Insects and recent climate change.

abstract：:There has been an increasing interest in cyanobacteria because these photosynthetic organisms convert solar energy into biomass and because of their potential for the production of biofuels. However, the exploitation of cyanobacteria for bioengineering requires knowledge of their transcriptional organization. Using di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitschke J,Georg J,Scholz I,Sharma CM,Dienst D,Bantscheff J,Voss B,Steglich C,Wilde A,Vogel J,Hess WR

更新日期：2011-02-01 00:00:00

abstract：:The approximately 30-kb coronavirus (+)RNA genome is replicated and transcribed by a membrane-bound replicase complex made up of 16 viral nonstructural proteins (nsp) with multiple enzymatic activities. The complex includes an RNA endonuclease, NendoU, that is conserved among nidoviruses but no other RNA virus, making...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ricagno S,Egloff MP,Ulferts R,Coutard B,Nurizzo D,Campanacci V,Cambillau C,Ziebuhr J,Canard B

更新日期：2006-08-08 00:00:00

abstract：:Adult human brains retain the capacity to undergo tissue reorganization during second-language learning. Brain-imaging studies show a relationship between neuroanatomical properties and learning for adults exposed to a second language. However, the role of genetic factors in this relationship has not been investigated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mamiya PC,Richards TL,Coe BP,Eichler EE,Kuhl PK

更新日期：2016-06-28 00:00:00

abstract：:Mobile ectothermic animals can control their body temperatures by selecting specific thermal conditions in the environment, but embryos--trapped within an immobile egg and lacking locomotor structures--have been assumed to lack that ability. Falsifying that assumption, our experimental studies show that even early sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du WG,Zhao B,Chen Y,Shine R

更新日期：2011-06-07 00:00:00

abstract：:The periaqueductal gray (PAG) and amygdala are known to be important for defensive responses, and many contemporary fear-conditioning models present the PAG as downstream of the amygdala, directing the appropriate behavior (i.e., freezing or fleeing). However, empirical studies of this circuitry are inconsistent and w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim EJ,Horovitz O,Pellman BA,Tan LM,Li Q,Richter-Levin G,Kim JJ

更新日期：2013-09-03 00:00:00

abstract：:We performed label-free observation of molecular dynamics in apoptotic cells by Raman microscopy. Dynamic changes in cytochrome c distribution at the Raman band of 750 cm(-1) were observed after adding an apoptosis inducer to the cells. The comparison of mitochondria fluorescence images and Raman images of cytochrome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada M,Smith NI,Palonpon AF,Endo H,Kawata S,Sodeoka M,Fujita K

更新日期：2012-01-03 00:00:00

abstract：:Organic matter is responsible for the generation of hydrocarbons during the thermal maturation of source rock formation. This geochemical process engenders a network of organic hosted pores that governs the flow of hydrocarbons from the organic matter to fractures created during the stimulation of production wells. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berthonneau J,Obliger A,Valdenaire PL,Grauby O,Ferry D,Chaudanson D,Levitz P,Kim JJ,Ulm FJ,Pellenq RJ

更新日期：2018-12-04 00:00:00

abstract：:Suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability. However, the mechanism for regulation of the enzymatic activity of SUV39H1 in cancer cells is not yet well known. In this stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Zhou J,Liu X,Lu D,Shen C,Du Y,Wei FZ,Song B,Lu X,Yu Y,Wang L,Zhao Y,Wang H,Yang Y,Akiyama Y,Zhang H,Zhu WG

更新日期：2013-04-02 00:00:00

abstract：:Cosuppression results in the degradation of RNA from host genes and homologous transgenes after transcription in the nucleus. By using grafting experiments, we have shown previously that a systemic signal mediates the propagation of cosuppression of Nia host genes and 35S-Nia2 transgenes from silenced 35S-Nia2 transge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palauqui JC,Vaucheret H

更新日期：1998-08-04 00:00:00

abstract：:Mutant alleles at the dilute unconventional myosin heavy chain locus cause diluted coat color, opisthotonic seizures, and death. The dilute coat color phenotype is caused by irregular clumping of pigment in the hair, but amounts of melanin are unchanged from wild-type controls. The melanocyte phenotype has been descri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Provance DW Jr,Wei M,Ipe V,Mercer JA

