Photosynthesis-assisted remodeling of three-dimensional printed structures.

abstract：:We discuss some recent progress on the regularity theory of the elliptic Yang-Mills equation. We start with some basic properties of the elliptic Yang-Mills equation, such as Coulomb gauges, monotonicity, and curvature estimates. Next we discuss singularity of stationary Yang-Mills connections and compactness theorems...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian G

更新日期：2002-11-26 00:00:00

abstract：:The ability of bacteria to regulate gene expression in response to changes in cell density is termed quorum sensing. This behavior involves the synthesis and recognition of extracellular, hormone-like compounds known as autoinducers. Here we report the structure of an autoinducer synthase, LuxS from Bacillus subtilis,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilgers MT,Ludwig ML

更新日期：2001-09-25 00:00:00

abstract：:Model organism studies have demonstrated that cell fate specification decisions play an important role in normal brain development. Their role in human neurodevelopmental disorders, however, is poorly understood, with very few examples described. The cerebellum is an excellent system to study mechanisms of cell fate s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millen KJ,Steshina EY,Iskusnykh IY,Chizhikov VV

更新日期：2014-04-29 00:00:00

abstract：:We have developed an efficient method to target lentivirus-mediated gene transduction to a desired cell type. It involves incorporation of antibody and fusogenic protein as two distinct molecules into the lentiviral surface. The fusogen is constructed by modifying viral envelope proteins, so that they lack the ability...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang L,Bailey L,Baltimore D,Wang P

更新日期：2006-08-01 00:00:00

abstract：:Cytoplasmic RNA extracted from human tissue culture cells infected with adenovirus type 2 was used to program protein synthesis in a cell-free system derived from mammalian cells. Analysis of the protein product by polyacrylamide gel electrophoresis revealed ten adenovirus-specific polypeptides. Five of these were fur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson CW,Lewis JB,Atkins JF,Gesteland RF

更新日期：1974-07-01 00:00:00

abstract：:We report on preparation of rhodopsin proteoliposomes with the cytoplasmic domain of rhodopsin facing the exterior of the proteoliposomes. Rhodopsin purified from rod outer segments of bovine retinae by immunoaffinity chromatography in octyl glucoside was reconstituted into liposomes prepared from soybean phospholipid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Niu L,Kim JM,Khorana HG

更新日期：2002-10-15 00:00:00

abstract：:Lung adenocarcinomas harboring activating mutations in the epidermal growth factor receptor (EGFR) represent a common molecular subset of non-small cell lung cancer (NSCLC) cases. EGFR mutations predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs) and thus represent a dependency in NSCLCs harboring these alte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharifnia T,Rusu V,Piccioni F,Bagul M,Imielinski M,Cherniack AD,Pedamallu CS,Wong B,Wilson FH,Garraway LA,Altshuler D,Golub TR,Root DE,Subramanian A,Meyerson M

更新日期：2014-12-30 00:00:00

abstract：:Eleven amino acid positions in the helix-turn-helix of lambda repressor have been mutagenized by using a combinatorial method in which alanine is substituted at each position with a probability of 0.5. Approximately 25% of the 2048 proteins in the resulting binomial library are active, including some variants with as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregoret LM,Sauer RT

更新日期：1993-05-01 00:00:00

abstract：:A cDNA clone that hybridizes to an mRNA (1A10) that accumulates to a substantial level in the axis of the germinating soybean seed was sequenced. The amino acid sequence of the clone indicates an almost perfect repeat of Pro-Pro-Val-Tyr-Lys resulting in a protein containing 40% proline and lacking serine and histidine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averyhart-Fullard V,Datta K,Marcus A

更新日期：1988-02-01 00:00:00

abstract：:The eukaryotic proteasome mediates degradation of polyubiquitinated proteins. Here we report the single-particle cryoelectron microscopy (cryo-EM) structures of the endogenous 26S proteasome from Saccharomyces cerevisiae at 4.6- to 6.3-Å resolution. The fine features of the cryo-EM maps allow modeling of 18 subunits i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luan B,Huang X,Wu J,Mei Z,Wang Y,Xue X,Yan C,Wang J,Finley DJ,Shi Y,Wang F

