The pleura: a combined light microscopic, scanning, and transmission electron microscopic study in the sheep. I. Normal pleura.

abstract：:Lung disorders such as asthma, acute respiratory distress syndrome (ARDS), chronic obstructive lung disease (COPD), and interstitial lung disease (ILD) show a few common threads of pathogenic mechanisms: inflammation, aberrant immune activity, infection, and fibrosis. Currently no modes of effective treatment are avai...

journal_title：Experimental lung research

authors： Inamdar AC,Inamdar AA

更新日期：2013-10-01 00:00:00

abstract：:It is evident that much remains to be learned about the nasal passages and their responses to toxic materials. For the nose of both laboratory animals and humans, information is needed in the areas of anatomy, physiology, biochemistry, neurobiology, physiopathology, and oncology. This article briefly discussed toxic a...

journal_title：Experimental lung research

authors： Bonnefoi M,Monticello TM,Morgan KT

更新日期：1991-09-01 00:00:00

abstract：:Aims:Bronchopulmonary dysplasia (BPD) is characterized by alveolarization arrest. During alveolarization, alveolar myofibroblasts are thought to migrate into the septal tips and elongate secondary septa. Lipopolysaccharide (LPS) exposure has been reported to disrupt directional migration and final location of alveolar...

journal_title：Experimental lung research

authors： Li J,Gong X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Pulmonary ischemia-reperfusion (IR) is a biopathological event detectable in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation, and pulmonary embolism. The understanding behind the activation of various inflammatory mediators regulating the apoptotic pathways ...

journal_title：Experimental lung research

authors： Dolkart O,E A,S S,S M,P G,Aa W

更新日期：2014-02-01 00:00:00

abstract：:Distinct barrier lesions and an apical-basal distribution of alveolar edema fluid in either moderate or high elevated pressure edema lungs have been found in previous studies. In the present study, quantitative measurements were obtained by using electron microscopy and morphometry of extravascular lung water and barr...

journal_title：Experimental lung research

authors： Wu DX,Weibel ER,Bachofen H,Schürch S

更新日期：1995-09-01 00:00:00

abstract：:In both ovalbumin-sensitized and ovalbumin-challenged guinea pigs, the phospholipid content of bronchoalveolar lavage fluid is decreased with respect to that of controls. In the sensitized guinea pig, the activity of lung membrane phospholipase is increased and the phospholipid content of lung membranes is decreased. ...

journal_title：Experimental lung research

authors： Rami J,Brondel L,Rivière D,Besombes JP

更新日期：1990-03-01 00:00:00

abstract：:It was hypothesized that IL-8, a neutrophil chemotaxin, contributes to the influx of neutrophils into the pleural cavity of patients with pleural effusions. Pleural fluids were collected from 57 patients including 13 with effusions due to congestive heart failure, 28 with pleural involvement by carcinoma, 5 with empye...

journal_title：Experimental lung research

authors： Miller EJ,Idell S

更新日期：1993-09-01 00:00:00

abstract：:Verapamil, a calcium channel blocker has been used with partial success in cases of primary pulmonary hypertension, as well as to reduce hypoxia-induced pulmonary hypertension (PH) in rats. However, its effect on monocrotaline (MCT)-induced PH in rats is not known. We studied the effect of verapamil on MCT-induced PH....

journal_title：Experimental lung research

authors： Mathew R,Guzowski DE,Gloster ES

更新日期：1990-11-01 00:00:00

abstract：:The effect of a receptor binding protein for tumor necrosis factor (TNFrbp) on cell infiltration, bronchial hyperreactivity, and release of inflammatory mediators were studied following antigen challenge in sensitized rats. A 3-fold increase in total cell number, mainly neutrophils and eosinophils, was noted in bronch...

journal_title：Experimental lung research

authors： Carvalho CR,Jancar S,Conroy D,Sirois P

更新日期：2001-03-01 00:00:00

abstract：:Basement membranes (BM) are specialized extracellular matrices (ECM) which serve as complex interfaces between epithelia, peripheral nerves, or muscle cells and their surrounding tissue microenvironments. Their composition is known to include type IV collagen, laminin, entactin, heparan sulfate proteoglycan (HSPG, per...

journal_title：Experimental lung research

authors： Sannes PL,Wang J

更新日期：1997-03-01 00:00:00

abstract：:During lung development, the extracellular matrix undergoes dynamic remodeling. Matrix metalloproteinases (MMPs), and tissue inhibitors of matrix metalloproteinases (TIMPs), are important enzymes that participate in regulating tissue remodeling. There is an abnormal balance of the synthesis and degradation of collagen...

