Characteristic plethysmographic findings in a guinea pig model of COPD.

abstract：:Administering liposome-encapsulated drugs by aerosols could be a feasible way of targeting drugs to the lung, specifically to pulmonary alveolar macrophages (AM). In the mouse model, we characterized uptake of carboxyfluorescein- (CF-) labeled liposomes by AM in vivo after acute inhalation of liposome aerosols, and th...

journal_title：Experimental lung research

authors： Myers MA,Thomas DA,Straub L,Soucy DW,Niven RW,Kaltenbach M,Hood CI,Schreier H,Gonzalez-Rothi RJ

更新日期：1993-01-01 00:00:00

abstract：:Hypercholesterolemia contributes to cardiovascular diseases, but its direct effect on lung is little known. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been shown to exert numerous effects that are dependent and independent of their cholesterol-lowering property. The authors hyp...

journal_title：Experimental lung research

authors： Duan S,Zhang Y,Wu SJ,Jiang LZ,Zhang J,Gan Y,Chen P,Zhao SP,Li GY

更新日期：2010-12-01 00:00:00

abstract：:Hypothyroid adult rats were injected intravenously with [3, 5, 3'-125I]triiodothyronine (T3) or [125I]thyroxine (T4). Others were similarly treated except for the addition of a 500-fold excess of the appropriate unlabeled hormone. Light microscopic autoradiography of semithin sections of lung from these animals demons...

journal_title：Experimental lung research

authors： Smith DM,Hitchcock KR

更新日期：1983-09-01 00:00:00

abstract：:The structural features of the ovine pleura are described using light, scanning, and transmission electron microscopy. Extensive sampling of the visceral and parietal pleura revealed considerable variation in both surface morphology and pleural interstitial anatomy. Variations of mesothelial surface were encountered a...

journal_title：Experimental lung research

authors： Mariassy AT,Wheeldon EB

更新日期：1983-05-01 00:00:00

abstract：:The central intrapulmonary bronchi of hamsters were examined by transmission electron microscopy at varying times following intratracheal instillation of human neutrophil elastase (HNE) or its vehicle, saline. Two hours after HNE treatment, there was a marked irregularity of the surfaces of many nonciliated epithelial...

journal_title：Experimental lung research

authors： Christensen TG,Breuer R,Hornstra LJ,Lucey EC,Stone PJ,Snider GL

更新日期：1987-01-01 00:00:00

abstract：:We studied lung clearance of aerosolized technetium-labeled diethylenetriamine pentaacetic acid (99mTcDTPA), plasma concentrations of 6-keto-PGF1 alpha and thromboxane B2, and pulmonary edema as indices of lung injury in rabbits exposed to cigarette smoke (CSE). Forty-six rabbits were randomly assigned to 4 groups: co...

journal_title：Experimental lung research

authors： Witten ML,Lemen RJ,Quan SF,Sobonya RE,Magarelli JL,Bruck DC

更新日期：1987-01-01 00:00:00

abstract：:Recently there has been a great deal of interest in exploring possible ways to protect the lung from oxidant damage. Since sulfhydryl compounds are among the most important endogenous antioxidants, their therapeutic use has been proposed. Glutathione (GSH), the main intracellular nonprotein sulfhydryl, plays an import...

journal_title：Experimental lung research

authors： Patterson CE,Rhoades RA

更新日期：1988-01-01 00:00:00

abstract：:Direct measurements of pleural fluid hydrostatic and colloid osmotic pressures after infusion of saline, bovine serum albumin, or silicone into the pleural space were coupled with ultrastructural morphometric analyses to assess the response of pleural mesothelial cells to hydrothorax. Increases of hydrostatic pressure...

journal_title：Experimental lung research

authors： Shumko JZ,Feinberg RN,Shalvoy RM,DeFouw DO

更新日期：1993-05-01 00:00:00

abstract：:The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF...

journal_title：Experimental lung research

authors： Alho HS,Maasilta PK,Vainikka T,Salminen US

更新日期：2007-08-01 00:00:00

abstract：PURPOSE OF THE STUDY:Pulmonary infection with Klebsiella pneumoniae (KP) and carbapenem-resistant Klebsiella pneumoniae (CRKP) significantly contribute to morbidity and mortality in pneumonia. Recent studies have indicated that High-Mobility Group Box 1 Protein (HMGB1) plays an important role in the prevention and trea...

