Long-term intermittent exposure to sulfuric acid aerosol, ozone, and their combination: alterations in tracheobronchial mucociliary clearance and epithelial secretory cells.

abstract：:The role of bombesin was investigated in the course of the pulmonary inflammation and fibrosis (PF) elicited by the intratracheal (IT) or intravenous (i.v.) administration of bleomycin in mice. Bleomycin-induced alveolitis was associated with an accumulation of cells, presumably macrophages, containing bombesin, as ev...

journal_title：Experimental lung research

authors： Piguet PF,Vesin C,Thomas F

更新日期：1995-03-01 00:00:00

abstract：:Previous studies have indicated increased plasma levels of inducible nitric oxide synthase in lung. This study further examines the pulmonary expression of nitric oxide synthase (NOS) isoforms in an ovine model of acute lung injury induced by smoke inhalation and burn injury (S+B injury). Female range bred sheep (4 pe...

journal_title：Experimental lung research

authors： Cox RA,Jacob S,Oliveras G,Murakami K,Enkhbaatar P,Traber L,Schmalstieg FC,Herndon DN,Traber DL,Hawkins HK

更新日期：2009-03-01 00:00:00

abstract：:The role of type II epithelial cell proliferation in repair of diffuse alveolar epithelial injury was examined using two pneumotoxicants, 3-methylindole (3-MI) and monocrotaline (MCT). It was hypothesized that if MCT inhibits type II epithelial cell mitosis, then pulmonary fibrosis would result after diffuse 3-MI-indu...

journal_title：Experimental lung research

authors： Woods LW,Wilson DW,Segall HJ

更新日期：1999-03-01 00:00:00

abstract：:Aberrant expression of key cell cycle regulatory genes is essential for the immortalization and transformation of cells in vitro. We examined 20 mouse lung epithelial cell lines (2 nontumorigenic, 5 nonmetastatic, and 13 metastatic) for mutations or alterations in the expression of key components of the Rb pathway (pR...

journal_title：Experimental lung research

authors： McDoniels-Silvers AL,Herzog CR,Tyson FL,Malkinson AM,You M

更新日期：2001-04-01 00:00:00

abstract：:CTP:cholinephosphate cytidylyltransferase (CT) is a key enzyme required for surfactant phosphatidylcholine synthesis, and its activity is regulated by lung lipids. This study evaluated the effect of epidermal growth factor (EGF) on the phospholipid content and the expression of CT in the lung following direct in vivo ...

journal_title：Experimental lung research

authors： Mallampalli RK,Salome RG,Hunninghake GW

更新日期：1994-01-01 00:00:00

abstract：:In vitro observations of fetal lung maturation are complicated by continued epithelial cell maturation in culture. Removal of trace quantities of cortisol from the culture system has been reported elsewhere by Torday to prevent epithelial cell differentiation, but also prevent cell growth. In this report we have devel...

journal_title：Experimental lung research

authors： Tanswell AK,Joneja MG,Lindsay J,Vreeken E

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:Inhaled capsaicin (8-methyl-N-vanillyl-6-nonenamide) has been used to induce cough in a safe and dose-dependent manner. Chronic cough is associated with an increased sensitivity to inhaled capsaicin in patients with asthma. The aim of this study was to evaluate clinical impact of capsaicin provocation test f...

journal_title：Experimental lung research

authors： Park KH,Kim BG,Lee PH,Hong J,Lee J,Park SW,Kim DJ,Jang AS

更新日期：2021-02-01 00:00:00

abstract：:Lamellar bodies, the intracellular storage form of pulmonary surfactant, were isolated from adult human lung tissue. As shown by electron microscopy, the isolated human lamellar bodies resembled the lamellar bodies isolated from experimental animals. Chemical analysis revealed that the lamellar bodies consisted largel...

journal_title：Experimental lung research

authors： Post M,Batenburg JJ,Schuurmans EA,Laros CD,van Golde LM

更新日期：1982-02-01 00:00:00

abstract：:Verapamil, a calcium channel blocker has been used with partial success in cases of primary pulmonary hypertension, as well as to reduce hypoxia-induced pulmonary hypertension (PH) in rats. However, its effect on monocrotaline (MCT)-induced PH in rats is not known. We studied the effect of verapamil on MCT-induced PH....

journal_title：Experimental lung research

authors： Mathew R,Guzowski DE,Gloster ES

更新日期：1990-11-01 00:00:00

abstract：:The authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours after tetracycline-induced pleural injury in rabbits. Both scuPA a...

journal_title：Experimental lung research

authors： Idell S,Azghani A,Chen S,Koenig K,Mazar A,Kodandapani L,Bdeir K,Cines D,Kulikovskaya I,Allen T

