Inactivation of both Rb and p53 pathways in mouse lung epithelial cell lines.

abstract：:Administering liposome-encapsulated drugs by aerosols could be a feasible way of targeting drugs to the lung, specifically to pulmonary alveolar macrophages (AM). In the mouse model, we characterized uptake of carboxyfluorescein- (CF-) labeled liposomes by AM in vivo after acute inhalation of liposome aerosols, and th...

journal_title：Experimental lung research

authors： Myers MA,Thomas DA,Straub L,Soucy DW,Niven RW,Kaltenbach M,Hood CI,Schreier H,Gonzalez-Rothi RJ

更新日期：1993-01-01 00:00:00

abstract：:A specific form of flavin monooxygenase has been identified in the lungs of a number of species. Distribution of the pulmonary flavin-containing monooxygenase (FMOp) is of interest because it oxidatively metabolizes a wide variety of nitrogen-, sulfur-, and phosphorous-containing xenobiotics, some of which form highly...

journal_title：Experimental lung research

authors： Overby L,Nishio SJ,Lawton MP,Plopper CG,Philpot RM

更新日期：1992-01-01 00:00:00

abstract：:Acute lung injury (ALI) is often associated with sepsis and is the most common cause of acute respiratory failure. The authors evaluated the role of the heme oxygenase (HO)/carbon monoxide (CO) system on lung injury in a cecal ligation and puncture (CLP)-induced mouse model of ALI. The authors established CLP-induced ...

journal_title：Experimental lung research

authors： Fei D,Meng X,Kang K,Nan C,Zhao M,Pan S,Gao M,Yang S,Zhao M

更新日期：2012-05-01 00:00:00

abstract：:Lung disorders such as asthma, acute respiratory distress syndrome (ARDS), chronic obstructive lung disease (COPD), and interstitial lung disease (ILD) show a few common threads of pathogenic mechanisms: inflammation, aberrant immune activity, infection, and fibrosis. Currently no modes of effective treatment are avai...

journal_title：Experimental lung research

authors： Inamdar AC,Inamdar AA

更新日期：2013-10-01 00:00:00

abstract：:Human and canine airway mucosal explants synthesize and secrete high molecular weight glycoconjugates, incorporating 14C-glucosamine, a radioactive precursor to epithelial glycoprotein. Our examination of secretions produced by several individual specimens, however, did not reveal epithelial glycoprotein of typical bu...

journal_title：Experimental lung research

authors： Bhaskar KR,O'Sullivan DD,Opaskar-Hincman H,Reid LM,Coles SJ

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:This study was prospectively designed to investigate the effects of different concentrations of isoflurane (ISO) pretreatment on respiratory mechanics, oxygenation, and hemodynamics in lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) model of juvenile piglets. METHODS:Twenty-four pig...

journal_title：Experimental lung research

authors： Fu H,Sun M,Miao C

更新日期：2015-01-01 00:00:00

abstract：:In a recent study of the sheep tracheal lobe model, we have demonstrated that surface chemistry modification of quartz by aluminum lactate significantly alters the biological activity of quartz for at least 2 months after exposure. In the present study, we have extended our observations of the biological reaction of t...

journal_title：Experimental lung research

authors： Bégin R,Massé S,Sébastien P,Martel M,Bossé J,Dubois F,Geoffroy M,Labbé J

更新日期：1987-01-01 00:00:00

abstract：:Confluent cultures of primary hamster tracheal surface epithelial cells are highly enriched with secretory cells resembling airway goblet cells. The cultures secrete lipids, most of which appear to be associated with high-molecular-weight mucinlike glycoproteins (HMW MLGP). In the present communication, we examined th...

journal_title：Experimental lung research

authors： Kim KC,Singh BN

更新日期：1990-05-01 00:00:00

abstract：:Volcanic ash was collected from the Moses Lake region of Washington State after the 18 May 1980 eruption of Mt. St. Helens. The ash was tested in a short-term bioassay system using hamsters exposed by intratracheal instillation. One day after exposure the lungs were lavaged and the fluid collected was characterized us...

journal_title：Experimental lung research

authors： Beck BD,Brain JD,Bohannon DE

更新日期：1981-11-01 00:00:00

abstract：:During lung development, the extracellular matrix undergoes dynamic remodeling. Matrix metalloproteinases (MMPs), and tissue inhibitors of matrix metalloproteinases (TIMPs), are important enzymes that participate in regulating tissue remodeling. There is an abnormal balance of the synthesis and degradation of collagen...