journal_title：Experimental lung research

authors： Lemke RP,Zhang W,Balcerazak D,Kobayashi K,Schwingshackl A,Cheung PY,Dixon WT,Baracos VE,Greer JJ

更新日期：2003-06-01 00:00:00

abstract：:Paraquat accumulation into rat lung slices was unaffected by hypoxia (PO2 = 645 mm Hg) but was inhibited by hypoxia. The IC50 (IC50 = partial pressure of O2 resulting in a 50% inhibition of paraquat accumulation) for paraquat accumulation was P02 = 50 mm Hg; significant accumulation could be observed after 1 or 2 hr o...

journal_title：Experimental lung research

authors： Montgomery MR,Wyatt I,Smith LL

更新日期：1980-08-01 00:00:00

abstract：:Increase in intracellular adenosine 3', 5'-cyclic monophosphate (cAMP) is a common pathway for many clinically used drugs to cause pulmonary artery (PA) relaxation. Activity of sarcolemmal K+ and Cl(-)-channels is an important determinant of membrane potential (Em), which, in turn, plays a critical role in regulating ...

journal_title：Experimental lung research

authors： Zhao YJ,Wang J,Rubin LJ,Yuan XJ

更新日期：1998-01-01 00:00:00

abstract：:Activity for nonspecific esterases has been demonstrated histochemically in fetal rabbit lungs using alpha-naphthyl acetate as substrate. Commencing with a homogeneous distribution in pseudoglandular lungs, activity gradually heightens in the epithelium, progresses centrifugally along the bronchial tree, and reaches f...

journal_title：Experimental lung research

authors： Sorokin SP,Hoyt RF Jr

更新日期：1982-11-01 00:00:00

abstract：:The authors recently showed that preterm birth per se, in the absence of assisted ventilation or elevated inhaled oxygen levels, alters the structure of the airway walls in young lambs. The initial aim of the present study was to determine whether these changes persist into adulthood. Preterm (P; n = 7) lambs were del...

journal_title：Experimental lung research

authors： Snibson K,Harding R

更新日期：2008-02-01 00:00:00

abstract：:Human and canine airway mucosal explants synthesize and secrete high molecular weight glycoconjugates, incorporating 14C-glucosamine, a radioactive precursor to epithelial glycoprotein. Our examination of secretions produced by several individual specimens, however, did not reveal epithelial glycoprotein of typical bu...

journal_title：Experimental lung research

authors： Bhaskar KR,O'Sullivan DD,Opaskar-Hincman H,Reid LM,Coles SJ

更新日期：1986-01-01 00:00:00

abstract：:CTP:cholinephosphate cytidylyltransferase (CT) is a key enzyme required for surfactant phosphatidylcholine synthesis, and its activity is regulated by lung lipids. This study evaluated the effect of epidermal growth factor (EGF) on the phospholipid content and the expression of CT in the lung following direct in vivo ...

journal_title：Experimental lung research

authors： Mallampalli RK,Salome RG,Hunninghake GW

更新日期：1994-01-01 00:00:00

abstract：AIM OF THE STUDY:Nucleic acid-based therapies have the potential to provide clinically meaningful benefit across a wide spectrum of lung disease. However, in vivo delivery remains a challenge. Here we examined the feasibility of using electrospray to deliver nucleic acids to both porcine tracheal tissue sections and wh...

journal_title：Experimental lung research

authors： Riddell P,Gilbert JL,Molloy EL,Finnegan S,Egan JJ,O'Dea S

更新日期：2018-01-01 00:00:00

abstract：:TRPV1 is a modulator of noxious stimuli known to be important in the cough reflex. We have compared the expression of TRPV1 in normal human airways and those from patients with chronic cough and found that there is up regulation in airways smooth muscle in disease. This increased expression appears to be intracellular...

journal_title：Experimental lung research

authors： Mitchell JE,Campbell AP,New NE,Sadofsky LR,Kastelik JA,Mulrennan SA,Compton SJ,Morice AH

更新日期：2005-04-01 00:00:00

abstract：:The inhalation of inorganic dust can lead to the development of interstitial pulmonary fibrosis, characterized by the accumulation of fibroblasts and connective tissue matrix in the lung interstitium. The fibrosis causes alterations in the architecture of the lung parenchyma, resulting in abnormal gas exchange and hyp...

