Chronic zinc deficiency induces an antioxidant adaptive response in rat lung.

abstract：:ABSTRACT During fetal development physiological stretching helps drive lung growth and maturation. At birth, the α-subunit of the alveolar epithelial sodium channel (α-ENaC) is a critical factor in helping to facilitate clearance of lung fluid during the perinatal period. The effects of stretch, however, on α-ENaC exp...

journal_title：Experimental lung research

authors： Mustafa SB,Isaac J,Seidner SR,Dixon PS,Henson BM,DiGeronimo RJ

更新日期：2014-10-01 00:00:00

abstract：:Protein tyrosine phosphatase is an important class of enzymes that plays an essential role in the cellular proliferation, differentiation, and oncogenesis. In this paper we report characterization of a low-molecular-weight protein tyrosine phosphatase purified from bovine lung. The enzyme activity was essentially inde...

journal_title：Experimental lung research

authors： Buzalaf MA,Taga EM,Granjeiro JM,Ferreira CV,Lourenção VA,Ortega MM,Poletto DW,Aoyama H

更新日期：1998-05-01 00:00:00

abstract：:Suboptimal intake of dietary zinc (Zn) is one of the most common nutritional problems worldwide. Previously, the authors have shown that zinc deficiency (ZD) produces oxidative and nitrosative stress in lung of male rats. The goal of this study is to test the effect of moderate ZD on insulin-like growth factor (IGF)-1...

journal_title：Experimental lung research

authors： Biaggio VS,Pérez Chaca MV,Valdéz SR,Gómez NN,Gimenez MS

更新日期：2010-02-01 00:00:00

abstract：:Recently there has been a great deal of interest in exploring possible ways to protect the lung from oxidant damage. Since sulfhydryl compounds are among the most important endogenous antioxidants, their therapeutic use has been proposed. Glutathione (GSH), the main intracellular nonprotein sulfhydryl, plays an import...

journal_title：Experimental lung research

authors： Patterson CE,Rhoades RA

更新日期：1988-01-01 00:00:00

abstract：:The separate effects of positive end-expiratory pressure (PEEP) and intravascular volume administration on the histopathologic lung injury were not investigated in experimental lung injury previously. The authors hypothesized that high PEEP and a restrictive volume therapy would yield the best oxygenation and the leas...

journal_title：Experimental lung research

authors： Kredel M,Muellenbach RM,Schlegel N,Wunder C,Klingelhöfer M,Lange M,Roewer N,Waschke J,Brederlau J

更新日期：2011-02-01 00:00:00

abstract：:In order to study the kinetics and pathways of protein transfer in pleural effusion, rats with pleurisy associated with hyperoxic pulmonary edema were injected either intrapleurally or intravenously with tracers. 125I-Albumin was used to obtain quantitative data. Anti horseradish peroxidase used as a morphological tra...

journal_title：Experimental lung research

authors： Bernaudin JF,Theven D,Pinchon MC,Brun-Pascaud M,Bellon B,Pocidalo JJ

更新日期：1986-01-01 00:00:00

abstract：:Lung cancer, specifically non-small cell lung cancer (NSCLC), is a leading cause of mortality worldwide. In China, a dramatic increase in the incidence of NSCLC is expected in the next 20 years (Molina et al. Mayo Clin Proc. 2008;83:584–594). Mutated epidermal growth factor receptor (EGFR) status is a known predictor ...

journal_title：Experimental lung research

authors： McMillen E,Ye F,Li G,Wu Y,Yin G,Liu W

更新日期：2010-11-01 00:00:00

abstract：:In order to investigate some of the characteristics of superoxide anion release from alveolar macrophages, the effects of substances known to influence superoxide release from polymorphonuclear leukocytes (PMN) were studied in rat alveolar macrophages. There is a relatively small, but constant, amount of superoxide re...

journal_title：Experimental lung research

authors： Sweeney TD,Castranova V,Bowman L,Miles PR

更新日期：1981-05-01 00:00:00

abstract：:The studies presented were designed to test the efficacy of farnesyltransferase inhibitors (FTIs) as potential chemopreventive compounds in the mouse lung tumor model, and in tumor cell lines. The compounds included manumycin, gliotoxin, dihydroepiandrosterone (DHEA), perillyl alcohol (POH), and FTI-276. Each of these...

journal_title：Experimental lung research

authors： Lantry LE,Zhang Z,Crist KA,Wang Y,Hara M,Zeeck A,Lubet RA,You M

更新日期：2000-12-01 00:00:00

abstract：:Investigators disagree on the amount of hydrogen peroxide (H2O2) released by resting and stimulated alveolar macrophages. The method commonly used to measure H2O2 release involves horseradish peroxidase (HRP)-catalyzed oxidation of scopoletin by H2O2. We describe an artifact in this method that may explain the seeming...