更新日期：2007-10-01 00:00:00

abstract：:Cyclin D1 dysregulation and differential inactivation of p16INK4a and Rb have been observed in human lung cancer. In chemically induced mouse lung tumors, the p16INK4a gene is a target of inactivation, and Rb is reduced at the mRNA level (Northern blot) although similar at the protein level (Western blot) when compare...

journal_title：Experimental lung research

authors： Sabourin CL,Wang QS,Ralston SL,Evans J,Coate J,Herzog CR,Jones SL,Weghorst CM,Kelloff GJ,Lubet RA,You M,Stoner GD

更新日期：1998-07-01 00:00:00

abstract：:The lung is affected by a variety of disease processes that can lead to considerable morbidity and mortality. As the lung is the only organ for respiration and gas exchange, the structural and functional integrity of the lung is of primary importance. Various pathological processes affect the extracellular matrix (ECM...

journal_title：Experimental lung research

authors： Chakrabarti S,Patel KD

更新日期：2005-07-01 00:00:00

abstract：:Because high partial pressures of oxygen (O2) can cause peroxidative cleavage of membrane lipids, it is plausible to hypothesize that hyperoxia alters the physical state and composition of lipids in the membranes of pulmonary endothelial cells and that manipulation of the lipid profile may modify endothelial cell tole...

journal_title：Experimental lung research

authors： Block ER

更新日期：1988-01-01 00:00:00

abstract：:The role of the Clara and type II cell in the development of pulmonary tumors in the A/J mouse and Fischer rat was investigated by determining the relationship of DNA methylation and repair in pulmonary cells to oncogene activation and by characterizing the morphology of pulmonary tumors induced by treatment with 4-(m...

journal_title：Experimental lung research

authors： Belinsky SA,Devereux TR,White CM,Foley JF,Maronpot RR,Anderson MW

更新日期：1991-03-01 00:00:00

abstract：:Transforming growth factor alpha (TGF(alpha)) stimulates type II alveolar epithelial cell proliferation and also is associated with fibrosis. We studied the changes in bronchoalveolar lavage (BAL) TGF(alpha) protein in a neonatal rabbit hyperoxia-fibrosis model (100% O(2) for 8 to 9 days, followed by 60% O(2) to 36 da...

journal_title：Experimental lung research

authors： Waheed S,D'Angio CT,Wagner CL,Madtes DK,Finkelstein JN,Paxhia A,Ryan RM

更新日期：2002-07-01 00:00:00

abstract：:We quantified in vivo pulmonary vascular remodeling in a large animal model of pulmonary hypertension (PH). In group PH (n = 6), 3 mg/kg dehydromonocrotaline (DHMC) was administered to 12-week-old beagles via a right atrial injection. Eight weeks after DHMC in group PH, pulmonary artery pressure increased significantl...

journal_title：Experimental lung research

authors： Gust R,Schuster DP

更新日期：2001-01-01 00:00:00

abstract：:The effects of activated leukocytes on surfactant function and composition were examined to better define the mechanisms by which acute inflammation contributes to respiratory distress syndrome (ARDS). Peripheral blood leukocytes from healthy volunteers were incubated in vitro with surfactant for 4 hours: (1) in the a...

journal_title：Experimental lung research

authors： Schochett P,Mora R,Mark L,Butler M,Ingenito EP

更新日期：1999-10-01 00:00:00

abstract：:Previously, the authors have shown that tracheal occlusion (TO) partially reverses the onset of congenital diaphragmatic hernia (CDH)-induced pulmonary hypertension (PH) and abnormal pulmonary vascular development whereas release of the occlusion (TR) abolishes these clinical benefits. As a consequence of their mitoge...

journal_title：Experimental lung research

authors： Cloutier M,Seaborn T,Piedboeuf B,Bratu I,Flageole H,Laberge JM

更新日期：2005-05-01 00:00:00

abstract：:Lung injury and inflammation are associated with exposure to various types of particulate air pollutants. The present study was used to determine whether metalloproteinases (MMPs) are secreted after instilling dust samples into the lung, and to relate levels of specific MMPs to different fractions of the ambient air p...

journal_title：Experimental lung research

authors： Adamson IY,Vincent R,Bakowska J

更新日期：2003-09-01 00:00:00

abstract：:Investigators disagree on the amount of hydrogen peroxide (H2O2) released by resting and stimulated alveolar macrophages. The method commonly used to measure H2O2 release involves horseradish peroxidase (HRP)-catalyzed oxidation of scopoletin by H2O2. We describe an artifact in this method that may explain the seeming...

