听力与言语-语言病理学

行为科学

医学伦理学

  • Cross-talk of insulin-like peptides, juvenile hormone, and 20-hydroxyecdysone in regulation of metabolism in the mosquito Aedes aegypti.

    abstract::Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2023470118

    authors: Ling L,Raikhel AS

    更新日期:2021-02-09 00:00:00

  • The novel PII-interactor PirC identifies phosphoglycerate mutase as key control point of carbon storage metabolism in cyanobacteria.

    abstract::Nitrogen limitation imposes a major transition in the lifestyle of nondiazotrophic cyanobacteria that is controlled by a complex interplay of regulatory factors involving the pervasive signal processor PII Immediately upon nitrogen limitation, newly fixed carbon is redirected toward glycogen synthesis. How the metabol...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2019988118

    authors: Orthwein T,Scholl J,Spät P,Lucius S,Koch M,Macek B,Hagemann M,Forchhammer K

    更新日期:2021-02-09 00:00:00

  • Observing ozone chemistry in an occupied residence.

    abstract::Outdoor ozone transported indoors initiates oxidative chemistry, forming volatile organic products. The influence of ozone chemistry on indoor air composition has not been directly quantified in normally occupied residences. Here, we explore indoor ozone chemistry in a house in California with two adult inhabitants. W...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2018140118

    authors: Liu Y,Misztal PK,Arata C,Weschler CJ,Nazaroff WW,Goldstein AH

    更新日期:2021-02-09 00:00:00

  • The KRAS and other prenylated polybasic domain membrane anchors recognize phosphatidylserine acyl chain structure.

    abstract::KRAS interacts with the inner leaflet of the plasma membrane (PM) using a hybrid anchor that comprises a lysine-rich polybasic domain (PBD) and a C-terminal farnesyl chain. Electrostatic interactions have been envisaged as the primary determinant of interactions between KRAS and membranes. Here, we integrated molecula...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2014605118

    authors: Zhou Y,Prakash PS,Liang H,Gorfe AA,Hancock JF

    更新日期:2021-02-09 00:00:00

  • High-resolution imaging reveals compartmentalization of mitochondrial protein synthesis in cultured human cells.

    abstract::Human mitochondria contain their own genome, mitochondrial DNA, that is expressed in the mitochondrial matrix. This genome encodes 13 vital polypeptides that are components of the multisubunit complexes that couple oxidative phosphorylation (OXPHOS). The inner mitochondrial membrane that houses these complexes compris...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2008778118

    authors: Zorkau M,Albus CA,Berlinguer-Palmini R,Chrzanowska-Lightowlers ZMA,Lightowlers RN

    更新日期:2021-02-09 00:00:00

  • Early phonetic learning without phonetic categories: Insights from large-scale simulations on realistic input.

    abstract::Before they even speak, infants become attuned to the sounds of the language(s) they hear, processing native phonetic contrasts more easily than nonnative ones. For example, between 6 to 8 mo and 10 to 12 mo, infants learning American English get better at distinguishing English and [l], as in "rock" vs. "lock," relat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2001844118

    authors: Schatz T,Feldman NH,Goldwater S,Cao XN,Dupoux E

    更新日期:2021-02-09 00:00:00

  • Benthic invaders control the phosphorus cycle in the world's largest freshwater ecosystem.

    abstract::The productivity of aquatic ecosystems depends on the supply of limiting nutrients. The invasion of the Laurentian Great Lakes, the world's largest freshwater ecosystem, by dreissenid (zebra and quagga) mussels has dramatically altered the ecology of these lakes. A key open question is how dreissenids affect the cycli...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2008223118

    authors: Li J,Ianaiev V,Huff A,Zalusky J,Ozersky T,Katsev S

    更新日期:2021-02-09 00:00:00

  • Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit.

    abstract::RNA-dependent RNA polymerases (RdRps) of the Nidovirales (Coronaviridae, Arteriviridae, and 12 other families) are linked to an amino-terminal (N-terminal) domain, called NiRAN, in a nonstructural protein (nsp) that is released from polyprotein 1ab by the viral main protease (Mpro). Previously, self-GMPylation/UMPylat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2022310118

    authors: Slanina H,Madhugiri R,Bylapudi G,Schultheiß K,Karl N,Gulyaeva A,Gorbalenya AE,Linne U,Ziebuhr J

    更新日期:2021-02-09 00:00:00

  • Adenovirus-vectored vaccine containing multidimensionally conserved parts of the HIV proteome is immunogenic in rhesus macaques.

