Characterization of proteoglycans synthesized by fetal rat lung type II pneumonocytes in vitro and the effects of cortisol.

abstract：:Variable numbers of composite repetitive motifs are found in different individuals within intron 4 of the surfactant protein B (SP-B) gene (Biochem J. 1995;305:583). This study tests the hypothesis that the distribution of SP-B alleles differs among racial/ethnic groups. A total of 412 SP-B alleles were analyzed: 206 ...

journal_title：Experimental lung research

authors： Veletza SV,Rogan PK,TenHave T,Olowe SA,Floros J

更新日期：1996-07-01 00:00:00

abstract：:Previous experiments with the sheep model of silicosis have demonstrated a reduction of the pathological activity of quartz after treatments with aluminum lactate (Al-lac), such as Al-lac pretreatment of intratracheally injected quartz or Al-lac inhalation of quartz-exposed animals. Preliminary data also suggested a m...

journal_title：Experimental lung research

authors： Dufresne A,Sébastien P,Michaud D,Perrault G,Bégin R

更新日期：1994-03-01 00:00:00

abstract：:Eprazinone therapy improves pulmonary function and arterial pO2 in patients with chronic bronchitis; however, the mechanism of action is unknown. The purpose of this study was to determine if eprazinone alters either lung surfactant levels in bronchoalveolar lavage fluid (BAL) of normal rats, or ion transport across c...

journal_title：Experimental lung research

authors： Thrall RS,Cloutier MM,Guernsey L,Swayne E,Gionfriddo M

更新日期：1992-05-01 00:00:00

abstract：:The studies presented were designed to test the efficacy of farnesyltransferase inhibitors (FTIs) as potential chemopreventive compounds in the mouse lung tumor model, and in tumor cell lines. The compounds included manumycin, gliotoxin, dihydroepiandrosterone (DHEA), perillyl alcohol (POH), and FTI-276. Each of these...

journal_title：Experimental lung research

authors： Lantry LE,Zhang Z,Crist KA,Wang Y,Hara M,Zeeck A,Lubet RA,You M

更新日期：2000-12-01 00:00:00

abstract：:We have previously shown that intratracheally instilled silica (quartz) produces both morphologic evidence of emphysema and small-airway changes, and functional evidence of airflow obstruction. To further define the nature of the airflow-associated lesions induced by silica, we compared silica-exposed rats to rats giv...

journal_title：Experimental lung research

authors： Churg A,Hobson J,Wright J

更新日期：1989-12-01 00:00:00

abstract：:Sirius Red staining is presented as a method for collagen determination, enabling quantitative morphometric measurements to be performed in locally defined tissue areas. The advantage of this method is especially shown for alveolar lung tissue. By excluding the bronchial areas in the tissue sections, the differences i...

journal_title：Experimental lung research

authors： Malkusch W,Rehn B,Bruch J

更新日期：1995-01-01 00:00:00

abstract：:Suboptimal intake of dietary zinc (Zn) is one of the most common nutritional problems worldwide. Previously, the authors have shown that zinc deficiency (ZD) produces oxidative and nitrosative stress in lung of male rats. The goal of this study is to test the effect of moderate ZD on insulin-like growth factor (IGF)-1...

journal_title：Experimental lung research

authors： Biaggio VS,Pérez Chaca MV,Valdéz SR,Gómez NN,Gimenez MS

更新日期：2010-02-01 00:00:00

abstract：:To study the pattern of lymphokines in bleomycin-induced lung injury, T cells were isolated from lung interstitial tissue (LIL), peribronchial lymphatic tissue (PBLT), and bronchoalveolar lavage (BAL) fluid of bleomycin-"sensitive" C57Bl/6 and bleomycin-"resistant" BALB/c mice at 3, 6, and 14 days following intratrach...

journal_title：Experimental lung research

authors： Gur I,Or R,Segel MJ,Shriki M,Izbicki G,Breuer R

更新日期：2000-10-01 00:00:00

abstract：:Leptin, an adipocyte-secreted hormone that regulates food intake and metabolic response, has been recently reported to increase in the serum during inflammatory airway disease associated with mucus-hypersecretion. We investigated the effects of leptin on mucin expression in human airway epithelial cells and the signal...

journal_title：Experimental lung research

authors： Woo HJ,Yoo WJ,Bae CH,Song SY,Kim YW,Park SY,Kim YD

更新日期：2010-06-01 00:00:00

abstract：:Immunosuppressive and antiproliferative effects of heparin may be beneficial in the field of solid organ transplantation. The aim of this study was to examine the effect of low-molecular-weight heparin (LMWH) compounds on the development of obliterative airway disease (OAD) in the rat tracheal transplant model. Alloge...

