解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Differential gene expression across cell types underlies development and cell physiology in multicellular organisms. Caenorhabditis elegans is a powerful, extensively used model to address these biological questions. A remaining bottleneck relates to the difficulty to obtain comprehensive tissue-specific gene transcri...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303774
更新日期:2020-12-01 00:00:00
abstract::Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combatin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303577
更新日期:2020-12-01 00:00:00
abstract::Small regulatory RNAs, such as small interfering RNAs (siRNAs) and PIWI-interacting RNAs, regulate splicing, transcription, and genome integrity in many eukaryotes. In Caenorhabditis elegans, siRNAs bind nuclear Argonautes (AGOs), which interact with homologous premessenger RNAs to recruit downstream silencing effecto...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303631
更新日期:2020-12-01 00:00:00
abstract::The biological basis of exercise behavior is increasingly relevant for maintaining healthy lifestyles. Various quantitative genetic studies and selection experiments have conclusively demonstrated substantial heritability for exercise behavior in both humans and laboratory rodents. In the "High Runner" selection exper...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303668
更新日期:2020-11-01 00:00:00
abstract::The polarized partitioning of proteins in cells underlies asymmetric cell division, which is an important driver of development and cellular diversity. The budding yeast Saccharomyces cerevisiae divides asymmetrically, like many other cells, to generate two distinct progeny cells. A well-known example of an asymmetric...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303439
更新日期:2020-11-01 00:00:00
abstract::Genetic drift is an important evolutionary force of strength inversely proportional to Ne , the effective population size. The impact of drift on genome diversity and evolution is known to vary among species, but quantifying this effect is a difficult task. Here we assess the magnitude of variation in drift power amon...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303622
更新日期:2020-10-01 00:00:00
abstract::Caenorhabditis elegans' behavioral states, like those of other animals, are shaped by its immediate environment, its past experiences, and by internal factors. We here review the literature on C. elegans behavioral states and their regulation. We discuss dwelling and roaming, local and global search, mate finding, sle...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303539
更新日期:2020-10-01 00:00:00
abstract::Temporally spaced genetic data allow for more accurate inference of population genetic parameters and hypothesis testing on the recent action of natural selection. In this work, we develop a novel likelihood-based method for jointly estimating selection coefficient and allele age from time series data of allele freque...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303400
更新日期:2020-10-01 00:00:00
abstract::Hybrid male sterility (HMS) contributes to reproductive isolation commonly observed among house mouse (Mus musculus) subspecies, both in the wild and in laboratory crosses. Incompatibilities involving specific Prdm9 alleles and certain Chromosome (Chr) X genotypes are known determinants of fertility and HMS, and previ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303474
更新日期:2020-10-01 00:00:00
abstract::Promoter proximal pausing (PPP) of RNA polymerase II has emerged as a crucial rate-limiting step in the regulation of gene expression. Regulation of PPP is brought about by complexes 7SK snRNP, P-TEFb (Cdk9/cycT), and the negative elongation factor (NELF), which are highly conserved from Drosophila to humans. Here, we...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303419
更新日期:2020-09-01 00:00:00
abstract::Remarkably complex patterns of aneuploidy have been observed in the genomes of many eukaryotic cell types, ranging from brewing yeasts to tumor cells. Such aberrant karyotypes are generally thought to take shape progressively over many generations, but evidence also suggests that genomes may undergo faster modes of ev...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303536
更新日期:2020-09-01 00:00:00
abstract::Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A To characterize the pathogenic substitution (p.H939R) of a local individual with Dravet syndrome, fibroblast cells from the individual were reprogrammed to pluripotent stem cells and differentiated into neurons. Sodium ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303399
更新日期:2020-08-01 00:00:00
abstract::Site-specific recombinases are widely used tools for analysis of genetics, development, and cell biology, and many schemes have been devised to alter gene expression by recombinase-mediated DNA rearrangements. Because the FRT and lox target sites for the commonly used FLP and Cre recombinases are asymmetrical, and mus...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303394
更新日期:2020-08-01 00:00:00
