Roles of K+ and Cl- channels in cAMP-induced pulmonary vasodilation.

abstract：:The effects of urban air and diesel particles on inflammatory cytokine gene expression, tumor necrosis factor alpha (TNF-alpha) in particular, were studied in rat alveolar macrophages. TNF-alpha, interleukin (IL)-1, IL-6, cytokine-induced neutrophil chemoattractant (CINC), and macrophage inflammatory protein (MIP)-2 g...

journal_title：Experimental lung research

authors： Dong W,Lewtas J,Luster MI

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Serum amyloid A (SAA), an acute-phase protein whose level tracks infection and inflammation, is the precursor protein of amyloid A (AA) fibrils that is thought to cause AA amyloidosis in human and animals. SAA protein has several isoforms based on the difference of amino acid sequence, such as SA...

journal_title：Experimental lung research

authors： Kawasaki H,Murakami T,Badr Y,Kamiya S,Shimizu K,Okada A,Inoshima Y

更新日期：2020-11-01 00:00:00

abstract：:The aim of the study was to identify the effects on the lung after subchronic glass fiber intratracheal instillation study on rats. We evaluated the toxicological effects on the lung: persistent inflammatory reaction, cell proliferation, and pulmonary fibrosis on histopathological examination. We performed a glass fib...

journal_title：Experimental lung research

authors： Domokos-Hancu B,Man MA,Liana H,Pop CM

更新日期：2014-03-01 00:00:00

abstract：:The production of reactive oxygen species (ROS) during hyperoxia contribute to alveolar epithelial apoptosis. In the present study, the molecular mechanisms of oxidative stress-induced alveolar epithelial cell apoptosis were investigated. The cytoprotective effects of N-acetylcysteine (NAC) were evaluated. Treatments ...

journal_title：Experimental lung research

authors： Fu YQ,Fang F,Lu ZY,Kuang FW,Xu F

更新日期：2010-08-01 00:00:00

abstract：:Retention in the extrathoracic airways, and clearance by nose blowing, of monodisperse indium-111-labeled polystyrene particles were followed for at least 2 days after inhalation by healthy volunteers. Nine volunteers inhaled 3-μm aerodynamic diameter particles while sitting at rest, whereas subgroups of 3 or 4 inhale...

journal_title：Experimental lung research

authors： Smith JR,Bailey MR,Etherington G,Shutt AL,Youngman MJ

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We have previously reported that N-acetylcysteine (NAC), ambroxol and azithromycin (AZM) (partially) correct the chloride efflux dysfunction in cystic fibrosis bronchial epithelial (CFBE) cells with the ΔF508 homozygous mutation in vitro. METHODS:In the present paper, we further investigated p...

journal_title：Experimental lung research

authors： Hussain S,Varelogianni G,Särndahl E,Roomans GM

更新日期：2015-06-01 00:00:00

abstract：:Despite extensive research and clinical efforts made in the management of acute pancre-atitis during the past few decades, to date no effective cure is available and the mortality from severe acute pancre-atitis remains high. Given that lung is the primary cause of early death in acute pancreatitis patients, novel the...

journal_title：Experimental lung research

authors： Wang H,Wang S,Tang A,Gong H,Ma P,Chen L

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:As an angiotensin converting enzyme (ACE) inhibitor, the effects of captopril on inflammation has been previously examined. Captopril has been shown to have anti-inflammatory and antioxidant effects. Imbalance in the oxidant/antioxidant system is one of the major causes of inflammation. In the present study, th...

journal_title：Experimental lung research

authors： Boskabadi J,Mokhtari-Zaer A,Abareshi A,Khazdair MR,Emami B,Mohammadian Roshan N,Hosseini M,Boskabady MH

更新日期：2018-01-01 00:00:00

abstract：:Sex-related differences may be present during fetal lung growth and at the onset of surfactant synthesis. In this study we investigated the role of dihydrotestosterone (DHT) and estrogen (EST) on cell division and on labeled palmitate incorporation into disaturated phosphatidylcholine (DSPC) at various times of gestat...

journal_title：Experimental lung research

authors： McMillan EM,King GM,Adamson IY

更新日期：1989-03-01 00:00:00

abstract：:Prostaglandins (PGs) synthesized by fetal and neonatal lungs play pivotal roles in pulmonary physiology, especially during the transition from uterine to independent life. One regulator of prostaglandin synthesis at this time may be oxygen. We examined the effects of 1% O2, 21% O2 and 50% O2 in 5% CO2, balance N2 (PO2...

