Alteration of TGF-β-ALK-Smad signaling in hyperoxia-induced bronchopulmonary dysplasia model of newborn rats.

abstract：:Neutrophilic inflammation is responsible for much of the tissue damage seen in many lung diseases. For resolution of inflammation to occur, neutrophils must die by apoptosis, allowing their recognition and removal by macrophages. The molecular events controlling this important regulatory step are poorly understood, in...

journal_title：Experimental lung research

authors： Renshaw SA,Loynes CA,Elworthy S,Ingham PW,Whyte MK

更新日期：2007-12-01 00:00:00

abstract：:During lung development, the extracellular matrix undergoes dynamic remodeling. Matrix metalloproteinases (MMPs), and tissue inhibitors of matrix metalloproteinases (TIMPs), are important enzymes that participate in regulating tissue remodeling. There is an abnormal balance of the synthesis and degradation of collagen...

journal_title：Experimental lung research

authors： Lemke RP,Zhang W,Balcerazak D,Kobayashi K,Schwingshackl A,Cheung PY,Dixon WT,Baracos VE,Greer JJ

更新日期：2003-06-01 00:00:00

abstract：:Lamellar bodies, the intracellular storage form of pulmonary surfactant, were isolated from adult human lung tissue. As shown by electron microscopy, the isolated human lamellar bodies resembled the lamellar bodies isolated from experimental animals. Chemical analysis revealed that the lamellar bodies consisted largel...

journal_title：Experimental lung research

authors： Post M,Batenburg JJ,Schuurmans EA,Laros CD,van Golde LM

更新日期：1982-02-01 00:00:00

abstract：:A past study demonstrated that all-trans-retinoic acid (ATRA) treatment by intraperitoneal injection in a rat model of elastase-induced emphysema caused tissue regeneration as evidenced by a decrease in alveolar size and lung volume and an increase in alveolar number. We postulated that treatment with this retinoid by...

journal_title：Experimental lung research

authors： March TH,Cossey PY,Esparza DC,Dix KJ,McDonald JD,Bowen LE

更新日期：2004-07-01 00:00:00

abstract：:COPD remains a public health problem that has yet to be fully recognized by the public, the medical community or public health (government) officials, and much work remains to be done worldwide to reverse the increasing trends of this chronic lung disease. ...

journal_title：Experimental lung research

authors： Hurd S

更新日期：2005-09-01 00:00:00

abstract：:A cast of human tracheobronchial airways, which is complete to airways less than 0.1 cm in diameter, was employed for experimental studies of gas convective transport by high-frequency ventilation (HFV). The cast was ventilated with gases of different kinematic viscosity (He, air, and SF6) and tidal volumes of 10-60 m...

journal_title：Experimental lung research

authors： Fang CP,Cohen BS,Lippmann M

更新日期：1992-09-01 00:00:00

abstract：:Despite extensive research and clinical efforts made in the management of acute pancre-atitis during the past few decades, to date no effective cure is available and the mortality from severe acute pancre-atitis remains high. Given that lung is the primary cause of early death in acute pancreatitis patients, novel the...

journal_title：Experimental lung research

authors： Wang H,Wang S,Tang A,Gong H,Ma P,Chen L

更新日期：2014-08-01 00:00:00

abstract：:ABSTRACT During fetal development physiological stretching helps drive lung growth and maturation. At birth, the α-subunit of the alveolar epithelial sodium channel (α-ENaC) is a critical factor in helping to facilitate clearance of lung fluid during the perinatal period. The effects of stretch, however, on α-ENaC exp...

journal_title：Experimental lung research

authors： Mustafa SB,Isaac J,Seidner SR,Dixon PS,Henson BM,DiGeronimo RJ

更新日期：2014-10-01 00:00:00

abstract：:The molecular events involved in both the initiation and development of silicosis are at present poorly defined, although mediators released from macrophages exposed to silica particles are believed to play a role. We have investigated the in vitro production of arachidonic acid (AA) metabolites in adherent bovine alv...

journal_title：Experimental lung research

authors： Englen MD,Taylor SM,Laegreid WW,Liggitt HD,Silflow RM,Breeze RG,Leid RW

更新日期：1989-07-01 00:00:00

abstract：AIM OF THE STUDY:Interleukin (IL)-10 is an anti-inflammatory cytokine, but its role in cigarette smoke (CS)-induced inflammation and chronic obstructive pulmonary disease (COPD) has not been fully elucidated. The purpose of this study was to investigate the effect of IL-10 deficiency on CS-induced pulmonary inflammatio...

journal_title：Experimental lung research

authors： Higaki M,Wada H,Mikura S,Yasutake T,Nakamura M,Niikura M,Kobayashi F,Kamma H,Kamiya S,Ito K,Barnes PJ,Goto H,Takizawa H

