PPAR-α activation reduced LPS-induced inflammation in alveolar epithelial cells.

abstract：BACKGROUND AND OBJECTIVE:We have previously reported that N-acetylcysteine (NAC), ambroxol and azithromycin (AZM) (partially) correct the chloride efflux dysfunction in cystic fibrosis bronchial epithelial (CFBE) cells with the ΔF508 homozygous mutation in vitro. METHODS:In the present paper, we further investigated p...

journal_title：Experimental lung research

authors： Hussain S,Varelogianni G,Särndahl E,Roomans GM

更新日期：2015-06-01 00:00:00

abstract：:Survival of mice after Klebsiella pneumoniae infection and phagocytosis by alveolar macrophages (AMs), in the presence or absence of ozone (O(3)) exposure prior to infection, is sex dependent. The objective of this work was to study the role of gonadal hormones, 5α-dihydrotestosterone (DHT) and 17β-estradiol (E(2)), o...

journal_title：Experimental lung research

authors： Durrani F,Phelps DS,Weisz J,Silveyra P,Hu S,Mikerov AN,Floros J

更新日期：2012-05-01 00:00:00

abstract：:A cast of human tracheobronchial airways, which is complete to airways less than 0.1 cm in diameter, was employed for experimental studies of gas convective transport by high-frequency ventilation (HFV). The cast was ventilated with gases of different kinematic viscosity (He, air, and SF6) and tidal volumes of 10-60 m...

journal_title：Experimental lung research

authors： Fang CP,Cohen BS,Lippmann M

更新日期：1992-09-01 00:00:00

abstract：:In order to investigate some of the characteristics of superoxide anion release from alveolar macrophages, the effects of substances known to influence superoxide release from polymorphonuclear leukocytes (PMN) were studied in rat alveolar macrophages. There is a relatively small, but constant, amount of superoxide re...

journal_title：Experimental lung research

authors： Sweeney TD,Castranova V,Bowman L,Miles PR

更新日期：1981-05-01 00:00:00

abstract：:Salvianolic acid B (Sal B), one of the major water-soluble compounds of Danshen (a popular Chinese herb), possesses many of the biological activities, such as antifibrogenic effect in liver and renal diseases. Transforming growth factor-β1 (TGF-β1) plays a central role in the development of pulmonary fibrosis by stimu...

journal_title：Experimental lung research

authors： Zhang M,Cao SR,Zhang R,Jin JL,Zhu YF

更新日期：2014-04-01 00:00:00

abstract：:Neutrophilic inflammation is responsible for much of the tissue damage seen in many lung diseases. For resolution of inflammation to occur, neutrophils must die by apoptosis, allowing their recognition and removal by macrophages. The molecular events controlling this important regulatory step are poorly understood, in...

journal_title：Experimental lung research

authors： Renshaw SA,Loynes CA,Elworthy S,Ingham PW,Whyte MK

更新日期：2007-12-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) generates angiotensin II and degrades bradykinin. This ectopeptidase acts as a marker in pathologic conditions, showing tissue and vascular damage. In order to evaluate serum and tissue ACE activity in bleomycin-associated lung damage, the authors studied morphological and enzymatic...

journal_title：Experimental lung research

authors： Ziai SA,Salehian P,Mahmoudian M

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:This study aimed to investigate differential cell responses of alveolar epithelial cells (AECs) after treatments with lipopolysaccharide (LPS) and hydrogen peroxide (H2O2) to mimic the exposure to inflammation and oxidative stress and the mechanisms of a double-hit model of apoptosis. MATERIALS AND METHODS:AEC...

journal_title：Experimental lung research

authors： Kang EK,Kim HS

更新日期：2017-10-01 00:00:00

abstract：:Inflammation plays a key role in lung injury and in the pathogenesis of asthma. Two murine models of allergic airway inflammation-sensitization and challenge to ovalbumin (OVA) and intratracheal exposure to interleukin-13 (IL13)-were used to evaluate the expression of poly(ADP-ribose) polymerase-1 (PARP-1) in allergic...

journal_title：Experimental lung research

authors： Havranek T,Aujla PK,Nickola TJ,Rose MC,Scavo LM

更新日期：2010-09-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) during hyperoxia contribute to alveolar epithelial apoptosis. In the present study, the molecular mechanisms of oxidative stress-induced alveolar epithelial cell apoptosis were investigated. The cytoprotective effects of N-acetylcysteine (NAC) were evaluated. Treatments ...