journal_title：Experimental lung research

authors： Van Scott MR,Miles PR,Castranova V

更新日期：1984-01-01 00:00:00

abstract：:To study the pattern of lymphokines in bleomycin-induced lung injury, T cells were isolated from lung interstitial tissue (LIL), peribronchial lymphatic tissue (PBLT), and bronchoalveolar lavage (BAL) fluid of bleomycin-"sensitive" C57Bl/6 and bleomycin-"resistant" BALB/c mice at 3, 6, and 14 days following intratrach...

journal_title：Experimental lung research

authors： Gur I,Or R,Segel MJ,Shriki M,Izbicki G,Breuer R

更新日期：2000-10-01 00:00:00

abstract：:Electrical stimulation of the cervical vagus nerve of rats is known to increase vascular permeability in the trachea. In the present study, we sought to further characterize this neurogenic inflammatory response by defining the relationship between the parameters of electrical stimulation of the vagus nerve and the ma...

journal_title：Experimental lung research

authors： Brokaw JJ,McDonald DM

更新日期：1988-01-01 00:00:00

abstract：:The authors recently showed that preterm birth per se, in the absence of assisted ventilation or elevated inhaled oxygen levels, alters the structure of the airway walls in young lambs. The initial aim of the present study was to determine whether these changes persist into adulthood. Preterm (P; n = 7) lambs were del...

journal_title：Experimental lung research

authors： Snibson K,Harding R

更新日期：2008-02-01 00:00:00

abstract：:Leptin, an adipocyte-secreted hormone that regulates food intake and metabolic response, has been recently reported to increase in the serum during inflammatory airway disease associated with mucus-hypersecretion. We investigated the effects of leptin on mucin expression in human airway epithelial cells and the signal...

journal_title：Experimental lung research

authors： Woo HJ,Yoo WJ,Bae CH,Song SY,Kim YW,Park SY,Kim YD

更新日期：2010-06-01 00:00:00

abstract：:A deletional analysis of the SP-A1 promoter in NCI-H441 cells was performed to identify potential cis-acting elements involved in phorbol ester-mediated repression of human SP-A transcription. The phorbol ester TPA reduced SP-A1 and SP-A2 promoter activity to approximately 35% to 45% compared to that of control cells....

journal_title：Experimental lung research

authors： Hoover RR,Pavlovic J,Floros J

更新日期：2000-07-01 00:00:00

abstract：:A specific form of flavin monooxygenase has been identified in the lungs of a number of species. Distribution of the pulmonary flavin-containing monooxygenase (FMOp) is of interest because it oxidatively metabolizes a wide variety of nitrogen-, sulfur-, and phosphorous-containing xenobiotics, some of which form highly...

journal_title：Experimental lung research

authors： Overby L,Nishio SJ,Lawton MP,Plopper CG,Philpot RM

更新日期：1992-01-01 00:00:00

abstract：:Intraphagosomal pH in rabbit alveolar macrophages was studied using amorphous silica particles (FSP) and yeast particles (FYP) labeled with fluorescein. The pH was estimated from the quotient between the fluorescence intensity at wavelength 519 nm with excitation at wavelengths 495 and 450 nm. Within a factor of 10, p...

journal_title：Experimental lung research

authors： Nyberg K,Johansson A,Camner P

更新日期：1989-01-01 00:00:00

abstract：:The streptozotocin-induced diabetic (STZ-DB) rat model is associated with fetal hyperglycemia, but with low to normal plasma insulin concentration. Because surfactant protein (SP) mRNA content in fetal rat lung is decreased in STZ-DB pregnancy, we investigated the effect of increasing concentrations of glucose on SP g...

journal_title：Experimental lung research

authors： Rayani HH,Gewolb IH,Floros J

更新日期：1999-01-01 00:00:00

abstract：:In a number of recent studies, a lung tumor resistance locus designated either Par2 or Pas7 was mapped to distal chromosome 18 in crosses between susceptible A/J and more resistant BALB/c mice. This locus is important in that it accounts for as much as 60% of the difference in lung tumor susceptibility between the A/J...

journal_title：Experimental lung research

authors： Zhang Z,Lin L,Liu G,Wang M,Hill J,Wang Y,You M,Devereux TR

更新日期：2000-12-01 00:00:00

abstract：:The morphology and phagocytic capacities of pulmonary macrophages recovered by lavage from normal rats were studied in vitro after incubation under various culture conditions. Most adherent macrophages (73 +/- 6%) were flat and exhibited ruffled surfaces. Phagocytosis of carbonyl iron beads by pulmonary macrophages wa...

journal_title：Experimental lung research

authors： Warheit DB,Hill LH,Brody AR

更新日期：1984-01-01 00:00:00