更新日期：2015-01-01 00:00:00

abstract：:The inhalation of inorganic dust can lead to the development of interstitial pulmonary fibrosis, characterized by the accumulation of fibroblasts and connective tissue matrix in the lung interstitium. The fibrosis causes alterations in the architecture of the lung parenchyma, resulting in abnormal gas exchange and hyp...

journal_title：Experimental lung research

authors： Schapira RM,Osornio-Vargas AR,Brody AR

更新日期：1991-11-01 00:00:00

abstract：:The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF...

journal_title：Experimental lung research

authors： Alho HS,Maasilta PK,Vainikka T,Salminen US

更新日期：2007-08-01 00:00:00

abstract：:Leukotrienes (LTs) are potent vasoconstrictors in the pulmonary circulation. We investigated LTB4 and LTE4 metabolism by intrapulmonary arteries and veins of 2 to 9 days old lambs (n = 6). Paired vessels were incubated under baseline, and stimulated conditions. LTB4 and LTE4 were extracted from media, quantfied by enz...

journal_title：Experimental lung research

authors： Ibe BO,Raj JU

更新日期：2001-06-01 00:00:00

abstract：:The integrity of the respiratory epithelium is crucial for airway homeostasis. Tobacco smoke exposure and recurrent infections of the airways play a crucial role in the progression and in the decline of the respiratory function in chronic obstructive pulmonary disease (COPD). The aim of this study was to detect differ...

journal_title：Experimental lung research

authors： D'Anna C,Cigna D,Di Sano C,Di Vincenzo S,Dino P,Ferraro M,Bini L,Bianchi L,Di Gaudio F,Gjomarkaj M,Pace E

更新日期：2017-01-01 00:00:00

abstract：:We studied lung clearance of aerosolized technetium-labeled diethylenetriamine pentaacetic acid (99mTcDTPA), plasma concentrations of 6-keto-PGF1 alpha and thromboxane B2, and pulmonary edema as indices of lung injury in rabbits exposed to cigarette smoke (CSE). Forty-six rabbits were randomly assigned to 4 groups: co...

journal_title：Experimental lung research

authors： Witten ML,Lemen RJ,Quan SF,Sobonya RE,Magarelli JL,Bruck DC

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Serum amyloid A (SAA), an acute-phase protein whose level tracks infection and inflammation, is the precursor protein of amyloid A (AA) fibrils that is thought to cause AA amyloidosis in human and animals. SAA protein has several isoforms based on the difference of amino acid sequence, such as SA...

journal_title：Experimental lung research

authors： Kawasaki H,Murakami T,Badr Y,Kamiya S,Shimizu K,Okada A,Inoshima Y

更新日期：2020-11-01 00:00:00

abstract：:The authors recently showed that preterm birth per se, in the absence of assisted ventilation or elevated inhaled oxygen levels, alters the structure of the airway walls in young lambs. The initial aim of the present study was to determine whether these changes persist into adulthood. Preterm (P; n = 7) lambs were del...

journal_title：Experimental lung research

authors： Snibson K,Harding R

更新日期：2008-02-01 00:00:00

abstract：:Verapamil, a calcium channel blocker has been used with partial success in cases of primary pulmonary hypertension, as well as to reduce hypoxia-induced pulmonary hypertension (PH) in rats. However, its effect on monocrotaline (MCT)-induced PH in rats is not known. We studied the effect of verapamil on MCT-induced PH....

journal_title：Experimental lung research

authors： Mathew R,Guzowski DE,Gloster ES

更新日期：1990-11-01 00:00:00

abstract：:Transforming growth factor alpha (TGF(alpha)) stimulates type II alveolar epithelial cell proliferation and also is associated with fibrosis. We studied the changes in bronchoalveolar lavage (BAL) TGF(alpha) protein in a neonatal rabbit hyperoxia-fibrosis model (100% O(2) for 8 to 9 days, followed by 60% O(2) to 36 da...

journal_title：Experimental lung research

authors： Waheed S,D'Angio CT,Wagner CL,Madtes DK,Finkelstein JN,Paxhia A,Ryan RM

更新日期：2002-07-01 00:00:00

abstract：:Activity for nonspecific esterases has been demonstrated histochemically in fetal rabbit lungs using alpha-naphthyl acetate as substrate. Commencing with a homogeneous distribution in pseudoglandular lungs, activity gradually heightens in the epithelium, progresses centrifugally along the bronchial tree, and reaches f...

journal_title：Experimental lung research

authors： Sorokin SP,Hoyt RF Jr

更新日期：1982-11-01 00:00:00

abstract：:The percentage 24-h lung retention of 4-micrometers monodispersed Teflon particles, aerodynamic diameter about 6 micrometers, was studied twice in 8 healthy nonsmokers. The particles were inhaled at 0.5 liter/sec with maximally deep breaths. Bronchoconstriction was induced by inhalation of a methacholine-bromide aeros...

