Density gradient analysis of secretions produced in vitro by human and canine airway mucosa: identification of lipids and proteoglycans in such secretions.

abstract：:Acute exposure to NO2 is reported to disrupt tight junctions in lung epithelium. We have studied the effects of chronic NO2 exposure and recovery breathing clean air to tight junctions of distal airway and alveolar epithelium. Syrian Golden hamsters were exposed to NO2 (30 PPM) for 5 or 9 months and a group of those a...

journal_title：Experimental lung research

authors： Gordon RE,Solano D,Kleinerman J

更新日期：1986-01-01 00:00:00

abstract：:The objective of this study was to evaluate the protective effects of resveratrol on lung injury in rats with severe acute pancreatitis. Ninety-six male Sprague-Dawley rats were randomly classified into 4 equal groups (n = 24): control, model, resveratrol-treated, and dexamethasone-treated. The rats were evaluated at ...

journal_title：Experimental lung research

authors： Sha H,Ma Q,Jha RK,Wang Z

更新日期：2009-05-01 00:00:00

abstract：:Lung cancer is the leading cause of death of both men and women across the world. Overexpression and activating mutations of the epidermal growth factor receptor-1 (EGFR1) are frequently observed and associated with poor prognosis. To inhibit the function of EGFR1, multiple antibodies and small-molecule tyrosine kinas...

journal_title：Experimental lung research

authors： Gorgisen G,Ozes D,Pehlivanoglu S,Erdogan A,Dertsiz L,Ozbilim G,Ozbudak IH,Savas B,Ozes ON

更新日期：2013-11-01 00:00:00

abstract：:The authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours after tetracycline-induced pleural injury in rabbits. Both scuPA a...

journal_title：Experimental lung research

authors： Idell S,Azghani A,Chen S,Koenig K,Mazar A,Kodandapani L,Bdeir K,Cines D,Kulikovskaya I,Allen T

更新日期：2007-10-01 00:00:00

abstract：PURPOSE:As an angiotensin converting enzyme (ACE) inhibitor, the effects of captopril on inflammation has been previously examined. Captopril has been shown to have anti-inflammatory and antioxidant effects. Imbalance in the oxidant/antioxidant system is one of the major causes of inflammation. In the present study, th...

journal_title：Experimental lung research

authors： Boskabadi J,Mokhtari-Zaer A,Abareshi A,Khazdair MR,Emami B,Mohammadian Roshan N,Hosseini M,Boskabady MH

更新日期：2018-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) as a complex disease with genetic and environmental compound is one of the leading causes of death in worldwide. This disease is characterized by lower airway inflammation, and increases risk of lung cancer in smokers. Micro-RNA (miRNA) molecules are key regulators in gene ...

journal_title：Experimental lung research

authors： Akbas F,Coskunpinar E,Aynaci E,Oltulu YM,Yildiz P

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF THE STUDY:Acute respiratory distress syndrome (ARDS) represents a major cause of mortality in intensive care patients. Activation of peroxisome proliferator-activated receptor-α (PPAR-α) by fibrates, such as WY-14643 (WY), has been described to beneficially influence inflammation and experimental lung injury...

journal_title：Experimental lung research

authors： Hecker M,Behnk A,Morty RE,Sommer N,Vadász I,Herold S,Seeger W,Mayer K

更新日期：2015-01-01 00:00:00

abstract：:Excess production of neutrophil elastase contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the role of neutrophil elastase in the repair process following ALI/ARDS is not well understood. The objective of this study was to evaluate the effect of neutrop...

journal_title：Experimental lung research

authors： Fujino N,Kubo H,Suzuki T,He M,Suzuki T,Yamada M,Takahashi T,Ota C,Yamaya M

更新日期：2012-02-01 00:00:00

abstract：:A tandem repeat region in the second intron of the K-ras gene has been reported to be a possible regulatory site for transcription. In this study, a second protein-binding site was identified and characterized. It lies downstream (nucleotides 463 to 509) of the tandem repeat region. A T--> C base variation at nucleoti...

journal_title：Experimental lung research

authors： Chen B,Wang Y,You M

更新日期：2005-03-01 00:00:00

abstract：:Variable numbers of composite repetitive motifs are found in different individuals within intron 4 of the surfactant protein B (SP-B) gene (Biochem J. 1995;305:583). This study tests the hypothesis that the distribution of SP-B alleles differs among racial/ethnic groups. A total of 412 SP-B alleles were analyzed: 206 ...

