Abstract:
:Previous experiments with the sheep model of silicosis have demonstrated a reduction of the pathological activity of quartz after treatments with aluminum lactate (Al-lac), such as Al-lac pretreatment of intratracheally injected quartz or Al-lac inhalation of quartz-exposed animals. Preliminary data also suggested a more effective alveolar clearance of quartz treated with Al-lac. The present study was undertaken to fully document the effect of Al-lac treatments on the pulmonary retention of quartz. Sheep (on average, 27 per group) received a single injection in the tracheal lobe of either 100 mg/100 mL of alpha-quartz, 100 mg/100 mL of alpha-quartz followed by Al-lac inhalations at 1-month intervals, or 100 mg/100 mL of alpha-quartz Al-lac pretreated in vitro. Samples of lung parenchyma were analyzed at 2, 6, and 10 months after the injection. The quartz concentration in each sample was measured using the X-ray diffraction method. The concentrations were expressed in micrograms of quartz per milligram of dry lung parenchyma. The geometric mean concentrations in each of the three groups at 2 months were statistically different (ANOVA of the log values; p = .016) as well as at 6 months (ANOVA of the log values; p = .001). Al-lac clearly reduced the pulmonary retention of quartz. Both modalities of Al delivery were equally effective in clearing quartz up to 2 months, which may explain the documented reduction in pathological activities after in both forms of therapy. However, quartz soaked in Al-Lac solution was more effective than inhalation of Al-lac after quartz exposure. The half-life of both native quartz and quartz Al-lactate inhaled was 5.05 and 4.99 months, respectively, while it was 3.1 months for Al-treated quartz. Al-lac inhalations after the second month of exposure do not significantly affect the rate of clearance of deposited quartz.
journal_name
Exp Lung Resjournal_title
Experimental lung researchauthors
Dufresne A,Sébastien P,Michaud D,Perrault G,Bégin Rdoi
10.3109/01902149409064380subject
Has Abstractpub_date
1994-03-01 00:00:00pages
157-68issue
2eissn
0190-2148issn
1521-0499journal_volume
20pub_type
杂志文章abstract::We set out to determine whether or not the "mucolytic" drug N-acetylcysteine would speed the reversal of cigarette smoke-induced secretory-cell hyperplasia to normal, similar to that found previously for two nonsteroidal antiinflammatory drugs. Cigarette smoke alone significantly (p less than 0.01) increased the numbe...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148809062848
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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更新日期:1990-07-01 00:00:00
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journal_title:Experimental lung research
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更新日期:1980-03-01 00:00:00
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更新日期:2012-09-01 00:00:00
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更新日期:2012-05-01 00:00:00
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journal_title:Experimental lung research
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更新日期:2015-01-01 00:00:00
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journal_title:Experimental lung research
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更新日期:1988-01-01 00:00:00
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