journal_title：Experimental lung research

authors： Liming S,Guixia L,Wenxin S,Guirong T

更新日期：2018-08-01 00:00:00

abstract：:Emerging data indicate that endothelial-mesenchymal transition (EndMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). A previous study noted that blocking the activity of protein phosphatase 2 A (PP2A) could attenuate EndMT. However, the treatment effects of PP2A inhibitors in pulmonary fibros...

journal_title：Experimental lung research

authors： Yu J,Deng Y,Han M

更新日期：2020-09-01 00:00:00

abstract：:The diabetic pregnancy is characterized by a delay in the process of fetal lung maturation. To determine whether high glucose conditions per se have an adverse impact on fetal lung phospholipid metabolism, 20-day fetal rat lung explants were cultured in F-12 medium (10 mM glucose) to which glucose was added to achieve...

journal_title：Experimental lung research

authors： Gewolb IH

更新日期：1993-11-01 00:00:00

abstract：:Electrical stimulation of the cervical vagus nerve of rats is known to increase vascular permeability in the trachea. In the present study, we sought to further characterize this neurogenic inflammatory response by defining the relationship between the parameters of electrical stimulation of the vagus nerve and the ma...

journal_title：Experimental lung research

authors： Brokaw JJ,McDonald DM

更新日期：1988-01-01 00:00:00

abstract：:A number of novel chemotactic cytokines are becoming increasingly recognized as important participants in the elicitation of specific inflammatory cells from the peripheral blood to sites of inflammation. Recent observations have now demonstrated that certain chemotactic cytokines possess specificity for the selected ...

journal_title：Experimental lung research

authors： Kunkel SL,Standiford T,Kasahara K,Strieter RM

更新日期：1991-01-01 00:00:00

abstract：:The influence of gas composition on convective and diffusive gas transport in the lungs was assessed by studying the dispersion of combined particle and argon (Ar) boluses induced by the passage through the lungs filled with three different gas mixtures. Particles, as a "nondiffusing gas," served as a tracer for conve...

journal_title：Experimental lung research

authors： Schulz H,Schulz A,Eder G,Heyder J

更新日期：1995-11-01 00:00:00

abstract：:Diesel exhaust particles (DEP) are associated with respiratory disease and exposure to diesel exhaust induces an inflammatory response associated with marked leukocytic infiltration in the lung. This study examined whether neutrophils are activated by the active component of DEP (methanol extract of DEP [me-DEP]). The...

journal_title：Experimental lung research

authors： Matsuzaki T,Amakawa K,Yamaguchi K,Ishizaka A,Terashima T,Matsumaru A,Morishita T

更新日期：2006-10-01 00:00:00

abstract：PURPOSE OF THE STUDY:Acute respiratory distress syndrome (ARDS) represents a major cause of mortality in intensive care patients. Activation of peroxisome proliferator-activated receptor-α (PPAR-α) by fibrates, such as WY-14643 (WY), has been described to beneficially influence inflammation and experimental lung injury...

journal_title：Experimental lung research

authors： Hecker M,Behnk A,Morty RE,Sommer N,Vadász I,Herold S,Seeger W,Mayer K

更新日期：2015-01-01 00:00:00

abstract：:Eprazinone therapy improves pulmonary function and arterial pO2 in patients with chronic bronchitis; however, the mechanism of action is unknown. The purpose of this study was to determine if eprazinone alters either lung surfactant levels in bronchoalveolar lavage fluid (BAL) of normal rats, or ion transport across c...

journal_title：Experimental lung research

authors： Thrall RS,Cloutier MM,Guernsey L,Swayne E,Gionfriddo M

更新日期：1992-05-01 00:00:00

abstract：:In order to study the kinetics and pathways of protein transfer in pleural effusion, rats with pleurisy associated with hyperoxic pulmonary edema were injected either intrapleurally or intravenously with tracers. 125I-Albumin was used to obtain quantitative data. Anti horseradish peroxidase used as a morphological tra...

journal_title：Experimental lung research

authors： Bernaudin JF,Theven D,Pinchon MC,Brun-Pascaud M,Bellon B,Pocidalo JJ

更新日期：1986-01-01 00:00:00

abstract：:Intraphagosomal pH in rabbit alveolar macrophages was studied using amorphous silica particles (FSP) and yeast particles (FYP) labeled with fluorescein. The pH was estimated from the quotient between the fluorescence intensity at wavelength 519 nm with excitation at wavelengths 495 and 450 nm. Within a factor of 10, p...

journal_title：Experimental lung research

authors： Nyberg K,Johansson A,Camner P

更新日期：1989-01-01 00:00:00

abstract：:Chymase is a chymotrypsin-like serine protease that is present in mast cells. Its activities include various effects associated with inflammatory responses. But little is known about the effects of chymase in pulmonary fibrosis. The mouse silicosis model was induced by intratracheal injection of 10 mg silica. The Ashc...