abstract::Many genetic variants identified in genome-wide association studies (GWAS) are associated with multiple, sometimes seemingly unrelated, traits. This motivates multi-trait association analyses, which have successfully identified novel associated loci for many complex diseases. While appealing, most existing methods foc...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303242
更新日期:2020-08-01 00:00:00
abstract::Plant breeders make selection decisions based on multiple traits, such as yield, plant height, flowering time, and disease resistance. A commonly used approach in multi-trait genomic selection is index selection, which assigns weights to different traits relative to their economic importance. However, classical index ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303305
更新日期:2020-08-01 00:00:00
abstract::As a genetic mutation is passed down across generations, it distinguishes those genomes that have inherited it from those that have not, providing a glimpse of the genealogical tree relating the genomes to each other at that site. Statistical summaries of genetic variation therefore also describe the underlying geneal...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303253
更新日期:2020-07-01 00:00:00
abstract::Whereas nonlinear relationships between genes are acknowledged, there exist only a few methods for estimating nonlinear gene coexpression networks or gene regulatory networks (GCNs/GRNs) with common deficiencies. These methods often consider only pairwise associations between genes, and are, therefore, poorly capable ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303186
更新日期:2020-07-01 00:00:00
abstract::The Genetics Society of America (GSA) Medal recognizes researchers who have made outstanding contributions to the field of genetics in the past 15 years. The 2019 GSA Medal is awarded to Bonnie L. Bassler of Princeton University and the Howard Hughes Medical Institute in recognition of her groundbreaking studies of ba...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303285
更新日期:2020-06-01 00:00:00
abstract::Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303120
更新日期:2020-05-01 00:00:00
abstract::The vertebrate limb serves as an experimental paradigm to study mechanisms that regulate development of the stereotypical skeletal elements. In this study, we simultaneously inactivated Sall4 using Hoxb6Cre and Plzf in mouse embryos, and found that their combined function regulates development of the proximal-anterior...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303069
更新日期:2020-05-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) are used widely for detecting quantitative trait loci, or for searching for causal variants of diseases. Nevertheless, structural variations such as copy-number variants (CNVs) represent a large part of natural genetic diversity, and contribute significantly to trait variation. N...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302881
更新日期:2020-03-01 00:00:00
abstract::Ribosome biogenesis is tightly regulated through stress-sensing pathways that impact genome stability, aging and senescence. In Saccharomyces cerevisiae, ribosomal RNAs are transcribed from rDNA located on the right arm of chromosome XII. Numerous studies reveal that rDNA decondenses into a puff-like structure during ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302994
更新日期:2020-03-01 00:00:00
abstract::The three-dimensional (3D) organization of chromosomes can influence transcription. However, the frequency and magnitude of these effects remain debated. To determine how changes in chromosome positioning affect transcription across thousands of genes with minimal perturbation, we characterized nuclear organization an...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302978
更新日期:2020-03-01 00:00:00
abstract::The past century has seen substantial theoretical and empirical progress on the genetic basis of adaptation. Over this same period, a pressing need to prevent the evolution of drug resistance has uncovered much about the potential genetic basis of persistence in declining populations. However, we have little theory to...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302890
更新日期:2020-02-01 00:00:00
abstract::The challenges of breeding autotetraploid potato (Solanum tuberosum) have motivated the development of alternative breeding strategies. A common approach is to obtain uniparental dihaploids from a tetraploid of interest through pollination with S. tuberosum Andigenum Group (formerly S. phureja) cultivars. The mechanis...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302843
更新日期:2020-02-01 00:00:00
abstract::Gastrulation is fundamental to the development of multicellular animals. Along with neurulation, gastrulation is one of the major processes of morphogenesis in which cells or whole tissues move from the surface of an embryo to its interior. Cell internalization mechanisms that have been discovered to date in Caenorhab...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.119.300240
更新日期:2020-02-01 00:00:00