更新日期：2016-03-08 00:00:00

abstract：:A series of pyrimidine nucleoside analogues containing [2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino- 1'',2''-oxathiole-2'',2''-dioxide)]-beta-D-ribofuranose as the pentose were found to inhibit human immunodeficiency virus type 1 [HIV-1(IIIB)] replication at a concentration of 0.06-0.8 microM but wer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balzarini J,Pérez-Pérez MJ,San-Félix A,Schols D,Perno CF,Vandamme AM,Camarasa MJ,De Clercq E

更新日期：1992-05-15 00:00:00

abstract：:A central tenet of evolutionary social science holds that behaviors, such as those associated with social dominance, produce fitness effects that are subject to cultural selection. However, evidence for such selection is inconclusive because it is based on short-term statistical associations between behavior and ferti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lansing JS,Watkins JC,Hallmark B,Cox MP,Karafet TM,Sudoyo H,Hammer MF

更新日期：2008-08-19 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF)/usual interstitial pneumonia is a ravaging condition of progressive lung scarring and destruction. Anti-inflammatory therapies including corticosteroids have limited efficacy in this ultimately fatal disorder. An important unmet need is to identify new agents that interact with key ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henderson WR Jr,Chi EY,Ye X,Nguyen C,Tien YT,Zhou B,Borok Z,Knight DA,Kahn M

更新日期：2010-08-10 00:00:00

abstract：:We determined the genomic sequence at the site of insertion in 2,266 unselected P element insertion events. Estimating physical properties of the genomic DNA at these insertion sites-such as base composition, bendability, A-philicity, protein-induced deformability, and B-DNA twist-revealed that they differ significant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao GC,Rehm EJ,Rubin GM

更新日期：2000-03-28 00:00:00

abstract：:Certain mutations at the glaB locus result in the failure to fully derepress glutamine synthetase [L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2] and to convert it to the active nonadenylylated form in response to nitrogen limitation. In these mutants the PII regulatory protein is altered such that it cannot be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foor F,Reuveny Z,Magasanik B

更新日期：1980-05-01 00:00:00

abstract：:Neutron diffraction maps have been used to assign the rotor conformations of the hydroxyl hydrogens in trypsin. Knowledge of these conformations is used to assess the relative importance of steric and electrostatic effects in conferring the H-bonding geometries of these groups. A general finding was that most hydroxyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kossiakoff AA,Shpungin J,Sintchak MD

更新日期：1990-06-01 00:00:00

abstract：:Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs). The Escherichia coli class Ia RNR uses a mechanism of radical propagation by which a cysteine in the active site of the RNR large (α2) subunit is transiently oxidized by a stable tyrosyl radical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minnihan EC,Ando N,Brignole EJ,Olshansky L,Chittuluru J,Asturias FJ,Drennan CL,Nocera DG,Stubbe J

更新日期：2013-03-05 00:00:00

abstract：:FAP48 was identified and cloned thanks to its interaction with FK506-binding proteins (FKBPs) such as FKBP52 and FKBP12, which belong to the large family of immunophilins that bind the macrolide immunosuppressant drugs FK506 and rapamycin. We have previously shown that FAP48-FKBP complexes are dissociated by FK506 and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krummrei U,Baulieu EE,Chambraud B

更新日期：2003-03-04 00:00:00

abstract：:CCAAT displacement protein (CDP), a nuclear protein of 180-190 kDa, contains a triplicated motif, the cut domain, similar (80-90% conserved) to three repeats of 60-65 amino acids first identified in Drosophila cut, a homeo-domain protein involved in cell-fate decisions in development. Cut repeats bind DNA and exhibit ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aufiero B,Neufeld EJ,Orkin SH

更新日期：1994-08-02 00:00:00

abstract：:A hierarchy of residue density assessments and packing properties in protein structures are contrasted, including a regular density, a variety of charge densities, a hydrophobic density, a polar density, and an aromatic density. These densities are investigated by alternative distance measures and also at the interfac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baud F,Karlin S

更新日期：1999-10-26 00:00:00

abstract：:Synapsins are abundant synaptic-vesicle phosphoproteins that are known to regulate neurotransmitter release but whose precise function has been difficult to pinpoint. Here, we use knockout mice to analyze the role of synapsins 1 and 2 in the calyx of Held synapse, allowing precise measurements of neurotransmitter rele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun J,Bronk P,Liu X,Han W,Südhof TC

