Abstract:
:Mesothelial cells proliferate soon after asbestos deposition in the lung. The present study investigates whether the known mesothelial cell mitogens keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF) are present in the lung and specifically in the pleural cavity during the phase of mesothelial cell growth. Rats received 1 mg crocidolite asbestos in 0.5 mL water by intratracheal instillation and were killed up to 2 weeks later; tritiated thymidine was injected 1 hour before death. Bronchoalveolar lavage (BAL) and pleural lavage (PLL) were performed. Increased inflammatory cell numbers and protein levels were found in BAL but also in PLL at 1 day after asbestos deposition. In lung sections, labeling of mesothelial cells increased > 10-fold at day 1 and stayed above normal for 1 week. During this period, the levels of HGF and KGF were significantly raised in both BAL and PLL fluids. The PLL fluid had mitogenic activity for mesothelial cells in culture and this effect was significantly reduced by antibodies to HGF and KGF. The results indicate that fiber deposition in the airspaces rapidly induces lung injury and inflammation, in which growth factors for mesothelial cells KGF and HGF are secreted. These factors reach the pleural cavity at the time when mesothelial cell proliferation occurs. It is possible that the activated, dividing mesothelial population may then be more susceptible to DNA damage by any translocated fibers.
journal_name
Exp Lung Resjournal_title
Experimental lung researchauthors
Adamson IY,Bakowska Jdoi
10.1080/019021401753181854subject
Has Abstractpub_date
2001-10-01 00:00:00pages
605-16issue
7eissn
0190-2148issn
1521-0499journal_volume
27pub_type
杂志文章abstract::Confluent cultures of primary hamster tracheal surface epithelial cells are highly enriched with secretory cells resembling airway goblet cells. The cultures secrete lipids, most of which appear to be associated with high-molecular-weight mucinlike glycoproteins (HMW MLGP). In the present communication, we examined th...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149009108845
更新日期:1990-05-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149809041534
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902140252964366
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journal_title:Experimental lung research
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doi:10.3109/01902148709064319
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doi:10.3109/01902148909087864
更新日期:1989-05-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148709064301
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journal_title:Experimental lung research
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doi:10.3109/01902148409069675
更新日期:1984-01-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148009065460
更新日期:1980-08-01 00:00:00
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更新日期:2010-09-01 00:00:00
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journal_title:Experimental lung research
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abstract::In vitro observations of fetal lung maturation are complicated by continued epithelial cell maturation in culture. Removal of trace quantities of cortisol from the culture system has been reported elsewhere by Torday to prevent epithelial cell differentiation, but also prevent cell growth. In this report we have devel...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148309061503
更新日期:1983-07-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章,评审
doi:10.3109/01902148.2011.580416
更新日期:2011-08-01 00:00:00
abstract::Hypercholesterolemia contributes to cardiovascular diseases, but its direct effect on lung is little known. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been shown to exert numerous effects that are dependent and independent of their cholesterol-lowering property. The authors hyp...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902141003739715
更新日期:2010-12-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148409087917
更新日期:1984-01-01 00:00:00
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journal_title:Experimental lung research
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doi:10.3109/01902148309061510
更新日期:1983-09-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148.2012.689088
更新日期:2012-08-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902140490517782
更新日期:2004-12-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148009065463
更新日期:1980-08-01 00:00:00
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doi:10.3109/01902148309055016
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journal_title:Experimental lung research
pub_type: 杂志文章
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更新日期:2000-07-01 00:00:00
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-03-01 00:00:00
abstract::We have previously shown that intratracheally instilled silica (quartz) produces both morphologic evidence of emphysema and small-airway changes, and functional evidence of airflow obstruction. To further define the nature of the airflow-associated lesions induced by silica, we compared silica-exposed rats to rats giv...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148909069628
更新日期:1989-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:1980-06-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902140590918803
更新日期:2005-04-01 00:00:00