abstract::Cell surface immunoglobulin superfamily (IgSF) proteins play important roles in the development and function of the nervous system . Here we define the role of a Caenorhabditis elegans IgSF protein, RIG-3, in the function of the AVA command interneuron. This study reveals that RIG-3 regulates the abundance of the glut...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302872
更新日期:2020-01-01 00:00:00
abstract::Life-history traits or "fitness components"-such as age and size at maturity, fecundity and fertility, age-specific rates of survival, and life span-are the major phenotypic determinants of Darwinian fitness. Analyzing the evolution and genetics of these phenotypic targets of selection is central to our understanding ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.119.300160
更新日期:2020-01-01 00:00:00
abstract::Previous models suggested that regulation of telomere length in Saccharomyces cerevisiae by Tel1(ATM) and Mec1(ATR) would parallel the established pathways regulating the DNA damage response. Here, we provide evidence that telomere length regulation differs from the DNA damage response in both the Tel1 and Mec1 pathwa...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302713
更新日期:2019-12-01 00:00:00
abstract::Lineage specification in early development is the basis for the exquisitely precise body plan of multicellular organisms. It is therefore critical to understand cell fate decisions in early development. Moreover, for regenerative medicine, the accurate specification of cell types to replace damaged/diseased tissue is ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.119.302661
更新日期:2019-12-01 00:00:00
abstract::In meiosis, multiple different DNA sequence motifs help to position homologous recombination at hotspots in the genome. How do the seemingly disparate cis-acting regulatory modules each promote locally the activity of the basal recombination machinery? We defined molecular mechanisms of action for five different hotsp...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302679
更新日期:2019-11-01 00:00:00
abstract::F1 hybrids between mouse inbred strains PWD and C57BL/6 represent the most thoroughly genetically defined model of hybrid sterility in vertebrates. Hybrid male sterility can be fully reconstituted from three components of this model, the Prdm9 gene, intersubspecific homeology of Mus musculus musculus and Mus musculus ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302554
更新日期:2019-11-01 00:00:00
abstract::The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302324
更新日期:2019-10-01 00:00:00
abstract::Crossovers (COs) between homologous chromosomes are critical for meiotic chromosome segregation and form in the context of the synaptonemal complex (SC), a meiosis-specific structure that assembles between aligned homologs. During Caenorhabditis elegans meiosis, central region components of the SC (SYP proteins) are e...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302625
更新日期:2019-10-01 00:00:00
abstract::A subset of cancers rely on telomerase-independent mechanisms to maintain their chromosome ends. The predominant "alternative lengthening of telomeres" pathway appears dependent on homology-directed repair (HDR) to maintain telomeric DNA. However, the molecular changes needed for cells to productively engage in telome...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302606
更新日期:2019-10-01 00:00:00
abstract::The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA variation may play in diverse cellular functions, aside from ribosome production, hig...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302351
更新日期:2019-09-01 00:00:00
abstract::As multi-individual population-scale data become available, more complex modeling strategies are needed to quantify genome-wide patterns of nucleotide usage and associated mechanisms of evolution. Recently, the multivariate neutral Moran model was proposed. However, it was shown insufficient to explain the distributio...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302074
更新日期:2019-08-01 00:00:00
abstract::The concept of haplotype blocks has been shown to be useful in genetics. Fields of application range from the detection of regions under positive selection to statistical methods that make use of dimension reduction. We propose a novel approach ("HaploBlocker") for defining and inferring haplotype blocks that focuses ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302283
更新日期:2019-08-01 00:00:00
abstract::Cell diversity in multicellular organisms relies on coordination between cell proliferation and the acquisition of cell identity. The equilibrium between these two processes is essential to assure the correct number of determined cells at a given time at a given place. Using genetic approaches and correlative microsco...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302234
更新日期:2019-07-01 00:00:00
abstract::Condensins are evolutionarily conserved protein complexes that are required for chromosome segregation during cell division and genome organization during interphase. In Caenorhabditis elegans, a specialized condensin, which forms the core of the dosage compensation complex (DCC), binds to and represses X chromosome t...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302254
更新日期:2019-07-01 00:00:00