journal_title：Experimental lung research

authors： Svartengren M,Philipson K,Linnman L,Camner P

更新日期：1984-01-01 00:00:00

abstract：:Previously, the authors have shown that tracheal occlusion (TO) partially reverses the onset of congenital diaphragmatic hernia (CDH)-induced pulmonary hypertension (PH) and abnormal pulmonary vascular development whereas release of the occlusion (TR) abolishes these clinical benefits. As a consequence of their mitoge...

journal_title：Experimental lung research

authors： Cloutier M,Seaborn T,Piedboeuf B,Bratu I,Flageole H,Laberge JM

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Mechanisms linking behavioral stress and inflammation are poorly understood, mainly in distal lung tissue. OBJECTIVE:We have investigated whether the forced swim stress (FS) could modulate lung tissue mechanics, iNOS, cytokines, oxidative stress activation, eosinophilic recruitment, and remodeling in guinea...

journal_title：Experimental lung research

authors： Reis FG,Marques RH,Starling CM,Almeida-Reis R,Vieira RP,Cabido CT,Silva LF,Lanças T,Dolhnikoff M,Martins MA,Leick-Maldonado EA,Prado CM,Tibério IF

更新日期：2012-09-01 00:00:00

abstract：:The effects of Zizyphi fructus, a major constituent of Chinese anti-asthmatic herbal medicine, on ciliary motility and nitric oxide (NO) generation in canine cultured tracheal epithelium were studied by the microphoto-oscillation method and the specific amperometric method, respectively. Addition of Zizyphi fructus at...

journal_title：Experimental lung research

authors： Tamaoki J,Kondo M,Tagaya E,Takemura K,Konno K

更新日期：1996-05-01 00:00:00

abstract：AIM OF THE STUDY:Nucleic acid-based therapies have the potential to provide clinically meaningful benefit across a wide spectrum of lung disease. However, in vivo delivery remains a challenge. Here we examined the feasibility of using electrospray to deliver nucleic acids to both porcine tracheal tissue sections and wh...

journal_title：Experimental lung research

authors： Riddell P,Gilbert JL,Molloy EL,Finnegan S,Egan JJ,O'Dea S

更新日期：2018-01-01 00:00:00

abstract：:Two morphologic characteristics have been used to define the nonciliated bronchiolar epithelial cell: abundant agranular endoplasmic reticulum (AER) and membrane-bound avoid granules. To assess the ultrastructural homogeneity of this cell type in the lungs of large domestic mammals used as experimental models in pulmo...

journal_title：Experimental lung research

authors： Plopper CG,Mariassy AT,Hill LH

更新日期：1980-06-01 00:00:00

abstract：:To better understand the mechanisms by which neutrophils migrate into the airways, we constructed a novel in vitro model system with human umbilical vein endothelial cell (HUVE) monolayers grown on top of permeable filters and human lung Type II-like alveolar epithelial cell (A549) monolayers grown on the undersurface...

journal_title：Experimental lung research

authors： Casale TB,Mower DA,Carolan EJ

更新日期：1998-11-01 00:00:00

abstract：:We set out to determine whether or not the "mucolytic" drug N-acetylcysteine would speed the reversal of cigarette smoke-induced secretory-cell hyperplasia to normal, similar to that found previously for two nonsteroidal antiinflammatory drugs. Cigarette smoke alone significantly (p less than 0.01) increased the numbe...

journal_title：Experimental lung research

authors： Rogers DF,Godfrey RW,Majumdar S,Jeffery PK

更新日期：1988-01-01 00:00:00

abstract：:We studied lung clearance of technetium-labeled diethylenetriamine pentaacetic acid [( 99mTc]DTPA), plasma and bronchoalveolar lavage fluid (BALF) concentrations of 6-keto-PGF1 alpha (stable metabolite of prostacyclin, prostaglandin I2, PGI2), TxB2 (stable metabolite of thromboxane A2, TxA2), and leukotriene B4 (LTB4)...

journal_title：Experimental lung research

authors： Witten ML,Quan SF,Sobonya RE,Bruck D,Devine L,Lemen RJ

更新日期：1988-01-01 00:00:00

abstract：:A small subpopulation of pulmonary epithelial cells (PE) proliferates in low-density primary culture of alveolar type II cells and forms colonies of cells that could be passaged for several generations and that in some respects maintain a differentiated phenotype of the alveolar type II cells. At this time it is not k...

journal_title：Experimental lung research

authors： Kalina M,Riklis S,Blau H

更新日期：1993-03-01 00:00:00