journal_title：Experimental lung research

authors： Fu YQ,Fang F,Lu ZY,Kuang FW,Xu F

更新日期：2010-08-01 00:00:00

abstract：:Lamellar bodies, the intracellular storage form of pulmonary surfactant, were isolated from adult human lung tissue. As shown by electron microscopy, the isolated human lamellar bodies resembled the lamellar bodies isolated from experimental animals. Chemical analysis revealed that the lamellar bodies consisted largel...

journal_title：Experimental lung research

authors： Post M,Batenburg JJ,Schuurmans EA,Laros CD,van Golde LM

更新日期：1982-02-01 00:00:00

abstract：:Immunosuppressive and antiproliferative effects of heparin may be beneficial in the field of solid organ transplantation. The aim of this study was to examine the effect of low-molecular-weight heparin (LMWH) compounds on the development of obliterative airway disease (OAD) in the rat tracheal transplant model. Alloge...

journal_title：Experimental lung research

authors： Fillinger J,Antus B

更新日期：2010-12-01 00:00:00

abstract：:The influence of gas composition on convective and diffusive gas transport in the lungs was assessed by studying the dispersion of combined particle and argon (Ar) boluses induced by the passage through the lungs filled with three different gas mixtures. Particles, as a "nondiffusing gas," served as a tracer for conve...

journal_title：Experimental lung research

authors： Schulz H,Schulz A,Eder G,Heyder J

更新日期：1995-11-01 00:00:00

abstract：:Electrical stimulation of the cervical vagus nerve of rats is known to increase vascular permeability in the trachea. In the present study, we sought to further characterize this neurogenic inflammatory response by defining the relationship between the parameters of electrical stimulation of the vagus nerve and the ma...

journal_title：Experimental lung research

authors： Brokaw JJ,McDonald DM

更新日期：1988-01-01 00:00:00

abstract：:Protein tyrosine phosphatase is an important class of enzymes that plays an essential role in the cellular proliferation, differentiation, and oncogenesis. In this paper we report characterization of a low-molecular-weight protein tyrosine phosphatase purified from bovine lung. The enzyme activity was essentially inde...

journal_title：Experimental lung research

authors： Buzalaf MA,Taga EM,Granjeiro JM,Ferreira CV,Lourenção VA,Ortega MM,Poletto DW,Aoyama H

更新日期：1998-05-01 00:00:00

abstract：:Eprazinone therapy improves pulmonary function and arterial pO2 in patients with chronic bronchitis; however, the mechanism of action is unknown. The purpose of this study was to determine if eprazinone alters either lung surfactant levels in bronchoalveolar lavage fluid (BAL) of normal rats, or ion transport across c...

journal_title：Experimental lung research

authors： Thrall RS,Cloutier MM,Guernsey L,Swayne E,Gionfriddo M

更新日期：1992-05-01 00:00:00

abstract：:It was hypothesized that IL-8, a neutrophil chemotaxin, contributes to the influx of neutrophils into the pleural cavity of patients with pleural effusions. Pleural fluids were collected from 57 patients including 13 with effusions due to congestive heart failure, 28 with pleural involvement by carcinoma, 5 with empye...

journal_title：Experimental lung research

authors： Miller EJ,Idell S

更新日期：1993-09-01 00:00:00

abstract：AIM OF THE STUDY:Interleukin (IL)-10 is an anti-inflammatory cytokine, but its role in cigarette smoke (CS)-induced inflammation and chronic obstructive pulmonary disease (COPD) has not been fully elucidated. The purpose of this study was to investigate the effect of IL-10 deficiency on CS-induced pulmonary inflammatio...

journal_title：Experimental lung research

authors： Higaki M,Wada H,Mikura S,Yasutake T,Nakamura M,Niikura M,Kobayashi F,Kamma H,Kamiya S,Ito K,Barnes PJ,Goto H,Takizawa H

更新日期：2015-01-01 00:00:00

abstract：:Variable numbers of composite repetitive motifs are found in different individuals within intron 4 of the surfactant protein B (SP-B) gene (Biochem J. 1995;305:583). This study tests the hypothesis that the distribution of SP-B alleles differs among racial/ethnic groups. A total of 412 SP-B alleles were analyzed: 206 ...

journal_title：Experimental lung research

authors： Veletza SV,Rogan PK,TenHave T,Olowe SA,Floros J

更新日期：1996-07-01 00:00:00

abstract：:Lung injury and inflammation are associated with exposure to various types of particulate air pollutants. The present study was used to determine whether metalloproteinases (MMPs) are secreted after instilling dust samples into the lung, and to relate levels of specific MMPs to different fractions of the ambient air p...

