An experimental study of clearance of inhaled particles from the human nose.

abstract：:Three-day-old rabbits were given intratracheal injections of radiolabeled natural sheep surfactant, rabbit surfactant, or liposomes of dipalmitoylphosphatidylcholine that contained greater than three times the quantity of phosphatidylcholine present in the endogenous surfactant pool. The recoveries of radiolabeled pho...

journal_title：Experimental lung research

authors： Oguchi K,Ikegami M,Jacobs H,Jobe A

更新日期：1985-01-01 00:00:00

abstract：:Investigators disagree on the amount of hydrogen peroxide (H2O2) released by resting and stimulated alveolar macrophages. The method commonly used to measure H2O2 release involves horseradish peroxidase (HRP)-catalyzed oxidation of scopoletin by H2O2. We describe an artifact in this method that may explain the seeming...

journal_title：Experimental lung research

authors： Van Scott MR,Miles PR,Castranova V

更新日期：1984-01-01 00:00:00

abstract：:Toluene diisocyanate (TDI) is known as one of causes of occupational asthma and hypersensitivity pneumonitis. To investigate the stimulatory effect on bronchial epithelial cells in response to TDI, the authors examined production of cytokines by the bronchial epithelial cell line BEAS-2B and intercellular signal trans...

journal_title：Experimental lung research

authors： Ogawa H,Inoue S,Ogushi F,Ogura H,Nakamura Y

更新日期：2006-06-01 00:00:00

abstract：:To better understand the mechanisms by which neutrophils migrate into the airways, we constructed a novel in vitro model system with human umbilical vein endothelial cell (HUVE) monolayers grown on top of permeable filters and human lung Type II-like alveolar epithelial cell (A549) monolayers grown on the undersurface...

journal_title：Experimental lung research

authors： Casale TB,Mower DA,Carolan EJ

更新日期：1998-11-01 00:00:00

abstract：PURPOSE/AIM:Intravitreal bevacizumab (Avastin) is an irreversible vascular endothelial growth factor (VEGF) inhibitor used to treat severe retinopathy of prematurity (ROP) in extremely low gestational age neonates (ELGANs). ELGANs who are at the highest risk for developing severe ROP often experience brief intermittent...

journal_title：Experimental lung research

authors： Duggan TJ,Cai CL,Aranda JV,Beharry KD

更新日期：2020-12-30 00:00:00

abstract：:Cyclin D1 dysregulation and differential inactivation of p16INK4a and Rb have been observed in human lung cancer. In chemically induced mouse lung tumors, the p16INK4a gene is a target of inactivation, and Rb is reduced at the mRNA level (Northern blot) although similar at the protein level (Western blot) when compare...

journal_title：Experimental lung research

authors： Sabourin CL,Wang QS,Ralston SL,Evans J,Coate J,Herzog CR,Jones SL,Weghorst CM,Kelloff GJ,Lubet RA,You M,Stoner GD

更新日期：1998-07-01 00:00:00

abstract：:In both ovalbumin-sensitized and ovalbumin-challenged guinea pigs, the phospholipid content of bronchoalveolar lavage fluid is decreased with respect to that of controls. In the sensitized guinea pig, the activity of lung membrane phospholipase is increased and the phospholipid content of lung membranes is decreased. ...

journal_title：Experimental lung research

authors： Rami J,Brondel L,Rivière D,Besombes JP

更新日期：1990-03-01 00:00:00

abstract：:In three experiments, we have explored the uptake and transport of colloidal gold (Au) and iron oxide (Fe2O3) by normal and SO2-injured bronchial epithelium. In the first experiment, mice were exposed to a 2-hr aerosol of Au; in the second experiment, mice were exposed to SO2 (250 ppm) for 3 hr, then to Au; and in the...

journal_title：Experimental lung research

authors： Watson AY,Brain JD

更新日期：1980-03-01 00:00:00

abstract：:We determined optimum conditions for delivering DNA to transformed human bronchial epithelial cells expressing wild-type (BEAS) or abnormal (2CF) cystic fibrosis transmembrane conductance regulator (CFTR) using cationic liposomes (Lipofectin, [N-(N,N-dimethylaminoethane)carbamyl] cholesterol[DC-Chol]/dioleoylphosphati...

journal_title：Experimental lung research

authors： Peters MT,Brigham KL,King GA,Meyrick BO,Gao X,Stecenko AA

更新日期：1999-04-01 00:00:00

abstract：BACKGROUND:Pulmonary ischemia-reperfusion (IR) is a biopathological event detectable in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation, and pulmonary embolism. The understanding behind the activation of various inflammatory mediators regulating the apoptotic pathways ...