journal_title：Experimental lung research

authors： Takato H,Yasui M,Ichikawa Y,Waseda Y,Inuzuka K,Nishizawa Y,Tagami A,Fujimura M,Nakao S

更新日期：2011-03-01 00:00:00

abstract：:The streptozotocin-induced diabetic (STZ-DB) rat model is associated with fetal hyperglycemia, but with low to normal plasma insulin concentration. Because surfactant protein (SP) mRNA content in fetal rat lung is decreased in STZ-DB pregnancy, we investigated the effect of increasing concentrations of glucose on SP g...

journal_title：Experimental lung research

authors： Rayani HH,Gewolb IH,Floros J

更新日期：1999-01-01 00:00:00

abstract：:The effect of glucocorticoids on the response of adenylate cyclase in fetal rat lung fibroblast and Type II epithelial cell cultures to beta-agonists and prostaglandin E2 (PGE2) was investigated. There was significant stimulation of cyclic AMP synthesis by adrenalin in both fibroblasts and Type II cells, which was pot...

journal_title：Experimental lung research

authors： Skinner SJ,Lowe C,Ashby CJ,Liggins GC

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Pulmonary ischemia-reperfusion (IR) is a biopathological event detectable in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation, and pulmonary embolism. The understanding behind the activation of various inflammatory mediators regulating the apoptotic pathways ...

journal_title：Experimental lung research

authors： Dolkart O,E A,S S,S M,P G,Aa W

更新日期：2014-02-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is characterized by systemic and local chronic inflammation and oxidative stress. The sources of the increased oxidative stress in COPD patients derive from the increased burden of inhaled oxidants such as cigarette smoke and other forms of particulate or gaseous air pollut...

journal_title：Experimental lung research

authors： Lakhdar R,Denden S,Kassab A,Leban N,Knani J,Lefranc G,Miled A,Chibani JB,Khelil AH

更新日期：2011-08-01 00:00:00

abstract：:Aims:Bronchopulmonary dysplasia (BPD) is characterized by alveolarization arrest. During alveolarization, alveolar myofibroblasts are thought to migrate into the septal tips and elongate secondary septa. Lipopolysaccharide (LPS) exposure has been reported to disrupt directional migration and final location of alveolar...

journal_title：Experimental lung research

authors： Li J,Gong X

更新日期：2020-01-01 00:00:00

abstract：:Cyclin D1 dysregulation and differential inactivation of p16INK4a and Rb have been observed in human lung cancer. In chemically induced mouse lung tumors, the p16INK4a gene is a target of inactivation, and Rb is reduced at the mRNA level (Northern blot) although similar at the protein level (Western blot) when compare...

journal_title：Experimental lung research

authors： Sabourin CL,Wang QS,Ralston SL,Evans J,Coate J,Herzog CR,Jones SL,Weghorst CM,Kelloff GJ,Lubet RA,You M,Stoner GD

更新日期：1998-07-01 00:00:00

abstract：:The Ca(2+)-mobilizing actions of adenosine 5'-triphosphate (ATP), bradykinin, and histamine were compared in phenotypically distinct human nasal epithelial (HNE) cell types and as a function of time in cell culture. Single-cell measurements of intracellular free Ca2+ (Ca2+i, Fura-2 fluorescence) were recorded in cilia...

journal_title：Experimental lung research

authors： Paradiso AM,Brown HA,Ye H,Harden TK,Boucher RC

更新日期：1999-06-01 00:00:00

abstract：:Studies demonstrated that pathophysiological abnormalities of airway smooth muscle (ASM) contribute significantly to chronic obstructive pulmonary disease (COPD) pathogenesis, the aim of this study is to investigate heat shock protein 70 (Hsp70) in ASM in COPD. ASM from 8 COPD patients and 6 controls were isolated for...

journal_title：Experimental lung research

authors： Xie J,Zhao J,Xiao C,Xu Y,Yang S,Ni W

更新日期：2010-05-01 00:00:00

abstract：:Investigators disagree on the amount of hydrogen peroxide (H2O2) released by resting and stimulated alveolar macrophages. The method commonly used to measure H2O2 release involves horseradish peroxidase (HRP)-catalyzed oxidation of scopoletin by H2O2. We describe an artifact in this method that may explain the seeming...

journal_title：Experimental lung research

authors： Van Scott MR,Miles PR,Castranova V

更新日期：1984-01-01 00:00:00