Factors which affect superoxide anion release from rat alveolar macrophages.

abstract：:The production of reactive oxygen species (ROS) during hyperoxia contribute to alveolar epithelial apoptosis. In the present study, the molecular mechanisms of oxidative stress-induced alveolar epithelial cell apoptosis were investigated. The cytoprotective effects of N-acetylcysteine (NAC) were evaluated. Treatments ...

journal_title：Experimental lung research

authors： Fu YQ,Fang F,Lu ZY,Kuang FW,Xu F

更新日期：2010-08-01 00:00:00

abstract：:Toluene diisocyanate (TDI) is known as one of causes of occupational asthma and hypersensitivity pneumonitis. To investigate the stimulatory effect on bronchial epithelial cells in response to TDI, the authors examined production of cytokines by the bronchial epithelial cell line BEAS-2B and intercellular signal trans...

journal_title：Experimental lung research

authors： Ogawa H,Inoue S,Ogushi F,Ogura H,Nakamura Y

更新日期：2006-06-01 00:00:00

abstract：:Inflammation plays a key role in lung injury and in the pathogenesis of asthma. Two murine models of allergic airway inflammation-sensitization and challenge to ovalbumin (OVA) and intratracheal exposure to interleukin-13 (IL13)-were used to evaluate the expression of poly(ADP-ribose) polymerase-1 (PARP-1) in allergic...

journal_title：Experimental lung research

authors： Havranek T,Aujla PK,Nickola TJ,Rose MC,Scavo LM

更新日期：2010-09-01 00:00:00

abstract：:The molecular events involved in both the initiation and development of silicosis are at present poorly defined, although mediators released from macrophages exposed to silica particles are believed to play a role. We have investigated the in vitro production of arachidonic acid (AA) metabolites in adherent bovine alv...

journal_title：Experimental lung research

authors： Englen MD,Taylor SM,Laegreid WW,Liggitt HD,Silflow RM,Breeze RG,Leid RW

更新日期：1989-07-01 00:00:00

abstract：:Male Sprague-Dawley rats were placed in hypobaric hypoxia for 17-21 d (FIO2 10%) to establish pulmonary hypertension (PH) and control rats were kept in normobaric room air. Right mean atrial and ventricular pressures (PRA, PRV) were recorded, left ventricular (LV) blood was collected, and lungs were perfused with hepa...

journal_title：Experimental lung research

authors： Keith IM,Ekman R

更新日期：1992-03-01 00:00:00

abstract：:Biochemical characterization of human respiratory mucus has generally utilized expectorated specimens. In order to exclude extraneous contaminants in the analysis of airway glycoproteins, human airways were cultured and the mucous glycoprotein released into the supernatant analyzed. By incorporating 3H-labeled glucosa...

journal_title：Experimental lung research

authors： Shelhamer JH,Marom Z,Logun C,Kaliner M

更新日期：1984-01-01 00:00:00

abstract：:The role of type II epithelial cell proliferation in repair of diffuse alveolar epithelial injury was examined using two pneumotoxicants, 3-methylindole (3-MI) and monocrotaline (MCT). It was hypothesized that if MCT inhibits type II epithelial cell mitosis, then pulmonary fibrosis would result after diffuse 3-MI-indu...

journal_title：Experimental lung research

authors： Woods LW,Wilson DW,Segall HJ

更新日期：1999-03-01 00:00:00

abstract：:Thrombin activates protease-activated receptor (PAR)-1 and induces a myofibroblast phenotype in normal lung fibroblasts. The origins of myofibroblasts are resident fibroblasts, fibrocytes, and epithelial-mesenchymal transition (EMT). We investigated the effects of thrombin, an important mediator of interstitial lung f...

journal_title：Experimental lung research

authors： Song JS,Kang CM,Park CK,Yoon HK

更新日期：2013-10-01 00:00:00

abstract：:Immunosuppressive and antiproliferative effects of heparin may be beneficial in the field of solid organ transplantation. The aim of this study was to examine the effect of low-molecular-weight heparin (LMWH) compounds on the development of obliterative airway disease (OAD) in the rat tracheal transplant model. Alloge...

journal_title：Experimental lung research

authors： Fillinger J,Antus B

更新日期：2010-12-01 00:00:00

abstract：:Freeze-fracture was used to study the nonciliated epithelial (Clara) cell of rat bronchiole. En face views of the P face of the luminal cell membrane reveal particle-free bulging and circular depressions at the presumptive sites of the membrane fusion between the cell membrane and secretory granule membrane. Cross fra...

