Matrix metalloproteinases (MMPs), and tissue inhibitors of matrix metalloproteinases (TIMPs), are important enzymes that participate in regulating tissue remodeling. There is an abnormal balance of the synthesis and degradation of collagen...

journal_title：Experimental lung research

authors： Lemke RP,Zhang W,Balcerazak D,Kobayashi K,Schwingshackl A,Cheung PY,Dixon WT,Baracos VE,Greer JJ

更新日期：2003-06-01 00:00:00

abstract：:Male Sprague-Dawley rats were placed in hypobaric hypoxia for 17-21 d (FIO2 10%) to establish pulmonary hypertension (PH) and control rats were kept in normobaric room air. Right mean atrial and ventricular pressures (PRA, PRV) were recorded, left ventricular (LV) blood was collected, and lungs were perfused with hepa...

journal_title：Experimental lung research

authors： Keith IM,Ekman R

更新日期：1992-03-01 00:00:00

abstract：:Purpose/Aim: More and more evidences suggest that airway remodeling of fibrotic lung diseases may be associated with epithelial-mesenchymal transition (EMT) of human A549 cells induced by transforming growth factor (TGF)-β1. Schisandrin B (Sch B) is the highest content of dibenzocyclooctadiene lignans in Schisandra ch...

journal_title：Experimental lung research

authors： Zhuang W,Li Z,Dong X,Zhao N,Liu Y,Wang C,Chen J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Inhaled capsaicin (8-methyl-N-vanillyl-6-nonenamide) has been used to induce cough in a safe and dose-dependent manner. Chronic cough is associated with an increased sensitivity to inhaled capsaicin in patients with asthma. The aim of this study was to evaluate clinical impact of capsaicin provocation test f...

journal_title：Experimental lung research

authors： Park KH,Kim BG,Lee PH,Hong J,Lee J,Park SW,Kim DJ,Jang AS

更新日期：2021-02-01 00:00:00

abstract：:The streptozotocin-induced diabetic (STZ-DB) rat model is associated with fetal hyperglycemia, but with low to normal plasma insulin concentration. Because surfactant protein (SP) mRNA content in fetal rat lung is decreased in STZ-DB pregnancy, we investigated the effect of increasing concentrations of glucose on SP g...

journal_title：Experimental lung research

authors： Rayani HH,Gewolb IH,Floros J

更新日期：1999-01-01 00:00:00

abstract：:The structural features of the ovine pleura are described using light, scanning, and transmission electron microscopy. Extensive sampling of the visceral and parietal pleura revealed considerable variation in both surface morphology and pleural interstitial anatomy. Variations of mesothelial surface were encountered a...

journal_title：Experimental lung research

authors： Mariassy AT,Wheeldon EB

更新日期：1983-05-01 00:00:00

abstract：:Volcanic ash was collected from the Moses Lake region of Washington State after the 18 May 1980 eruption of Mt. St. Helens. The ash was tested in a short-term bioassay system using hamsters exposed by intratracheal instillation. One day after exposure the lungs were lavaged and the fluid collected was characterized us...

journal_title：Experimental lung research

authors： Beck BD,Brain JD,Bohannon DE

更新日期：1981-11-01 00:00:00

abstract：:The authors recently showed that preterm birth per se, in the absence of assisted ventilation or elevated inhaled oxygen levels, alters the structure of the airway walls in young lambs. The initial aim of the present study was to determine whether these changes persist into adulthood. Preterm (P; n = 7) lambs were del...

journal_title：Experimental lung research

authors： Snibson K,Harding R

更新日期：2008-02-01 00:00:00

abstract：PURPOSE OF THE STUDY:Pulmonary infection with Klebsiella pneumoniae (KP) and carbapenem-resistant Klebsiella pneumoniae (CRKP) significantly contribute to morbidity and mortality in pneumonia. Recent studies have indicated that High-Mobility Group Box 1 Protein (HMGB1) plays an important role in the prevention and trea...

journal_title：Experimental lung research

authors： Liming S,Guixia L,Wenxin S,Guirong T

更新日期：2018-08-01 00:00:00

abstract：:Recently there has been a great deal of interest in exploring possible ways to protect the lung from oxidant damage. Since sulfhydryl compounds are among the most important endogenous antioxidants, their therapeutic use has been proposed. Glutathione (GSH), the main intracellular nonprotein sulfhydryl, plays an import...

journal_title：Experimental lung research

authors： Patterson CE,Rhoades RA

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:HSPGs are glycoproteins containing covalently attached heparan sulfate (HS) chains which bind to growth factors, chemokines, etc., and regulate various aspects of inflammation including cell recruitment. We previously showed that deletion of endothelial N-acetylglucosamine N-deacetylase-N-sulfotransferase-1 ...

journal_title：Experimental lung research

authors： Ge XN,Bastan I,Ha SG,Greenberg YG,Esko JD,Rao SP,Sriramarao P

更新日期：2018-03-01 00:00:00

abstract：:Salvianolic acid B (Sal B), one of the major water-soluble compounds of Danshen (a popular Chinese herb), possesses many of the biological activities, such as antifibrogenic effect in liver and renal diseases. Transforming growth factor-β1 (TGF-β1) plays a central role in the development of pulmonary fibrosis by stimu...

journal_title：Experimental lung research

authors： Zhang M,Cao SR,Zhang R,Jin JL,Zhu YF

更新日期：2014-04-01 00:00:00

abstract：:The inhalation of inorganic dust can lead to the development of interstitial pulmonary fibrosis, characterized by the accumulation of fibroblasts and connective tissue matrix in the lung interstitium. The fibrosis causes alterations in the architecture of the lung parenchyma, resulting in abnormal gas exchange and hyp...

journal_title：Experimental lung research

authors： Schapira RM,Osornio-Vargas AR,Brody AR

更新日期：1991-11-01 00:00:00

abstract：:The aim of this study was to determine influence of prenatal granulocyte-macrophage colony-stimulating factor (GM-CSF) administration on lung growth, maturation, and vascular endothelial growth factor (VEGF) expression. Twenty Wistar rats received sterile saline (1 mL) or recombinant human GM-CSF (50 micro g/kg) on da...

journal_title：Experimental lung research

authors： Yuksel H,Yilmaz O,Baytur YB,Ozbilgin K

更新日期：2008-11-01 00:00:00

abstract：:The diabetic pregnancy is characterized by a delay in the process of fetal lung maturation. To determine whether high glucose conditions per se have an adverse impact on fetal lung phospholipid metabolism, 20-day fetal rat lung explants were cultured in F-12 medium (10 mM glucose) to which glucose was added to achieve...

journal_title：Experimental lung research

authors： Gewolb IH

更新日期：1993-11-01 00:00:00

abstract：:The aim of the study was to identify the effects on the lung after subchronic glass fiber intratracheal instillation study on rats. We evaluated the toxicological effects on the lung: persistent inflammatory reaction, cell proliferation, and pulmonary fibrosis on histopathological examination. We performed a glass fib...

journal_title：Experimental lung research

authors： Domokos-Hancu B,Man MA,Liana H,Pop CM

更新日期：2014-03-01 00:00:00