journal_title：Experimental lung research

authors： Lemke RP,Zhang W,Balcerazak D,Kobayashi K,Schwingshackl A,Cheung PY,Dixon WT,Baracos VE,Greer JJ

更新日期：2003-06-01 00:00:00

abstract：:Tannic acid was used as a mordant to enhance the preservation of lung phospholipids during fixation and processing for electron microscopy. We found multilamellar bodies within alveolar septa (including type I pneumocytes, capillary endothelial cells, and interstitium) which have not been described previously and whic...

journal_title：Experimental lung research

authors： Kalina M,Young SL

更新日期：1980-08-01 00:00:00

abstract：:Few studies are available about the role of dietary zinc (Zn) in respiratory diseases. Adult male rats were divided into 2 groups and fed respectively a moderate Zn-deficient diet and a Zn-adequate control diet. In lung tissue at 2 months, thiobarbituric acid-reactive species (TBARS), total glutathione, glutathione di...

journal_title：Experimental lung research

authors： Gomez NN,Fernandez MR,Zirulnik F,Gil E,Scardapane L,Ojeda MS,Gimenez MS

更新日期：2003-10-01 00:00:00

abstract：:We quantified in vivo pulmonary vascular remodeling in a large animal model of pulmonary hypertension (PH). In group PH (n = 6), 3 mg/kg dehydromonocrotaline (DHMC) was administered to 12-week-old beagles via a right atrial injection. Eight weeks after DHMC in group PH, pulmonary artery pressure increased significantl...

journal_title：Experimental lung research

authors： Gust R,Schuster DP

更新日期：2001-01-01 00:00:00

abstract：:The effects of activated leukocytes on surfactant function and composition were examined to better define the mechanisms by which acute inflammation contributes to respiratory distress syndrome (ARDS). Peripheral blood leukocytes from healthy volunteers were incubated in vitro with surfactant for 4 hours: (1) in the a...

journal_title：Experimental lung research

authors： Schochett P,Mora R,Mark L,Butler M,Ingenito EP

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:This study aimed to develop and evaluate an adaptive control system for volume-controlled ventilation (VCV) in small animals to guarantee accurate delivery of tidal volume (VT) in the presence of changes in lung mechanics. METHODS:The adaptive control system to control the Harvard Inspira ventilator was des...

journal_title：Experimental lung research

authors： Huhle R,Spieth PM,Güldner A,Koch T,de Abreu MG

更新日期：2014-04-01 00:00:00

abstract：:The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF...

journal_title：Experimental lung research

authors： Alho HS,Maasilta PK,Vainikka T,Salminen US

更新日期：2007-08-01 00:00:00

abstract：:The objective of this study was to determine if prolonged hyperoxia exposure would deplete antioxidants, resulting in excessive oxidative stress that would lead to oxidation of pulmonary surfactant and contribute to lung dysfunction. Rats were exposed to either hyperoxic (> 95% O(2)) or normoxic (21% O(2)) oxygen conc...

journal_title：Experimental lung research

authors： Pace PW,Yao LJ,Wilson JX,Possmayer F,Veldhuizen RA,Lewis JF

更新日期：2009-06-01 00:00:00

abstract：:The influence of gas composition on convective and diffusive gas transport in the lungs was assessed by studying the dispersion of combined particle and argon (Ar) boluses induced by the passage through the lungs filled with three different gas mixtures. Particles, as a "nondiffusing gas," served as a tracer for conve...

journal_title：Experimental lung research

authors： Schulz H,Schulz A,Eder G,Heyder J

更新日期：1995-11-01 00:00:00

abstract：:Verapamil, a calcium channel blocker has been used with partial success in cases of primary pulmonary hypertension, as well as to reduce hypoxia-induced pulmonary hypertension (PH) in rats. However, its effect on monocrotaline (MCT)-induced PH in rats is not known. We studied the effect of verapamil on MCT-induced PH....

journal_title：Experimental lung research

authors： Mathew R,Guzowski DE,Gloster ES

更新日期：1990-11-01 00:00:00

abstract：AIM OF THE STUDY:Interleukin (IL)-10 is an anti-inflammatory cytokine, but its role in cigarette smoke (CS)-induced inflammation and chronic obstructive pulmonary disease (COPD) has not been fully elucidated. The purpose of this study was to investigate the effect of IL-10 deficiency on CS-induced pulmonary inflammatio...

journal_title：Experimental lung research

authors： Higaki M,Wada H,Mikura S,Yasutake T,Nakamura M,Niikura M,Kobayashi F,Kamma H,Kamiya S,Ito K,Barnes PJ,Goto H,Takizawa H