journal_title：Experimental lung research

authors： Dolkart O,E A,S S,S M,P G,Aa W

更新日期：2014-02-01 00:00:00

abstract：:The streptozotocin-induced diabetic (STZ-DB) rat model is associated with fetal hyperglycemia, but with low to normal plasma insulin concentration. Because surfactant protein (SP) mRNA content in fetal rat lung is decreased in STZ-DB pregnancy, we investigated the effect of increasing concentrations of glucose on SP g...

journal_title：Experimental lung research

authors： Rayani HH,Gewolb IH,Floros J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Serum amyloid A (SAA), an acute-phase protein whose level tracks infection and inflammation, is the precursor protein of amyloid A (AA) fibrils that is thought to cause AA amyloidosis in human and animals. SAA protein has several isoforms based on the difference of amino acid sequence, such as SA...

journal_title：Experimental lung research

authors： Kawasaki H,Murakami T,Badr Y,Kamiya S,Shimizu K,Okada A,Inoshima Y

更新日期：2020-11-01 00:00:00

abstract：:This study investigated whether interleukin-1 (IL-1) inhibitory activity in LPS-stimulated culture supernatants of alveolar macrophages and epithelioid cells obtained from rabbit lung granulomas induced by complete Freund's adjuvant (CFA) was identical to IL-1 receptor antagonist (IL-1ra) and examined the changes of I...

journal_title：Experimental lung research

authors： Shigenaga T,Abe Y,Miyazaki E,Kita S,Tsuda T

更新日期：1995-03-01 00:00:00

abstract：:Paraquat accumulation into rat lung slices was unaffected by hypoxia (PO2 = 645 mm Hg) but was inhibited by hypoxia. The IC50 (IC50 = partial pressure of O2 resulting in a 50% inhibition of paraquat accumulation) for paraquat accumulation was P02 = 50 mm Hg; significant accumulation could be observed after 1 or 2 hr o...

journal_title：Experimental lung research

authors： Montgomery MR,Wyatt I,Smith LL

更新日期：1980-08-01 00:00:00

abstract：:We studied lung clearance of aerosolized technetium-labeled diethylenetriamine pentaacetic acid (99mTcDTPA), plasma concentrations of 6-keto-PGF1 alpha and thromboxane B2, and pulmonary edema as indices of lung injury in rabbits exposed to cigarette smoke (CSE). Forty-six rabbits were randomly assigned to 4 groups: co...

journal_title：Experimental lung research

authors： Witten ML,Lemen RJ,Quan SF,Sobonya RE,Magarelli JL,Bruck DC

更新日期：1987-01-01 00:00:00

abstract：:A tandem repeat region in the second intron of the K-ras gene has been reported to be a possible regulatory site for transcription. In this study, a second protein-binding site was identified and characterized. It lies downstream (nucleotides 463 to 509) of the tandem repeat region. A T--> C base variation at nucleoti...

journal_title：Experimental lung research

authors： Chen B,Wang Y,You M

更新日期：2005-03-01 00:00:00

abstract：:Purpose/Aim of Study: Studies of pulmonary fibrosis (PF) have resulted in DNA damage, inflammatory response, and cellular senescence being widely hypothesized to play a role in the progression of the disease. Utilizing these aforementioned terms, genomics databases were interrogated along with the term, "pulmonary fib...

journal_title：Experimental lung research

authors： Beach TA,Johnston CJ,Groves AM,Williams JP,Finkelstein JN

更新日期：2017-04-01 00:00:00

abstract：:Excess production of neutrophil elastase contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the role of neutrophil elastase in the repair process following ALI/ARDS is not well understood. The objective of this study was to evaluate the effect of neutrop...

journal_title：Experimental lung research

authors： Fujino N,Kubo H,Suzuki T,He M,Suzuki T,Yamada M,Takahashi T,Ota C,Yamaya M

更新日期：2012-02-01 00:00:00

abstract：:Verapamil, a calcium channel blocker has been used with partial success in cases of primary pulmonary hypertension, as well as to reduce hypoxia-induced pulmonary hypertension (PH) in rats. However, its effect on monocrotaline (MCT)-induced PH in rats is not known. We studied the effect of verapamil on MCT-induced PH....

journal_title：Experimental lung research

authors： Mathew R,Guzowski DE,Gloster ES

更新日期：1990-11-01 00:00:00

abstract：:Eprazinone therapy improves pulmonary function and arterial pO2 in patients with chronic bronchitis; however, the mechanism of action is unknown. The purpose of this study was to determine if eprazinone alters either lung surfactant levels in bronchoalveolar lavage fluid (BAL) of normal rats, or ion transport across c...