journal_title：Experimental lung research

authors： Van Scott MR,Miles PR,Castranova V

更新日期：1984-01-01 00:00:00

abstract：:The structural features of the ovine pleura are described using light, scanning, and transmission electron microscopy. Extensive sampling of the visceral and parietal pleura revealed considerable variation in both surface morphology and pleural interstitial anatomy. Variations of mesothelial surface were encountered a...

journal_title：Experimental lung research

authors： Mariassy AT,Wheeldon EB

更新日期：1983-05-01 00:00:00

abstract：:Three-day-old rabbits were given intratracheal injections of radiolabeled natural sheep surfactant, rabbit surfactant, or liposomes of dipalmitoylphosphatidylcholine that contained greater than three times the quantity of phosphatidylcholine present in the endogenous surfactant pool. The recoveries of radiolabeled pho...

journal_title：Experimental lung research

authors： Oguchi K,Ikegami M,Jacobs H,Jobe A

更新日期：1985-01-01 00:00:00

abstract：:Direct measurements of pleural fluid hydrostatic and colloid osmotic pressures after infusion of saline, bovine serum albumin, or silicone into the pleural space were coupled with ultrastructural morphometric analyses to assess the response of pleural mesothelial cells to hydrothorax. Increases of hydrostatic pressure...

journal_title：Experimental lung research

authors： Shumko JZ,Feinberg RN,Shalvoy RM,DeFouw DO

更新日期：1993-05-01 00:00:00

abstract：:We hypothesized that replication-deficient adenovirus (Ad), when complexed with plasmid DNA (pl) and cationic liposomes (L), would enhance liposome-mediated gene transfer in cultured human airway epithelial cells. Pl/L/Ad complexes were formed using charge-charge interactions. A gel electrophoresis retardation assay s...

journal_title：Experimental lung research

authors： Stecenko A,King G,Torii K,Gao X,Persmark M,Shih K,Brigham K,Raja-Walia R

更新日期：2000-04-01 00:00:00

abstract：:Paraquat accumulation into rat lung slices was unaffected by hypoxia (PO2 = 645 mm Hg) but was inhibited by hypoxia. The IC50 (IC50 = partial pressure of O2 resulting in a 50% inhibition of paraquat accumulation) for paraquat accumulation was P02 = 50 mm Hg; significant accumulation could be observed after 1 or 2 hr o...

journal_title：Experimental lung research

authors： Montgomery MR,Wyatt I,Smith LL

更新日期：1980-08-01 00:00:00

abstract：:A specific form of flavin monooxygenase has been identified in the lungs of a number of species. Distribution of the pulmonary flavin-containing monooxygenase (FMOp) is of interest because it oxidatively metabolizes a wide variety of nitrogen-, sulfur-, and phosphorous-containing xenobiotics, some of which form highly...

journal_title：Experimental lung research

authors： Overby L,Nishio SJ,Lawton MP,Plopper CG,Philpot RM

更新日期：1992-01-01 00:00:00

abstract：:The role of the Clara and type II cell in the development of pulmonary tumors in the A/J mouse and Fischer rat was investigated by determining the relationship of DNA methylation and repair in pulmonary cells to oncogene activation and by characterizing the morphology of pulmonary tumors induced by treatment with 4-(m...

journal_title：Experimental lung research

authors： Belinsky SA,Devereux TR,White CM,Foley JF,Maronpot RR,Anderson MW

更新日期：1991-03-01 00:00:00

abstract：:Salvianolic acid B (Sal B), one of the major water-soluble compounds of Danshen (a popular Chinese herb), possesses many of the biological activities, such as antifibrogenic effect in liver and renal diseases. Transforming growth factor-β1 (TGF-β1) plays a central role in the development of pulmonary fibrosis by stimu...

journal_title：Experimental lung research

authors： Zhang M,Cao SR,Zhang R,Jin JL,Zhu YF

更新日期：2014-04-01 00:00:00

abstract：:Biochemical characterization of human respiratory mucus has generally utilized expectorated specimens. In order to exclude extraneous contaminants in the analysis of airway glycoproteins, human airways were cultured and the mucous glycoprotein released into the supernatant analyzed. By incorporating 3H-labeled glucosa...

journal_title：Experimental lung research

authors： Shelhamer JH,Marom Z,Logun C,Kaliner M

更新日期：1984-01-01 00:00:00

abstract：:Octapeptide R2 (KVLDGQDP), which has anti-transglutaminas (TGase) activity, decreases inflammation in allergic conjunctivitis model in guinea pigs. The authors examined the effect of R2 on lipopolysaccharide (LPS)-induced lung injury in BALB/c mice. R2 inhalation significantly decreased neutrophil count and cytokine m...