更新日期：2015-01-01 00:00:00

abstract：:Basement membranes (BM) are specialized extracellular matrices (ECM) which serve as complex interfaces between epithelia, peripheral nerves, or muscle cells and their surrounding tissue microenvironments. Their composition is known to include type IV collagen, laminin, entactin, heparan sulfate proteoglycan (HSPG, per...

journal_title：Experimental lung research

authors： Sannes PL,Wang J

更新日期：1997-03-01 00:00:00

abstract：:Intraphagosomal pH in rabbit alveolar macrophages was studied using amorphous silica particles (FSP) and yeast particles (FYP) labeled with fluorescein. The pH was estimated from the quotient between the fluorescence intensity at wavelength 519 nm with excitation at wavelengths 495 and 450 nm. Within a factor of 10, p...

journal_title：Experimental lung research

authors： Nyberg K,Johansson A,Camner P

更新日期：1989-01-01 00:00:00

abstract：:Mechanical strain initiates a variety of responses in pulmonary epithelial cells. The signaling pathways and molecular alterations leading to these responses remain unclear To identify novel signal transduction pathways activated by strain, macroarray analysis was performed on strained pulmonary epithelial cells. Glut...

journal_title：Experimental lung research

authors： Chess PR,O'Reilly MA,Toia L

更新日期：2004-12-01 00:00:00

abstract：:Long-term, low-dose macrolide therapy has been proven to improve survival in patients with diffuse panbronchiolitis and cystic fibrosis, although the mechanisms by which it does so remain unknown. To elucidate the molecular mechanisms of the anti-inflammatory effects of macrolides, the authors examined the effects of ...

journal_title：Experimental lung research

authors： Yu C,Azuma A,Li Y,Wang C,Abe S,Usuki J,Matsuda K,Kudoh S,Sunazuka T,Omura S

更新日期：2008-08-01 00:00:00

abstract：:The percentage 24-h lung retention of 4-micrometers monodispersed Teflon particles, aerodynamic diameter about 6 micrometers, was studied twice in 8 healthy nonsmokers. The particles were inhaled at 0.5 liter/sec with maximally deep breaths. Bronchoconstriction was induced by inhalation of a methacholine-bromide aeros...

journal_title：Experimental lung research

authors： Svartengren M,Philipson K,Linnman L,Camner P

更新日期：1984-01-01 00:00:00

abstract：:Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary sm...

journal_title：Experimental lung research

authors： Miko E,Czimmerer Z,Csánky E,Boros G,Buslig J,Dezso B,Scholtz B

更新日期：2009-10-01 00:00:00

abstract：:To study the pattern of lymphokines in bleomycin-induced lung injury, T cells were isolated from lung interstitial tissue (LIL), peribronchial lymphatic tissue (PBLT), and bronchoalveolar lavage (BAL) fluid of bleomycin-"sensitive" C57Bl/6 and bleomycin-"resistant" BALB/c mice at 3, 6, and 14 days following intratrach...

journal_title：Experimental lung research

authors： Gur I,Or R,Segel MJ,Shriki M,Izbicki G,Breuer R

更新日期：2000-10-01 00:00:00

abstract：:The developmental regulation of the rabbit surfactant-associated proteins, SP-A, SP-B, and SP-C, was investigated using Northern blot analysis. These proteins comprise approximately 10% by weight of pulmonary surfactant, a lipoprotein secreted by type II cells that reduces surface tension at the air-alveolar interface...

journal_title：Experimental lung research

authors： Durham PL,Nanthakumar EJ,Snyder JM

更新日期：1992-11-01 00:00:00

abstract：INTRODUCTION:Nintedanib is a multi-tyrosine kinase receptor inhibitor recently approved for treatment of idiopathic pulmonary fibrosis. Although angiogenesis is a key process involved in airway structural changes in patients with bronchial asthma, the effect of nintedanib targeting the angiokinase pathway on airway inf...

journal_title：Experimental lung research

authors： Lee HY,Hur J,Kim IK,Kang JY,Yoon HK,Lee SY,Kwon SS,Kim YK,Rhee CK

更新日期：2017-01-01 00:00:00

abstract：:Alveolar cells were evaluated in BALB/c mice exposed to smoke from 9 cigarettes per day. The mice were sacrificed at 1, 5, and 10 days and examined by lung morphometry and immunohistochemical staining of alveolar macrophages for tumor necrosis factor (TNF)-alpha, matrix metalloproteinase (MMP)-12, and tissue inhibitor...

journal_title：Experimental lung research

authors： da Hora K,Valença SS,Porto LC

更新日期：2005-10-01 00:00:00