journal_title：Experimental lung research

authors： Fillinger J,Antus B

更新日期：2010-12-01 00:00:00

abstract：:The aim of the study was to identify the effects on the lung after subchronic glass fiber intratracheal instillation study on rats. We evaluated the toxicological effects on the lung: persistent inflammatory reaction, cell proliferation, and pulmonary fibrosis on histopathological examination. We performed a glass fib...

journal_title：Experimental lung research

authors： Domokos-Hancu B,Man MA,Liana H,Pop CM

更新日期：2014-03-01 00:00:00

abstract：:Inflammation plays a key role in lung injury and in the pathogenesis of asthma. Two murine models of allergic airway inflammation-sensitization and challenge to ovalbumin (OVA) and intratracheal exposure to interleukin-13 (IL13)-were used to evaluate the expression of poly(ADP-ribose) polymerase-1 (PARP-1) in allergic...

journal_title：Experimental lung research

authors： Havranek T,Aujla PK,Nickola TJ,Rose MC,Scavo LM

更新日期：2010-09-01 00:00:00

abstract：:Retention in the extrathoracic airways, and clearance by nose blowing, of monodisperse indium-111-labeled polystyrene particles were followed for at least 2 days after inhalation by healthy volunteers. Nine volunteers inhaled 3-μm aerodynamic diameter particles while sitting at rest, whereas subgroups of 3 or 4 inhale...

journal_title：Experimental lung research

authors： Smith JR,Bailey MR,Etherington G,Shutt AL,Youngman MJ

更新日期：2011-03-01 00:00:00

abstract：:Emerging data indicate that endothelial-mesenchymal transition (EndMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). A previous study noted that blocking the activity of protein phosphatase 2 A (PP2A) could attenuate EndMT. However, the treatment effects of PP2A inhibitors in pulmonary fibros...

journal_title：Experimental lung research

authors： Yu J,Deng Y,Han M

更新日期：2020-09-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is a leading cause of mortality worldwide. In China, a dramatic increase in the incidence of NSCLC is expected in the next 20 years (Molina et al. Mayo Clin Proc. 2008;83:584–594). Mutated epidermal growth factor receptor (EGFR) status is a known predictor ...

journal_title：Experimental lung research

authors： McMillen E,Ye F,Li G,Wu Y,Yin G,Liu W

更新日期：2010-11-01 00:00:00

abstract：:A small subpopulation of pulmonary epithelial cells (PE) proliferates in low-density primary culture of alveolar type II cells and forms colonies of cells that could be passaged for several generations and that in some respects maintain a differentiated phenotype of the alveolar type II cells. At this time it is not k...

journal_title：Experimental lung research

authors： Kalina M,Riklis S,Blau H

更新日期：1993-03-01 00:00:00

abstract：:The developmental regulation of the rabbit surfactant-associated proteins, SP-A, SP-B, and SP-C, was investigated using Northern blot analysis. These proteins comprise approximately 10% by weight of pulmonary surfactant, a lipoprotein secreted by type II cells that reduces surface tension at the air-alveolar interface...

journal_title：Experimental lung research

authors： Durham PL,Nanthakumar EJ,Snyder JM

更新日期：1992-11-01 00:00:00

abstract：:Confluent cultures of primary hamster tracheal surface epithelial cells are highly enriched with secretory cells resembling airway goblet cells. The cultures secrete lipids, most of which appear to be associated with high-molecular-weight mucinlike glycoproteins (HMW MLGP). In the present communication, we examined th...

journal_title：Experimental lung research

authors： Kim KC,Singh BN

更新日期：1990-05-01 00:00:00

abstract：:We studied lung clearance of technetium-labeled diethylenetriamine pentaacetic acid [( 99mTc]DTPA), plasma and bronchoalveolar lavage fluid (BALF) concentrations of 6-keto-PGF1 alpha (stable metabolite of prostacyclin, prostaglandin I2, PGI2), TxB2 (stable metabolite of thromboxane A2, TxA2), and leukotriene B4 (LTB4)...

journal_title：Experimental lung research

authors： Witten ML,Quan SF,Sobonya RE,Bruck D,Devine L,Lemen RJ

更新日期：1988-01-01 00:00:00

abstract：:The influence of gas composition on convective and diffusive gas transport in the lungs was assessed by studying the dispersion of combined particle and argon (Ar) boluses induced by the passage through the lungs filled with three different gas mixtures. Particles, as a "nondiffusing gas," served as a tracer for conve...

journal_title：Experimental lung research

authors： Schulz H,Schulz A,Eder G,Heyder J

更新日期：1995-11-01 00:00:00

abstract：:Biochemical characterization of human respiratory mucus has generally utilized expectorated specimens. In order to exclude extraneous contaminants in the analysis of airway glycoproteins, human airways were cultured and the mucous glycoprotein released into the supernatant analyzed. By incorporating 3H-labeled glucosa...

