Abstract:
:This study describes the morphology of the adaptive response of the pulmonary parenchyma after the resection of lung tissue. Rats aged 23 days were subjected to the bilobectomy of the right upper and middle lobes representing 25% of the total lung volume. On the postoperative Days 1, 4, 6, 9, 12, 18, and 30, the lungs were fixed by standardized intratracheal instillation of fixative, their volume determined by water displacement, and pieces of the left lung prepared for scanning electron microscopy (SEM). Age-matched normal and sham-operated animals served as controls. Lung volumes of operated rats rapidly matched control values. In SEM, the volume gain appeared to be achieved by a widening of the airspaces affecting primarily the alveolar ducts on postoperative Day 1 and shifting later to the alveolar level (Day 4). On Days 4 and 6, the interalveolar septa were slightly thickened, presumably due to a proliferative response in the tissue, which is well documented in the literature. From Day 9 onwards, morphology of bilobectomized lungs did not differ from normal. At no instances we could detect clues for the formation of new alveoli. Several possible explanations for this structural recovery of the pulmonary parenchyma are discussed. Among these, a model is presented illustrating how the parenchymal morphology can be apparently normalized by the tissue proliferation, which renders the original widening of the airspaces unobtrusive on random sections through the respiratory tissue.
journal_name
Exp Lung Resjournal_title
Experimental lung researchauthors
Burri PH,Pfrunder HB,Berger LCdoi
10.3109/01902148209039246subject
Has Abstractpub_date
1982-12-01 00:00:00pages
11-28issue
1eissn
0190-2148issn
1521-0499journal_volume
4pub_type
杂志文章abstract::In order to investigate some of the characteristics of superoxide anion release from alveolar macrophages, the effects of substances known to influence superoxide release from polymorphonuclear leukocytes (PMN) were studied in rat alveolar macrophages. There is a relatively small, but constant, amount of superoxide re...
journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902148109052305
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journal_title:Experimental lung research
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doi:10.3109/01902141003678582
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journal_title:Experimental lung research
pub_type: 杂志文章
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.1080/01902140601047641
更新日期:2006-10-01 00:00:00
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journal_title:Experimental lung research
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journal_title:Experimental lung research
pub_type: 杂志文章
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更新日期:1980-03-01 00:00:00
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journal_title:Experimental lung research
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更新日期:1995-01-01 00:00:00
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149609046037
更新日期:1996-07-01 00:00:00
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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journal_title:Experimental lung research
pub_type: 杂志文章
doi:10.3109/01902149309064361
更新日期:1993-11-01 00:00:00
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journal_title:Experimental lung research
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更新日期:2002-10-01 00:00:00
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journal_title:Experimental lung research
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更新日期:2017-03-01 00:00:00
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journal_title:Experimental lung research
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journal_title:Experimental lung research
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更新日期:1987-01-01 00:00:00