journal_title：Experimental lung research

authors： Thrall RS,Cloutier MM,Guernsey L,Swayne E,Gionfriddo M

更新日期：1992-05-01 00:00:00

abstract：:Electrical stimulation of the cervical vagus nerve of rats is known to increase vascular permeability in the trachea. In the present study, we sought to further characterize this neurogenic inflammatory response by defining the relationship between the parameters of electrical stimulation of the vagus nerve and the ma...

journal_title：Experimental lung research

authors： Brokaw JJ,McDonald DM

更新日期：1988-01-01 00:00:00

abstract：:The cigarette smoke-induced rat model of chronic bronchitis was used to study the time course of the return of cigarette smoke-induced secretory cell hyperplasia to the normal and the capacity of two non-steroidal anti-inflammatory drugs to speed this recovery. Cigarette smoke alone significantly increased (P less tha...

journal_title：Experimental lung research

authors： Rogers DF,Jeffery PK

更新日期：1986-01-01 00:00:00

abstract：:A past study demonstrated that all-trans-retinoic acid (ATRA) treatment by intraperitoneal injection in a rat model of elastase-induced emphysema caused tissue regeneration as evidenced by a decrease in alveolar size and lung volume and an increase in alveolar number. We postulated that treatment with this retinoid by...

journal_title：Experimental lung research

authors： March TH,Cossey PY,Esparza DC,Dix KJ,McDonald JD,Bowen LE

更新日期：2004-07-01 00:00:00

abstract：:Human and canine airway mucosal explants synthesize and secrete high molecular weight glycoconjugates, incorporating 14C-glucosamine, a radioactive precursor to epithelial glycoprotein. Our examination of secretions produced by several individual specimens, however, did not reveal epithelial glycoprotein of typical bu...

journal_title：Experimental lung research

authors： Bhaskar KR,O'Sullivan DD,Opaskar-Hincman H,Reid LM,Coles SJ

更新日期：1986-01-01 00:00:00

abstract：:The effects of urban air and diesel particles on inflammatory cytokine gene expression, tumor necrosis factor alpha (TNF-alpha) in particular, were studied in rat alveolar macrophages. TNF-alpha, interleukin (IL)-1, IL-6, cytokine-induced neutrophil chemoattractant (CINC), and macrophage inflammatory protein (MIP)-2 g...

journal_title：Experimental lung research

authors： Dong W,Lewtas J,Luster MI

更新日期：1996-09-01 00:00:00

abstract：PURPOSE:This study was prospectively designed to investigate the effects of different concentrations of isoflurane (ISO) pretreatment on respiratory mechanics, oxygenation, and hemodynamics in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) model of juvenile piglets. METHODS:Twenty-four pig...

journal_title：Experimental lung research

authors： Fu H,Sun M,Miao C

更新日期：2015-01-01 00:00:00

abstract：:Thrombin activates protease-activated receptor (PAR)-1 and induces a myofibroblast phenotype in normal lung fibroblasts. The origins of myofibroblasts are resident fibroblasts, fibrocytes, and epithelial-mesenchymal transition (EMT). We investigated the effects of thrombin, an important mediator of interstitial lung f...

journal_title：Experimental lung research

authors： Song JS,Kang CM,Park CK,Yoon HK

更新日期：2013-10-01 00:00:00

abstract：:The morphology and phagocytic capacities of pulmonary macrophages recovered by lavage from normal rats were studied in vitro after incubation under various culture conditions. Most adherent macrophages (73 +/- 6%) were flat and exhibited ruffled surfaces. Phagocytosis of carbonyl iron beads by pulmonary macrophages wa...

journal_title：Experimental lung research

authors： Warheit DB,Hill LH,Brody AR

更新日期：1984-01-01 00:00:00

abstract：:Mechanical ventilation (MV) is well known to potentially cause ventilator-associated lung injury (VALI). It has also been reported recently that activation of invariant natural killer T (iNKT) cells is involved in the onset/progression of airway inflammation. We analyzed the roles of inflammatory cells, including iNKT...

journal_title：Experimental lung research

authors： Shiga Y,Sugamata R,Iwamura C,Nagao T,Zao J,Kawakami K,Kawachi S,Nakayama T,Suzuki K

更新日期：2014-02-01 00:00:00

abstract：:Pathophysiologic changes induced by phospholipase A2 (PLA2), a lipolytic enzyme implicated in a variety of pulmonary diseases, were examined in the isolated, perfused guinea pig lung. Thirty microliters of vehicle (saline) or 30 units of PLA2 suspended in saline was given as a bolus injection into either the trachea o...

journal_title：Experimental lung research

authors： Durham SK,Selig WM

更新日期：1990-07-01 00:00:00