journal_title：Experimental lung research

authors： Shelhamer JH,Marom Z,Logun C,Kaliner M

更新日期：1984-01-01 00:00:00

abstract：:The separate effects of positive end-expiratory pressure (PEEP) and intravascular volume administration on the histopathologic lung injury were not investigated in experimental lung injury previously. The authors hypothesized that high PEEP and a restrictive volume therapy would yield the best oxygenation and the leas...

journal_title：Experimental lung research

authors： Kredel M,Muellenbach RM,Schlegel N,Wunder C,Klingelhöfer M,Lange M,Roewer N,Waschke J,Brederlau J

更新日期：2011-02-01 00:00:00

abstract：:To better understand the mechanisms by which neutrophils migrate into the airways, we constructed a novel in vitro model system with human umbilical vein endothelial cell (HUVE) monolayers grown on top of permeable filters and human lung Type II-like alveolar epithelial cell (A549) monolayers grown on the undersurface...

journal_title：Experimental lung research

authors： Casale TB,Mower DA,Carolan EJ

更新日期：1998-11-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) as a complex disease with genetic and environmental compound is one of the leading causes of death in worldwide. This disease is characterized by lower airway inflammation, and increases risk of lung cancer in smokers. Micro-RNA (miRNA) molecules are key regulators in gene ...

journal_title：Experimental lung research

authors： Akbas F,Coskunpinar E,Aynaci E,Oltulu YM,Yildiz P

更新日期：2012-08-01 00:00:00

abstract：:It was hypothesized that IL-8, a neutrophil chemotaxin, contributes to the influx of neutrophils into the pleural cavity of patients with pleural effusions. Pleural fluids were collected from 57 patients including 13 with effusions due to congestive heart failure, 28 with pleural involvement by carcinoma, 5 with empye...

journal_title：Experimental lung research

authors： Miller EJ,Idell S

更新日期：1993-09-01 00:00:00

abstract：INTRODUCTION:Nintedanib is a multi-tyrosine kinase receptor inhibitor recently approved for treatment of idiopathic pulmonary fibrosis. Although angiogenesis is a key process involved in airway structural changes in patients with bronchial asthma, the effect of nintedanib targeting the angiokinase pathway on airway inf...

journal_title：Experimental lung research

authors： Lee HY,Hur J,Kim IK,Kang JY,Yoon HK,Lee SY,Kwon SS,Kim YK,Rhee CK

更新日期：2017-01-01 00:00:00

abstract：:Previous studies have indicated increased plasma levels of inducible nitric oxide synthase in lung. This study further examines the pulmonary expression of nitric oxide synthase (NOS) isoforms in an ovine model of acute lung injury induced by smoke inhalation and burn injury (S+B injury). Female range bred sheep (4 pe...

journal_title：Experimental lung research

authors： Cox RA,Jacob S,Oliveras G,Murakami K,Enkhbaatar P,Traber L,Schmalstieg FC,Herndon DN,Traber DL,Hawkins HK

更新日期：2009-03-01 00:00:00

abstract：AIM OF THE STUDY:The current investigation was taken to scrutinize the action of tranilast on the airway remodeling in chronic asthma in mice. MATERIALS AND METHODS:Intraperitoneal injection of ovalbumin was applied to mice for sensitization and subsequent inhalation of 1% ovalbumin three times week for 10 weeks for c...

journal_title：Experimental lung research

authors： Nader MA,Gameil N,Abdelaziz RR,Zalata KR,Osman A,Zedan MM,Abo-Elkheir N,Elsiddig AA,Zedan M

更新日期：2016-08-01 00:00:00

abstract：:The objective of this study was to assess the radioprotective effects of amifostine in the rat model of radiation-induced lung injury using fractionated doses of radiation, to determine whether amifostine given before irradiation protects tumor from radiation cytotoxicity, and to determine whether changes in plasma le...

journal_title：Experimental lung research

authors： Vujaskovic Z,Feng QF,Rabbani ZN,Samulski TV,Anscher MS,Brizel DM

更新日期：2002-10-01 00:00:00

abstract：:Salvianolic acid B (Sal B), one of the major water-soluble compounds of Danshen (a popular Chinese herb), possesses many of the biological activities, such as antifibrogenic effect in liver and renal diseases. Transforming growth factor-β1 (TGF-β1) plays a central role in the development of pulmonary fibrosis by stimu...

journal_title：Experimental lung research

authors： Zhang M,Cao SR,Zhang R,Jin JL,Zhu YF

更新日期：2014-04-01 00:00:00