journal_title：Experimental lung research

authors： Adamson IY,Vincent R,Bakowska J

更新日期：2003-09-01 00:00:00

abstract：:The integrity of the respiratory epithelium is crucial for airway homeostasis. Tobacco smoke exposure and recurrent infections of the airways play a crucial role in the progression and in the decline of the respiratory function in chronic obstructive pulmonary disease (COPD). The aim of this study was to detect differ...

journal_title：Experimental lung research

authors： D'Anna C,Cigna D,Di Sano C,Di Vincenzo S,Dino P,Ferraro M,Bini L,Bianchi L,Di Gaudio F,Gjomarkaj M,Pace E

更新日期：2017-01-01 00:00:00

abstract：:The cigarette smoke-induced rat model of chronic bronchitis was used to study the time course of the return of cigarette smoke-induced secretory cell hyperplasia to the normal and the capacity of two non-steroidal anti-inflammatory drugs to speed this recovery. Cigarette smoke alone significantly increased (P less tha...

journal_title：Experimental lung research

authors： Rogers DF,Jeffery PK

更新日期：1986-01-01 00:00:00

abstract：:The inhalation of inorganic dust can lead to the development of interstitial pulmonary fibrosis, characterized by the accumulation of fibroblasts and connective tissue matrix in the lung interstitium. The fibrosis causes alterations in the architecture of the lung parenchyma, resulting in abnormal gas exchange and hyp...

journal_title：Experimental lung research

authors： Schapira RM,Osornio-Vargas AR,Brody AR

更新日期：1991-11-01 00:00:00

abstract：:Verapamil, a calcium channel blocker has been used with partial success in cases of primary pulmonary hypertension, as well as to reduce hypoxia-induced pulmonary hypertension (PH) in rats. However, its effect on monocrotaline (MCT)-induced PH in rats is not known. We studied the effect of verapamil on MCT-induced PH....

journal_title：Experimental lung research

authors： Mathew R,Guzowski DE,Gloster ES

更新日期：1990-11-01 00:00:00

abstract：:Prostaglandins (PGs) synthesized by fetal and neonatal lungs play pivotal roles in pulmonary physiology, especially during the transition from uterine to independent life. One regulator of prostaglandin synthesis at this time may be oxygen. We examined the effects of 1% O2, 21% O2 and 50% O2 in 5% CO2, balance N2 (PO2...

journal_title：Experimental lung research

authors： Olson DM,Tanswell AK

更新日期：1987-01-01 00:00:00

abstract：:A small subpopulation of pulmonary epithelial cells (PE) proliferates in low-density primary culture of alveolar type II cells and forms colonies of cells that could be passaged for several generations and that in some respects maintain a differentiated phenotype of the alveolar type II cells. At this time it is not k...

journal_title：Experimental lung research

authors： Kalina M,Riklis S,Blau H

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Hypoperfusion of the pulmonary vascular bed under the condition of congenital cardiac malformations may lead to progressive pulmonary vascular disease. To improve the mechanistic understanding of this disease, we examined the biochemical and morphological changes of the lung in a relevant animal model and pr...

journal_title：Experimental lung research

authors： Xu Y,Liu Y,Li Z,Su J,Li G,Sun L

更新日期：2012-09-01 00:00:00

abstract：:Toluene diisocyanate (TDI) is known as one of causes of occupational asthma and hypersensitivity pneumonitis. To investigate the stimulatory effect on bronchial epithelial cells in response to TDI, the authors examined production of cytokines by the bronchial epithelial cell line BEAS-2B and intercellular signal trans...

journal_title：Experimental lung research

authors： Ogawa H,Inoue S,Ogushi F,Ogura H,Nakamura Y

更新日期：2006-06-01 00:00:00

abstract：:We determined optimum conditions for delivering DNA to transformed human bronchial epithelial cells expressing wild-type (BEAS) or abnormal (2CF) cystic fibrosis transmembrane conductance regulator (CFTR) using cationic liposomes (Lipofectin, [N-(N,N-dimethylaminoethane)carbamyl] cholesterol[DC-Chol]/dioleoylphosphati...

journal_title：Experimental lung research

authors： Peters MT,Brigham KL,King GA,Meyrick BO,Gao X,Stecenko AA

更新日期：1999-04-01 00:00:00

abstract：:We set out to determine whether or not the "mucolytic" drug N-acetylcysteine would speed the reversal of cigarette smoke-induced secretory-cell hyperplasia to normal, similar to that found previously for two nonsteroidal antiinflammatory drugs. Cigarette smoke alone significantly (p less than 0.01) increased the numbe...

journal_title：Experimental lung research

authors： Rogers DF,Godfrey RW,Majumdar S,Jeffery PK

更新日期：1988-01-01 00:00:00