    abstract::An effective vaccine that can protect against HIV infection does not exist. A major reason why a vaccine is not available is the high mutability of the virus, which enables it to evolve mutations that can evade human immune responses. This challenge is exacerbated by the ability of the virus to evolve compensatory mut...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2022496118

    authors: Murakowski DK,Barton JP,Peter L,Chandrashekar A,Bondzie E,Gao A,Barouch DH,Chakraborty AK

    更新日期:2021-02-02 00:00:00

  • Tissue-specific dynamic codon redefinition in Drosophila.

    abstract::Translational stop codon readthrough occurs in organisms ranging from viruses to mammals and is especially prevalent in decoding Drosophila and viral mRNAs. Recoding of UGA, UAG, or UAA to specify an amino acid allows a proportion of the protein encoded by a single gene to be C-terminally extended. The extended produc...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2012793118

    authors: Hudson AM,Szabo NL,Loughran G,Wills NM,Atkins JF,Cooley L

    更新日期:2021-02-02 00:00:00

  • Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.

    abstract::Glyco-immune checkpoint receptors, molecules that inhibit immune cell activity following binding to glycosylated cell-surface antigens, are emerging as attractive targets for cancer immunotherapy. Defining biologically relevant ligands that bind and activate such receptors, however, has historically been a significant...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2015024118

    authors: Wisnovsky S,Möckl L,Malaker SA,Pedram K,Hess GT,Riley NM,Gray MA,Smith BAH,Bassik MC,Moerner WE,Bertozzi CR

    更新日期:2021-02-02 00:00:00

  • Bistability in oxidative stress response determines the migration behavior of phytoplankton in turbulence.

    abstract::Turbulence is an important determinant of phytoplankton physiology, often leading to cell stress and damage. Turbulence affects phytoplankton migration both by transporting cells and by triggering switches in migratory behavior, whereby vertically migrating cells can actively invert their direction of migration upon e...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2005944118

    authors: Carrara F,Sengupta A,Behrendt L,Vardi A,Stocker R

    更新日期:2021-02-02 00:00:00

  • Efficient detection and post-surgical monitoring of colon cancer with a multi-marker DNA methylation liquid biopsy.

    abstract::Multiplex assays, involving the simultaneous use of multiple circulating tumor DNA (ctDNA) markers, can improve the performance of liquid biopsies so that they are highly predictive of cancer recurrence. We have developed a single-tube methylation-specific quantitative PCR assay (mqMSP) that uses 10 different methylat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2017421118

    authors: Jin S,Zhu D,Shao F,Chen S,Guo Y,Li K,Wang Y,Ding R,Gao L,Ma W,Lu T,Li D,Zhang Z,Cai S,Liang X,Song H,Ji L,Li J,Zheng Z,Jiang F,Wu X,Luan J,Zhang H,Yang Z,Cantor CR,Xu C,Ding C

    更新日期:2021-02-02 00:00:00

  • Wireless, soft electronics for rapid, multisensor measurements of hydration levels in healthy and diseased skin.

    abstract::Precise, quantitative measurements of the hydration status of skin can yield important insights into dermatological health and skin structure and function, with additional relevance to essential processes of thermoregulation and other features of basic physiology. Existing tools for determining skin water content expl...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2020398118

    authors: Kwon K,Wang H,Lim J,Chun KS,Jang H,Yoo I,Wu D,Chen AJ,Gu CG,Lipschultz L,Kim JU,Kim J,Jeong H,Luan H,Park Y,Su CJ,Ishida Y,Madhvapathy SR,Ikoma A,Kwak JW,Yang DS,Banks A,Xu S,Huang Y,Chang JK,Rogers JA

    更新日期:2021-02-02 00:00:00

  • Bayesian estimation of SARS-CoV-2 prevalence in Indiana by random testing.

    abstract::From 25 to 29 April 2020, the state of Indiana undertook testing of 3,658 randomly chosen state residents for the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, the agent causing COVID-19 disease. This was the first statewide randomized study of COVID-19 testing in the United States. Both PC...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2013906118

    authors: Yiannoutsos CT,Halverson PK,Menachemi N

    更新日期:2021-02-02 00:00:00

  • The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.

    abstract::RNA helicases play roles in various essential biological processes such as RNA splicing and editing. Recent in vitro studies show that RNA helicases are involved in immune responses toward viruses, serving as viral RNA sensors or immune signaling adaptors. However, there is still a lack of in vivo data to support the ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2017432118

    authors: Wang Y,He K,Sheng B,Lei X,Tao W,Zhu X,Wei Z,Fu R,Wang A,Bai S,Zhang Z,Hong N,Ye C,Tian Y,Wang J,Li M,Zhang K,Li L,Yang H,Li HB,Flavell RA,Zhu S