journal_title：Experimental lung research

authors： Yoneda K,Birk MG

更新日期：1981-08-01 00:00:00

abstract：AIMS:As a transcription factor of the nuclear receptor superfamily, neuron-derived orphan receptor 1 (NOR1) is induced rapidly in response to various extracellular stimuli. But, it is still unclear its role in pulmonary artery smooth muscle cells proliferation. MATERIALS AND METHODS:Human PASMCs were cultured in vitro...

journal_title：Experimental lung research

authors： Wang CG,Lei W,Li C,Zeng DX,Huang JA

更新日期：2015-05-01 00:00:00

abstract：:The central intrapulmonary bronchi of hamsters were examined by transmission electron microscopy at varying times following intratracheal instillation of human neutrophil elastase (HNE) or its vehicle, saline. Two hours after HNE treatment, there was a marked irregularity of the surfaces of many nonciliated epithelial...

journal_title：Experimental lung research

authors： Christensen TG,Breuer R,Hornstra LJ,Lucey EC,Stone PJ,Snider GL

更新日期：1987-01-01 00:00:00

abstract：:The effects of urban air and diesel particles on inflammatory cytokine gene expression, tumor necrosis factor alpha (TNF-alpha) in particular, were studied in rat alveolar macrophages. TNF-alpha, interleukin (IL)-1, IL-6, cytokine-induced neutrophil chemoattractant (CINC), and macrophage inflammatory protein (MIP)-2 g...

journal_title：Experimental lung research

authors： Dong W,Lewtas J,Luster MI

更新日期：1996-09-01 00:00:00

abstract：:Understanding the effects from long-term exposure to individual ambient air pollutants and mixtures of pollutants is necessary for adequate assessment of health risk. This study examined quantitative and temporal alterations in tracheobronchial mucociliary clearance function and bronchial epithelial secretory cells in...

journal_title：Experimental lung research

authors： Schlesinger RB,Gorczynski JE,Dennison J,Richards L,Kinney PL,Bosland MC

更新日期：1992-07-01 00:00:00

abstract：:Both hyperoxia-induced proapoptotic sensitization of alveolar type II cells (TII cells) and high-stretch mechanical ventilation induced pulmonary inflammation are tumor necrosis factor alpha (TNFalpha) mediated. Therefore, binding of free TNFalpha should protect from TNFalpha-mediated acute lung injury and ameliorate ...

journal_title：Experimental lung research

authors： Guthmann F,Wissel H,Rüstow B

更新日期：2009-11-01 00:00:00

abstract：:In both ovalbumin-sensitized and ovalbumin-challenged guinea pigs, the phospholipid content of bronchoalveolar lavage fluid is decreased with respect to that of controls. In the sensitized guinea pig, the activity of lung membrane phospholipase is increased and the phospholipid content of lung membranes is decreased. ...

journal_title：Experimental lung research

authors： Rami J,Brondel L,Rivière D,Besombes JP

更新日期：1990-03-01 00:00:00

abstract：:Urban air consists of a combination of environmental pollutants. Recent studies have suggested that normally innocuous doses of a particular pollutant may be rendered more toxic to the lung if primed by earlier events. Pulmonary inflammation has been observed in humans and in many animal species after endotoxin and oz...

journal_title：Experimental lung research

authors： Johnston CJ,Oberdörster G,Gelein R,Finkelstein JN

更新日期：2002-09-01 00:00:00

abstract：:In three experiments, we have explored the uptake and transport of colloidal gold (Au) and iron oxide (Fe2O3) by normal and SO2-injured bronchial epithelium. In the first experiment, mice were exposed to a 2-hr aerosol of Au; in the second experiment, mice were exposed to SO2 (250 ppm) for 3 hr, then to Au; and in the...

journal_title：Experimental lung research

authors： Watson AY,Brain JD

更新日期：1980-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) as a complex disease with genetic and environmental compound is one of the leading causes of death in worldwide. This disease is characterized by lower airway inflammation, and increases risk of lung cancer in smokers. Micro-RNA (miRNA) molecules are key regulators in gene ...

journal_title：Experimental lung research

authors： Akbas F,Coskunpinar E,Aynaci E,Oltulu YM,Yildiz P

更新日期：2012-08-01 00:00:00

abstract：:This study investigated whether interleukin-1 (IL-1) inhibitory activity in LPS-stimulated culture supernatants of alveolar macrophages and epithelioid cells obtained from rabbit lung granulomas induced by complete Freund's adjuvant (CFA) was identical to IL-1 receptor antagonist (IL-1ra) and examined the changes of I...