journal_title：Experimental lung research

authors： Olson DM,Tanswell AK

更新日期：1987-01-01 00:00:00

abstract：:Diesel exhaust particles (DEP) are associated with respiratory disease and exposure to diesel exhaust induces an inflammatory response associated with marked leukocytic infiltration in the lung. This study examined whether neutrophils are activated by the active component of DEP (methanol extract of DEP [me-DEP]). The...

journal_title：Experimental lung research

authors： Matsuzaki T,Amakawa K,Yamaguchi K,Ishizaka A,Terashima T,Matsumaru A,Morishita T

更新日期：2006-10-01 00:00:00

abstract：:Aims:Bronchopulmonary dysplasia (BPD) is characterized by alveolarization arrest. During alveolarization, alveolar myofibroblasts are thought to migrate into the septal tips and elongate secondary septa. Lipopolysaccharide (LPS) exposure has been reported to disrupt directional migration and final location of alveolar...

journal_title：Experimental lung research

authors： Li J,Gong X

更新日期：2020-01-01 00:00:00

abstract：:Emerging data indicate that endothelial-mesenchymal transition (EndMT) is involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). A previous study noted that blocking the activity of protein phosphatase 2 A (PP2A) could attenuate EndMT. However, the treatment effects of PP2A inhibitors in pulmonary fibros...

journal_title：Experimental lung research

authors： Yu J,Deng Y,Han M

更新日期：2020-09-01 00:00:00

abstract：:Suboptimal intake of dietary zinc (Zn) is one of the most common nutritional problems worldwide. Previously, the authors have shown that zinc deficiency (ZD) produces oxidative and nitrosative stress in lung of male rats. The goal of this study is to test the effect of moderate ZD on insulin-like growth factor (IGF)-1...

journal_title：Experimental lung research

authors： Biaggio VS,Pérez Chaca MV,Valdéz SR,Gómez NN,Gimenez MS

更新日期：2010-02-01 00:00:00

abstract：:The effect of a receptor binding protein for tumor necrosis factor (TNFrbp) on cell infiltration, bronchial hyperreactivity, and release of inflammatory mediators were studied following antigen challenge in sensitized rats. A 3-fold increase in total cell number, mainly neutrophils and eosinophils, was noted in bronch...

journal_title：Experimental lung research

authors： Carvalho CR,Jancar S,Conroy D,Sirois P

更新日期：2001-03-01 00:00:00

abstract：:In vitro observations of fetal lung maturation are complicated by continued epithelial cell maturation in culture. Removal of trace quantities of cortisol from the culture system has been reported elsewhere by Torday to prevent epithelial cell differentiation, but also prevent cell growth. In this report we have devel...

journal_title：Experimental lung research

authors： Tanswell AK,Joneja MG,Lindsay J,Vreeken E

更新日期：1983-07-01 00:00:00

abstract：:Mechanical strain initiates a variety of responses in pulmonary epithelial cells. The signaling pathways and molecular alterations leading to these responses remain unclear To identify novel signal transduction pathways activated by strain, macroarray analysis was performed on strained pulmonary epithelial cells. Glut...

journal_title：Experimental lung research

authors： Chess PR,O'Reilly MA,Toia L

更新日期：2004-12-01 00:00:00

abstract：:Variable numbers of composite repetitive motifs are found in different individuals within intron 4 of the surfactant protein B (SP-B) gene (Biochem J. 1995;305:583). This study tests the hypothesis that the distribution of SP-B alleles differs among racial/ethnic groups. A total of 412 SP-B alleles were analyzed: 206 ...

journal_title：Experimental lung research

authors： Veletza SV,Rogan PK,TenHave T,Olowe SA,Floros J

更新日期：1996-07-01 00:00:00

abstract：:Salvianolic acid B (Sal B), one of the major water-soluble compounds of Danshen (a popular Chinese herb), possesses many of the biological activities, such as antifibrogenic effect in liver and renal diseases. Transforming growth factor-β1 (TGF-β1) plays a central role in the development of pulmonary fibrosis by stimu...

journal_title：Experimental lung research

authors： Zhang M,Cao SR,Zhang R,Jin JL,Zhu YF

更新日期：2014-04-01 00:00:00

abstract：:Basement membranes (BM) are specialized extracellular matrices (ECM) which serve as complex interfaces between epithelia, peripheral nerves, or muscle cells and their surrounding tissue microenvironments. Their composition is known to include type IV collagen, laminin, entactin, heparan sulfate proteoglycan (HSPG, per...