    更新日期:2021-01-26 00:00:00

  • A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.

    abstract::An ability to safely harness the powerful regenerative potential of adult stem cells for clinical applications is critically dependent on a comprehensive understanding of the underlying mechanisms regulating their activity. Epithelial organoid cultures accurately recapitulate many features of in vivo stem cell-driven ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2016806118

    authors: Murakami K,Terakado Y,Saito K,Jomen Y,Takeda H,Oshima M,Barker N

    更新日期:2021-01-26 00:00:00

  • Tocopherol controls D1 amino acid oxidation by oxygen radicals in Photosystem II.

    abstract::Photosystem II (PSII) is an intrinsic membrane protein complex that functions as a light-driven water:plastoquinone oxidoreductase in oxygenic photosynthesis. Electron transport in PSII is associated with formation of reactive oxygen species (ROS) responsible for oxidative modifications of PSII proteins. In this study...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2019246118

    authors: Kumar A,Prasad A,Sedlářová M,Kale R,Frankel LK,Sallans L,Bricker TM,Pospíšil P

    更新日期:2021-01-26 00:00:00

  • Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the N-nitrosourea-producing enzyme SznF.

    abstract::In biosynthesis of the pancreatic cancer drug streptozotocin, the tridomain nonheme-iron oxygenase SznF hydroxylates Nδ and Nω' of Nω-methyl-l-arginine before oxidatively rearranging the triply modified guanidine to the N-methyl-N-nitrosourea pharmacophore. A previously published structure visualized the monoiron cofa...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2015931118

    authors: McBride MJ,Pope SR,Hu K,Okafor CD,Balskus EP,Bollinger JM Jr,Boal AK

    更新日期:2021-01-26 00:00:00

  • Evolution and demise of passive margins through grain mixing and damage.

    abstract::How subduction-the sinking of cold lithospheric plates into the mantle-is initiated is one of the key mysteries in understanding why Earth has plate tectonics. One of the favored locations for subduction triggering is at passive margins, where sea floor abuts continental margins. Such passive margin collapse is proble...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2011247118

    authors: Bercovici D,Mulyukova E

    更新日期:2021-01-26 00:00:00

  • Long-range structural defects by pathogenic mutations in most severe glucose-6-phosphate dehydrogenase deficiency.

    abstract::Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common blood disorder, presenting multiple symptoms, including hemolytic anemia. It affects 400 million people worldwide, with more than 160 single mutations reported in G6PD. The most severe mutations (about 70) are classified as class I, leading to more...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2022790118

    authors: Horikoshi N,Hwang S,Gati C,Matsui T,Castillo-Orellana C,Raub AG,Garcia AA,Jabbarpour F,Batyuk A,Broweleit J,Xiang X,Chiang A,Broweleit R,Vöhringer-Martinez E,Mochly-Rosen D,Wakatsuki S

    更新日期:2021-01-26 00:00:00

  • Bifurcation of excited state trajectories toward energy transfer or electron transfer directed by wave function symmetry.

    abstract::This work explores the concept that differential wave function overlap between excited states can be engineered within a molecular chromophore. The aim is to control excited state wave function symmetries, so that symmetry matches or mismatches result in differential orbital overlap and define low-energy trajectories ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2018521118

    authors: Oviedo PS,Baraldo LM,Cadranel A

    更新日期:2021-01-26 00:00:00

  • An evidence review of face masks against COVID-19.

    abstract::The science around the use of masks by the public to impede COVID-19 transmission is advancing rapidly. In this narrative review, we develop an analytical framework to examine mask usage, synthesizing the relevant literature to inform multiple areas: population impact, transmission characteristics, source control, wea...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,评审

    doi:10.1073/pnas.2014564118

    authors: Howard J,Huang A,Li Z,Tufekci Z,Zdimal V,van der Westhuizen HM,von Delft A,Price A,Fridman L,Tang LH,Tang V,Watson GL,Bax CE,Shaikh R,Questier F,Hernandez D,Chu LF,Ramirez CM,Rimoin AW

    更新日期:2021-01-26 00:00:00

  • Ferric heme as a CO/NO sensor in the nuclear receptor Rev-Erbß by coupling gas binding to electron transfer.

    abstract::Rev-Erbβ is a nuclear receptor that couples circadian rhythm, metabolism, and inflammation. Heme binding to the protein modulates its function as a repressor, its stability, its ability to bind other proteins, and its activity in gas sensing. Rev-Erbβ binds Fe3+-heme more tightly than Fe2+-heme, suggesting its activit...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2016717118

    authors: Sarkar A,Carter EL,Harland JB,Speelman AL,Lehnert N,Ragsdale SW

    更新日期:2021-01-19 00:00:00

  • Vaccinology in the post-COVID-19 era.

