Hydrophobicity of mucin-like glycoproteins secreted by cultured tracheal epithelial cells: association with lipids.

abstract：:Verapamil, a calcium channel blocker has been used with partial success in cases of primary pulmonary hypertension, as well as to reduce hypoxia-induced pulmonary hypertension (PH) in rats. However, its effect on monocrotaline (MCT)-induced PH in rats is not known. We studied the effect of verapamil on MCT-induced PH....

journal_title：Experimental lung research

authors： Mathew R,Guzowski DE,Gloster ES

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:This study aims to explore the effect of thymoquinone (TQ) on particulate matter 2.5 (PM2.5)-induced lung injury. METHODS:The PM2.5 sample was provided by Shenyang Environment Monitor Central Station. Lung injury was established by intratracheal instillation PM2.5 (7.5 mg/kg) followed by TQ treatment (20 an...

journal_title：Experimental lung research

authors： Mao M,Li J,Bi A,Jia H,Li Q,Liu Y,Jiang X,Huang D,Xia S

更新日期：2020-10-01 00:00:00

abstract：:Hypothyroid adult rats were injected intravenously with [3, 5, 3'-125I]triiodothyronine (T3) or [125I]thyroxine (T4). Others were similarly treated except for the addition of a 500-fold excess of the appropriate unlabeled hormone. Light microscopic autoradiography of semithin sections of lung from these animals demons...

journal_title：Experimental lung research

authors： Smith DM,Hitchcock KR

更新日期：1983-09-01 00:00:00

abstract：PURPOSE OF THE STUDY:Pulmonary infection with Klebsiella pneumoniae (KP) and carbapenem-resistant Klebsiella pneumoniae (CRKP) significantly contribute to morbidity and mortality in pneumonia. Recent studies have indicated that High-Mobility Group Box 1 Protein (HMGB1) plays an important role in the prevention and trea...

journal_title：Experimental lung research

authors： Liming S,Guixia L,Wenxin S,Guirong T

更新日期：2018-08-01 00:00:00

abstract：AIM OF THE STUDY:Long-term exposure to cigarette smoke generates chronic obstructive pulmonary disease (COPD) in guinea pigs, but a comprehensive evaluation of changes in lung function, as assessed by barometric whole body plethysmography (WBP), is lacking. MATERIALS AND METHODS:Female guinea pigs were exposed to the ...

journal_title：Experimental lung research

authors： Ramírez-Ramírez E,Torres-Ramírez A,Alquicira-Mireles J,Cañavera-Constantino A,Segura-Medina P,Montaño-Ramírez M,Ramos-Abraham C,Vargas MH,Arreola-Ramírez JL

更新日期：2017-03-01 00:00:00

abstract：:Activity for nonspecific esterases has been demonstrated histochemically in fetal rabbit lungs using alpha-naphthyl acetate as substrate. Commencing with a homogeneous distribution in pseudoglandular lungs, activity gradually heightens in the epithelium, progresses centrifugally along the bronchial tree, and reaches f...

journal_title：Experimental lung research

authors： Sorokin SP,Hoyt RF Jr

更新日期：1982-11-01 00:00:00

abstract：:The cigarette smoke-induced rat model of chronic bronchitis was used to study the time course of the return of cigarette smoke-induced secretory cell hyperplasia to the normal and the capacity of two non-steroidal anti-inflammatory drugs to speed this recovery. Cigarette smoke alone significantly increased (P less tha...

journal_title：Experimental lung research

authors： Rogers DF,Jeffery PK

更新日期：1986-01-01 00:00:00

abstract：PURPOSE OF THE STUDY:Workers in enclosed hogbarns experience an increased incidence of airway inflammation and obstructive lung disease, and an aqueous hogbarn dust extract (HDE) induces multiple inflammation-related responses in cultured airway epithelial cells. Epidermal growth factor receptor (EGFR) phosphorylation ...

journal_title：Experimental lung research

authors： Dodmane PR,Schulte NA,Heires AJ,Band H,Romberger DJ,Toews ML

更新日期：2018-12-01 00:00:00

abstract：:Chymase is a chymotrypsin-like serine protease that is present in mast cells. Its activities include various effects associated with inflammatory responses. But little is known about the effects of chymase in pulmonary fibrosis. The mouse silicosis model was induced by intratracheal injection of 10 mg silica. The Ashc...

journal_title：Experimental lung research

authors： Takato H,Yasui M,Ichikawa Y,Waseda Y,Inuzuka K,Nishizawa Y,Tagami A,Fujimura M,Nakao S

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:HSPGs are glycoproteins containing covalently attached heparan sulfate (HS) chains which bind to growth factors, chemokines, etc., and regulate various aspects of inflammation including cell recruitment. We previously showed that deletion of endothelial N-acetylglucosamine N-deacetylase-N-sulfotransferase-1 ...