journal_title：Experimental lung research

authors： Shigenaga T,Abe Y,Miyazaki E,Kita S,Tsuda T

更新日期：1995-03-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is a leading cause of mortality worldwide. In China, a dramatic increase in the incidence of NSCLC is expected in the next 20 years (Molina et al. Mayo Clin Proc. 2008;83:584–594). Mutated epidermal growth factor receptor (EGFR) status is a known predictor ...

journal_title：Experimental lung research

authors： McMillen E,Ye F,Li G,Wu Y,Yin G,Liu W

更新日期：2010-11-01 00:00:00

abstract：:Leukotrienes (LTs) are potent vasoconstrictors in the pulmonary circulation. We investigated LTB4 and LTE4 metabolism by intrapulmonary arteries and veins of 2 to 9 days old lambs (n = 6). Paired vessels were incubated under baseline, and stimulated conditions. LTB4 and LTE4 were extracted from media, quantfied by enz...

journal_title：Experimental lung research

authors： Ibe BO,Raj JU

更新日期：2001-06-01 00:00:00

abstract：:Transforming growth factor alpha (TGF(alpha)) stimulates type II alveolar epithelial cell proliferation and also is associated with fibrosis. We studied the changes in bronchoalveolar lavage (BAL) TGF(alpha) protein in a neonatal rabbit hyperoxia-fibrosis model (100% O(2) for 8 to 9 days, followed by 60% O(2) to 36 da...

journal_title：Experimental lung research

authors： Waheed S,D'Angio CT,Wagner CL,Madtes DK,Finkelstein JN,Paxhia A,Ryan RM

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:This study aimed to investigate differential cell responses of alveolar epithelial cells (AECs) after treatments with lipopolysaccharide (LPS) and hydrogen peroxide (H2O2) to mimic the exposure to inflammation and oxidative stress and the mechanisms of a double-hit model of apoptosis. MATERIALS AND METHODS:AEC...

journal_title：Experimental lung research

authors： Kang EK,Kim HS

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:This study aimed to develop and evaluate an adaptive control system for volume-controlled ventilation (VCV) in small animals to guarantee accurate delivery of tidal volume (VT) in the presence of changes in lung mechanics. METHODS:The adaptive control system to control the Harvard Inspira ventilator was des...

journal_title：Experimental lung research

authors： Huhle R,Spieth PM,Güldner A,Koch T,de Abreu MG

更新日期：2014-04-01 00:00:00

abstract：:The objective of this study was to assess the radioprotective effects of amifostine in the rat model of radiation-induced lung injury using fractionated doses of radiation, to determine whether amifostine given before irradiation protects tumor from radiation cytotoxicity, and to determine whether changes in plasma le...

journal_title：Experimental lung research

authors： Vujaskovic Z,Feng QF,Rabbani ZN,Samulski TV,Anscher MS,Brizel DM

更新日期：2002-10-01 00:00:00

abstract：:We determined optimum conditions for delivering DNA to transformed human bronchial epithelial cells expressing wild-type (BEAS) or abnormal (2CF) cystic fibrosis transmembrane conductance regulator (CFTR) using cationic liposomes (Lipofectin, [N-(N,N-dimethylaminoethane)carbamyl] cholesterol[DC-Chol]/dioleoylphosphati...

journal_title：Experimental lung research

authors： Peters MT,Brigham KL,King GA,Meyrick BO,Gao X,Stecenko AA

更新日期：1999-04-01 00:00:00

abstract：:The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF...

journal_title：Experimental lung research

authors： Alho HS,Maasilta PK,Vainikka T,Salminen US

更新日期：2007-08-01 00:00:00

abstract：:Mesothelial cells proliferate soon after asbestos deposition in the lung. The present study investigates whether the known mesothelial cell mitogens keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF) are present in the lung and specifically in the pleural cavity during the phase of mesothelial cell gr...

journal_title：Experimental lung research

authors： Adamson IY,Bakowska J

更新日期：2001-10-01 00:00:00

abstract：:B6C3F1 female mice were exposed to cigarette smoke (CS) (250 mg/m3 total particulate material) or filtered air (FA), 6 hours/day, 5 days/week, for 6, 7, or 10 weeks, or to CS for 6 weeks, then FA for 1 or 4 additional weeks. Exposure to CS increased macrophages, neutrophils, lymphocytes, and matrix metalloproteinase (...

journal_title：Experimental lung research

authors： Seagrave J,Barr EB,March TH,Nikula KJ

更新日期：2004-01-01 00:00:00