Abstract:
:Nicotine appears to be the primary pharmacologic agent that causes smoking-related pulmonary diseases. An understanding of the effect of nicotine on lungs is essential to develop interventions that can be used to counter smoking-related diseases. Further, it is shown that physical exercise may partially reverse smoking-induced pathological changes in experimental animals. Hence, this study focuses on the pathological changes in rat lung following nicotine administration and the role of exercise in reversing the nicotine-induced lung injury. This is a randomized controlled trial with 3 groups of rats. Control (CG), nicotine-exposed (NG), and nicotine-exposed and exercise group (NEG). Control group received no intervention. Both NG and NEG were given 1.5 mg/kg nicotine base, daily, subcutaneously, but NEG were also subjected to an intensive daily swimming protocol. The rats were sacrificed and the lung tissue was processed for light and transmission electron microscopic and immunohistochemical studies. Compared with the control group, the nicotine group showed enlargement and destruction of the alveolar septum, cellular hyperplasia and interstitial fibrosis, and interstitial mononuclear cell infiltration with increased intraluminal macrophages. There was only modest morphological change between the nicotine administered and nicotine and exercise groups. Expression of superoxide dismutase (SOD) and catalase showed a mild increase in the NEG, whereas glutathione peroxidase (GPX) showed mild and moderate increase in the expression in the NG and NEG, respectively. This study shows that nicotine induces substantial pathological changes in the lung and prolonged exercise may have some beneficial effects in partially reversing the nicotine-induced lung injury by inducing the expression of antioxidants.
journal_name
Exp Lung Resjournal_title
Experimental lung researchauthors
Al-Obaidi S,Mathew TC,Dean Edoi
10.3109/01902148.2012.666331subject
Has Abstractpub_date
2012-05-01 00:00:00pages
211-21issue
4eissn
0190-2148issn
1521-0499journal_volume
38pub_type
杂志文章abstract::Aims:Bronchopulmonary dysplasia (BPD) is characterized by alveolarization arrest. During alveolarization, alveolar myofibroblasts are thought to migrate into the septal tips and elongate secondary septa. Lipopolysaccharide (LPS) exposure has been reported to disrupt directional migration and final location of alveolar...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902148.2019.1711464
更新日期:2020-01-01 00:00:00
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journal_title:Experimental lung research
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doi:10.1080/01902140490252858
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journal_title:Experimental lung research
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doi:10.3109/01902149509031767
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journal_title:Experimental lung research
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doi:10.3109/01902149809041534
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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doi:10.3109/01902148709064319
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902148.2018.1563924
更新日期:2018-01-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902140600817515
更新日期:2006-06-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148.2012.704484
更新日期:2012-09-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902148.2016.1207727
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Serum amyloid A (SAA), an acute-phase protein whose level tracks infection and inflammation, is the precursor protein of amyloid A (AA) fibrils that is thought to cause AA amyloidosis in human and animals. SAA protein has several isoforms based on the difference of amino acid sequence, such as SA...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902148.2020.1809750
更新日期:2020-11-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149109064428
更新日期:1991-03-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148.2015.1046200
更新日期:2015-01-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148.2012.660559
更新日期:2012-05-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148709064304
更新日期:1987-01-01 00:00:00
abstract::The role of bombesin was investigated in the course of the pulmonary inflammation and fibrosis (PF) elicited by the intratracheal (IT) or intravenous (i.v.) administration of bleomycin in mice. Bleomycin-induced alveolitis was associated with an accumulation of cells, presumably macrophages, containing bombesin, as ev...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509068829
更新日期:1995-03-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149209031681
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148009065460
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148609064295
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journal_title:Experimental lung research
pub_type: 杂志文章
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更新日期:1990-03-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148209039246
更新日期:1982-12-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148.2010.482176
更新日期:2010-11-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902148.2017.1294632
更新日期:2017-03-01 00:00:00
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更新日期:2000-10-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149509031756
更新日期:1995-07-01 00:00:00
abstract::CTP:cholinephosphate cytidylyltransferase (CT) is a key enzyme required for surfactant phosphatidylcholine synthesis, and its activity is regulated by lung lipids. This study evaluated the effect of epidermal growth factor (EGF) on the phospholipid content and the expression of CT in the lung following direct in vivo ...
journal_title:Experimental lung research
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doi:10.3109/01902149409064369
更新日期:1994-01-01 00:00:00