journal_title：Experimental lung research

authors： Suh GY,Ham HS,Lee SH,Choi JC,Koh WJ,Kim SY,Lee J,Han J,Kim HP,Choi AM,Kwon OJ

更新日期：2006-01-01 00:00:00

abstract：:Survival of mice after Klebsiella pneumoniae infection and phagocytosis by alveolar macrophages (AMs), in the presence or absence of ozone (O(3)) exposure prior to infection, is sex dependent. The objective of this work was to study the role of gonadal hormones, 5α-dihydrotestosterone (DHT) and 17β-estradiol (E(2)), o...

journal_title：Experimental lung research

authors： Durrani F,Phelps DS,Weisz J,Silveyra P,Hu S,Mikerov AN,Floros J

更新日期：2012-05-01 00:00:00

abstract：:The morphology and phagocytic capacities of pulmonary macrophages recovered by lavage from normal rats were studied in vitro after incubation under various culture conditions. Most adherent macrophages (73 +/- 6%) were flat and exhibited ruffled surfaces. Phagocytosis of carbonyl iron beads by pulmonary macrophages wa...

journal_title：Experimental lung research

authors： Warheit DB,Hill LH,Brody AR

更新日期：1984-01-01 00:00:00

abstract：:COPD remains a public health problem that has yet to be fully recognized by the public, the medical community or public health (government) officials, and much work remains to be done worldwide to reverse the increasing trends of this chronic lung disease. ...

journal_title：Experimental lung research

authors： Hurd S

更新日期：2005-09-01 00:00:00

abstract：:The effects of urban air and diesel particles on inflammatory cytokine gene expression, tumor necrosis factor alpha (TNF-alpha) in particular, were studied in rat alveolar macrophages. TNF-alpha, interleukin (IL)-1, IL-6, cytokine-induced neutrophil chemoattractant (CINC), and macrophage inflammatory protein (MIP)-2 g...

journal_title：Experimental lung research

authors： Dong W,Lewtas J,Luster MI

更新日期：1996-09-01 00:00:00

abstract：:The molecular events involved in both the initiation and development of silicosis are at present poorly defined, although mediators released from macrophages exposed to silica particles are believed to play a role. We have investigated the in vitro production of arachidonic acid (AA) metabolites in adherent bovine alv...

journal_title：Experimental lung research

authors： Englen MD,Taylor SM,Laegreid WW,Liggitt HD,Silflow RM,Breeze RG,Leid RW

更新日期：1989-07-01 00:00:00

abstract：:It was hypothesized that IL-8, a neutrophil chemotaxin, contributes to the influx of neutrophils into the pleural cavity of patients with pleural effusions. Pleural fluids were collected from 57 patients including 13 with effusions due to congestive heart failure, 28 with pleural involvement by carcinoma, 5 with empye...

journal_title：Experimental lung research

authors： Miller EJ,Idell S

更新日期：1993-09-01 00:00:00

abstract：:Diesel exhaust particles (DEP) are associated with respiratory disease and exposure to diesel exhaust induces an inflammatory response associated with marked leukocytic infiltration in the lung. This study examined whether neutrophils are activated by the active component of DEP (methanol extract of DEP [me-DEP]). The...

journal_title：Experimental lung research

authors： Matsuzaki T,Amakawa K,Yamaguchi K,Ishizaka A,Terashima T,Matsumaru A,Morishita T

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Pulmonary ischemia-reperfusion (IR) is a biopathological event detectable in several clinical conditions, including lung transplantation, cardiopulmonary bypass, resuscitation, and pulmonary embolism. The understanding behind the activation of various inflammatory mediators regulating the apoptotic pathways ...

journal_title：Experimental lung research

authors： Dolkart O,E A,S S,S M,P G,Aa W

更新日期：2014-02-01 00:00:00

abstract：:Freeze-fracture was used to study the nonciliated epithelial (Clara) cell of rat bronchiole. En face views of the P face of the luminal cell membrane reveal particle-free bulging and circular depressions at the presumptive sites of the membrane fusion between the cell membrane and secretory granule membrane. Cross fra...

journal_title：Experimental lung research

authors： Yoneda K,Birk MG

更新日期：1981-08-01 00:00:00

abstract：:Aerosol bolus dispersion was measured in the first branching generations of a replicate hollow cast. The cast was made from a solid cast of a beagle-dog tracheobronchial tree. The dispersion was measured after penetration of boluses into different volumetric depths, with different particle sizes and flow rates into th...

journal_title：Experimental lung research

authors： Scheuch G,Stahlhofen W,Fang CP,Lippmann M

更新日期：1995-07-01 00:00:00