journal_title：Experimental lung research

authors： Schapira RM,Osornio-Vargas AR,Brody AR

更新日期：1991-11-01 00:00:00

abstract：:A tandem repeat region in the second intron of the K-ras gene has been reported to be a possible regulatory site for transcription. In this study, a second protein-binding site was identified and characterized. It lies downstream (nucleotides 463 to 509) of the tandem repeat region. A T--> C base variation at nucleoti...

journal_title：Experimental lung research

authors： Chen B,Wang Y,You M

更新日期：2005-03-01 00:00:00

abstract：:Silicosis is a serious occupational disease characterized by lung fibrosis that is caused by long-term inhalation of silica-containing fine particles. Lysophosphatidic acid (LPA) and LPA1/3 plays a role in lung fibrosis. Until recently, there has been little research investigating the role of LPA and LPA receptors (LP...

journal_title：Experimental lung research

authors： Cong C,Mao L,Zhang Y,Zhao Z,Xu X,Zhao J

更新日期：2014-09-01 00:00:00

abstract：:COPD remains a public health problem that has yet to be fully recognized by the public, the medical community or public health (government) officials, and much work remains to be done worldwide to reverse the increasing trends of this chronic lung disease. ...

journal_title：Experimental lung research

authors： Hurd S

更新日期：2005-09-01 00:00:00

abstract：:Previous experiments with the sheep model of silicosis have demonstrated a reduction of the pathological activity of quartz after treatments with aluminum lactate (Al-lac), such as Al-lac pretreatment of intratracheally injected quartz or Al-lac inhalation of quartz-exposed animals. Preliminary data also suggested a m...

journal_title：Experimental lung research

authors： Dufresne A,Sébastien P,Michaud D,Perrault G,Bégin R

更新日期：1994-03-01 00:00:00

abstract：:Tracheal occlusion (TO) performed surgically in utero near the end of gestation causes a rapid increase in the distension of future airspaces, resulting in accelerated lung development. The authors hypothesize that TO stimulates microvascular growth concomitant with a rapid increase in the expression of genes implicat...

journal_title：Experimental lung research

authors： Cloutier M,Maltais F,Piedboeuf B

更新日期：2008-03-01 00:00:00

abstract：:The molecular events involved in both the initiation and development of silicosis are at present poorly defined, although mediators released from macrophages exposed to silica particles are believed to play a role. We have investigated the in vitro production of arachidonic acid (AA) metabolites in adherent bovine alv...

journal_title：Experimental lung research

authors： Englen MD,Taylor SM,Laegreid WW,Liggitt HD,Silflow RM,Breeze RG,Leid RW

更新日期：1989-07-01 00:00:00

abstract：:We compared the effects of dexamethasone given to rats from age 4 to 14 days, on alveolar development at age 99 days. Judged by similar nose-to-tail length and body weight, somatic growth was not altered by dexamethasone treatment. Lung volumes in both air- and saline-filled lungs and mean chord length (Lm) were incre...

journal_title：Experimental lung research

authors： Sahebjami H,Domino M

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Mechanisms linking behavioral stress and inflammation are poorly understood, mainly in distal lung tissue. OBJECTIVE:We have investigated whether the forced swim stress (FS) could modulate lung tissue mechanics, iNOS, cytokines, oxidative stress activation, eosinophilic recruitment, and remodeling in guinea...

journal_title：Experimental lung research

authors： Reis FG,Marques RH,Starling CM,Almeida-Reis R,Vieira RP,Cabido CT,Silva LF,Lanças T,Dolhnikoff M,Martins MA,Leick-Maldonado EA,Prado CM,Tibério IF

更新日期：2012-09-01 00:00:00

abstract：:The objective of this study was to determine if prolonged hyperoxia exposure would deplete antioxidants, resulting in excessive oxidative stress that would lead to oxidation of pulmonary surfactant and contribute to lung dysfunction. Rats were exposed to either hyperoxic (> 95% O(2)) or normoxic (21% O(2)) oxygen conc...

journal_title：Experimental lung research

authors： Pace PW,Yao LJ,Wilson JX,Possmayer F,Veldhuizen RA,Lewis JF

更新日期：2009-06-01 00:00:00

abstract：:Three-day-old rabbits were given intratracheal injections of radiolabeled natural sheep surfactant, rabbit surfactant, or liposomes of dipalmitoylphosphatidylcholine that contained greater than three times the quantity of phosphatidylcholine present in the endogenous surfactant pool. The recoveries of radiolabeled pho...

journal_title：Experimental lung research

authors： Oguchi K,Ikegami M,Jacobs H,Jobe A

更新日期：1985-01-01 00:00:00