journal_title：Experimental lung research

authors： Ge XN,Bastan I,Ha SG,Greenberg YG,Esko JD,Rao SP,Sriramarao P

更新日期：2018-03-01 00:00:00

abstract：:Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine m...

journal_title：Experimental lung research

authors： Suh GY,Ham HS,Lee SH,Choi JC,Koh WJ,Kim SY,Lee J,Han J,Kim HP,Choi AM,Kwon OJ

更新日期：2006-01-01 00:00:00

abstract：:The studies presented were designed to test the efficacy of farnesyltransferase inhibitors (FTIs) as potential chemopreventive compounds in the mouse lung tumor model, and in tumor cell lines. The compounds included manumycin, gliotoxin, dihydroepiandrosterone (DHEA), perillyl alcohol (POH), and FTI-276. Each of these...

journal_title：Experimental lung research

authors： Lantry LE,Zhang Z,Crist KA,Wang Y,Hara M,Zeeck A,Lubet RA,You M

更新日期：2000-12-01 00:00:00

abstract：:Immunosuppressive and antiproliferative effects of heparin may be beneficial in the field of solid organ transplantation. The aim of this study was to examine the effect of low-molecular-weight heparin (LMWH) compounds on the development of obliterative airway disease (OAD) in the rat tracheal transplant model. Alloge...

journal_title：Experimental lung research

authors： Fillinger J,Antus B

更新日期：2010-12-01 00:00:00

abstract：:Understanding the effects from long-term exposure to individual ambient air pollutants and mixtures of pollutants is necessary for adequate assessment of health risk. This study examined quantitative and temporal alterations in tracheobronchial mucociliary clearance function and bronchial epithelial secretory cells in...

journal_title：Experimental lung research

authors： Schlesinger RB,Gorczynski JE,Dennison J,Richards L,Kinney PL,Bosland MC

更新日期：1992-07-01 00:00:00

abstract：:Protein tyrosine phosphatase is an important class of enzymes that plays an essential role in the cellular proliferation, differentiation, and oncogenesis. In this paper we report characterization of a low-molecular-weight protein tyrosine phosphatase purified from bovine lung. The enzyme activity was essentially inde...

journal_title：Experimental lung research

authors： Buzalaf MA,Taga EM,Granjeiro JM,Ferreira CV,Lourenção VA,Ortega MM,Poletto DW,Aoyama H

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We have previously reported that N-acetylcysteine (NAC), ambroxol and azithromycin (AZM) (partially) correct the chloride efflux dysfunction in cystic fibrosis bronchial epithelial (CFBE) cells with the ΔF508 homozygous mutation in vitro. METHODS:In the present paper, we further investigated p...

journal_title：Experimental lung research

authors： Hussain S,Varelogianni G,Särndahl E,Roomans GM

更新日期：2015-06-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) generates angiotensin II and degrades bradykinin. This ectopeptidase acts as a marker in pathologic conditions, showing tissue and vascular damage. In order to evaluate serum and tissue ACE activity in bleomycin-associated lung damage, the authors studied morphological and enzymatic...

journal_title：Experimental lung research

authors： Ziai SA,Salehian P,Mahmoudian M

更新日期：2004-03-01 00:00:00

abstract：:We compared the effects of dexamethasone given to rats from age 4 to 14 days, on alveolar development at age 99 days. Judged by similar nose-to-tail length and body weight, somatic growth was not altered by dexamethasone treatment. Lung volumes in both air- and saline-filled lungs and mean chord length (Lm) were incre...

journal_title：Experimental lung research

authors： Sahebjami H,Domino M

更新日期：1989-12-01 00:00:00

abstract：:Two morphologic characteristics have been used to define the nonciliated bronchiolar epithelial cell: abundant agranular endoplasmic reticulum (AER) and membrane-bound avoid granules. To assess the ultrastructural homogeneity of this cell type in the lungs of large domestic mammals used as experimental models in pulmo...

journal_title：Experimental lung research

authors： Plopper CG,Mariassy AT,Hill LH

更新日期：1980-06-01 00:00:00

abstract：:The morphology and phagocytic capacities of pulmonary macrophages recovered by lavage from normal rats were studied in vitro after incubation under various culture conditions. Most adherent macrophages (73 +/- 6%) were flat and exhibited ruffled surfaces. Phagocytosis of carbonyl iron beads by pulmonary macrophages wa...

journal_title：Experimental lung research

authors： Warheit DB,Hill LH,Brody AR

更新日期：1984-01-01 00:00:00

abstract：:The lung is affected by a variety of disease processes that can lead to considerable morbidity and mortality. As the lung is the only organ for respiration and gas exchange, the structural and functional integrity of the lung is of primary importance. Various pathological processes affect the extracellular matrix (ECM...