journal_title：Experimental lung research

authors： Veletza SV,Rogan PK,TenHave T,Olowe SA,Floros J

更新日期：1996-07-01 00:00:00

abstract：:A specific form of flavin monooxygenase has been identified in the lungs of a number of species. Distribution of the pulmonary flavin-containing monooxygenase (FMOp) is of interest because it oxidatively metabolizes a wide variety of nitrogen-, sulfur-, and phosphorous-containing xenobiotics, some of which form highly...

journal_title：Experimental lung research

authors： Overby L,Nishio SJ,Lawton MP,Plopper CG,Philpot RM

更新日期：1992-01-01 00:00:00

abstract：:The effects of urban air and diesel particles on inflammatory cytokine gene expression, tumor necrosis factor alpha (TNF-alpha) in particular, were studied in rat alveolar macrophages. TNF-alpha, interleukin (IL)-1, IL-6, cytokine-induced neutrophil chemoattractant (CINC), and macrophage inflammatory protein (MIP)-2 g...

journal_title：Experimental lung research

authors： Dong W,Lewtas J,Luster MI

更新日期：1996-09-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is a leading cause of mortality worldwide. In China, a dramatic increase in the incidence of NSCLC is expected in the next 20 years (Molina et al. Mayo Clin Proc. 2008;83:584–594). Mutated epidermal growth factor receptor (EGFR) status is a known predictor ...

journal_title：Experimental lung research

authors： McMillen E,Ye F,Li G,Wu Y,Yin G,Liu W

更新日期：2010-11-01 00:00:00

abstract：:We studied lung clearance of aerosolized technetium-labeled diethylenetriamine pentaacetic acid (99mTcDTPA), plasma concentrations of 6-keto-PGF1 alpha and thromboxane B2, and pulmonary edema as indices of lung injury in rabbits exposed to cigarette smoke (CSE). Forty-six rabbits were randomly assigned to 4 groups: co...

journal_title：Experimental lung research

authors： Witten ML,Lemen RJ,Quan SF,Sobonya RE,Magarelli JL,Bruck DC

更新日期：1987-01-01 00:00:00

abstract：:We have previously shown that intratracheally instilled silica (quartz) produces both morphologic evidence of emphysema and small-airway changes, and functional evidence of airflow obstruction. To further define the nature of the airflow-associated lesions induced by silica, we compared silica-exposed rats to rats giv...

journal_title：Experimental lung research

authors： Churg A,Hobson J,Wright J

更新日期：1989-12-01 00:00:00

abstract：:The effects of Zizyphi fructus, a major constituent of Chinese anti-asthmatic herbal medicine, on ciliary motility and nitric oxide (NO) generation in canine cultured tracheal epithelium were studied by the microphoto-oscillation method and the specific amperometric method, respectively. Addition of Zizyphi fructus at...

journal_title：Experimental lung research

authors： Tamaoki J,Kondo M,Tagaya E,Takemura K,Konno K

更新日期：1996-05-01 00:00:00

abstract：:The objective of this study was to determine if prolonged hyperoxia exposure would deplete antioxidants, resulting in excessive oxidative stress that would lead to oxidation of pulmonary surfactant and contribute to lung dysfunction. Rats were exposed to either hyperoxic (> 95% O(2)) or normoxic (21% O(2)) oxygen conc...

journal_title：Experimental lung research

authors： Pace PW,Yao LJ,Wilson JX,Possmayer F,Veldhuizen RA,Lewis JF

更新日期：2009-06-01 00:00:00

abstract：:Freeze-fracture was used to study the nonciliated epithelial (Clara) cell of rat bronchiole. En face views of the P face of the luminal cell membrane reveal particle-free bulging and circular depressions at the presumptive sites of the membrane fusion between the cell membrane and secretory granule membrane. Cross fra...

journal_title：Experimental lung research

authors： Yoneda K,Birk MG

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Pulmonary ischemia-reperfusion (IR) is a biopathological event detectable in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation, and pulmonary embolism. The understanding behind the activation of various inflammatory mediators regulating the apoptotic pathways ...

journal_title：Experimental lung research

authors： Dolkart O,E A,S S,S M,P G,Aa W

更新日期：2014-02-01 00:00:00

abstract：:In a recent study of the sheep tracheal lobe model, we have demonstrated that surface chemistry modification of quartz by aluminum lactate significantly alters the biological activity of quartz for at least 2 months after exposure. In the present study, we have extended our observations of the biological reaction of t...