更新日期：2006-02-21 00:00:00

abstract：:Whereas amyloid-β (Aβ) accumulates in the brain of normal animals dosed with low levels of copper (Cu), the mechanism is not completely known. Cu could contribute to Aβ accumulation by altering its clearance and/or its production. Because Cu homeostasis is altered in transgenic mice overexpressing Aβ precursor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh I,Sagare AP,Coma M,Perlmutter D,Gelein R,Bell RD,Deane RJ,Zhong E,Parisi M,Ciszewski J,Kasper RT,Deane R

更新日期：2013-09-03 00:00:00

abstract：:The nucleotide sequences of eight origin-defective mutants of simian virus 40 have been determined. All of the mutants have suffered deletions, which range in size from 4 to 241 nucleotides. Some of the mutants induce the synthesis of tumor (T) antigen, others do not. Viral mRNA extracted from rat cells transformed by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gluzman Y,Sambrook JF,Frisque RJ

更新日期：1980-07-01 00:00:00

abstract：:We present a mandible recovered in 2003 from the Aurora Stratum of the TD6 level of the Gran Dolina site (Sierra de Atapuerca, northern Spain). The specimen, catalogued as ATD6-96, adds to the hominin sample recovered from this site in 1994-1996, and assigned to Homo antecessor. ATD6-96 is the left half of a gracile m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carbonell E,Bermúdez de Castro JM,Arsuaga JL,Allue E,Bastir M,Benito A,Cáceres I,Canals T,Díez JC,van der Made J,Mosquera M,Ollé A,Pérez-González A,Rodríguez J,Rodríguez XP,Rosas A,Rosell J,Sala R,Vallverdú J,Vergés

更新日期：2005-04-19 00:00:00

abstract：:To identify genetic factors that interact with social environments to impact human health, we used a bioinformatic strategy that couples expression array-based detection of environmentally responsive transcription factors with in silico discovery of regulatory polymorphisms to predict genetic loci that modulate transc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole SW,Arevalo JM,Takahashi R,Sloan EK,Lutgendorf SK,Sood AK,Sheridan JF,Seeman TE

更新日期：2010-03-23 00:00:00

abstract：:The CRR1 (Copper Response Regulator) locus, required for both activating and repressing target genes of a copper- and hypoxia-sensing pathway in Chlamydomonas, encodes a 1,232-residue candidate transcription factor with a plant-specific DNA-binding domain named SBP, ankyrin repeats, and a C-terminal Cys-rich region, w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kropat J,Tottey S,Birkenbihl RP,Depège N,Huijser P,Merchant S

更新日期：2005-12-20 00:00:00

abstract：:We have previously shown that lymphoblasts alloactivated in vitro acquire the capacity of stimulating the autologous mixed lymphocyte response. This response is anti-idiotypic in nature because lymphocytes so primed display accelerated memory responses only when restimulated by autologous lymphoblasts that have been a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suciu-Foca N,Reed E,Rohowsky C,Kung P,King DW

更新日期：1983-02-01 00:00:00

abstract：:The sensitive and accurate quantification of protein biomarkers plays important roles in clinical diagnostics and biomedical research. Sandwich ELISA and its variants accomplish the capture and detection of a target protein via two antibodies that tightly bind at least two distinct epitopes of the same antigen and hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chatterjee T,Knappik A,Sandford E,Tewari M,Choi SW,Strong WB,Thrush EP,Oh KJ,Liu N,Walter NG,Johnson-Buck A

更新日期：2020-09-15 00:00:00

abstract：:The 1987 Montreal Protocol on Substances that Deplete the Ozone Layer is a landmark agreement that has successfully reduced the global production, consumption, and emissions of ozone-depleting substances (ODSs). ODSs are also greenhouse gases that contribute to the radiative forcing of climate change. Using historical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Velders GJ,Andersen SO,Daniel JS,Fahey DW,McFarland M

更新日期：2007-03-20 00:00:00

abstract：:IFN-gamma treatment of cells leads to tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 followed by dimerization through a reciprocal Src homology 2-phosphotyrosine interaction near the -COOH end of each monomer, forming a parallel structure that accumulates in the nucleus to drive ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong M,Henriksen MA,Takeuchi K,Schaefer O,Liu B,ten Hoeve J,Ren Z,Mao X,Chen X,Shuai K,Darnell JE Jr

更新日期：2005-03-15 00:00:00