journal_title：Experimental lung research

authors： Chakrabarti S,Patel KD

更新日期：2005-07-01 00:00:00

abstract：:B6C3F1 female mice were exposed to cigarette smoke (CS) (250 mg/m3 total particulate material) or filtered air (FA), 6 hours/day, 5 days/week, for 6, 7, or 10 weeks, or to CS for 6 weeks, then FA for 1 or 4 additional weeks. Exposure to CS increased macrophages, neutrophils, lymphocytes, and matrix metalloproteinase (...

journal_title：Experimental lung research

authors： Seagrave J,Barr EB,March TH,Nikula KJ

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Nintedanib is a multi-tyrosine kinase receptor inhibitor recently approved for treatment of idiopathic pulmonary fibrosis. Although angiogenesis is a key process involved in airway structural changes in patients with bronchial asthma, the effect of nintedanib targeting the angiokinase pathway on airway inf...

journal_title：Experimental lung research

authors： Lee HY,Hur J,Kim IK,Kang JY,Yoon HK,Lee SY,Kwon SS,Kim YK,Rhee CK

更新日期：2017-01-01 00:00:00

abstract：:Biochemical characterization of human respiratory mucus has generally utilized expectorated specimens. In order to exclude extraneous contaminants in the analysis of airway glycoproteins, human airways were cultured and the mucous glycoprotein released into the supernatant analyzed. By incorporating 3H-labeled glucosa...

journal_title：Experimental lung research

authors： Shelhamer JH,Marom Z,Logun C,Kaliner M

更新日期：1984-01-01 00:00:00

abstract：:In order to study the kinetics and pathways of protein transfer in pleural effusion, rats with pleurisy associated with hyperoxic pulmonary edema were injected either intrapleurally or intravenously with tracers. 125I-Albumin was used to obtain quantitative data. Anti horseradish peroxidase used as a morphological tra...

journal_title：Experimental lung research

authors： Bernaudin JF,Theven D,Pinchon MC,Brun-Pascaud M,Bellon B,Pocidalo JJ

更新日期：1986-01-01 00:00:00

abstract：:A past study demonstrated that all-trans-retinoic acid (ATRA) treatment by intraperitoneal injection in a rat model of elastase-induced emphysema caused tissue regeneration as evidenced by a decrease in alveolar size and lung volume and an increase in alveolar number. We postulated that treatment with this retinoid by...

journal_title：Experimental lung research

authors： March TH,Cossey PY,Esparza DC,Dix KJ,McDonald JD,Bowen LE

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Asthma is a chronic inflammatory disease of the airway that is mediated by T-helper 2(TH2) cells. Thymic stromal lymphopoietin (TSLP) can aggravate asthmatic lung inflammation by activating dendritic cells (DCs) to promote TH2 differentiation. TSLP promoter polymorphisms are associated with susceptibility to...

journal_title：Experimental lung research

authors： Liu W,Xu LS,Liu QJ,Dong FZ,Qiu RF,Wen MC,Han YL,Tang NB,Kang LJ,Wu JX,Liu F,Zhao JP,Yang MM,Wang JF,Ding MJ,Sun YM,Fei WJ,Dong L

更新日期：2012-10-01 00:00:00

abstract：:Suboptimal intake of dietary zinc (Zn) is one of the most common nutritional problems worldwide. Previously, the authors have shown that zinc deficiency (ZD) produces oxidative and nitrosative stress in lung of male rats. The goal of this study is to test the effect of moderate ZD on insulin-like growth factor (IGF)-1...

journal_title：Experimental lung research

authors： Biaggio VS,Pérez Chaca MV,Valdéz SR,Gómez NN,Gimenez MS

更新日期：2010-02-01 00:00:00

abstract：:We studied lung clearance of technetium-labeled diethylenetriamine pentaacetic acid [( 99mTc]DTPA), plasma and bronchoalveolar lavage fluid (BALF) concentrations of 6-keto-PGF1 alpha (stable metabolite of prostacyclin, prostaglandin I2, PGI2), TxB2 (stable metabolite of thromboxane A2, TxA2), and leukotriene B4 (LTB4)...

journal_title：Experimental lung research

authors： Witten ML,Quan SF,Sobonya RE,Bruck D,Devine L,Lemen RJ

更新日期：1988-01-01 00:00:00

abstract：:Alveolar cells were evaluated in BALB/c mice exposed to smoke from 9 cigarettes per day. The mice were sacrificed at 1, 5, and 10 days and examined by lung morphometry and immunohistochemical staining of alveolar macrophages for tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-12, and tissue inhibitor...

journal_title：Experimental lung research

authors： da Hora K,Valença SS,Porto LC

更新日期：2005-10-01 00:00:00