journal_title：Experimental lung research

authors： Bégin R,Massé S,Sébastien P,Martel M,Bossé J,Dubois F,Geoffroy M,Labbé J

更新日期：1987-01-01 00:00:00

abstract：:Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary sm...

journal_title：Experimental lung research

authors： Miko E,Czimmerer Z,Csánky E,Boros G,Buslig J,Dezso B,Scholtz B

更新日期：2009-10-01 00:00:00

abstract：:Sirius Red staining is presented as a method for collagen determination, enabling quantitative morphometric measurements to be performed in locally defined tissue areas. The advantage of this method is especially shown for alveolar lung tissue. By excluding the bronchial areas in the tissue sections, the differences i...

journal_title：Experimental lung research

authors： Malkusch W,Rehn B,Bruch J

更新日期：1995-01-01 00:00:00

abstract：:We studied lung clearance of technetium-labeled diethylenetriamine pentaacetic acid [( 99mTc]DTPA), plasma and bronchoalveolar lavage fluid (BALF) concentrations of 6-keto-PGF1 alpha (stable metabolite of prostacyclin, prostaglandin I2, PGI2), TxB2 (stable metabolite of thromboxane A2, TxA2), and leukotriene B4 (LTB4)...

journal_title：Experimental lung research

authors： Witten ML,Quan SF,Sobonya RE,Bruck D,Devine L,Lemen RJ

更新日期：1988-01-01 00:00:00

abstract：:To better understand the mechanisms by which neutrophils migrate into the airways, we constructed a novel in vitro model system with human umbilical vein endothelial cell (HUVE) monolayers grown on top of permeable filters and human lung Type II-like alveolar epithelial cell (A549) monolayers grown on the undersurface...

journal_title：Experimental lung research

authors： Casale TB,Mower DA,Carolan EJ

更新日期：1998-11-01 00:00:00

abstract：:Leptin, an adipocyte-secreted hormone that regulates food intake and metabolic response, has been recently reported to increase in the serum during inflammatory airway disease associated with mucus-hypersecretion. We investigated the effects of leptin on mucin expression in human airway epithelial cells and the signal...

journal_title：Experimental lung research

authors： Woo HJ,Yoo WJ,Bae CH,Song SY,Kim YW,Park SY,Kim YD

更新日期：2010-06-01 00:00:00

abstract：:We set out to determine whether or not the "mucolytic" drug N-acetylcysteine would speed the reversal of cigarette smoke-induced secretory-cell hyperplasia to normal, similar to that found previously for two nonsteroidal antiinflammatory drugs. Cigarette smoke alone significantly (p less than 0.01) increased the numbe...

journal_title：Experimental lung research

authors： Rogers DF,Godfrey RW,Majumdar S,Jeffery PK

更新日期：1988-01-01 00:00:00

abstract：:Hypercholesterolemia contributes to cardiovascular diseases, but its direct effect on lung is little known. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been shown to exert numerous effects that are dependent and independent of their cholesterol-lowering property. The authors hyp...

journal_title：Experimental lung research

authors： Duan S,Zhang Y,Wu SJ,Jiang LZ,Zhang J,Gan Y,Chen P,Zhao SP,Li GY

更新日期：2010-12-01 00:00:00

abstract：:Aerosol bolus dispersion was measured in the first branching generations of a replicate hollow cast. The cast was made from a solid cast of a beagle-dog tracheobronchial tree. The dispersion was measured after penetration of boluses into different volumetric depths, with different particle sizes and flow rates into th...

journal_title：Experimental lung research

authors： Scheuch G,Stahlhofen W,Fang CP,Lippmann M

更新日期：1995-07-01 00:00:00

abstract：:Investigations on leukocyte populations in the lung have shown that lymphocytes are found in different anatomical compartments. Lymphocytes can be seen to a different extent in the lung interstitium, the epithelium and lamina propria of the bronchi, the bronchoalveolar space, and the marginal lung vascular bed. Previo...

journal_title：Experimental lung research

authors： Fliegert FG,Tschernig T,Pabst R

更新日期：1996-11-01 00:00:00

abstract：:COPD remains a public health problem that has yet to be fully recognized by the public, the medical community or public health (government) officials, and much work remains to be done worldwide to reverse the increasing trends of this chronic lung disease. ...

journal_title：Experimental lung research

authors： Hurd S

更新日期：2005-09-01 00:00:00