更新日期：1996-12-10 00:00:00

abstract：:In colloidal systems, the interplay between the short range attraction and long-range repulsion can lead to a low density associated state consisting of clusters of individual particles. Recently, such an equilibrium cluster phase was also reported for concentrated solutions of lysozyme at low ionic strength and close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla A,Mylonas E,Di Cola E,Finet S,Timmins P,Narayanan T,Svergun DI

更新日期：2008-04-01 00:00:00

abstract：:Bloom syndrome is a disorder of profound and early cancer predisposition in which cells become hypermutable, exhibit high frequency of sister chromatid exchanges, and show increased micronuclei. BLM, the gene mutated in Bloom syndrome, has been cloned previously, and the BLM protein is a member of the RecQ family of D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imamura O,Campbell JL

更新日期：2003-07-08 00:00:00

abstract：:Sequencing of a 360-nucleotide segment of the mitochondrial control region for 63 individuals from an Amerindian tribe, the Nuu-Chah-Nulth of the Pacific Northwest, revealed the existence of 28 lineages defined by 26 variable positions. This represents a substantial level of mitochondrial diversity for a small local p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ward RH,Frazier BL,Dew-Jager K,Pääbo S

更新日期：1991-10-01 00:00:00

abstract：:The glycosyltransferases of the mammalian Golgi complex must recycle between the stacked cisternae of that organelle to maintain their proper steady-state localization. This trafficking is mediated by COPI-coated vesicles, but how the glycosyltransferases are incorporated into these transport vesicles is poorly unders...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Doray B,Kornfeld S

更新日期：2018-09-04 00:00:00

abstract：:In liquids realm, surface tension and capillarity are the key forces driving the formation of the shapes pervading the nature. The steady dew drops appearing on plant leaves and spider webs result from the minimization of the overall surface energy [Zheng Y, et al. (2010) Nature 463:640-643]. Thanks to the surface ten...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grilli S,Coppola S,Vespini V,Merola F,Finizio A,Ferraro P

更新日期：2011-09-13 00:00:00

abstract：:BACE1 is the rate-limiting enzyme for amyloid-β peptides (Aβ) generation, a key event in the pathogenesis of Alzheimer's disease (AD). By an unknown mechanism, levels of BACE1 and a BACE1 mRNA-stabilizing antisense RNA (BACE1-AS) are elevated in the brains of AD patients, implicating that dysregulation of BACE1 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bahn G,Park JS,Yun UJ,Lee YJ,Choi Y,Park JS,Baek SH,Choi BY,Cho YS,Kim HK,Han J,Sul JH,Baik SH,Lim J,Wakabayashi N,Bae SH,Han JW,Arumugam TV,Mattson MP,Jo DG

更新日期：2019-06-18 00:00:00

abstract：:Children who are treated for congenital cataracts later exhibit impairments in configural face analysis. This has been explained in terms of a critical period for the acquisition of normal face processing. Here, we consider a more parsimonious account according to which deficits in configural analysis result from the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vogelsang L,Gilad-Gutnick S,Ehrenberg E,Yonas A,Diamond S,Held R,Sinha P

更新日期：2018-10-30 00:00:00

abstract：:Land plants have distinct developmental programs in haploid (gametophyte) and diploid (sporophyte) generations. Although usually the two programs strictly alternate at fertilization and meiosis, one program can be induced during the other program. In a process called apogamy, cells of the gametophyte other than the eg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okano Y,Aono N,Hiwatashi Y,Murata T,Nishiyama T,Ishikawa T,Kubo M,Hasebe M

更新日期：2009-09-22 00:00:00

abstract：:We report the crystal structure of a translation termination complex formed by the Thermus thermophilus 70S ribosome bound with release factor RF2, in response to a UAA stop codon, solved at 3 A resolution. The backbone of helix alpha5 and the side chain of serine of the conserved SPF motif of RF2 recognize U1 and A2 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korostelev A,Asahara H,Lancaster L,Laurberg M,Hirschi A,Zhu J,Trakhanov S,Scott WG,Noller HF

更新日期：2008-12-16 00:00:00

abstract：:Campylobacter jejuni has a general N-linked glycosylation pathway (encoded by the pgl gene cluster), which culminates in the transfer of a heptasaccharide: GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac [where Bac is bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glover KJ,Weerapana E,Imperiali B