    abstract::The COVID-19 pandemic is a shocking reminder of how our world would look in the absence of vaccination. Fortunately, new technologies, the pace of understanding new and existing pathogens, and the increased knowledge of the immune system allow us today to develop vaccines at an unprecedented speed. Some of the vaccine...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2020368118

    authors: Rappuoli R,De Gregorio E,Del Giudice G,Phogat S,Pecetta S,Pizza M,Hanon E

    更新日期:2021-01-19 00:00:00

  • Photosynthesis-assisted remodeling of three-dimensional printed structures.

    abstract::The mechanical properties of engineering structures continuously weaken during service life because of material fatigue or degradation. By contrast, living organisms are able to strengthen their mechanical properties by regenerating parts of their structures. For example, plants strengthen their cell structures by tra...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2016524118

    authors: Yu K,Feng Z,Du H,Xin A,Lee KH,Li K,Su Y,Wang Q,Fang NX,Daraio C

    更新日期:2021-01-19 00:00:00

  • Emergence of homochirality in large molecular systems.

    abstract::The selection of a single molecular handedness, or homochirality across all living matter, is a mystery in the origin of life. Frank's seminal model showed in the '50s how chiral symmetry breaking can occur in nonequilibrium chemical networks. However, an important shortcoming in this classic model is that it consider...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2012741118

    authors: Laurent G,Lacoste D,Gaspard P

    更新日期:2021-01-19 00:00:00

  • Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity.

    abstract::In many eukaryotic systems during immune responses, mitogen-activated protein kinases (MAPKs) link cytoplasmic signaling to chromatin events by targeting transcription factors, chromatin remodeling complexes, and the RNA polymerase machinery. So far, knowledge on these events is scarce in plants and no attempts have b...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2004670118

    authors: Rayapuram N,Jarad M,Alhoraibi HM,Bigeard J,Abulfaraj AA,Völz R,Mariappan KG,Almeida-Trapp M,Schlöffel M,Lastrucci E,Bonhomme L,Gust AA,Mithöfer A,Arold ST,Pflieger D,Hirt H

    更新日期:2021-01-19 00:00:00

  • Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance.

    abstract::Genetic variants underlying life-threatening diseases, being unlikely to be transmitted to the next generation, are gradually and selectively eliminated from the population through negative selection. We study the determinants of this evolutionary process in human genes underlying monogenic diseases by comparing vario...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2001248118

    authors: Rapaport F,Boisson B,Gregor A,Béziat V,Boisson-Dupuis S,Bustamante J,Jouanguy E,Puel A,Rosain J,Zhang Q,Zhang SY,Gleeson JG,Quintana-Murci L,Casanova JL,Abel L,Patin E

    更新日期:2021-01-19 00:00:00

  • Induced transparency by interference or polarization.

    abstract::Polarization of optical fields is a crucial degree of freedom in the all-optical analogue of electromagnetically induced transparency (EIT). However, the physical origins of EIT and polarization-induced phenomena have not been well distinguished, which can lead to confusion in associated applications such as slow ligh...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2012982118

    authors: Wang C,Jiang X,Sweeney WR,Hsu CW,Liu Y,Zhao G,Peng B,Zhang M,Jiang L,Stone AD,Yang L

    更新日期:2021-01-19 00:00:00

  • A rate threshold mechanism regulates MAPK stress signaling and survival.

    abstract::Cells are exposed to changes in extracellular stimulus concentration that vary as a function of rate. However, how cells integrate information conveyed from stimulation rate along with concentration remains poorly understood. Here, we examined how varying the rate of stress application alters budding yeast mitogen-act...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2004998118

    authors: Johnson AN,Li G,Jashnsaz H,Thiemicke A,Kesler BK,Rogers DC,Neuert G

    更新日期:2021-01-12 00:00:00

  • Nonlinear trends in abundance and diversity and complex responses to climate change in Arctic arthropods.

    abstract::Time series data on arthropod populations are critical for understanding the magnitude, direction, and drivers of change. However, most arthropod monitoring programs are short-lived and restricted in taxonomic resolution. Monitoring data from the Arctic are especially underrepresented, yet critical to uncovering and u...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2002557117

    authors: Høye TT,Loboda S,Koltz AM,Gillespie MAK,Bowden JJ,Schmidt NM

    更新日期:2021-01-12 00:00:00

  • Insects and recent climate change.