journal_title：Experimental lung research

authors： Sannes PL,Wang J

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Inflammation is believed to play a key role in the pathophysiology of meconium aspiration syndrome (MAS). PURPOSE OF THE STUDY:The objective was to determine whether the recombinant human Erythropoietin (rhEPO) pretreatment could attenuate meconium-induced inflammation. MATERIALS AND METHODS:In this study,...

journal_title：Experimental lung research

authors： Turhan AH,Atici A,Muşlu N,Polat A,Sungur MA

更新日期：2016-05-01 00:00:00

abstract：:Irreversible lung parenchymal injury is usually healed by fibrosis, which depends on the abilities of fibroblasts to proliferate, migrate into the wound, and survive. Because the lung is frequently exposed to increased oxidative stress, which is thought to mediate apoptosis, we examined whether oxidative stress induce...

journal_title：Experimental lung research

authors： Takahashi A,Aoshiba K,Nagai A

更新日期：2002-06-01 00:00:00

abstract：:Distinct barrier lesions and an apical-basal distribution of alveolar edema fluid in either moderate or high elevated pressure edema lungs have been found in previous studies. In the present study, quantitative measurements were obtained by using electron microscopy and morphometry of extravascular lung water and barr...

journal_title：Experimental lung research

authors： Wu DX,Weibel ER,Bachofen H,Schürch S

更新日期：1995-09-01 00:00:00

abstract：:Thrombin activates protease-activated receptor (PAR)-1 and induces a myofibroblast phenotype in normal lung fibroblasts. The origins of myofibroblasts are resident fibroblasts, fibrocytes, and epithelial-mesenchymal transition (EMT). We investigated the effects of thrombin, an important mediator of interstitial lung f...

journal_title：Experimental lung research

authors： Song JS,Kang CM,Park CK,Yoon HK

更新日期：2013-10-01 00:00:00

abstract：:Previously, this laboratory has shown that intratracheally administered hyaluronic acid (HA) significantly reduces air-space enlargement in a hamster model of emphysema induced with pancreatic elastase. Whereas HA was given immediately following elastase in those initial studies, the current investigation determined t...

journal_title：Experimental lung research

authors： Cantor JO,Cerreta JM,Armand G,Turino GM

更新日期：1997-05-01 00:00:00

abstract：:Administering liposome-encapsulated drugs by aerosols could be a feasible way of targeting drugs to the lung, specifically to pulmonary alveolar macrophages (AM). In the mouse model, we characterized uptake of carboxyfluorescein- (CF-) labeled liposomes by AM in vivo after acute inhalation of liposome aerosols, and th...

journal_title：Experimental lung research

authors： Myers MA,Thomas DA,Straub L,Soucy DW,Niven RW,Kaltenbach M,Hood CI,Schreier H,Gonzalez-Rothi RJ

更新日期：1993-01-01 00:00:00

abstract：:Amiodarone, a cardiac antiarrhythmic agent, has been associated with the development of interstitial pulmonary fibrosis in patients receiving prolonged therapy with the drug. To further assess the toxic effects of amiodarone on lung tissue, Syrian hamsters were given a single intratracheal insufflation of the agent an...

journal_title：Experimental lung research

authors： Cantor JO,Osman M,Cerreta JM,Suarez R,Mandl I,Turino GM

更新日期：1984-01-01 00:00:00

abstract：:The morphology and phagocytic capacities of pulmonary macrophages recovered by lavage from normal rats were studied in vitro after incubation under various culture conditions. Most adherent macrophages (73 +/- 6%) were flat and exhibited ruffled surfaces. Phagocytosis of carbonyl iron beads by pulmonary macrophages wa...

journal_title：Experimental lung research

authors： Warheit DB,Hill LH,Brody AR

更新日期：1984-01-01 00:00:00

abstract：:This study evaluated polymorphonuclear leukocyte (PMN) involvement in translocation of dust to bronchial lymph nodes after deposition of dust in the lungs of control and neutropenic F344/N rats. Rats were rendered neutropenic with an intraperitoneal (IP) injection of anti-rat PMN antiserum (APA); control rats were inj...

journal_title：Experimental lung research

authors： Snipes MB,Harkema JR,Hotchkiss JA,Bice DE

更新日期：1997-01-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) generates angiotensin II and degrades bradykinin. This ectopeptidase acts as a marker in pathologic conditions, showing tissue and vascular damage. In order to evaluate serum and tissue ACE activity in bleomycin-associated lung damage, the authors studied morphological and enzymatic...

journal_title：Experimental lung research

authors： Ziai SA,Salehian P,Mahmoudian M

更新日期：2004-03-01 00:00:00