更新日期：2005-10-04 00:00:00

abstract：:Human cytomegalovirus (HCMV) infection alters the expression of many cellular genes, including IFN-stimulated genes (ISGs) [Zhu, H., Cong, J.-P., Mamtora, G., Gingeras, T. & Shenk, T. (1998) Proc. Natl. Acad. Sci. USA 95, 14470-14475]. By using high-density cDNA microarrays, we show that the HCMV-regulated gene expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simmen KA,Singh J,Luukkonen BG,Lopper M,Bittner A,Miller NE,Jackson MR,Compton T,Früh K

更新日期：2001-06-19 00:00:00

abstract：:The amino-terminal amino acid sequence and several internal peptide sequences of angiotensin I-converting enzyme (ACE; peptidyl-dipeptidase A, kininase II; EC 3.4.15.1) purified from human kidney were used to design oligonucleotide probes. The nucleotide sequence of ACE mRNA was determined by molecular cloning of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soubrier F,Alhenc-Gelas F,Hubert C,Allegrini J,John M,Tregear G,Corvol P

更新日期：1988-12-01 00:00:00

abstract：:The Schiff base adducts of glyceraldehyde with hemoglobin undergo Amadori rearrangement to form stable ketoamine structures; this reaction is similar to the nonenzymic glucosylation of proteins. In the present studies the analogous rearrangement of the Schiff base adducts of glycolaldehyde with proteins has been demon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acharya AS,Manning JM

更新日期：1983-06-01 00:00:00

abstract：:As a direct simulation of a multistep proton transfer reaction involving protein residues, the proton relay shuttle between A and I forms of green fluorescent protein (GFP) is simulated in atomic detail by using a special molecular dynamics simulation technique. Electronic excitation of neutral chromophore in wild-typ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lill MA,Helms V

更新日期：2002-03-05 00:00:00

abstract：:An electrophoretic karyotype of Aspergillus nidulans has been obtained using contour-clamped homogeneous electric field gel electrophoresis. Six chromosomal bands were separated, with two of the bands migrating as doublets. Using the Schizosaccharomyces pombe and Saccharomyces cerevisiae chromosomes as size standards,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brody H,Carbon J

更新日期：1989-08-01 00:00:00

abstract：:Here we show how a simple inorganic salt can spontaneously form autocatalytic sets of replicating inorganic molecules that work via molecular recognition based on the {PMo12} ≡ [PMo12O40]3- Keggin ion, and {Mo36} ≡ [H3Mo57M6(NO)6O183(H2O)18]22- cluster. These small clusters are able to catalyze their own formation via...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miras HN,Mathis C,Xuan W,Long DL,Pow R,Cronin L

更新日期：2020-05-19 00:00:00

abstract：:Glycoprotein Ib is a surface membrane glycoprotein of platelets that functions as a receptor for von Willebrand factor. It is a heterodimer composed of an alpha and a beta chain linked by a disulfide bond(s). A phage lambda gt11 cDNA expression library prepared from mRNA from a human erythroleukemia cell line, HEL, wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lopez JA,Chung DW,Fujikawa K,Hagen FS,Papayannopoulou T,Roth GJ

更新日期：1987-08-01 00:00:00

abstract：:Two human 12-lipoxygenase enzyme (arachidonate:oxygen 12-oxidoreductase, EC 1.13.11.31)-related genes were characterized from 13 distinct clones isolated from three genomic bacteriophage and cosmid libraries. A complete gene (12-lipoxygenase gene 1) spanning approximately 17 kilobases and consisting of 14 exons with s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Funk CD,Funk LB,FitzGerald GA,Samuelsson B

更新日期：1992-05-01 00:00:00

abstract：:Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability and microenvironment-induced resistance. Herein, we engineered bone-homing polymeric nanopartic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swami A,Reagan MR,Basto P,Mishima Y,Kamaly N,Glavey S,Zhang S,Moschetta M,Seevaratnam D,Zhang Y,Liu J,Memarzadeh M,Wu J,Manier S,Shi J,Bertrand N,Lu ZN,Nagano K,Baron R,Sacco A,Roccaro AM,Farokhzad OC,Ghobrial

更新日期：2014-07-15 00:00:00

abstract：:Administration of gamma-glutamylcysteinylglycyl monomethyl (or monoethyl) ester to mice leads to substantial increases in the levels of glutathione in the liver and kidney. Mice depleted of glutathione by treatment with buthionine sulfoximine, a potent inhibitor of gamma-glutamylcysteine synthetase, exhibited about a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puri RN,Meister A

更新日期：1983-09-01 00:00:00