    abstract::Insects have diversified through more than 450 million y of Earth's changeable climate, yet rapidly shifting patterns of temperature and precipitation now pose novel challenges as they combine with decades of other anthropogenic stressors including the conversion and degradation of land. Here, we consider how insects ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2002543117

    authors: Halsch CA,Shapiro AM,Fordyce JA,Nice CC,Thorne JH,Waetjen DP,Forister ML

    更新日期:2021-01-12 00:00:00

  • Lithogenic hydrogen supports microbial primary production in subglacial and proglacial environments.

    abstract::Life in environments devoid of photosynthesis, such as on early Earth or in contemporary dark subsurface ecosystems, is supported by chemical energy. How, when, and where chemical nutrients released from the geosphere fuel chemosynthetic biospheres is fundamental to understanding the distribution and diversity of life...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2007051117

    authors: Dunham EC,Dore JE,Skidmore ML,Roden EE,Boyd ES

    更新日期:2021-01-12 00:00:00

  • Measuring the subcellular compartmentalization of viral infections by protein complementation assay.

    abstract::The recent emergence and reemergence of viruses in the human population has highlighted the need to develop broader panels of therapeutic molecules. High-throughput screening assays opening access to untargeted steps of the viral replication cycle will provide powerful leverage to identify innovative antiviral molecul...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2010524118

    authors: Fernandez J,Hassen-Khodja C,Georget V,Rose T,Jacob Y,Janin YL,Nisole S,Vidalain PO,Arhel NJ

    更新日期:2021-01-12 00:00:00

  • Doping evolution of the Mott-Hubbard landscape in infinite-layer nickelates.

    abstract::The recent observation of superconductivity in [Formula: see text] has raised fundamental questions about the hierarchy of the underlying electronic structure. Calculations suggest that this system falls in the Mott-Hubbard regime, rather than the charge-transfer configuration of other nickel oxides and the supercondu...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2007683118

    authors: Goodge BH,Li D,Lee K,Osada M,Wang BY,Sawatzky GA,Hwang HY,Kourkoutis LF

    更新日期:2021-01-12 00:00:00

  • Cross-subunit interactions that stabilize open states mediate gating in NMDA receptors.

    abstract::NMDA receptors are excitatory channels with critical functions in the physiology of central synapses. Their activation reaction proceeds as a series of kinetically distinguishable, reversible steps, whose structural bases are currently under investigation. Very likely, the earliest steps include glutamate binding to g...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2007511118

    authors: Iacobucci GJ,Wen H,Helou M,Liu B,Zheng W,Popescu GK

    更新日期:2021-01-12 00:00:00

  • Acidity across the interface from the ocean surface to sea spray aerosol.

    abstract::Aerosols impact climate, human health, and the chemistry of the atmosphere, and aerosol pH plays a major role in the physicochemical properties of the aerosol. However, there remains uncertainty as to whether aerosols are acidic, neutral, or basic. In this research, we show that the pH of freshly emitted (nascent) sea...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2018397118

    authors: Angle KJ,Crocker DR,Simpson RMC,Mayer KJ,Garofalo LA,Moore AN,Mora Garcia SL,Or VW,Srinivasan S,Farhan M,Sauer JS,Lee C,Pothier MA,Farmer DK,Martz TR,Bertram TH,Cappa CD,Prather KA,Grassian VH

    更新日期:2021-01-12 00:00:00

  • Ocean melting of the Zachariae Isstrøm and Nioghalvfjerdsfjorden glaciers, northeast Greenland.

    abstract::Zachariae Isstrøm (ZI) and Nioghalvfjerdsfjorden (79N) are marine-terminating glaciers in northeast Greenland that hold an ice volume equivalent to a 1.1-m global sea level rise. ZI lost its floating ice shelf, sped up, retreated at 650 m/y, and experienced a 5-gigaton/y mass loss. Glacier 79N has been more stable des...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2015483118

    authors: An L,Rignot E,Wood M,Willis JK,Mouginot J,Khan SA

    更新日期:2021-01-12 00:00:00

  • Mechanisms and plasticity of chemogenically induced interneuronal suppression of principal cells.

    abstract::How do firing patterns in a cortical circuit change when inhibitory neurons are excited? We virally expressed an excitatory designer receptor exclusively activated by a designer drug (Gq-DREADD) in all inhibitory interneuron types of the CA1 region of the hippocampus in the rat. While clozapine N-oxide (CNO) activatio...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2014157118

    authors: Rogers S,Rozman PA,Valero M,Doyle WK,Buzsáki G

    更新日期:2021-01-12 00:00:00

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